Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献

{"title":"Clinicopathologic correlation case 2: multifocal, symptomatic oral mucosal lesions","authors":"Spencer Roark DDS , Vikki Noonan DMD, DMSc","doi":"10.1016/j.oooo.2025.01.721","DOIUrl":"10.1016/j.oooo.2025.01.721","url":null,"abstract":"<div><h3>Clinical Presentation</h3><div>A 25-year-old otherwise healthy female presented for evaluation of mildly painful, multifocal, episodic oral mucosal lesions. The lesions had been present for several months, and predominantly involved the tongue, buccal mucosa, and soft palatal mucosa. Despite efforts to expedite resolution with topical 0.05% clobetasol gel, a multivalent mouthwash, and 2 regimens of systemic prednisone under the care of her physician, the lesions continued to wax and wane. Upon further inquiry, she noted hair loss around the temples and also endorsed a recent history of an enigmatic, pruritic dermal rash that since resolved. Clinical evaluation revealed superficial white patches of the anterior and posterior dorsolateral and ventral tongue as well as several areas of erythematous mucosa surrounded by yellow-white borders of the bilateral buccal mucosa and soft palate extending to the hard and soft palate junction. (Figures 1, 2a, and 2b). The remainder of the oral mucosa was generally moist, pink, and of uniform contour and consistency.</div></div><div><h3>Differential Diagnosis</h3><div>The differential diagnosis for white and erythematous lesions affecting multiple sites within the oral cavity is broad and comprises a variety of disorders ranging from immune-mediated conditions to infectious diseases. Considerations in the differential diagnosis include contact hypersensitivity stomatitis, benign migratory stomatitis (geographic stomatitis), lichenoid mucositis, candidiasis, oral hairy leukoplakia, and syphilis.</div><div>Contact hypersensitivity stomatitis is a mucosal allergic hypersensitivity reaction to contactants characterized by variably symptomatic white, erythematous, or mixed red and white macular lesions or plaques involving the oral mucosa. This represents a type IV hypersensitivity reaction and is caused by a variety of inciting agents including flavorings found in mouthwashes, dentifrices, and candies/chewing gum, among others.<sup>1,2</sup> Although any mucosal site may be affected, the maxillary labial mucosa is frequently involved. In some instances, a temporal relationship exists between the onset of symptoms and exposition to the inciting agent; however, the underlying cause may not be readily identified. Although the possibility of a contact hypersensitivity reaction could not be entirely excluded in this case, topical corticosteroids are often helpful in expediting resolution, and as the patient endorsed breakthrough symptomatic lesions despite management with topical and systemic corticosteroids, this possibility seems less likely.</div><div>Benign migratory stomatitis (geographic stomatitis) is a chronic relapsing/recurring immune-mediated condition of unknown etiology that occurs in roughly 1% to 3% of the population. Although the etiopathogenesis is uncertain, predisposing factors include atopy (patients often endorse a history of environmental allergies, asthma, eczema, and food sensitivities) ","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 6","pages":"Pages e163-e167"},"PeriodicalIF":2.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LED-based low-level light therapy for oral mucositis in cancer patients: a systematic review and GRADE analysis.","authors":"Betsy Joseph, Matti Mauramo, Timo Sorsa, Sukumaran Anil, Tuomas Waltimo","doi":"10.1016/j.oooo.2025.04.095","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.04.095","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review aimed to evaluate the efficacy of light-emitting diode (LED) therapy in reducing oral mucositis (OM) severity, pain, and healing time in cancer patients and compare it to standard care or sham light.</p><p><strong>Materials and methods: </strong>A comprehensive search of major databases was conducted using relevant MeSH terms and keywords. Two authors independently screened studies meeting the eligibility criteria. The Cochrane Risk-of-Bias tool for randomized controlled trials (RoB-2) and the Risk of Bias in Non-Randomized Studies - of Interventions (ROBINS-I) were used to assess the methodological quality of included studies. The certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.</p><p><strong>Results: </strong>The review included five studies (256 participants). Four studies reported significant improvements in OM severity and pain with LED therapy while only one study suggested improved healing time. The risk of bias was moderate among the included studies. Due to heterogeneous data, a meta-analysis could not be performed. The GRADE assessment indicated low certainty of evidence, highlighting the need for further clinical research.</p><p><strong>Conclusion: </strong>LED therapy may effectively manage cancer therapy-induced OM by reducing patient-reported pain and OM duration. However, the low certainty of evidence warrants more well-designed, longitudinal studies with larger sample sizes to confirm these findings and establish optimal treatment protocols.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First case report of oral histoplasmosis in a patient receiving Secukinumab (Cosentyx): opportunistic infections as complication of emerging immunomodulatory therapies.","authors":"Hélen Kaline Farias Bezerra, Paulo Victor Mendes Penafort, Fábio de Abreu Alves, José Divaldo Prado, Pablo Agustin Vargas","doi":"10.1016/j.oooo.2025.04.096","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.04.096","url":null,"abstract":"<p><strong>Introduction: </strong>Histoplasmosis is an opportunistic infection that can manifest in immunosuppressed patients, particularly those on biologic therapies.</p><p><strong>Case report: </strong>This report presents a rare case of localized oral histoplasmosis in a 42-year-old Brazilian female undergoing treatment for ankylosing spondylitis (AS) with Secukinumab (Cosentyx), an interleukin-17 (IL-17) inhibitor. The patient presented with a painful, irregular gingival ulcer persisting for 4 months. Clinical examination revealed a 3 cm granular lesion involving the upper left gingiva. Histopathological analysis showed histiocytes containing yeast-like structures surrounded by a refractile halo, consistent with Histoplasma capsulatum by Grocott-Gomori methenamine silver staining. Chest computed tomography demonstrated no pulmonary involvement. Treatment consisted of oral itraconazole and discontinuation of Secukinumab, resulting in complete resolution of the lesion.</p><p><strong>Conclusion: </strong>Oral histoplasmosis, despite being rare, should be considered in immunosuppressed patients with persistent oral ulcers. IL-17 inhibitors, while effective for AS, increase the risk of fungal infections due to impaired mucocutaneous immune responses. This case highlights the importance of vigilance, early diagnosis, and appropriate management in patients on immunomodulators. It also underscores the need for clinical awareness and further research into the long-term risks of immunomodulatory agents. This report contributes to the growing evidence on opportunistic infections associated with immunomodulatory therapies.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between MTA1 and the outcome of oral leukoplakia: evidence from cohort studies and functional analyses.","authors":"Qiyue Zhang, Lin Ye, Ying Wang, Tiantian Xu, Shiyu Zhang, Zhiyong Wang, Qianming Chen, Jiang Liu, Xin Zeng, Jing Li","doi":"10.1016/j.oooo.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.04.005","url":null,"abstract":"<p><strong>Objective: </strong>To describe the relationship between MTA1 expression and Oral leukoplakia (OLK) prognosis in cohort studies and its possible mechanism.</p><p><strong>Materials and methods: </strong>We assessed MTA1 expression levels in OLK and OSCC tissues and cell lines using immunohistochemistry and Western blot. Functional analyses were performed in vitro by CCK-8 and Western blot assays. We analyzed overall survival in our OSCC cohort and TCGA dataset and analyzed the microenvironmental landscape of different MTA1 expression patterns in OLK and OSCC by multiplex immunohistochemistry. The Cox proportional hazards regression model was used to determine multivariate hazard ratios for overall survival.</p><p><strong>Results: </strong>MTA1 is abnormally highly expressed in OLK and OSCC both in cells and tissue, promoting DOK cell proliferation and altering EMT through E-cadherin, Wnt3a, and β-catenin. Moreover, MTA1 gradually increased with increasing abnormal OLK proliferation and negatively correlated with OSCC prognosis. Notably, MTA1 shows a positive correlation with M2 macrophage infiltration levels. Additionally, we found that low expression of MTA1 and a low M2/M1 ratio panel predict good patient prognosis in OSCC.</p><p><strong>Conclusion: </strong>We suggest that the aberrant expression of MTA1 may contribute to the malignant transformation of OLK and that MTA1 may represent a new prognostic marker for OLK and OSCC.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral potentially malignant disorders: clinical-pathological correlations in a dental institution in North Carolina.","authors":"Jarod Ruffing, Oscar Jaimes, David Paquette, Heather Khosa, Eric Holmes, Andres Flores-Hidalgo","doi":"10.1016/j.oooo.2025.04.003","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.04.003","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prevalence and diagnostic accuracy of oral potentially malignant disorders (OPMDs) in North Carolina, focusing on the agreement between clinical impressions and microscopic diagnoses.</p><p><strong>Study design: </strong>This retrospective study analyzed 76 patient records from the East Carolina University Oral Pathology Biopsy Service. Clinical impressions of OPMDs, including leukoplakia, erythroplakia, and chronic ulcers, were compared with histopathological diagnoses. Data were collected using HIPAA-compliant software, and Cohen's Kappa was used to evaluate diagnostic agreement.</p><p><strong>Results: </strong>The patient cohort had a mean age of 62.2 years, with 65.7% male and 60.5% identifying as Caucasian. The most common lesion locations were the lateral tongue (32.8%) and alveolar ridge mucosa (27.6%). Minimal agreement was observed between clinical impressions and microscopic diagnoses (Kappa: 0.0266 ± 0.0682, P = .6965). Smoking and alcohol use were significantly associated with higher grades of oral epithelial dysplasia.</p><p><strong>Conclusion(s): </strong>The study highlights significant diagnostic challenges in identifying OPMDs based on clinical impressions alone, emphasizing the need for histopathological evaluation. Improved diagnostic training and public health interventions are essential to enhance early detection and reduce the burden of oral cancer in North Carolina.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonal rearrangements of B and T lymphocytes in minor salivary gland biopsies of Sjögren's disease patients with a focus score of ≥1.","authors":"Juan Pablo Castañeda-González, Juan José Capasso, Andrea Viviana Gualteros Bustos, Alejandro Escobar, Ana María Arredondo, Jairo Cajamarca-Barón, Héctor Cubides, José Fernando Polo, Claudia Ibáñez-Antequera, Gabriel-Santiago Rodríguez-Vargas, Andrés Felipe Lamos-Duarte, Carlos Santiago Rivadeneira-Chamorro, Adriana Rojas-Villarraga, Rafael Parra-Medina","doi":"10.1016/j.oooo.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.04.004","url":null,"abstract":"<p><strong>Introduction: </strong>Sjögren's Disease (SjD) is a systemic autoimmune disease with an increased risk of developing hematolymphoid neoplasms, with mucosa-associated marginal zone lymphoma being the most common. This could be related to the lack of a diagnostic test to achieve early diagnosis. Clonal rearrangements are molecular tests used in the diagnosis of lymphoid neoplasms that have proven to be supportive in the diagnosis and may be useful in the early diagnosis process when applied to minor salivary gland biopsies (MSGB).</p><p><strong>Methods: </strong>Cross-sectional study including MSGB with a diagnosis of SjD between 2019 and 2022 at a university hospital in Bogota, Colombia. Sociodemographic data and histopathological characteristics were collected. Immunohistochemical studies and rearrangement tests were then performed according to the BIOMED-2 protocol.</p><p><strong>Results: </strong>Rearrangements were performed for T cell receptors and B cell immunoglobulins. A polyclonal result was found in most cases. Four cases were oligoclonal in IgH and two isolated clonal results: one in the TCR β segment and the other in the kappa light chain segment of immunoglobulin.</p><p><strong>Conclusion: </strong>Clonal rearrangements may be a useful tool for the early diagnosis of hematolymphoid neoplasms. Further studies with longer follow-up and application to MSGB are needed to better define a clonal pattern.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of a virtual assistant based on ChatGPT-4 in the diagnosis of syndromes with orofacial manifestations.","authors":"Marcos Paulo Maia-Lima, Livian Isabel de Medeiros Carvalho, Eduarda Gomes Onofre de Araújo, Hélder Domiciano Dantas Martins, Renato Assis Machado, Livia Maria Ferreira Sobrinho, Hercílio Martelli-Júnior, Paulo Rogério Ferreti Bonan","doi":"10.1016/j.oooo.2025.04.002","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.04.002","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the performance of the virtual assistant \"Syndromic Diseases and Orofacial Features\" (SDOF), developed based on the Generative Pre-trained Transformer 4 model, in formulating diagnostic hypotheses and recommendations for syndromes with orofacial manifestations.</p><p><strong>Study design: </strong>Twenty-six anonymized, previously diagnosed clinical cases, including clinical features and images, were selected. The assistant was trained using scientific references and configured to generate diagnostic hypotheses and suggest complementary exams. The responses were evaluated by two oral diagnosis specialists based on criteria such as accuracy, completeness, relevance, and comprehensibility. Statistical analysis was performed using RStudio software to calculate means and standard deviations.</p><p><strong>Results: </strong>The SDOF correctly identified 96.2% of the cases, with 80.8% being the first diagnostic hypothesis and 15.4% being the second. In only one case (3.8%), the correct diagnosis was presented as the third hypothesis. The assistant performed best in the criteria \"Relevance,\" \"Practicality,\" and \"Readability,\" while \"Completeness\" and \"Up-to-dateness\" scored the lowest. Despite the high accuracy rate, the assistant failed to mention all diagnostic steps in 7.69% of the cases.</p><p><strong>Conclusions: </strong>The SDOF demonstrated significant potential to assist in the diagnosis of orofacial syndromes, with promising accuracy rates. However, the tool still requires professional supervision and improvements in completeness and up-to-dateness.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of khat (Catha edulis) chewing on dry mouth and taste function: a comparative cross-sectional study.","authors":"Ola Mohsen Al-Akwa'a, Manal Mohammed Al-Hajri, Asma'a Mansour ALHowshabi, Sadeq Ali Al-Maweri, Esam Halboub","doi":"10.1016/j.oooo.2025.03.016","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.03.016","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was to evaluate oral dryness and the taste sensation threshold (sweet, salt, sour, and bitter) among khat chewers.</p><p><strong>Methods: </strong>This cross-sectional comparative study enrolled 140 healthy individuals divided into 2 groups: khat chewers (KCs; n = 73), and non-chewers (NCs; n = 67). Oral dryness was assessed using the Clinical Oral Dryness Score (CODS), whereas taste perception was assessed using the 4 primary tastes: sweet, salty, sour, and bitter, along with the Total Taste Score (TTS), each prepared as 7 chemical solutions representing 7 concentrations. SPSS version 26 was used for data analysis.</p><p><strong>Results: </strong>Overall, KC revealed significantly higher overall CODS scores compared to NCs (4.26 ± 1.39 vs 2.10 ± 1.15, P < .001). The TTS was significantly lower in KCs (16.52 ± 3.367) compared to NCs (18.87 ± 3.592, P < .001), owing to revealing significantly lower mean taste sensation scores for sweet, salty, and bitter tastes but not for sour taste. Up to 20.5% of KCs had hypogeusia compared with only 4.5% of NCs (P = .005). Multivariate analyses also revealed khat chewing as an independent determinant factor for oral dryness and hypogeusia.</p><p><strong>Conclusions: </strong>Chronic khat chewing is associated with mouth dryness and taste impairment, gravely impacting on the patients' quality of life. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teriparatide as an adjuvant therapy in the management of advanced-stage medication-related osteonecrosis of the jaw.","authors":"Annu Singh, Kevin Chung, Joseph M Huryn, Cherry L Estilo, Azeez Farooki, SaeHee K Yom","doi":"10.1016/j.oooo.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.04.001","url":null,"abstract":"<p><p>Teriparatide, recombinant human parathyroid hormone, is a US Food and Drug Administration (FDA)-approved drug used for the treatment of osteoporosis in men and postmenopausal women. Recent studies have shown that it may promote bone healing in medication-related osteonecrosis of the jaw (MRONJ). We describe a case of successful management of advanced-stage MRONJ with teriparatide therapy that was initially prescribed for osteoporosis. This case demonstrates that in patients with progressive MRONJ with significant pain and frequent flares of acute infection, teriparatide may be a viable adjunct in treating MRONJ, as well as helping alleviate symptoms and improve quality of life. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of antibiotic stewardship on infection rates in oral surgery procedures: a descriptive study","authors":"Gaurav Patri MDS ,&nbsp;Chintan Manjibhai Savani MDS ,&nbsp;Lisamarie S.L. Colaco MDS ,&nbsp;Supriya Sourabh MDS ,&nbsp;Lakshmi Priya MDS ,&nbsp;Paluck Meston","doi":"10.1016/j.oooo.2025.02.020","DOIUrl":"10.1016/j.oooo.2025.02.020","url":null,"abstract":"<div><h3>Background</h3><div>Antibiotic use in oral surgery procedures is common; and inappropriate prescribing may contribute to antibiotic resistance. However, the impact of antibiotic stewardship programs (ASPs) on infection rates in oral surgery settings is not well established. This study explores the effect of implementing an ASP in an oral surgery clinic to reduce infection rates.</div></div><div><h3>Methods</h3><div>A team comprising oral surgeons, pharmacists, and infection control specialists developed and implemented a targeted ASP focusing on patient education, prescribed guidelines, and infection prevention strategies. A retrospective review of patient records was conducted to evaluate infection rates in oral surgery procedures before and after the program’s implementation.</div></div><div><h3>Results</h3><div>Preintervention infection rates for oral surgery procedures were 8.3% (45/540). After the implementation of the ASP, infection rates decreased to 3.7% (15/400), representing a significant reduction (<strong><em>P</em> &lt; .001)</strong>. Compliance with the revised prescribing guidelines increased, and feedback from oral surgeons and patients was positive.</div></div><div><h3>Conclusions</h3><div>The implementation of an ASP in an oral surgery setting significantly reduced infection rates. This model, based on evidence-based practices and tailored interventions, can be adapted to other oral surgery practices to enhance patient outcomes and reduce antibiotic overuse.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 2","pages":"Pages e29-e34"},"PeriodicalIF":2.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}