Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"Safety of lipid-lowering therapies: it is time for a \"DOCebo\" effect.","authors":"Damiano D'Ardes","doi":"10.1016/j.numecd.2026.104964","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.104964","url":null,"abstract":"<p><p>The expanding range of lipid-lowering therapies offers clinicians unprecedented opportunities to tailor treatment according to efficacy, safety, patient characteristics and preferences. In this context, the systematic review and network meta-analysis by Xie and colleagues provides a timely comparison of the safety profiles of lipid-lowering drugs, drawing on 153 randomized trials involving more than 303,000 participants. The analysis suggests that PCSK9 monoclonal antibodies have the most favourable profile for creatine kinase elevation, new-onset diabetes and liver dysfunction, whereas bempedoic acid ranks best for myalgia risk. No clear increase in cognitive disorders was identified across treatment classes. These findings are clinically relevant because concerns regarding muscle symptoms, diabetes and cognitive impairment frequently contribute to treatment refusal, poor adherence and discontinuation, particularly with statins. The results support a personalized approach aimed at achieving the required LDL-C reduction while maximizing long-term persistence. Effective communication is equally important as misinformation and the nocebo effect may undermine adherence. Clinicians should therefore promote an evidence-based \"DOCebo\" effect through trust, shared decision-making and clear counselling. Ultimately, safety should guide treatment personalization without displacing absolute cardiovascular benefit as the primary determinant of therapy.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104964"},"PeriodicalIF":3.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-dependent versus single SCORE2 thresholds for identifying carotid atherosclerosis in primary prevention.","authors":"Anastasios Kollias, Dimitra Krystallaki, Eirini-Chrysovalanti Antonogiannaki, Aikaterini Komnianou, Thomas Tsaganos, Konstantinos G Kyriakoulis, Ariadni Menti, George S Stergiou","doi":"10.1016/j.numecd.2026.104962","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.104962","url":null,"abstract":"<p><strong>Background and aims: </strong>European Society of Cardiology guidelines permit either age-dependent or single age-independent SCORE2 thresholds for atherosclerotic cardiovascular disease (ASCVD) risk classification. This study examined their concordance with carotid atherosclerosis.</p><p><strong>Methods and results: </strong>We studied 954 adults aged 40-69 years without ASCVD, diabetes, or chronic kidney disease from community screening programs (mean age 56.7 ± 8.0 years, men 42.9%, antihypertensive/lipid-lowering drug treatment 40.9%/43.7% respectively, SCORE2 5.4 ± 3.4%). High ASCVD risk was defined using age-dependent or single age-independent (≥10%) SCORE2 thresholds. Non-high-density lipoprotein cholesterol was adjusted for lipid-lowering therapy. Carotid plaque score (CPS) was assessed by ultrasonography. Among 857 participants with SCORE2 <10%, age-dependent thresholds reclassified 453 (52.9%) as high/very-high risk. Carotid atherosclerosis (CPS≥1) was more frequent among reclassified versus low-moderate risk participants (52.8% versus 23.8%; OR 3.58, 95% CI 2.67-4.81; P < 0.001). In the total sample, agreement with CPS was higher using age-dependent versus single thresholds (64%, κ = 0.30 versus 62%, κ = 0.12; P < 0.05). Sensitivity/specificity for carotid atherosclerosis was 76%/56% and 16%/94%, respectively. Optimal SCORE2 cut-offs for identifying carotid atherosclerosis closely matched the guideline-recommended age-dependent thresholds.</p><p><strong>Conclusions: </strong>Age-dependent SCORE2 thresholds showed better agreement with imaging evidence of carotid atherosclerosis than a single age-independent threshold, supporting their preferential use for ASCVD risk stratification and treatment decision-making.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104962"},"PeriodicalIF":3.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiac arrhythmias: current evidence and future perspectives.","authors":"Alessandro Mantovani, Rosa Lombardi","doi":"10.1016/j.numecd.2026.104958","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.104958","url":null,"abstract":"<p><strong>Background and aims: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide and is increasingly recognized as a multisystem cardiometabolic disorder. Beyond its association with cardiovascular morbidity and mortality, growing evidence suggests that MASLD may contribute to cardiac arrhythmias.</p><p><strong>Methods and results: </strong>This narrative review summarizes current evidence from observational studies, systematic reviews, and meta-analyses investigating the association between MASLD and cardiac arrhythmias. Evidence indicates that MASLD is associated with an increased risk of cardiac arrhythmias, independently of traditional cardiometabolic risk factors. In this sense, MASLD has been consistently linked to a higher prevalence and incidence of AF, increased risk of AF recurrence after catheter ablation, QTc interval prolongation, ventricular arrhythmias, and conduction defects. Importantly, arrhythmic susceptibility appears to parallel liver disease severity, with advanced fibrosis emerging as a potential determinant of increased risk. Proposed mechanisms include insulin resistance, chronic low-grade inflammation, oxidative stress, endothelial dysfunction, autonomic imbalance, adipose tissue dysfunction, and systemic profibrotic pathways leading to myocardial structural and electrical remodeling.</p><p><strong>Conclusions: </strong>MASLD should be considered a cardiometabolic risk enhancer extending beyond hepatic complications. Although current evidence is mainly observational and does not establish causality, the consistent association between MASLD and cardiac arrhythmias supports greater awareness of arrhythmic risk, particularly among individuals with obesity, type 2 diabetes, or advanced fibrosis. Prospective studies are required to define optimal risk stratification strategies and determine whether effective MASLD treatment can reduce arrhythmia burden and improve cardiovascular outcomes.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104958"},"PeriodicalIF":3.9,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calculated remnant cholesterol and 7-day severe adverse events after carotid revascularization: A retrospective cohort study.","authors":"Muyuan Li, Shuaiwei Guo, Kai Wang, Ruhan Yi, Xiao Zhang, Xiaoxin He, Xuebing Feng, Xia Lu, Zhengyu Wang, Renjie Yang, Fei Chen, Peng Gao, Liqun Jiao","doi":"10.1016/j.numecd.2026.104960","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.104960","url":null,"abstract":"<p><strong>Background and aim: </strong>Remnant cholesterol (RC), calculated from routine lipid measurements, has been associated with atherosclerotic vascular disease, but its relationship with early severe adverse events (SAEs) after carotid revascularization remains uncertain. We examined the association between calculated preoperative RC and 7-day SAE after carotid endarterectomy or carotid artery stenting.</p><p><strong>Methods and results: </strong>This single-center retrospective cohort included 3361 consecutive patients undergoing carotid revascularization between January 2017 and July 2023. RC was calculated as total cholesterol minus low-density lipoprotein cholesterol minus high-density lipoprotein cholesterol. The primary outcome was a composite of ischemic stroke, hemorrhagic stroke, myocardial infarction, seizure, unplanned reoperation, or death within 7 days. Multivariable logistic regression modeled RC per 10-mg/dL increase. Seventy patients (2.1%) experienced a 7-day SAE. Each 10-mg/dL increase in RC was associated with higher adjusted odds of 7-day SAE (adjusted odds ratio, 1.325; 95% confidence interval, 1.206-1.456; P < 0.001). The association was consistent across prespecified RC-outlier, sparse-event, and adjustment-set sensitivity analyses. Restricted cubic spline analysis supported an overall association, although apparent nonlinearity was concentrated in the sparse upper tail and attenuated after outlier handling. In exploratory component analysis, the association was most evident for ischemic stroke.</p><p><strong>Conclusions: </strong>Higher calculated preoperative RC was associated with higher adjusted odds of 7-day SAE after carotid revascularization. RC may provide complementary lipid-related information for perioperative assessment, but external validation is required before clinical implementation.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104960"},"PeriodicalIF":3.9,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood misfortunes and metabolic syndrome in old age: European prospective cohort study.","authors":"Vanja Kistler, Stefan Sieber, Boris Cheval, Bernadette Wilhelmina Antonia van der Linden, Katharina Tabea Jungo, Josephine Jackisch, Andreas Ihle, Cristian Carmeli, Delphine S Courvoisier, Grégoire Lagger, Stéphane Cullati","doi":"10.1016/j.numecd.2026.104959","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.104959","url":null,"abstract":"<p><strong>Background and aims: </strong>The link between childhood misfortunes and the risk and trajectories of metabolic syndrome (MetS) in older age remains unclear. The study examined (1) whether childhood misfortunes are associated with self-reported MetS and its trajectories in older age, and (2) whether life course socioeconomic conditions and unhealthy behaviours attenuate these associations.</p><p><strong>Methods and results: </strong>Data from 39'251 respondents aged 50+ years, collected between 2004 and 2018 (Survey of Health, Ageing and Retirement in Europe - SHARE) were analysed using logistic and multinomial regressions. MetS was defined as obesity plus hypertension, high cholesterol or diabetes. Childhood socioeconomic conditions, adverse experiences, and poor health were treated as distinct exposures. Life course socioeconomic conditions included education, occupation and financial strain. Unhealthy behaviours included smoking, alcohol consumption, physical inactivity, and poor diet. Disadvantaged childhood socioeconomic conditions were associated with higher MetS risk, partially attenuated by life course socioeconomic conditions but not by unhealthy behaviours. Four MetS trajectories were observed: \"never MetS\" (81%), \"persistent MetS\" (8%), \"developed MetS\" (6%) and \"lost MetS\" (4%). Disadvantaged childhood socioeconomic conditions, not childhood adverse experiences, increased the risk of each trajectory, partially reduced by adjustment for life course socioeconomic conditions but unaffected by behaviours. Poor childhood health increased the risk of \"persistent MetS\", with no attenuation by life course conditions or behaviours.</p><p><strong>Conclusions: </strong>Childhood misfortune predicts elevated MetS risk and trajectory patterns in later life. Early-life misfortune warrants clinical consideration in metabolic risk assessment, as its effects may not be visible through current lifestyle or socioeconomic indicators, pending further research.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104959"},"PeriodicalIF":3.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific cardiometabolic remodeling induced by DPP-4 inhibition under high-fat diet: insights from cardiac proteomics.","authors":"Elisa Maffioli, Joshua Grana, Armando Negri, Elena Vianello, Paola Primignani, Francesca Bianchi, Lucia La Sala, Francesco Bandera, Lorenza Tacchini, Massimiliano M Corsi Romanelli, Aneta Aleksova, Antonio Beltrami, Gabriella Tedeschi, Elena Dozio","doi":"10.1016/j.numecd.2026.104956","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.104956","url":null,"abstract":"<p><strong>Background and aim: </strong>Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used in the management of type 2 diabetes and are generally considered cardiovascularly safe. However, their mechanistic actions on the heart under metabolic stress remain incompletely understood.</p><p><strong>Methods and results: </strong>In this study, we investigated sex-specific cardiac proteomic responses to the DPP-4 inhibitor linagliptin (L) in a mouse model of diet-induced obesity. Male and female C57BL/6 N mice were fed a normal chow or high-fat diet for 15 weeks and received L (0.003% w/w in the diet; estimated exposure ∼120 μg/day) through dietary supplementation. Cardiac tissues were analyzed using label-free shotgun proteomics. High-fat diet induced marked, sex-dependent remodeling of the cardiac proteome. L exerted distinct effects according to both sex and metabolic context, partially counteracting obesity-induced alterations, particularly in females. Under high-fat conditions, L modulated sex-specific proteomic signatures related to mitochondrial energetics, lipid metabolism, cardiac conduction, calcium-channel activity, and myocardial structural organization, biological processes that have previously been associated with cardiac remodeling in experimental and clinical studies. Notably, distinct molecular signatures emerged between males and females, highlighting a strong sexual dimorphism in cardiac responses to both metabolic stress and pharmacological intervention.</p><p><strong>Conclusion: </strong>These findings reveal a dual and context-dependent role of DPP-4 inhibition in the heart and suggest that metabolic status and sex may critically influence its cardiovascular effects. This study provides novel insights into the molecular mechanisms underlying the cardiac response to DPP-4 inhibition under conditions of metabolic stress and supports further investigation of sex-specific cardiometabolic effects.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104956"},"PeriodicalIF":3.9,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) and risk of subsequent Stanford type A aortic dissection in patients with acute coronary syndrome: a multicenter case-control study with Mendelian randomization analysis.","authors":"Zishuang Dong, Yanqi Wang, Sibo Wang, Jinyang Lu, Sen Wang, Min Xu, Sifang Zhong, Zishuang Dong","doi":"10.1016/j.numecd.2026.104952","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.104952","url":null,"abstract":"<p><strong>Background and aims: </strong>Lipoprotein(a) [Lp(a)] is associated with cardiovascular risk, but its role in Stanford type A aortic dissection (AD) following acute coronary syndrome (ACS) remains unclear. We evaluated whether Lp(a) at ACS presentation predicts subsequent type A AD, its incremental value, and to assess potential causal effects using a complementary two-sample Mendelian randomization (MR) analysis.</p><p><strong>Methods and results: </strong>In this bi-center retrospective case-control study, 222 patients with type A AD after ACS and 751 ACS controls were included. Overlap weighting balanced eight covariates. Lp(a) was analyzed as log-transformed values, tertiles, and >125 nmol/L. Dose-response was assessed with restricted cubic splines, and discrimination by AUC. Sensitivity analyses included matching and a time-restricted cohort. MR used 45 instruments with adjustment for low-density lipoprotein cholesterol (LDL-C) and systolic blood pressure. Lp(a) was higher in cases (P < 0.001). Each log-unit increase was associated with greater type A AD risk (OR 5.14, 95% CI 3.39-8.19). The highest tertile (OR 8.35, 95% CI 5.84-12.11) and >125 nmol/L (OR 1.82, 95% CI 1.06-3.16) also showed increased risk. Findings were consistent across analyses. Adding Lp(a) improved discrimination (AUC 0.820 vs 0.697). MR supported associations with aortic aneurysm and the composite outcome (IVW OR 1.196, 95% CI 1.083-1.320), independent of LDL-C and blood pressure.</p><p><strong>Conclusions: </strong>Higher Lp(a) at ACS presentation predicts type A AD and improves risk stratification. Genetic analyses suggest links with aortic aneurysm and the composite outcome, but not thoracic aneurysm; evidence for dissection was limited by low power.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104952"},"PeriodicalIF":3.9,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary ketogenic ratio and all-cause mortality among adults with cardiovascular-kidney-metabolic syndrome.","authors":"Hui Guo, Lei Wang, Fangping Xiao","doi":"10.1016/j.numecd.2026.104955","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.104955","url":null,"abstract":"<p><strong>Background and aim: </strong>Cardiovascular-kidney-metabolic (CKM) syndrome confers elevated mortality risk, but whether dietary ketogenic ratio (KDR) is associated with mortality in this population remains unclear. We examined the association of KDR with mortality in adults with CKM syndrome and whether it persisted after accounting for broader diet-quality metrics.</p><p><strong>Methods and results: </strong>We analysed adults with CKM stages 1-4 from NHANES 2003-2018 with mortality follow-up through 2019. Participants required a reliable Day 1 24-h dietary recall, non-missing KDR, and classifiable CKM stage. The primary cohort included 31,761 adults; 28,221 also contributed to a 2-day sensitivity analysis. Survey-weighted Cox models estimated hazard ratios (HRs) and 95% confidence intervals (CIs), with KDR analysed per 1-SD increase and by quartiles. During follow-up, 4481 all-cause deaths and 1199 heart disease deaths occurred. In the fully adjusted model, each 1-SD higher KDR was associated with lower all-cause mortality (HR 0.94, 95% CI 0.90-0.98), and the highest quartile had lower risk than the lowest quartile (HR 0.86, 95% CI 0.78-0.96). The association attenuated after adjustment for source-oriented low-carbohydrate diet (LCD) scores, changed little after Healthy Eating Index-2015 (HEI-2015) adjustment alone, and showed a similar pattern in the 2-day dietary cohort. Associations with heart disease mortality were not statistically robust.</p><p><strong>Conclusion: </strong>Higher KDR was associated with lower all-cause mortality in CKM syndrome, but this association was partly attenuated by broader diet-quality metrics. KDR may be better interpreted as a complementary dietary metric rather than an independent dietary target.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104955"},"PeriodicalIF":3.9,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic multimorbidity trajectories and incident non-steatotic chronic liver disease in middle-aged and older adults.","authors":"Jun Wei, Jun Zhang","doi":"10.1016/j.numecd.2026.104951","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.104951","url":null,"abstract":"<p><strong>Background and aims: </strong>Cardiometabolic multimorbidity (CMM) may increase the risk of chronic liver disease, but evidence on non-steatotic chronic liver disease (NSCLD) remains limited.</p><p><strong>Methods and results: </strong>We used data from the China Health and Retirement Longitudinal Study and included adults aged 45 years or older. Participants were classified into 4 mutually exclusive CMM trajectory groups: H→M, H→C, H→M→CMM, and H→C→CMM. Cox proportional hazards models were used to examine the associations between CMM trajectories and incident NSCLD. Potential heterogeneity by percent predicted peak expiratory flow (PEF% predicted) and the potential mediating role of frailty were further assessed. Among 8310 participants, incident NSCLD increased across trajectory groups from 6.36% in H→M to 15.43% in H→C→CMM; frailty prevalence increased from 16.98% to 32.20% (both P < 0.001). Kaplan-Meier curves differed significantly across trajectories (log-rank P < 0.0001). Associations varied by PEF% predicted (adjusted P for interaction = 0.0025). In the low PEF% predicted stratum, adjusted HRs were 2.48 for H→C, 1.99 for H→M→CMM, and 2.34 for H→C→CMM versus H→M. Frailty mediated 4.82% of the observed association.</p><p><strong>Conclusions: </strong>CMM trajectories were associated with incident NSCLD in middle-aged and older adults. These associations varied by respiratory function and appeared stronger in participants with lower PEF% predicted. Frailty accounted for a modest proportion of the observed association.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104951"},"PeriodicalIF":3.9,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"High LDL-cholesterol in children and adolescents with type 1 diabetes: the impact of body adiposity and sex\".","authors":"Anita Joeliantina, Sari Luthfiyah, Triwiyanto Triwiyanto, Wayan Suardana, Mohammed Ismath","doi":"10.1016/j.numecd.2026.104928","DOIUrl":"https://doi.org/10.1016/j.numecd.2026.104928","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104928"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}