Maria Izabel de Castro Magalhães Fortes, Vitória Ellen Ladeira, Cicília Alves de Souza, Mariana da Silveira Quaresma, Tatiane Moreira Alves Garcia, Luciana de Abreu Silva, Gabriella Duarte de Oliveira, Rackel Aguiar Mendes de Oliveira, Adriane Moreira Machado, Camila Kümmel Duarte
{"title":"心血管康复患者晚期糖基化终产物消费与营养参数的关系。","authors":"Maria Izabel de Castro Magalhães Fortes, Vitória Ellen Ladeira, Cicília Alves de Souza, Mariana da Silveira Quaresma, Tatiane Moreira Alves Garcia, Luciana de Abreu Silva, Gabriella Duarte de Oliveira, Rackel Aguiar Mendes de Oliveira, Adriane Moreira Machado, Camila Kümmel Duarte","doi":"10.1016/j.numecd.2025.104152","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and aim: </strong>Advanced glycation end products (AGEs) are formed during the cooking process or endogenous metabolism. AGEs contribute to the progression of many chronic diseases. This study hypothesizes that a greater AGEs intake would be associated with worse health habits and nutritional status, and therefore aims to analyze the consumption of AGEs in patients with cardiovascular disease (CVD) and identify eating habits and nutritional characteristics related to greater consumption of AGEs.</p><p><strong>Methods and results: </strong>We conducted a cross-sectional study with a sample composed of patients with cardiovascular disease. Patients' food consumption was evaluated by recording each meal in a span of 24 h. The quantification of AGEs consumption was obtained by calculating the amount of carboxymethyl lysine (CML) by each portion of food registered each day, in accordance with the AGEs index. The data concerning AGEs are expressed in kilounits (KU) by 100 g of food. The calculus of mean macronutrients ingested during the three days of evaluation was obtained using the Avanutri® software. The statistical analysis was conducted using the software IBM SPSS version 20.0. In total, 132 patients were analyzed. The mean estimated AGEs consumption was 9595.0 kU of CML/day (6256.25-16153.25). The consumption of total energy (r = 0.394; p = 0.001) and saturated fats (r = 0.323; p = 0.001) showed direct and stronger correlations with AGEs. It was observed that eating meals with distractions (p = 0.002) and present a greater neck (NC) (p = 0.008) was associated with higher AGEs intake.</p><p><strong>Conclusions: </strong>This study observed a significant consumption of AGEs associated with greater consumption of calories and saturated fats, and conversely with carbohydrates. Furthermore, the greater consumption of AGEs by patients with high NC and abdominal circumference highlights the importance of nutritional guidance in this patient profile. Even so, aspects related to eating habits also suggest that they favor greater consumption of AGEs, such as the presence of distractions during meals.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104152"},"PeriodicalIF":3.3000,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of advanced glycation end products consumption and nutritional parameters in cardiovscular rehabilitation patients.\",\"authors\":\"Maria Izabel de Castro Magalhães Fortes, Vitória Ellen Ladeira, Cicília Alves de Souza, Mariana da Silveira Quaresma, Tatiane Moreira Alves Garcia, Luciana de Abreu Silva, Gabriella Duarte de Oliveira, Rackel Aguiar Mendes de Oliveira, Adriane Moreira Machado, Camila Kümmel Duarte\",\"doi\":\"10.1016/j.numecd.2025.104152\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and aim: </strong>Advanced glycation end products (AGEs) are formed during the cooking process or endogenous metabolism. AGEs contribute to the progression of many chronic diseases. This study hypothesizes that a greater AGEs intake would be associated with worse health habits and nutritional status, and therefore aims to analyze the consumption of AGEs in patients with cardiovascular disease (CVD) and identify eating habits and nutritional characteristics related to greater consumption of AGEs.</p><p><strong>Methods and results: </strong>We conducted a cross-sectional study with a sample composed of patients with cardiovascular disease. Patients' food consumption was evaluated by recording each meal in a span of 24 h. The quantification of AGEs consumption was obtained by calculating the amount of carboxymethyl lysine (CML) by each portion of food registered each day, in accordance with the AGEs index. The data concerning AGEs are expressed in kilounits (KU) by 100 g of food. The calculus of mean macronutrients ingested during the three days of evaluation was obtained using the Avanutri® software. The statistical analysis was conducted using the software IBM SPSS version 20.0. In total, 132 patients were analyzed. The mean estimated AGEs consumption was 9595.0 kU of CML/day (6256.25-16153.25). The consumption of total energy (r = 0.394; p = 0.001) and saturated fats (r = 0.323; p = 0.001) showed direct and stronger correlations with AGEs. It was observed that eating meals with distractions (p = 0.002) and present a greater neck (NC) (p = 0.008) was associated with higher AGEs intake.</p><p><strong>Conclusions: </strong>This study observed a significant consumption of AGEs associated with greater consumption of calories and saturated fats, and conversely with carbohydrates. Furthermore, the greater consumption of AGEs by patients with high NC and abdominal circumference highlights the importance of nutritional guidance in this patient profile. Even so, aspects related to eating habits also suggest that they favor greater consumption of AGEs, such as the presence of distractions during meals.</p>\",\"PeriodicalId\":49722,\"journal\":{\"name\":\"Nutrition Metabolism and Cardiovascular Diseases\",\"volume\":\" \",\"pages\":\"104152\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-05-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition Metabolism and Cardiovascular Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.numecd.2025.104152\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Metabolism and Cardiovascular Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.numecd.2025.104152","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Association of advanced glycation end products consumption and nutritional parameters in cardiovscular rehabilitation patients.
Background and aim: Advanced glycation end products (AGEs) are formed during the cooking process or endogenous metabolism. AGEs contribute to the progression of many chronic diseases. This study hypothesizes that a greater AGEs intake would be associated with worse health habits and nutritional status, and therefore aims to analyze the consumption of AGEs in patients with cardiovascular disease (CVD) and identify eating habits and nutritional characteristics related to greater consumption of AGEs.
Methods and results: We conducted a cross-sectional study with a sample composed of patients with cardiovascular disease. Patients' food consumption was evaluated by recording each meal in a span of 24 h. The quantification of AGEs consumption was obtained by calculating the amount of carboxymethyl lysine (CML) by each portion of food registered each day, in accordance with the AGEs index. The data concerning AGEs are expressed in kilounits (KU) by 100 g of food. The calculus of mean macronutrients ingested during the three days of evaluation was obtained using the Avanutri® software. The statistical analysis was conducted using the software IBM SPSS version 20.0. In total, 132 patients were analyzed. The mean estimated AGEs consumption was 9595.0 kU of CML/day (6256.25-16153.25). The consumption of total energy (r = 0.394; p = 0.001) and saturated fats (r = 0.323; p = 0.001) showed direct and stronger correlations with AGEs. It was observed that eating meals with distractions (p = 0.002) and present a greater neck (NC) (p = 0.008) was associated with higher AGEs intake.
Conclusions: This study observed a significant consumption of AGEs associated with greater consumption of calories and saturated fats, and conversely with carbohydrates. Furthermore, the greater consumption of AGEs by patients with high NC and abdominal circumference highlights the importance of nutritional guidance in this patient profile. Even so, aspects related to eating habits also suggest that they favor greater consumption of AGEs, such as the presence of distractions during meals.
期刊介绍：
Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.
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