Habitual coarse grain intake, gut microbiota, and hyperuricemia in individuals with or at risk of metabolic syndrome: A post-hoc analysis.

Abstract

Background and aims: Grain intake and gut microbiota are associated with uric acid regulation, but it remains unknown which grains benefit more and how gut microbiota may interact with the effects. This post-hoc analysis evaluated the associations between 8 specific coarse grains intakes and hyperuricemia, and explored the roles of gut microbiota.

Methods and results: Gut microbial data and dietary information of 295 participants with or at risk of metabolic syndrome were characterized by 16 S rRNA sequencing and a food frequency questionnaire, respectively. The higher intakes of buckwheat, black rice, and black bean were associated with lower plasma uric acid levels (P < 0.05). Inverse associations were observed between the intake of oat, black rice, and black bean and hyperuricemia, with odds ratios (95 % confidence intervals) comparing extreme tertiles were 0.179 (0.027,0.664), 0.147 (0.023,0.539), and 0.395 (0.057,1.632) (all P trend<0.05). The abundance of Flavonifractor was higher, whereas that of Monoglobus was lower in hyperuricemia patients. Moreover, Monoglobus showed a potentially mediation effects on the black rice-uric acid association.

Conclusion: Our study identified associations between four specific coarse grains and hyperuricemia among individuals with or at risk of metabolic syndrome. Gut microbiota, notably Monoglobus may be involved in the association.