心血管-肾-代谢综合征0-3期患者脉搏波速度轨迹与心血管疾病风险的关系

IF 3.3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Tingting Chen, Huangyi Yin, Yubo Zhou, Min Liang
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引用次数: 0

摘要

背景和目的:心血管事件的发生率在被诊断为心血管肾代谢综合征(CKM)的个体中显著升高。本研究旨在研究早期CKM患者脉搏波速度(ePWV)随时间变化与心血管疾病(CVD)发病之间的关系。方法和结果:本研究包括6788名来自中国健康与退休纵向研究(CHARLS)的重复ePWV测量的个体。使用基于组的轨迹建模将参与者分为四个ePWV轨迹组:低、中低、中高和高。使用Cox回归模型评估ePWV轨迹与CVD风险之间的关系。与低ePWV组比较,中低、中高、高ePWV组CVD的95%可信区间(ci)分别为1.287(1.042 ~ 1.590)、1.891(1.453 ~ 2.462)、2.400(1.660 ~ 3.469)。此外,ePWV轨迹与基本风险模型的结合,改善了受试者工作特征(ROC)曲线对心血管疾病风险的预测,改善了净重分类改善(NRI)和综合判别改善(IDI)测量的风险重分类。结论:在中老年早期CKM患者中,ePWV的升高轨迹与CVD的风险增加显著相关。长期监测ePWV可能为这一人群的早期心血管风险评估和预防提供有价值的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship between estimated pulse wave velocity trajectories and cardiovascular disease risk in patients with cardiovascular-kidney-metabolic syndrome stages 0-3.

Background and aims: The incidence of cardiovascular events is markedly elevated in individuals diagnosed with cardiovascular-kidney-metabolic (CKM) syndrome. This study aims to examine the association between alterations in estimated pulse wave velocity (ePWV) over time and the onset of cardiovascular disease (CVD) in individuals with early CKM stages.

Methods and results: This study included 6788 individuals with repeated ePWV measurements from the China Health and Retirement Longitudinal Study (CHARLS). Participants were categorized into four ePWV trajectory groups using group-based trajectory modeling: low, moderate-low, moderate-high, and high. The association between ePWV trajectories and CVD risk was assessed using Cox regression models. In comparison to the low ePWV group as the reference, the hazard ratios (HRs) with 95 % confidence intervals (CIs) for the moderate-low, moderate-high, and high ePWV groups were 1.287 (1.042-1.590), 1.891 (1.453-2.462), and 2.400 (1.660-3.469) for CVD, respectively. Additionally, the incorporation of ePWV trajectories to the basic risk model resulted in improved CVD risk prediction as indicated by receiver operating characteristic (ROC) curves, as well as improved risk reclassification as measured by net reclassification improvement (NRI) and integrated discrimination improvement (IDI).

Conclusions: In middle-aged and older people with early CKM stages, elevated trajectories of ePWV are significantly associated with an increased risk of CVD. Monitoring ePWV over time may offer a valuable tool for early cardiovascular risk assessment and prevention in this population.

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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
332
审稿时长
57 days
期刊介绍: Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.
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