Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"Association of advanced glycation end products consumption and nutritional parameters in cardiovscular rehabilitation patients.","authors":"Maria Izabel de Castro Magalhães Fortes, Vitória Ellen Ladeira, Cicília Alves de Souza, Mariana da Silveira Quaresma, Tatiane Moreira Alves Garcia, Luciana de Abreu Silva, Gabriella Duarte de Oliveira, Rackel Aguiar Mendes de Oliveira, Adriane Moreira Machado, Camila Kümmel Duarte","doi":"10.1016/j.numecd.2025.104152","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104152","url":null,"abstract":"<p><strong>Background and aim: </strong>Advanced glycation end products (AGEs) are formed during the cooking process or endogenous metabolism. AGEs contribute to the progression of many chronic diseases. This study hypothesizes that a greater AGEs intake would be associated with worse health habits and nutritional status, and therefore aims to analyze the consumption of AGEs in patients with cardiovascular disease (CVD) and identify eating habits and nutritional characteristics related to greater consumption of AGEs.</p><p><strong>Methods and results: </strong>We conducted a cross-sectional study with a sample composed of patients with cardiovascular disease. Patients' food consumption was evaluated by recording each meal in a span of 24 h. The quantification of AGEs consumption was obtained by calculating the amount of carboxymethyl lysine (CML) by each portion of food registered each day, in accordance with the AGEs index. The data concerning AGEs are expressed in kilounits (KU) by 100 g of food. The calculus of mean macronutrients ingested during the three days of evaluation was obtained using the Avanutri® software. The statistical analysis was conducted using the software IBM SPSS version 20.0. In total, 132 patients were analyzed. The mean estimated AGEs consumption was 9595.0 kU of CML/day (6256.25-16153.25). The consumption of total energy (r = 0.394; p = 0.001) and saturated fats (r = 0.323; p = 0.001) showed direct and stronger correlations with AGEs. It was observed that eating meals with distractions (p = 0.002) and present a greater neck (NC) (p = 0.008) was associated with higher AGEs intake.</p><p><strong>Conclusions: </strong>This study observed a significant consumption of AGEs associated with greater consumption of calories and saturated fats, and conversely with carbohydrates. Furthermore, the greater consumption of AGEs by patients with high NC and abdominal circumference highlights the importance of nutritional guidance in this patient profile. Even so, aspects related to eating habits also suggest that they favor greater consumption of AGEs, such as the presence of distractions during meals.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104152"},"PeriodicalIF":3.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood-to-adolescence weight trajectories and adult hypertension: A systematic review and meta-analysis.","authors":"Tao Xu, Yuexian Tao, Yuling Lei","doi":"10.1016/j.numecd.2025.104160","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104160","url":null,"abstract":"<p><strong>Aims: </strong>Given the global burden of obesity, it is critically important to understand how different life-course weight trajectories influence the risk of hypertension in adulthood. Body weight changes across developmental stages may exert varying impacts on long-term cardiovascular health. This study aimed to evaluate the association between weight changes from childhood to adolescence and the subsequent risk of developing hypertension in adulthood.</p><p><strong>Data synthesis: </strong>This systematic review and meta-analysis was conducted in accordance with the PRISMA 2020 guidelines. A comprehensive literature search was performed using PubMed, EMBASE, Web of Science, and EBSCO databases from inception to July 26, 2023. Study selection and data extraction were independently carried out by two reviewers. Publication bias was assessed using Begg's and Egger's tests. Thirteen eligible studies comprising a total of 125,329 participants were included in the final analysis. Key findings were as follows: (i) Variations in weight trajectory were significantly associated with hypertension risk. (ii) Weight gain from childhood to adolescence was associated with a higher risk of hypertension (RR = 2.27; 95 % CI: 1.83-2.83). (iii) Persistent overweight status was linked to an even greater risk (RR = 3.29; 95 % CI: 2.18-5.28). (iv) Elevated BMI during youth correlated with increased adult blood pressure. (v) Females with persistent overweight had a significantly higher hypertension risk compared to males (RR = 3.23; 95 % CI: 2.35-4.43).</p><p><strong>Conclusion: </strong>Compared to maintaining a stable normal weight, both weight gain and persistent overweight from childhood to adolescence are strongly associated with an increased risk of hypertension in adulthood. Moreover, this association may differ by sex, suggesting the need for sex-specific prevention strategies targeting early-life weight management.</p><p><strong>Trial registration: </strong>PROSPERO CRD42022353522; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=353522.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104160"},"PeriodicalIF":3.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of intermittent fasting and Mediterranean diet on older adults' physical health and quality of life: A randomized clinical trial.","authors":"Sergio Couto, María Carmen Cenit, Jesica Montero, Isabel Iguacel","doi":"10.1016/j.numecd.2025.104132","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104132","url":null,"abstract":"<p><strong>Background and aims: </strong>Non-communicable chronic diseases are on the rise globally, and diet plays a crucial role. Intermittent fasting (IF), particularly time-restricted eating (TRE), has emerged as a potential strategy to manage these conditions. Research suggests that TRE, combined with healthy diets like the Mediterranean diet, may benefit populations, including older adults.</p><p><strong>Methods and results: </strong>Seventeen adults over 60 years of age were randomly assigned to the TRE + MED group (n = 8), following a 12-h fast with the Mediterranean diet, or the MED-DIET group (n = 9), following the diet without fasting. Over three months, changes in anthropometric, biochemical, and quality of life measures were assessed. The TRE + MED group showed significant reductions in BMI (p = 0.040), waist circumference (p < 0.001), hip circumference (p = 0.025), waist-to-hip ratio (p = 0.023), and systolic blood pressure (SBP) (p = 0.020), along with changes in fasting glucose. In the MED-DIET group, only SBP decreased significantly (p = 0.022). Between-group comparisons showed greater improvements in waist circumference (p = 0.001) and waist-to-hip ratio (WHR; p = 0.036) in the TRE + MED group. Conversely, gamma-glutamyl transferase (GGT) levels improved more in the MED-DIET group (p = 0.020). However, in the between-group comparison, only the reduction in waist circumference, WHR, and GGT levels reached statistical significance. Both groups improved Mediterranean diet adherence, quality of life, and stool regularity, but only 20 % of the TRE + MED group was willing to continue fasting, compared to 100 % in the MED-DIET group.</p><p><strong>Conclusion: </strong>TRE combined with the Mediterranean diet offers superior health benefits compared to the Mediterranean diet alone. In addition, adhering to a consistent meal schedule and regulating meal timing appear to be more challenging for the studied population.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104132"},"PeriodicalIF":3.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A shake with cashew and Brazil nuts decreased lipid peroxidation but did not improve antioxidant status in individuals with overweight or obesity: A randomized crossover clinical trial.","authors":"Mirian A C Costa, Daniela M U P Rocha, Ana P S Caldas, Dandara B Bonifácio, Alessandra da Silva, Sônia L Pinto, Helen H M Hermsdorff, Leandro L de Oliveira, Josefina Bressan","doi":"10.1016/j.numecd.2025.104131","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104131","url":null,"abstract":"<p><strong>Background and aims: </strong>Nuts are recognized for their potential health benefits, yet little is known about their postprandial impact on metabolic responses and oxidative stress. This study aimed to evaluate the acute effect of a shake containing a mixture of 30g cashew nuts (Anacardium occidentale L.) and 15g Brazil nuts (Bertholletia excelsa H.B.K.) on glucose levels, lipid profiles, and oxidative stress markers in individuals with overweight or obesity.</p><p><strong>Methods and results: </strong>This was a clinical, randomized, controlled, single-blind, crossover study. On two test days, fifteen subjects consumed either a control (without nuts) or a test shake. Metabolic biomarkers were analyzed at fasting and 60, 120, and 240 min after shake intake. Compared to the control, the shake with nuts promoted specific changes in oxidative stress and metabolic markers. Differences were observed at 120 min after beverage consumption regarding superoxide dismutase (SOD) (control: 117.7 ± 14.6 vs. test: 82.1 ± 10.0 U/mL; p < 0.05) and at 240 min regarding malondialdehyde (MDA) concentrations (control: 5.0 ± 0.2 vs. test: 4.4 ± 0.3 μM/mg; p < 0.05). Also, at 240 min postprandial, complement C3 and stearic acid concentrations were higher in the test group than in the control, and a positive correlation was observed between them (p < 0.05). However, no differences were observed when considering time x intervention.</p><p><strong>Conclusion: </strong>Our findings suggest that cashew and Brazil nuts did not promote acute metabolic changes. We highlight that the mixed nuts decreased lipid peroxidation but did not improve antioxidant status in individuals with overweight or obesity.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104131"},"PeriodicalIF":3.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased plasma thrombospondin-1 is associated with poor prognosis in ischemic stroke patients.","authors":"Yiming Jia, Lulu Sun, Yu He, Xinyue Chang, Yi Liu, Quan Yu, Zhengbao Zhu, Daoxia Guo, Aili Wang, Tan Xu, Hao Peng, Yonghong Zhang","doi":"10.1016/j.numecd.2025.104133","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104133","url":null,"abstract":"<p><strong>Background and aims: </strong>Thrombospondin-1 (THBS1) plays an important role in the modulation of coagulation, inflammatory response, vascular structure, and blood-brain barrier function, but its impact on clinical outcomes after ischemic stroke remains uncertain. We aimed to examine the relationship between plasma THBS1 levels and ischemic stroke prognosis in a multicenter observational study.</p><p><strong>Methods and results: </strong>Plasma THBS1 levels at baseline were measured in 3511 ischemic stroke patients enrolled between August 2009 and May 2013 in 26 hospitals across China. The primary outcome was the composite outcome of death or major disability (modified Rankin Scale score ≥3) at 3 months after stroke onset. During the 3 months of follow-up, 865 patients experienced the primary outcome. After multivariate adjustment, high THBS1 levels were significantly associated with an increased risk of the primary outcome (odds ratio, 1.52; 95 % confidence interval [CI], 1.09-2.12; P_trend = 0.014) when 2 extreme tertiles were compared. Each interquartile range increase in THBS1 was associated with a 16 % (95 % CI, 3 %-32 %) increased risk of the primary outcome. The spline regression model revealed a positive linear dose-response association between THBS1 levels and risk of the primary outcome (P_linearity = 0.020). Adding THBS1 to a model containing conventional risk factors improved risk prediction for the primary outcome (net reclassification index: 13.63 %, P = 0.014; integrated discrimination index: 0.33 %, P = 0.036).</p><p><strong>Conclusion: </strong>High plasma THBS1 levels are associated with poor prognosis at 3 months after ischemic stroke, suggesting that THBS1 may play a vital role in the development of ischemic stroke.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104133"},"PeriodicalIF":3.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of lifestyle interventions in reducing cardiovascular risk and risk factors in people with prediabetes: A systematic review and meta-analysis.","authors":"Getu Debalkie Demissie, Josephine Birungi, Abha Shrestha, Tilahun Haregu, Sathish Thirunavukkarasu, Brian Oldenburg","doi":"10.1016/j.numecd.2025.104130","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104130","url":null,"abstract":"<p><strong>Aim: </strong>This systematic review and meta-analysis examined the effectiveness of lifestyle interventions in reducing cardiovascular disease (CVD) risk, CVD events, and related risk factors among individuals with prediabetes.</p><p><strong>Data synthesis: </strong>We conducted a search of the MEDLINE, Embase, PsycINFO, CENTRAL, and Scopus databases, along with ClinicalTrials.gov, for lifestyle-based randomized controlled trials (RCTs) involving individuals with prediabetes. Our focus was on interventions that lasted at least six months and were published between 1997 and April 2024. Two authors independently screened the abstracts and titles of the retrieved articles, followed by full-text reviews and data extraction from forty-two eligible studies. The primary outcomes examined were changes in CVD risk and CVD events, and the secondary outcomes were changes in CVD risk factors. We utilized random-effects meta-analysis to calculate pooled effects. Forty-two studies (n=18,615, mean age =54.9, male (45.4 %)) were included. Lifestyle interventions reduced CVD risk (standardized mean difference (SMD): -1.91; 95 % CI: -2.89, -0.93, p<0.010) among the intervention group compared to the control group. Lifestyle interventions have also been shown to reduce various CVD risk factors, including the incidence of type 2 diabetes.</p><p><strong>Conclusion: </strong>This review demonstrates more evidence to support lifestyle interventions being an important strategy for individuals with prediabetes to reduce their risk of developing CVD and its associated risk factors. PROSPERO registration Number: CRD42023429869.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104130"},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dehydroepiandrosterone sulfate on lifespan in men and women using Mendelian randomization.","authors":"C Mary Schooling, Jie V Zhao","doi":"10.1016/j.numecd.2025.104128","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104128","url":null,"abstract":"<p><strong>Background and aim: </strong>Dehydroepiandrosterone (DHEA) and DHEA-sulfate (-s) fall with age and are implicated in aging. Observational studies suggest DHEA/DHEA-s could lengthen life in specifically older men. No trial has established the role of DHEA/DHEA-s in aging or lifespan. We assessed the role of DHEA-s in lifespan and key biological determinants, (blood pressure, Apolipoprotein B (ApoB), and haemoglobin A1C (HbA1c)), for men and women in a two-sample mendelian randomization (MR) study using naturally occurring genetic randomization to obviate confounding.</p><p><strong>Methods and results: </strong>We assessed associations of sex-specific DHEA-s from Life-Adult/Life-Heart (men = 4327, women = 3501) with lifespan, based on paternal (n = 415311) and maternal (n = 412937) attained age, and with blood pressure, ApoB and Hba1c (men = 167020, women = 194,174) from the UK Biobank. We used inverse variance weighted (IVW) estimates with sensitivity analysis. DHEA-s was unrelated to lifespan in women using IVW, 0.04 years per logged μmol/L DHEA-s, 95 % confidence interval (CI) -0.50 to 0.58, DHEA-s was associated with shorter lifespan in men (-1.15 years, 95 % CI -1.72 to -0.58) with a difference by sex (p = 0.0017), sensitivity analysis gave similar estimates. DHEA-s was unrelated to blood pressure in women and positively associated with systolic and diastolic blood pressure in men with a difference by sex for diastolic blood pressure. DHEA-s was possibly associated with lower ApoB in men.</p><p><strong>Conclusions: </strong>DHEA-s has different associations with lifespan and blood pressure in men and women. In settings where DHEA is an unregulated supplement, such as the United States, whether public health benefits might accrue from more regulation could be considered.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104128"},"PeriodicalIF":3.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A feasibility study for a trial testing the effects of reduced-sodium salt on the rise in blood pressure with age.","authors":"Katrina R Kissock, Clementina Okoro, Kathy Trieu, Nanna R Ripiye, Anthony Orji, Mark D Huffman, Bruce Neal, Dike Ojji","doi":"10.1016/j.numecd.2025.104129","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104129","url":null,"abstract":"<p><strong>Background and aims: </strong>Excess sodium intake is associated with elevated blood pressure, a major risk factor for cardiovascular disease. Lowering sodium intake by switching regular salt for reduced-sodium salt may attenuate rises in blood pressure with age. We aimed to assess project feasibility in Nigeria before testing in a large-scale clinical trial.</p><p><strong>Methods and results: </strong>We conducted an unblinded, non-randomised feasibility study in two rural Nigerian communities between March and May 2024. Participants (≥6 years) were recruited at the household level and provided with reduced-sodium salt (66 % KCl, 34 % NaCl) to replace all regular salt for cooking and seasoning over two months. Outcomes included recruitment rate, adherence and acceptability of the reduced-sodium salt, adherence to study procedures, and willingness to participate in a longer-term study. 41 households (148 participants) were recruited over five days. The median age of children, adolescents, and adults were 7, 11, and 35 years respectively, and 55 % were female. Nine participants (6 %) were lost to follow-up at 2-months (including two households), but 98 % of the scheduled follow-up visits were completed. At 2-months, 83 % of participants reported replacing all regular salt with reduced-sodium salt and most participants reported it was similar or better than regular salt for taste (94 %) and overall acceptability (93 %). All participants indicated willingness to engage in a 4-year study.</p><p><strong>Conclusion: </strong>It is feasible to conduct a large-scale clinical trial in Nigeria testing the effects of reduced-sodium salt compared to regular salt on the rise in blood pressure with age.</p><p><strong>Trial registration: </strong>NCT05912426.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104129"},"PeriodicalIF":3.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Habitual coarse grain intake, gut microbiota, and hyperuricemia in individuals with or at risk of metabolic syndrome: A post-hoc analysis.","authors":"Juan He, Yifei He, Junqi Li, Guoqing Ma, Yunfeng Li, Jiawen Xie, Chen He, Xinran Feng, Kaizhen Jia, Wei Li, Menghan Wang, Amei Tang, Tian Tian, Xia Liao, Weimin Li, Feng Yan, Ying Zhang, Xiaoxiao Cao, Yuelang Zhang, Nan Yang, Xin Liu, Qian Wang","doi":"10.1016/j.numecd.2025.104126","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104126","url":null,"abstract":"<p><strong>Background and aims: </strong>Grain intake and gut microbiota are associated with uric acid regulation, but it remains unknown which grains benefit more and how gut microbiota may interact with the effects. This post-hoc analysis evaluated the associations between 8 specific coarse grains intakes and hyperuricemia, and explored the roles of gut microbiota.</p><p><strong>Methods and results: </strong>Gut microbial data and dietary information of 295 participants with or at risk of metabolic syndrome were characterized by 16 S rRNA sequencing and a food frequency questionnaire, respectively. The higher intakes of buckwheat, black rice, and black bean were associated with lower plasma uric acid levels (P < 0.05). Inverse associations were observed between the intake of oat, black rice, and black bean and hyperuricemia, with odds ratios (95 % confidence intervals) comparing extreme tertiles were 0.179 (0.027,0.664), 0.147 (0.023,0.539), and 0.395 (0.057,1.632) (all P trend<0.05). The abundance of Flavonifractor was higher, whereas that of Monoglobus was lower in hyperuricemia patients. Moreover, Monoglobus showed a potentially mediation effects on the black rice-uric acid association.</p><p><strong>Conclusion: </strong>Our study identified associations between four specific coarse grains and hyperuricemia among individuals with or at risk of metabolic syndrome. Gut microbiota, notably Monoglobus may be involved in the association.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104126"},"PeriodicalIF":3.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of two weeks of daily consumption of (poly)phenol-rich red berry fruit juice, with and without high-intensity physical training, on health outcomes in individuals with pre-diabetes mellitus.","authors":"Sarah Valder, Friedrich Schick, Noel Pietsch, Tim Wagner, Hanna Urban, Pauline Lindemann, Lena Riemer, Sina Quenzer, Volker Herdegen, Patrick Diel, Eduard Isenmann, Christian Brinkmann","doi":"10.1016/j.numecd.2025.104121","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104121","url":null,"abstract":"<p><strong>Background and aims: </strong>The combination of the consumption of so-called superfoods and regular exercise is a promising approach for the prevention of chronic diseases. This study investigates the effects of two weeks of daily consumption of a red berry fruit juice (containing a high content of chokeberries), with or without high-intensity concurrent strength and endurance training, on body weight and composition, glucose metabolism, oxidative stress, pulse wave velocity, and peripheral resistance in individuals with pre-diabetes mellitus.</p><p><strong>Methods and results: </strong>Ten subjects participated in two crossover trials, each for 2 × 14 days: A): juice versus placebo, both without exercise, and B) juice versus placebo, both with concurrent strength and endurance training. Daily consumption of red berry fruit juice led to improvements in peripheral resistance, while no significant changes were observed in the placebo group (ANOVA: time x group, p ≤ 0.05). Participants in the juice + training group maintained their relative muscle mass, while those in the placebo + training group experienced a slight decline in their relative muscle mass (ANOVA: time x group, p ≤ 0.05).</p><p><strong>Conclusion: </strong>Short-term repeated consumption of a (poly)phenol-rich red berry fruit juice (in combination with physical training) presents an easy-to-apply strategy to improve health outcomes and may particularly be beneficial for vascular health and muscle mass in individuals with pre-diabetes.</p><p><strong>Registration number: </strong>DRKS00024969.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104121"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}