Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献_第4页

Assessment of salivary biomarkers in psoriasis: a comprehensive scoping review 银屑病唾液生物标志物的评估：一项全面的范围审查。

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-28 DOI: 10.1016/j.oooo.2025.03.013

Larissa Conrado da Silva DDS , Luana Côrtes Amorim Guimarães DDS , Diego Belmiro do Nascimento Santos DDS , Lucas Alves Jural DDS , Sílvia Paula de Oliveira DDS, MSc, PhD , Bruno Augusto Benevenuto de Andrade DDS, MSc, PhD , Jefferson R. Tenório DDS, MSc, PhD

{"title":"Assessment of salivary biomarkers in psoriasis: a comprehensive scoping review","authors":"Larissa Conrado da Silva DDS , Luana Côrtes Amorim Guimarães DDS , Diego Belmiro do Nascimento Santos DDS , Lucas Alves Jural DDS , Sílvia Paula de Oliveira DDS, MSc, PhD , Bruno Augusto Benevenuto de Andrade DDS, MSc, PhD , Jefferson R. Tenório DDS, MSc, PhD","doi":"10.1016/j.oooo.2025.03.013","DOIUrl":"10.1016/j.oooo.2025.03.013","url":null,"abstract":"<div><h3>Objective</h3><div>To map the evidence on altered salivary biomarkers in individuals with psoriasis.</div></div><div><h3>Study design</h3><div>A comprehensive literature search was conducted across six databases and gray literature sources using keywords related to psoriasis and salivary biomarkers, with no restrictions on time or language, up to November 2024. Studies evaluating salivary biomarkers in humans with psoriasis were considered eligible. Identified outcomes were categorized based on biomarker type and analyzed descriptively.</div></div><div><h3>Results</h3><div>A total of 661 studies were initially identified, of which 22 met the inclusion criteria. These comprised 15 cross-sectional studies, 6 cohort studies, and 1 randomized clinical trial, collectively involving 987 individuals with psoriasis. The primary altered salivary biomarkers identified included inflammatory cytokines (IL-1β, IL-2, IL-6, IL-10, TNF-α, INF-γ), oxidative stress mediators (nitric oxide, nitrotyrosine), antioxidant enzymes (catalase, superoxide dismutase), immunological markers (salivary alpha-amylase, secretory immunoglobulin A), and stress-related hormones. Many of these biomarkers were significantly associated with disease severity and therapeutic response.</div></div><div><h3>Conclusion</h3><div>Cortisol, inflammatory cytokines and oxidative stress mediators are the most frequently altered salivary biomarkers in individuals with psoriasis. However, the methodological heterogeneity among the studies highlights the need for well-designed prospective studies with representative sample sizes to validate these findings.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 2","pages":"Pages 186-197"},"PeriodicalIF":2.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor: Imaging anomaly associated with use of patient position orientation letter on panoramic radiography 给编辑的信：在全景x线摄影中使用患者位置定位信相关的成像异常。

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-26 DOI: 10.1016/j.oooo.2025.03.007

John K. Brooks DDS, Azin Parsa DDS, MSc, MS, PhD, Jeffery B. Price DDS, MS

引用次数: 0

Plexiform ameloblastoma: a potential diagnostic challenge. 丛状成釉细胞瘤：一个潜在的诊断挑战。

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-22 DOI: 10.1016/j.oooo.2025.03.006

Michelle Huang, Grace Bradley, Bayardo Perez-Ordonez, Hagen Klieb, Nick Blanas, Marco A O Magalhaes

{"title":"Plexiform ameloblastoma: a potential diagnostic challenge.","authors":"Michelle Huang, Grace Bradley, Bayardo Perez-Ordonez, Hagen Klieb, Nick Blanas, Marco A O Magalhaes","doi":"10.1016/j.oooo.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.03.006","url":null,"abstract":"<p><strong>Objective: </strong>Ameloblastoma is a benign, locally aggressive neoplasm of the jaws. Accurate diagnosis is important for providing timely treatment and reducing the risk of recurrence and local destruction. The criteria for diagnosing ameloblastoma are well-defined, however, rare cases have been observed with a multicystic/unicystic plexiform pattern that lacks pathognomonic histologic features, causing difficulties in differentiating them from less aggressive jaw lesions. Our main objective was to review these plexiform ameloblastomas that could prove challenging for pathologists on incisional biopsies.</p><p><strong>Study design: </strong>We reviewed cases of ameloblastoma in the University of Toronto diagnostic biopsy service from 2004 to 2024, n = 200. Cases with a microscopic description of cystic plexiform epithelial proliferation were retrieved for analysis of histopathologic features, clinical and radiographic information.</p><p><strong>Results: </strong>A rare subset of ameloblastoma (4%, 8 of 200) presented a distinctive histologic appearance of cystic plexiform proliferation lacking ameloblast-like cells, but clinical and radiographic features characteristic of ameloblastoma. Immunohistochemical staining for the BRAF p.V600E mutation was positive in 7 of 8 cases, demonstrating the importance of BRAF testing to aid in diagnosis.</p><p><strong>Conclusions: </strong>Our study highlights an uncommon and potentially challenging histologic pattern of ameloblastoma for which a coordinated approach using clinical, radiographic, histologic, and molecular studies are needed for timely and accurate diagnosis.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial photodynamic therapy in the treatment of oral lesions: experience report and clinical protocol 抗菌光动力疗法治疗口腔病变：经验报告和临床方案

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.059

Giovanna Meneses, Maria Paula Siqueira de Melo Peres, Juliana Bertoldi Franco

{"title":"Antimicrobial photodynamic therapy in the treatment of oral lesions: experience report and clinical protocol","authors":"Giovanna Meneses, Maria Paula Siqueira de Melo Peres, Juliana Bertoldi Franco","doi":"10.1016/j.oooo.2025.01.059","DOIUrl":"10.1016/j.oooo.2025.01.059","url":null,"abstract":"<div><div>Antimicrobial photodynamic therapy (aPDT) is based on the application of a photosensitizing agent on the injured tissue followed by low-level laser therapy (LLLT) emission on the region. The interaction generates free radicals and oxidation of the plasma membrane of microorganisms, providing antimicrobia, antiviral and antifungal activity without harming healthy host cells. Is considered a noninvasive, local, painless procedure, which has the advantage of tissue biostimulating, helping to reduce the administration of systemic medications in immunosuppressed patients. The photosensitizing agent (methylene blue 0.01%) was applied over all lesions and, after 5 minutes, LLLT was used at 660 nm, on contact mode, point by point, with 100 mW, 178 J/cm 2, 6J, and 60s per point, with sessions every 24 hours depending on clinical evolution. Widely used in the treatment of oral lesions in adult and pediatric patients, in herpetic lesions, candidiasis, Paracoccidioidomycosis, osteonecrosis of the jaws, and osteoradionecrosis, with success.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e11"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nevoid basal cell carcinoma syndrome: clinical presentation, diagnosis, and management in a pediatric patient 痣基底细胞癌综合征：临床表现，诊断和管理的儿科患者

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.037

Fabiana Ferreira Alves, Ana Claudia Garcia Rosa, Basilio de Almeida Milani

{"title":"Nevoid basal cell carcinoma syndrome: clinical presentation, diagnosis, and management in a pediatric patient","authors":"Fabiana Ferreira Alves, Ana Claudia Garcia Rosa, Basilio de Almeida Milani","doi":"10.1016/j.oooo.2025.01.037","DOIUrl":"10.1016/j.oooo.2025.01.037","url":null,"abstract":"<div><div>Nevoid Basal Cell Carcinoma Syndrome (NBCCS) is a hereditary condition caused by mutations in the PTCH gene, leading to multiple basal cell carcinomas on the skin, odontogenic keratocysts, intracranial calcifications, and anomalies of the ribs and vertebrae. A 10-year-old girl presented with maxillary and mandibular unicystic radiolucent lesions, a family history of cutaneous tumors, and physical characteristics such as palmoplantar depressions, hypertelorism, and bifid ribs. Incisional biopsy of the maxillary lesions revealed cysts lined with keratinized odontogenic epithelium with palisaded basal layer cells, diagnosed as keratocysts. Based on clinical features and complementary exams, the final diagnosis was NBCCS. Treatment involved the enucleation of keratocysts and peripheral ostectomy. The patient is under constant follow-up. Genetic counseling is crucial in NBCCS. Due to its impacts on various organs, treatment requires a multidisciplinary team and continuous monitoring. Early diagnosis is essential for screening neoplasms and reducing the morbidity associated with basal cell carcinomas.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e7"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral manifestations of congenital syphilis: a case report 先天性梅毒口腔表现1例

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.043

Paula Joaquim Bratfisch Lins, Fabiana Martins e Martins de Oliveira, Marina Gallottini

{"title":"Oral manifestations of congenital syphilis: a case report","authors":"Paula Joaquim Bratfisch Lins, Fabiana Martins e Martins de Oliveira, Marina Gallottini","doi":"10.1016/j.oooo.2025.01.043","DOIUrl":"10.1016/j.oooo.2025.01.043","url":null,"abstract":"<div><div>A 4-year-old girl presented for a dental appointment at the Special Care Dentistry Center, brought by her paternal grandmother complaining of dental hypersensitivity. The patient was born prematurely, with low birth weight, and congenital syphilis. She presents with deafness, prominent frontal bossing, and so far, has shown normal neuro-motor development. She has primary dentition with generalized enamel structure alterations, characterized by yellowish teeth, hypoplastic teeth, enamel prominences, and anterior open bite. Radiographic images and dental history revealed the congenital absence of mandibular second premolars and notched incisors. Interstitial keratitis, which completes the Hutchinson's triad, has not been investigated yet. The treatment plan includes preventive care, photobiomodulation protocol for dentin hypersensitivity, molar sealings, direct resin restorations for aesthetic purposes, and occlusal follow-up of permanent dentition. Congenital syphilis is a preventable disease, and its presence reflects a failure of the prenatal care delivery system, as well as syphilis control programs.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e8"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medication associated osteonecrosis: exploring the efficacy of sonodynamic therapy in a series of cases 药物相关性骨坏死：探讨声动力治疗在一系列病例中的疗效

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.026

Larissa Araujo Agatti, Paulo de Camargo Moraes, Aguinaldo Garcez, Daniela Prata Tacchelli, Marcelo Sperandio, Victor Montalli

{"title":"Medication associated osteonecrosis: exploring the efficacy of sonodynamic therapy in a series of cases","authors":"Larissa Araujo Agatti, Paulo de Camargo Moraes, Aguinaldo Garcez, Daniela Prata Tacchelli, Marcelo Sperandio, Victor Montalli","doi":"10.1016/j.oooo.2025.01.026","DOIUrl":"10.1016/j.oooo.2025.01.026","url":null,"abstract":"<div><div>This study explores Sonodynamic Therapy (SDT) for treating oral osteonecrosis in 6 patients, after cancer therapies including bisphosphonates, monoclonal antibodies, and corticosteroids. These treatments previously led to complications like pain, recurrent infections, and reduced quality of life, affecting dietary habits and social interactions due to the odor of lesions. Osteonecrosis, linked to medication, diminishes bone blood supply either temporarily or permanently. Comprehensive patient evaluations, including medication histories and clinical imaging, preceded SDT treatment. SDT, an innovative approach, uses low-frequency, high-intensity ultrasound to activate sonosensitizers, producing reactive oxygen species (ROS) for noninvasive infection control. Remarkable improvements were observed in all patients, demonstrating SDTs broader clinical utility, especially in resource-limited settings. This research underscores SDTs efficacy in improving osteonecrosis patients’ conditions, suggesting the need for further investigation and potential adoption in clinical practices. The study indicates SDTs promise to enhance quality of life and support its broader clinical application and research.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e5"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tyrosine kinase inhibitor as a cause of palatal pigmentation 酪氨酸激酶抑制剂作为腭色素沉着的原因

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.084

André Luis Santana de Freitas, Marcelo Sperandio, Rosane Rezende de Souza Giuliani, Alvaro Luiz Mendonça Pinheiro Barbosa, Tiago Tavares, Andresa Borges Soares, Fabricio Passador-Santos

引用次数: 0

Tongue neuroma in a pediatric patient 小儿舌神经瘤1例

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.052

Mariana Israel Rocha, Karine Duarte da Silva, Juliani Santana de Oliveira, Kelly Machado de Andrade e Reyes, Ingrid Akemi Morita Kataguiri, Tatiane Marega, Silvana Ribeiro Roda

引用次数: 0

Management of odontogenic myxoma and carcinoma cases for oral rehabilitation 牙源性黏液瘤及癌的口腔康复治疗

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.055

Leonardo Das Neves Souza, Daniel Yuydi Kawakami, Gisele Lie Fukuoka, Carina Domaneschi, Érico Castaldin Fraga Moreira, Rodrigo Diniz Gomes, Roberto Chaib Stegun

{"title":"Management of odontogenic myxoma and carcinoma cases for oral rehabilitation","authors":"Leonardo Das Neves Souza, Daniel Yuydi Kawakami, Gisele Lie Fukuoka, Carina Domaneschi, Érico Castaldin Fraga Moreira, Rodrigo Diniz Gomes, Roberto Chaib Stegun","doi":"10.1016/j.oooo.2025.01.055","DOIUrl":"10.1016/j.oooo.2025.01.055","url":null,"abstract":"<div><div>This study describes the rehabilitation of 2 patients, one with mandibular odontogenic myxoma and the other with epithelial-myoepithelial carcinoma (EMC) of the salivary gland. The first patient faced complications in speech, eating, and aesthetics after a mandibular resection performed in 2012. The second underwent chemotherapy and radiotherapy treatment in 2021 and began oral rehabilitation in 2022. The patients were submitted to clinical and radiographic exams, revealing that both presented loss of Vertical Dimension of Occlusion (VDO). Additionally, the patient with myxoma lost the alveolar ridge due to surgical treatment and the rehabilitation was done by using conventional removable partial dentures (RPD). The patient with EMC had an absence of 11 teeth, and the rehabilitation was done using thermoplastic resin RPD. Both patients are followed up twice a year. This study highlights that treatment with RPD provides a functional and cost-effective option for oral structure injuries.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e10"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0