{"title":"Deep learning in Oral Lichen Planus diagnosis: a systematic review of clinical image-based detection approaches.","authors":"Atessa Pakfetrat, Alireza Sarraf Shirazi, Amirhossein Saeedi, Nazanin Salmani, Shayan Yousefi, Zeynab Ghasemi, Hanieh Kazemi, Muhammad Islampanah","doi":"10.1016/j.oooo.2025.07.009","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.07.009","url":null,"abstract":"<p><strong>Objectives: </strong>To systematically evaluate the diagnostic performance of deep learning models in detecting Oral Lichen Planus (OLP) using clinical photographs.</p><p><strong>Study design: </strong>This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and included studies utilizing deep learning architectures (e.g., Convolutional Neural Networks (CNNs), and Vision Transformers) for OLP diagnosis. Performance metrics such as accuracy, sensitivity, specificity, and Area Under the Receiver Operating Characteristic Curve (AUC) were extracted. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool.</p><p><strong>Results: </strong>All included models showed high diagnostic accuracy, with some exceeding 95%. Architectures such as InceptionResNetV2 and Xception have achieved notable sensitivity and specificity. However, limitations include small, homogeneous datasets, inconsistent image preprocessing, and limited external validation.</p><p><strong>Conclusions: </strong>Deep learning shows strong potential for OLP diagnosis via clinical images, but the real-world application remains limited. Broader datasets, robust validation, and integration of explainable artificial intelligence (AI) are essential for clinical adoption.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the editor regarding \"effect of allograft and collagen membrane application on periapical and labial bone regeneration in apicomarginal defects treated with endodontic microsurgery: a randomized controlled trial\".","authors":"Parth Aphale, Shashank Dokania, Himanshu Shekhar","doi":"10.1016/j.oooo.2025.07.012","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.07.012","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to the letter to editor regarding \"effect of allograft and collagen membrane application on periapical and labial bone regeneration in apicomarginal defects treated with endodontic microsurgery: a randomized controlled trial\".","authors":"Rahul Sharma, Sanjay Tewari, Pankaj Sangwan, Ambika Gupta","doi":"10.1016/j.oooo.2025.07.011","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.07.011","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ritesh Rajan, Eshwar Thota, Jhawar Dinesh Kumar, Abhinand Potturi, Nalla Viveka Vardhan Reddy, Y W Bharath, Rishi Kamal Reddy Yeredla
{"title":"Role of transcutaneous electric nerve stimulation (TENS) in the mandibular third molar surgery-a clinical study.","authors":"Ritesh Rajan, Eshwar Thota, Jhawar Dinesh Kumar, Abhinand Potturi, Nalla Viveka Vardhan Reddy, Y W Bharath, Rishi Kamal Reddy Yeredla","doi":"10.1016/j.oooo.2025.07.010","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.07.010","url":null,"abstract":"<p><strong>Objectives: </strong>Surgical extraction of the impacted mandibular third molar has undesirable side effects such as pain, swelling, bleeding, alveolar osteitis, and trismus. This study evaluates the efficiency of transcutaneous electronic nerve stimulation (TENS) in the control of perioperative pain and postoperative oedema & trismus after the surgical extraction of impacted mandibular 3rd molars.</p><p><strong>Study design: </strong>A prospective, comparative, randomized, double-blind controlled clinical study was conducted on 23 patients requiring surgical extraction of bilateral impacted mandibular third molars. Each site was randomly allocated to the study site where a physio track TENS appliance was applied preoperatively, immediately postoperatively, and on the postoperative 3rd day. The assessed variables are peri and postoperative pain, postoperative oedema and trismus.</p><p><strong>Results: </strong>The results of the present study demonstrated that preoperative and postoperative application of TENS helps in achieving good perioperative pain control, decreased facial swelling and early return to normal mouth opening.</p><p><strong>Conclusion: </strong>Postoperative recovery following surgical extraction was better in the TENS site than in the control site; therefore, the peri and postoperative placement of TENS can be recommended for quicker recovery to function.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohd Rafi Lone, Kamil Khan Pathan, Ananya Srivastava, Priyanshu Mishra, Ashfaq Ahmad Najar
{"title":"Navigating the AI frontier in healthcare: challenges and opportunities for chatbots in maxillofacial radiology.","authors":"Mohd Rafi Lone, Kamil Khan Pathan, Ananya Srivastava, Priyanshu Mishra, Ashfaq Ahmad Najar","doi":"10.1016/j.oooo.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.05.011","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early detection of acute mandibular osteomyelitis using computed tomography texture analysis","authors":"Hirotaka Muraoka DDS, PhD, Takashi Kaneda DDS, PhD, Kotaro Ito DDS, PhD, Kohei Otsuka DDS, PhD, Satoshi Tokunaga DDS, PhD","doi":"10.1016/j.oooo.2025.07.008","DOIUrl":"10.1016/j.oooo.2025.07.008","url":null,"abstract":"<div><h3>Objectives</h3><div>Early detection of acute suppurative osteomyelitis is difficult in clinical practice. The aim of this study was to evaluate the usefulness of computed tomography (CT) texture analysis in diagnosing acute mandibular osteomyelitis.</div></div><div><h3>Materials and Methods</h3><div>Seventeen patients who complained of severe mandibular pain and underwent CT examinations between July 2018 and September 2023 were included in the study. MaZda ver.3.3 software was used to extract 279 texture features from region of interests (ROIs) on CT images of patients with osteomyelitis (n = 17) and controls (contralateral sides) (n = 17). The acute osteomyelitis sites and controls were compared for each feature, and the 6 features that differed most significantly between groups were selected using Fisher's coefficient. The groups were compared using the Wilcoxon signed-rank test or paired t-test. Significance was set at <em>P</em> < 0.05. Receiver operating characteristic curves were used to evaluate the ability of the CT texture features to detect acute osteomyelitis.</div></div><div><h3>Results</h3><div>Significant differences in all 6 features were observed between the acute osteomyelitis and controls (<em>P</em> < 0.001). The sensitivity, specificity, accuracy, and area under the curve for detecting acute osteomyelitis were 0.94–1.0, 0.94–1.0, 0.97–1.0, and 0.96–1.0, respectively.</div></div><div><h3>Conclusions</h3><div>CT texture analysis may be useful in the early detection of acute mandibular osteomyelitis.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 5","pages":"Pages 634-641"},"PeriodicalIF":1.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Possible pemphigus vulgaris outbreak: case series","authors":"Kittiphoj Tikkhanarak, Wattawan Wongpattaraworakul, Emily Lanzel, Sherry Timmons, John Hellstein, Nidhi Handoo","doi":"10.1016/j.oooo.2025.04.068","DOIUrl":"10.1016/j.oooo.2025.04.068","url":null,"abstract":"<div><h3>Background</h3><div>Pemphigus vulgaris is an autoimmune disease that causes blisters on skin and/or the mucous membrane. It is the most common suprabasilar splitting disease in the oral cavity, with the oral cavity often showing the first signs of this condition. Though still a serious disease, pemphigus vulgaris can usually be treated with modern medical advances. In clinical practice, pemphigus vulgaris is most often seen in middle-aged female. We describe three cases of pemphigus vulgaris in male patients.</div></div><div><h3>Case description</h3><div>25-year-old, 30-year-old, and 50-year-old healthy male patients presented with multifocal painful erosions and ulcerations in the oral cavity. The second and third patients also had blisters and ulcers on their skin. The lesions appeared a few weeks following the injection of the COVID-19 vaccine. Biopsies were performed from either the oral lesions or skin lesions. All specimens displayed suprabasilar epithelial separation with acantholysis. Further investigation with direct immunofluorescence testing, and anti-desmoglein ELISA were conducted. These tests confirmed the diagnosis of pemphigus vulgaris. The treatment included topical steroids, systemic steroids, and Rituximab (anti-CD20 monoclonal antibody, IV).</div></div><div><h3>Conclusion</h3><div>There may be a rise in immune-mediated diseases in previously healthy patients of atypical age and gender demographics. If pemphigus vulgaris is diagnosed, further clinical history to include asking about COVID-19 infection/vaccination may be of interest to further evaluate any possible connection.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Pages e88-e89"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nirmatrelvir/ritonavir-induced oral lichenoid mucositis: a case report","authors":"Aubryana Payne, Andres Flores-Hidalgo","doi":"10.1016/j.oooo.2025.04.059","DOIUrl":"10.1016/j.oooo.2025.04.059","url":null,"abstract":"<div><h3>Introduction</h3><div>Lichenoid Mucositis (LM) is a chronic T-cell immune-mediation disorder often characterized by the presence of inflammatory infiltrates present in the subepithelial mucosa. The exact etiology of LM remains unknown, however, medications, local irritants, autoimmunity, and others have been linked to the clinical presentation of LM.</div></div><div><h3>Case Presentation</h3><div>74-year-old female presented to the ECU School of Dental Medicine with a 6 cm x 2 cm flat erythroleukoplakia and focally ulcerated lesion on the right buccal mucosa and the right lateral border of the tongue. No other ulceration was present in the oral cavity at the examination time. The patient reported the presence of a “nodule” on the right buccal mucosa after the administration of Paxlovid for the treatment of a COVID-19 infection. The patient reported the lesion as mildly irritant. Medical history was significant for Type II DM, HTN, and a heart murmur. Other intraoral finding included chronic active periodontitis. An incisional biopsy confirmed the lesion as an inflammatory subepithelial disorder consistent with lichenoid mucositis.</div></div><div><h3>Discussion and Conclusion</h3><div>The clinical presentation and findings of this case show strong correlation to case reports of oral lichenoid mucositis following COVID-19 treatment. Literature suggests that the onset of the lesion is multifactorial, however, there are no reports of direct causation between oral lichenoid mucositis and the administration of Paxlovid. The case report highlights the need for better insight into oral manifestations following COVID-19 infection and treatment.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Pages e85-e86"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Follicular lymphoma of the maxilla as initial site of presentation","authors":"Dennis Shem, David Koslovsky, Elizabeth Philipone","doi":"10.1016/j.oooo.2025.04.043","DOIUrl":"10.1016/j.oooo.2025.04.043","url":null,"abstract":"<div><div>Follicular lymphomas represent one of the more common B-cell lymphomas, typically involving the lymph nodes. Extranodal presentation is uncommon with intraoral sites rarely involved. We present the case of a 55-year-old female who presented for evaluation of multiple periapical radiolucencies of the maxillary dentition. These teeth had all tested vital previously. She reported a long history of left-sided nasal congestion refractory to antibiotics and steroids but was otherwise healthy. She did not report any constitutional symptoms. On examination, diffuse gingival erythema and edema of the maxilla was noted in addition to the multiple periapical radiolucencies. A biopsy of the maxillary gingiva and vestibule revealed involvement by a CD10+ B-cell lymphoma, favored to represent follicular lymphoma. Treatment is pending medical workup of other potential sites of disease.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Pages e80-e81"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ewing sarcoma of the head and neck: a histopathologic report of 3 cases","authors":"Min Kyeong Kim, Sook-Bin Woo","doi":"10.1016/j.oooo.2025.04.050","DOIUrl":"10.1016/j.oooo.2025.04.050","url":null,"abstract":"<div><div>Ewing sarcoma is a highly aggressive malignancy of bone and soft tissues that primarily affects the long bones of children and young adults. Approximately 85% of Ewing sarcomas harbor the chromosomal translocation t(11;22), which produces the characteristic oncogenic fusion gene <em>EWSR1</em>::<em>FLI1</em>. Although head and neck Ewing sarcomas (HNESs) are rare and only few extraskeletal cases have been reported, these still present with the usual molecular, microscopic, and immunophenotypic features. This paper reports 3 cases of HNESs in the maxilla of a 71-year-old male, mandible of an 18-year-old female, and floor of the mouth of a 32-year-old male. Microscopically, the tumors consist of a monomorphic population of small round blue cells with indistinct cell borders, scant amounts of pale cytoplasm, and round to ovoid vesicular nuclei with finely dispersed chromatin. Immunohistochemistry reveals diffuse and strong membranous CD99 reactivity and nuclear positivity for NKX2.2 in the tumor cells. There have been 183 reported cases of HNESs, with the mean age at diagnosis of 25 years. The most commonly affected sites are bones of the skull and face (including maxilla) (40%), soft tissues (30%), and mandible (9%). HNESs are uncommon, especially in nonpediatric population but should be considered in the differential diagnosis for tumors composed of undifferentiated small round blue cells. Other tumors that share similar histology include rhabdomyosarcomas, lymphomas, neuroendocrine tumors, primary and metastatic, and BCOR- and CIC-rearranged sarcomas to name a few. Immunohistochemistry with CD99 and NKX2.2 and molecular studies help to differentiate between such tumors.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e82"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}