Biomedical Microdevices最新文献

{"title":"Engineering biocompatible polylactic acid (PLA) microcarriers for enhanced 3D cell culture","authors":"Ana Paula Salcedo-Uribe,&nbsp;Ivan Samayoa-Cortes,&nbsp;Natalia Ramírez-Zermeño,&nbsp;Sabrina Marcela Navarro-Navarro,&nbsp;Nestor Fabian Díaz,&nbsp;Daniela Avila-Gonzalez,&nbsp;David Mendoza-Aguayo,&nbsp;Nestor Emmanuel Diaz-Martinez","doi":"10.1007/s10544-026-00793-2","DOIUrl":"10.1007/s10544-026-00793-2","url":null,"abstract":"<div>\u0000 \u0000 <p>This study analyses the performance of polylactic acid (PLA)-collagen microcarriers engineered under laboratory-scale conditions with scalable potential for three-dimensional (3D) cell culture applications. The microcarriers were evaluated for their ability to support cell adhesion, viability, proliferation and conglomerate formation using Caco-2 cells. Results show that PLA-collagen microcarriers significantly improve cell density, with notable proliferation by day 7. Scanning Electron Microscopy (SEM) revealed a rough, porous surface topology that fosters cellular aggregation and conglomerate formation, essential for replicating complex tissue architectures. Multigenerational monitoring using epifluorescence assays demonstrated high nuclear density and sustained cell viability, further supporting the microcarriers’ ability to maintain dense and viable cellular environments. Additionally, Energy Dispersive X-ray Spectroscopy (EDS) confirmed effective cell-microcarrier interactions, validating the bioactivity of the PLA-collagen matrix. These findings underscore the potential of PLA-collagen microcarriers as a versatile and scalable tool for 3D cell culture, with significant applications in bioengineering tumour models, organoid formation, and drug testing. The technology offers a promising approach for advancing preclinical research and regenerative medicine.</p>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146256807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A portable and low-cost fluorescence reader for near-patient nucleic acid amplification assays","authors":"Ethan Rosenfeld,&nbsp;Kathryn Pacheco,&nbsp;Evan Benke,&nbsp;Ian M. White,&nbsp;Don L. DeVoe","doi":"10.1007/s10544-026-00801-5","DOIUrl":"10.1007/s10544-026-00801-5","url":null,"abstract":"<div><p>Nucleic acid amplification tests (NAATs) play a critical role in disease diagnostics by enabling rapid and highly sensitive detection of genomic sequences associated with specific pathogens. This paper presents a portable NAAT assay reader combining precise thermal control and spatially-multiplexed fluorescence detection that is designed to extend the applicability of nucleic acid testing across diverse environments. The compact and low cost Multiplexed Array Gene Imager (MAGI) system operates wirelessly, with assay control and readout enabled through a Web-based interface, and can be adapted to a broad range of NAAT formats and assay substrates. Thermal actuation is performed using a printed circuit board heater that provides stable closed-loop temperature control at low manufacturing cost. Performance of the MAGI system is evaluated using a spatially-multiplexed loop-mediated isothermal amplification (LAMP) assay implemented in a custom microfluidic 12-well plate. Overall, the presented system offers a manufacturable, adaptable, and functional platform for use in diverse environments where NAAT cost, portability, and assay flexibility are important considerations. </p></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12904924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ detection of dead cells from live cells via a DC plus low frequency AC resistive pulse sensor","authors":"Parker Lybrook,&nbsp;Heyi Chen,&nbsp;Emma Barna,&nbsp;Jacob Brown,&nbsp;Ashley Wong,&nbsp;Joseph Ketchum,&nbsp;Ge Zhang,&nbsp;Jiang Zhe","doi":"10.1007/s10544-026-00797-y","DOIUrl":"10.1007/s10544-026-00797-y","url":null,"abstract":"<div><p>Differentiation and detection of live and dead cells are critical for assessing cell viability in biomedical research, evaluating drug efficacy, and monitoring cytotoxicity in therapeutic applications. We present a microfluidic sensor that consists of two successive resistive pulse sensing channels. An excitation signal composed of a low-frequency AC (75 kHz) component and a DC bias was used to measure four key parameters. Through the AC measurement, differences in cell impedance causes variations in phase angle and voltage peak. From the DC measurement, cell size can be inferred from the resistive pulse magnitude, and the cell’s zeta potential is represented by the transit time difference. Human umbilical vein endothelial cells (HUVECs) and human mesenchymal stem cells (hMSCs) were used to demonstrate the device’s utility. A soft margin support vector machine (SVM) was applied to define the decision boundary based on analysis of the four parameters. For both cell types, live and dead cells formed distinct clusters, achieving maximum classification accuracies of up to 100%. Additionally, HUVECs treated with either ethanol or staurosporine (STS) were classified with accuracies up to 100%. Compared to previous microfluidic resistive pulse sensor (RPS), this approach can determine cell viability without the need for complex labeling or modifications. Unlike impedance cytometry, it does not require high-frequency measurements, significantly reducing hardware requirements and data processing complexity, while still providing multiparametric measurements of cells. These measurements allow the use of soft SVM to classify cell groups with higher accuracy than single-parameter differentiation.</p></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12904940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid equipment-free patterning of PDMS microchannel for the simple generation of high-order emulsion and hydrogel microcapsules","authors":"Lu-Lu Liu,&nbsp;Wen-Qi Ye,&nbsp;Chun-Guang Yang,&nbsp;Zhang-Run Xu","doi":"10.1007/s10544-026-00796-z","DOIUrl":"10.1007/s10544-026-00796-z","url":null,"abstract":"<div>\u0000 \u0000 <p>Multiple emulsions with excellent monodispersity and tailorable compositions exhibit great application potential in analytical detection, material synthesis and various other fields. To achieve the spatially patterned wettability that is essential for generating multiple emulsions in microfluidic chips, hydrophilic modification of polydimethylsiloxane (PDMS) microchannels is indispensable for constructing alternating hydrophilic-hydrophobic surface distributions. However, the complexity of such surface treatment increases with the order of multiple emulsions, rendering the development of a simple and controllable hydrophilic modification strategy for PDMS chips to fabricate high-order emulsions a persistent challenge. Herein, we present a rapid patterning method for PDMS microchannels dedicated to high-order emulsion generation. This approach enables the simultaneous hydrophilic treatment of multiple open microchannels on a PDMS substrate via manual polyvinyl alcohol (PVA) coating prior to chip bonding, obviating the need for additional instrumentation or precise fluid control operations. Furthermore, it allows for the selective modification of distinct microchannel regions, which well caters to the customized fabrication of multiple emulsions with designed structures. Based on the proposed protocol, multiple emulsions ranging from double to quintuple emulsions were successfully generated in a facile and highly stable manner. As a proof-of-concept application, these high-order emulsions were employed as sacrificial templates to fabricate onion-like hydrogel microcapsules, which featured uniform spherical morphologies and well-defined multilayer architectures. The coefficient of variation (CV) of the diameter for all prepared microcapsules was ≤ 2.3% (<i>n</i> = 50). Notably, the multilayer architecture of the hydrogel microcapsules can be precisely tailored by selective hydrophilic surface modification—switching from water/oil (W/O) to oil/water (O/W) wettability, or transforming core-shell structures into onion-like microcapsules. These tailor-made multilayer hydrogel microcapsules thus represent promising candidates for the encapsulation of various active substances and functional cargos in both industrial and scientific applications.</p>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond encapsulation: advanced hydrogels for extracellular vesicle therapeutics in peripheral nervous system repair","authors":"Yuwei Zou,&nbsp;Yue An,&nbsp;Lili Zhang","doi":"10.1007/s10544-025-00785-8","DOIUrl":"10.1007/s10544-025-00785-8","url":null,"abstract":"<div>\u0000 \u0000 <p>Small extracellular vesicles (sEVs) represent a promising therapeutic modality for peripheral nerve repair. By modulating inflammation, promoting axonal regeneration, and supporting remyelination, sEVs play a multifaceted role in restoring nerve structure and function following injury. Hydrogels provide protective, sustained release vehicles that can control sEV dosing and prolong local retention in the therapeutic delivery site. In this review, we summarize recent progress on sEV-incorporated hydrogels, including injectable, self-healing, electroconductive, and ECM-derived hydrogels that go beyond passive loading strategies to achieve responsive and tissue-specific delivery. Current preclinical results demonstrate improved nerve regeneration and functional outcomes from enhanced Schwann-cell activation and immune modulation. However, challenges remain in fine-tuning sEV stability and release kinetics, as well as developing scalable manufacturing processes. Future strategies like staged-release depots and biosensing hydrogels are accelerating the translation of sEV-hydrogel systems. Overall, sEVs embedded in hydrogels form a promising next-generation platform for controlled, local nerve regeneration therapeutics.</p>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PVA-coated 3D-printed molds for rapid prototyping of PDMS microdevices for stem cell culture","authors":"Yuma Abe,&nbsp;Daiki Fukai,&nbsp;Taro Toyoda,&nbsp;Naoto Fukumoto,&nbsp;Kyohei Terao","doi":"10.1007/s10544-026-00790-5","DOIUrl":"10.1007/s10544-026-00790-5","url":null,"abstract":"<div>\u0000 \u0000 <p>Three-dimensional (3D) printing technology is increasingly being utilized as a rapid prototyping method for manufacturing molds for polydimethylsiloxane (PDMS)-based microdevices. Residual photoinitiators and other leachable components derived from photocurable resins often inhibit PDMS curing, while the surface roughness introduced by layer-by-layer printing is known to degrade device performance in cell culture applications. In this study, we propose a surface modification strategy using dip coating with water-soluble and biocompatible poly(vinyl alcohol) (PVA) to improve the compatibility of 3D-printed molds with PDMS replication. Systematic characterization revealed that PVA concentration governs film viscosity and thickness, with the 3–18% (w/w) range yielding uniform and reproducible coatings. PVA-coated molds effectively suppressed PDMS curing inhibition and reduced surface roughness by up to 80%, enabling high-fidelity replication of microstructures. Furthermore, PDMS microwell arrays fabricated from PVA-coated molds supported efficient and uniform embryoid body (EB) formation from human induced pluripotent stem (iPS) cells, with an increased frequency of single EB per well compared to uncoated molds. These findings demonstrate that PVA coating provides a facile, biocompatible, and shape-preserving post-treatment to overcome key limitations of 3D-printed molds. The proposed method offers a robust and accessible pathway for the rapid prototyping of PDMS-based microdevices for stem cell culture and broader biomedical applications.</p>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146155693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geometry-dependent regulation of myogenic and osteogenic differentiation on microgeometry polystyrene substrates","authors":"Moe Kato,&nbsp;Tadashi Nakaji-Hirabayashi,&nbsp;Kazuaki Matsumura,&nbsp;Yoshinori Ikeda,&nbsp;Kazuya Hirota","doi":"10.1007/s10544-026-00792-3","DOIUrl":"10.1007/s10544-026-00792-3","url":null,"abstract":"<div><p>Advances in microfabrication technology have enabled precise control of surface geometry, which strongly influences cellular behavior, including adhesion, alignment, and differentiation. However, previous studies have employed diverse substrate materials and fabrication conditions, making it difficult to rigorously evaluate the pure geometric effects of the microstructures. Consequently, variations in physicochemical and mechanical properties, such as surface chemistry and stiffness, have confounded the interpretation of geometry-specific effects. To clarify the influence of microgeometry on cell behavior, particularly cell differentiation, stripe- and mesh-patterned polystyrene substrates were used to systematically investigate the relationship between surface geometry and cell behavior. Human mesenchymal stem cells (hMSCs) and C2C12 myoblasts were seeded on the substrates, and their adhesion morphology and alignment were observed using calcein-AM staining. Osteogenic and myogenic differentiation were subsequently induced, and the expression of differentiation markers was analyzed by immunostaining and RT-qPCR. In hMSCs, osteogenic differentiation was promoted in geometries that facilitated intercellular contact, whereas it was suppressed in highly confined geometries, such as stripes and meshes with greater ridge heights. In C2C12 myoblasts, a clear enhancement of myogenic differentiation was observed on striped substrates, where cells exhibited elongated morphologies aligned with the grooves, accompanied by an elevated expression of myogenin and dystrophin. These findings indicate that the differentiation-promoting or differentiation-suppressive effects of microgeometry are cell type-dependent and are governed by cellular alignment, intercellular interactions, and adhesion morphology. The insights gained from this study may contribute to the rational design of next-generation regenerative scaffolds and highlight the potential applications of microgeometric substrates in drug-screening platforms.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146130636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modular parallel plate flow chamber with tunable substrate mechanics and defined shear stress","authors":"Bryan J. Ferrick,&nbsp;Jason P. Gleghorn","doi":"10.1007/s10544-025-00787-6","DOIUrl":"10.1007/s10544-025-00787-6","url":null,"abstract":"<p>Cells integrate multiple mechanical cues simultaneously, yet most <i>in vitro</i> models examine extracellular matrix (ECM) stiffness and fluid shear stress (FSS) in isolation, limiting our understanding of mechanotransduction. We developed a parallel plate flow chamber with a polyacrylamide (PAA) substratum enabling independent, tunable control of substrate stiffness and FSS using readily available materials. We confirm that the PAA substratum has controllable mechanical properties that support the growth of Madin-Darby canine kidney epithelial cells across a range of stiffnesses. Furthermore, the flow chamber design accommodates the volumetric equilibrium swelling of the gel, maintaining a predictable fluid channel height that allows for the application of controlled fluid shear stress to cells within the device, confirmed through particle image velocimetry of perfused microspheres. Single flow chambers support the growth of sufficient cellular numbers for endpoint analyses, such as Western blots. Finally, quantitative analysis of F-actin organization revealed that substrate stiffness and FSS synergistically increase filament length with independent effects on filament width, demonstrating the ability and usefulness of this model as a tool for studying the effect of multiple concurrent forces on cell behavior.</p>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10544-025-00787-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146082660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“A nano-enabled screen-printed paper-based electrochemical device with a 3D-printed wristband cassette design for selective and real-time detection of club drug amphetamine in complex matrices”","authors":"Nigar Anzar,&nbsp;Shariq Suleman,&nbsp;Suhel Parvez,&nbsp;Jagriti Narang","doi":"10.1007/s10544-025-00784-9","DOIUrl":"10.1007/s10544-025-00784-9","url":null,"abstract":"<div><p>Increasing drug-facilitated crimes, mainly sexual assaults have intensified the necessity of accessible and efficient methods for club drugs detection especially in biological matrices and beverages that are served at parties and clubs. The recent development of 3D printing technology has markedly accelerated. One prominent application is the fabrication of wearable electrochemical sensors for the selective and sensitive detection of club drugs such as amphetamine. This class of drug is used as a stimulant in the treatment of conditions including attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. Monitoring amphetamine type drugs level in human body is critical due to the risks associated with its possible misuses and related health concerns. By employing the use of 3D printing, makers can create complex and customized sensors specially intended for drug detection. This compliance facilitates integrating diverse type of sensors, thereby improving detection accuracy also. Conventional diagnostic methods are frequently labor-intensive and time-consuming, positioning 3D printed sensors as an innovative approach for real-time monitoring applications. Integrating 3D printing technology in sensor development holds significant potential to transform personalized healthcare by enabling accurate, rapid, and safe detection of amphetamine. This novel study shows the development of a screen-printed paper based electrochemical device with a 3D printed wristband cassette design named “3DP-PWC”. This 3D printed paper based wristband cassette (3DP-PWC) features modified electrodes with amphetamine binding aptamer and copper nanoparticles (CuNPs). For electrochemical study, cyclic voltammetry (CV), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS) were used and further validated the sensor’s performance. Developed sensor demonstrated versatility across various beverage types (alcoholic and non-alcoholic) and biological matrices such as synthetic urine. The developed sensor achieved a low detection limit (LOD) of ~0.02 μg/mL with a linear range between 0.01 to 7 μg/mL. Promising results were obtained at an optimum response time of approximately 25 seconds.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetically-guided, stimuli-responsive microdevices for endovascular therapy","authors":"Sanjay Manoharan,&nbsp;Vivek Subramanian","doi":"10.1007/s10544-026-00791-4","DOIUrl":"10.1007/s10544-026-00791-4","url":null,"abstract":"<div><p>Current endovascular aneurysm treatments rely on catheter-based delivery systems, which inherently restrict access to tortuous anatomies and small-caliber vessels. To address this limitation, we introduce a tetherless microdevice platform that combines magnetic guidance with near-infrared (NIR) triggered shape-memory polymer (SMP) deployment for wireless aneurysm therapy. In this system, an external actuator magnet steers a microdevice-integrated effector magnet through anatomically realistic silicone vascular phantoms, while melanin-doped PLA structures enable precise NIR-induced shape recovery. Because NIR light penetrates biological tissue, deployment can be activated non-invasively from outside the body. The platform supports two device architectures tailored to different clinical needs: a spiral flow disruptor with a retrievable magnet for partial inflow modulation and a petalloid occluder designed for permanent sealing of narrow-neck aneurysms. Their navigation behavior was modelled using a flow-responsive, magnetically modulated stick–slip (F-MMSS) framework that captures the influence of pulsatile flow and wall interactions. Experimentally, magnetic steering was demonstrated under physiologically relevant flow rates and NIR activation achieved reliable deployment through ex vivo tissue. Particle image velocimetry and computational fluid dynamics confirmed substantial reductions in intra-aneurysmal velocity across multiple geometries. Material characterization further verified that PLA–melanin composites exhibit suitable bio and hemocompatibility for preliminary use. Together, these results establish a proof-of-concept platform for wireless navigation and remote deployment of endovascular microdevices, motivating future in vivo evaluation. </p><h3>Graphical abstract</h3><p>Schematic illustration of a magnetically guided, NIR-triggered microdevice enabling targeted deployment of shape-memory occluders for aneurysm and tumor vessel therapy.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}