Caterina Trevisan, Chiara Ceolin, Davide Liborio Vetrano, Mirko Petrovic, Gregory Y H Lip, Iain Buchan, Marina De Rui, Giuseppe Sergi, Stefania Maggi, Marianna Noale, Søren Påske Johnsen, Riccardo Proietti, Pia Cordsen, Gregory Lip, Deirdre Lane, Martin O'Flaherty, Carrol Gamble, Iain Buchan, Christodoulos Kypridemos, Brendan Collins, Donato Leo, Mirko Petrovic, Delphine De Smedt, Stefanie De Buyser, Cheima Amrouch, Davide Liborio Vetrano, Amaia Calderón-Larrañaga, Lu Dai, Stefania Maggi, Marianna Noale, D A N Gheorghe-Andrei, Anca Rodica Dan, Nicola Ferri, Alessandra Buja, Giuseppe Sergi, Vincenzo Stefano Rebba, Caterina Trevisan, Tatjana Potpara, Laura Vivani, Silvia Ananstasia, Alessandro Ferri, Gehad Shehata, Nadia Rosso, Marco Cicerone, Jacek Marczyk, Trudie Lobban, Georg Ruppe, Graziano Onder, Federica Censi, Robero Da Cas, Cecilia Damiano, Guendalina Graffigna, Caterina Bosio, Lorenzo Palamenghi, Serena Barello, Aldo Pietro Maggioni, Andrea Lorimer, Donata Lucci, Dipak Kalra, Nathan Lea, John Ainsworth, Charlotte Stockton-Powdrell, Alam Sanaullah, Francisco Marín, Vanessa Roldán, José Miguel Rivera-Caravaca, Mariya Tokmakova
{"title":"Frailty increases the risk of hospitalization for atrial fibrillation in older adults: a population-based cohort study.","authors":"Caterina Trevisan, Chiara Ceolin, Davide Liborio Vetrano, Mirko Petrovic, Gregory Y H Lip, Iain Buchan, Marina De Rui, Giuseppe Sergi, Stefania Maggi, Marianna Noale, Søren Påske Johnsen, Riccardo Proietti, Pia Cordsen, Gregory Lip, Deirdre Lane, Martin O'Flaherty, Carrol Gamble, Iain Buchan, Christodoulos Kypridemos, Brendan Collins, Donato Leo, Mirko Petrovic, Delphine De Smedt, Stefanie De Buyser, Cheima Amrouch, Davide Liborio Vetrano, Amaia Calderón-Larrañaga, Lu Dai, Stefania Maggi, Marianna Noale, D A N Gheorghe-Andrei, Anca Rodica Dan, Nicola Ferri, Alessandra Buja, Giuseppe Sergi, Vincenzo Stefano Rebba, Caterina Trevisan, Tatjana Potpara, Laura Vivani, Silvia Ananstasia, Alessandro Ferri, Gehad Shehata, Nadia Rosso, Marco Cicerone, Jacek Marczyk, Trudie Lobban, Georg Ruppe, Graziano Onder, Federica Censi, Robero Da Cas, Cecilia Damiano, Guendalina Graffigna, Caterina Bosio, Lorenzo Palamenghi, Serena Barello, Aldo Pietro Maggioni, Andrea Lorimer, Donata Lucci, Dipak Kalra, Nathan Lea, John Ainsworth, Charlotte Stockton-Powdrell, Alam Sanaullah, Francisco Marín, Vanessa Roldán, José Miguel Rivera-Caravaca, Mariya Tokmakova","doi":"10.1016/j.numecd.2025.104159","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and aims: </strong>Atrial fibrillation (AF) is more common with increasing age and older adults have greater prevalence of frailty, multimorbidity and polypharmacy, which may impact clinical outcomes. The present study aims to investigate the relationship between frailty and the risk of hospitalization for AF in older adults, and second, the possible interaction of multimorbidity in this association.</p><p><strong>Methods and results: </strong>Data from the Progetto Veneto Anziani (Pro.V.A.), an observational cohort study in north-eastern Italy, were utilised. The analyses included 2909 individuals aged ≥65 years without AF at baseline, assessed between 1995 and 1997, with follow-ups at 4.4 and 7 years. Frailty was defined according to Fried's criteria, and multimorbidity as the number of chronic diseases. AF-related hospitalizations and deaths were recorded up to December 31, 2018. Multi-adjusted mixed-effects Cox regressions were performed to test associations. Over the follow-up period, 318 (10.9 %) participants experienced AF-related hospitalizations. Compared to robust participants, the hazard ratio (HR) of hospitalizations due to AF was 1.42 (95 % Confidence Interval (95 %CI): 1.04-1.95) in pre-frail and 1.98 (95 %CI: 1.21-3.26) in frail individuals, even after adjusting for multimorbidity. The number of chronic diseases was only marginally and not significantly associated with AF-related hospitalizations (HR 1.07, 95 %CI: 0.99-1.15), but did not significantly interact with frailty in the association with AF-related hospitalizations.</p><p><strong>Conclusion: </strong>Older adults with frailty present with higher hazards of AF-related hospitalizations, irrespective of the presence of multimorbidity. Further studies are needed to evaluate whether reducing frailty may prevent AF development and improve health outcomes in older adults.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104159"},"PeriodicalIF":3.3000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Metabolism and Cardiovascular Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.numecd.2025.104159","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background and aims: Atrial fibrillation (AF) is more common with increasing age and older adults have greater prevalence of frailty, multimorbidity and polypharmacy, which may impact clinical outcomes. The present study aims to investigate the relationship between frailty and the risk of hospitalization for AF in older adults, and second, the possible interaction of multimorbidity in this association.
Methods and results: Data from the Progetto Veneto Anziani (Pro.V.A.), an observational cohort study in north-eastern Italy, were utilised. The analyses included 2909 individuals aged ≥65 years without AF at baseline, assessed between 1995 and 1997, with follow-ups at 4.4 and 7 years. Frailty was defined according to Fried's criteria, and multimorbidity as the number of chronic diseases. AF-related hospitalizations and deaths were recorded up to December 31, 2018. Multi-adjusted mixed-effects Cox regressions were performed to test associations. Over the follow-up period, 318 (10.9 %) participants experienced AF-related hospitalizations. Compared to robust participants, the hazard ratio (HR) of hospitalizations due to AF was 1.42 (95 % Confidence Interval (95 %CI): 1.04-1.95) in pre-frail and 1.98 (95 %CI: 1.21-3.26) in frail individuals, even after adjusting for multimorbidity. The number of chronic diseases was only marginally and not significantly associated with AF-related hospitalizations (HR 1.07, 95 %CI: 0.99-1.15), but did not significantly interact with frailty in the association with AF-related hospitalizations.
Conclusion: Older adults with frailty present with higher hazards of AF-related hospitalizations, irrespective of the presence of multimorbidity. Further studies are needed to evaluate whether reducing frailty may prevent AF development and improve health outcomes in older adults.
期刊介绍：
Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.
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