Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献_第3页

Preoperative Prediction of Lymph Node Status in Oral Squamous Cell Carcinoma: Value of Quantitative Dual-Energy CT Parameters. 口腔鳞状细胞癌术前淋巴结状态预测：定量双能CT参数的价值。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-19 DOI: 10.1016/j.oooo.2025.08.005

Fengqiong Huang, Xiaohua Ban, Yusong Jiang, Guoxiong Lu, Fang Zhang

{"title":"Preoperative Prediction of Lymph Node Status in Oral Squamous Cell Carcinoma: Value of Quantitative Dual-Energy CT Parameters.","authors":"Fengqiong Huang, Xiaohua Ban, Yusong Jiang, Guoxiong Lu, Fang Zhang","doi":"10.1016/j.oooo.2025.08.005","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.005","url":null,"abstract":"Objectives: The objective of this study was to explore whether parameters of dual-energy computed tomography (DECT) could help evaluate the status of cervical lymph nodes (LNs) in patients with oral squamous cell carcinoma (OSCC).Study design: Pathological and DECT parameters of patients with OSCC who underwent cervical lymph node dissection from December 2021 to December 2022 were collected. Quantitative DECT parameters of the primary lesions, including the slope of the spectral Hounsfield unit curve (λHU), iodine concentration (IC), electron density (Rho), normalized iodine concentration (NIC), and effective atomic number (Zeff), were measured between patients with different lymph node status (the presence of LN metastasis, lymph node ratio [LNR], and lymph node burden [LNB]). The receiver operating characteristic curves and logistic regression analysis were used to evaluate the diagnostic performance and the independent parameters, respectively.Results: The independent predictor for the detection of LN metastasis was λHU in venous phase, with an area under the curve (AUC) of 0.812. The mean precontrast Zeff was higher in the high metastatic LNB group than the low metastatic LNB group. The precontrast Zeff was the independent predictor of high LNR with an AUC of 0.726.Conclusions: DECT quantitative parameters of the primary lesions can facilitate the evaluation of cervical LN status.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging techniques for evaluating temporomandibular joint involvement in juvenile idiopathic arthritis: a systematic review. 评估青少年特发性关节炎颞下颌关节受累的影像学技术：系统综述。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-19 DOI: 10.1016/j.oooo.2025.08.006

Gianna Dipalma, Alessio Danilo Inchingolo, Mariafrancesca Guglielmo, Roberta Morolla, Irene Palumbo, Lilla Riccaldo, Daniela Di Venere, Andrea Palermo, Angelo Michele Inchingolo, Francesco Inchingolo

{"title":"Imaging techniques for evaluating temporomandibular joint involvement in juvenile idiopathic arthritis: a systematic review.","authors":"Gianna Dipalma, Alessio Danilo Inchingolo, Mariafrancesca Guglielmo, Roberta Morolla, Irene Palumbo, Lilla Riccaldo, Daniela Di Venere, Andrea Palermo, Angelo Michele Inchingolo, Francesco Inchingolo","doi":"10.1016/j.oooo.2025.08.006","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.006","url":null,"abstract":"Objective: Juvenile idiopathic arthritis (JIA) encompasses a group of chronic inflammatory disorders affecting children and adolescents, characterized by persistent arthritis of unknown etiology. Its pathogenesis is multifactorial, involving genetic, environmental, and immunological factors. This systematic review evaluates current diagnostic approaches for detecting temporomandibular joint (TMJ) involvement in JIA.Materials and methods: Following PRISMA guidelines and registered in PROSPERO (CRD 529873), a comprehensive search was conducted in PubMed, Scopus, and Web of Science for studies published between January 1, 2013, and August 1, 2024. SEARCH TERMS INCLUDED: (Imaging OR CBCT OR cone beam OR MRI OR ultrasound OR magnetic resonance imaging) AND (juvenile idiopathic arthritis OR JIA) AND (temporomandibular joint OR TMJ). Studies focusing on TMJ diagnostic techniques in JIA patients were included.Results: Out of 528 records, 18 studies met the inclusion criteria. The results emphasize the critical role of advanced imaging-particularly magnetic resonance imaging (MRI), cone beam computed tomography (CBCT), and ultrasound (US)-in detecting early TMJ changes. While MRI remains the gold standard for evaluating soft tissue and inflammatory activity, CBCT and US offer complementary insights. The review highlights the need for standardized diagnostic protocols and further studies to refine imaging strategies and improve clinical outcomes in JIA.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salivary flow and aging: a cross-sectional estimate of the annual decline per year of age. 唾液流量和衰老：每年年龄下降的横断面估计。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-19 DOI: 10.1016/j.oooo.2025.08.008

Camila Pinho E Souza Coelho, Joana Rodrigues da Silva, Rafaella Cristhina Rego Marques, Jéssica Luiza Mendonça Albuquerque de Melo, Larisse Mendonça Alves, Carlos Daniel Correa de Oliveira Melo, Eduarda Carvalho Leite, Priscilla Fernandes, Rafael Lara Brasil, Pedro Chagas Pereira Neto, Fernanda de Paula E Silva Nunes, Solange Baraldi, Debora Heller, Maria do Carmo Machado Guimarães, Érica Negrini Lia, Naile Dame-Teixeira

{"title":"Salivary flow and aging: a cross-sectional estimate of the annual decline per year of age.","authors":"Camila Pinho E Souza Coelho, Joana Rodrigues da Silva, Rafaella Cristhina Rego Marques, Jéssica Luiza Mendonça Albuquerque de Melo, Larisse Mendonça Alves, Carlos Daniel Correa de Oliveira Melo, Eduarda Carvalho Leite, Priscilla Fernandes, Rafael Lara Brasil, Pedro Chagas Pereira Neto, Fernanda de Paula E Silva Nunes, Solange Baraldi, Debora Heller, Maria do Carmo Machado Guimarães, Érica Negrini Lia, Naile Dame-Teixeira","doi":"10.1016/j.oooo.2025.08.008","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.008","url":null,"abstract":"Objective: Although reduced salivary flow is often linked to aging, the extent of this decline across different age groups remains unclear. This study investigated the relationship between salivary flow and age, accounting for type 2 diabetes (T2D), polypharmacy, and fiber intake, aiming to estimate an annual rate of decline.Study design: Adults and elderly participants (mean age 54 ± 11 years) were recruited for this cross-sectional study. Resting salivary flow (RSF), stimulated salivary flow (SSF), pH, buffering capacity, viscoelasticity, medication intake and, T2D diagnosis were the main variables analyzed. Participants were classified as having hyposalivation if RSF < 0.1 mL/min or SSF < 0.7 mL/min. Associations were tested using unadjusted and adjusted robust linear regression (P < .05).Results: Sialometry was completed for 166 individuals. Hyposalivation was identified in 31% by RSF and 89% by SSF. Among adults under 60 years(n = 118), 28 (24%) had RSF hyposalivation and 99 (85%) had SSF hyposalivation. Older participants had significantly lower RSF and SSF. Salivary flow was estimated to decrease by 0.005 mL/min per year of age, independent of T2D and medication use.Conclusion: Salivary flow is associated with age, independent of T2D and medication use. Although the decline appears predictable (0.005ml/min/year), its clinical relevance warrants further investigation through longitudinal studies.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apremilast for refractory major recurrent aphthous stomatitis involving the posterior pharyngeal wall: a case report. 阿普米司特治疗累及咽后壁的复发性口疮性难治性口腔炎1例。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-19 DOI: 10.1016/j.oooo.2025.08.003

Tinglan Yang, Jiankang Yang, Qing Liu, Zhenlai Zhu

引用次数: 0

Perception of advanced practice providers in academic oral and maxillofacial surgery. 学术口腔颌面外科先进实践提供者的认知。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-08 DOI: 10.1016/j.oooo.2025.07.017

Lauren Anderson, Janice Weinberg, Charles Henry, Pushkar Mehra

{"title":"Perception of advanced practice providers in academic oral and maxillofacial surgery.","authors":"Lauren Anderson, Janice Weinberg, Charles Henry, Pushkar Mehra","doi":"10.1016/j.oooo.2025.07.017","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.07.017","url":null,"abstract":"Objective: The objective of this study was to assess differences in the perception of the role of advanced practice providers (APPs) within an academic oral and maxillofacial surgery (OMS) department.Study design: We surveyed OMS providers including APPs, residents, and attending surgeons. The survey covered 5 areas: impact of APPs on resident training, knowledge of APP training, interaction with APPs, scope-of-practice of APPs, and role of APPs in the health care team.Results: The attendings and APPs felt that the APPs had a positive impact on resident education, although the residents disagreed. Attendings and residents had limited knowledge about the APP training background. There was general agreement in the APP scope-of-practice, excepting for procedures. Attendings and the APPs felt that the role of the APP was well defined, although the residents disagreed.Conclusions: As the role of APPs within academic OMS continues to evolve, it is important to address the differences in the perception of APPs among providers. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proliferative verrucous leukoplakia and unifocal verrucous leukoplakia in China: a comparative retrospective cohort study. 中国增殖性疣状白斑和单发性疣状白斑：一项比较回顾性队列研究。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-07 DOI: 10.1016/j.oooo.2025.07.013

Shuangshuang Wu, Linman Li, Xu Wang, Zhimin Yan

{"title":"Proliferative verrucous leukoplakia and unifocal verrucous leukoplakia in China: a comparative retrospective cohort study.","authors":"Shuangshuang Wu, Linman Li, Xu Wang, Zhimin Yan","doi":"10.1016/j.oooo.2025.07.013","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.07.013","url":null,"abstract":"Objective: There are limited data regarding the association and differentiation between proliferative verrucous leukoplakia (PVL) and unifocal verrucous leukoplakia (UVL).Methods: We retrospectively recruited oral leukoplakia (OL) patients from 2010 to 2024, analyzing the demographic, clinical, histopathological features, and malignant transformation of PVL and UVL.Results: Among 1756 OL subjects, PVL and UVL accounted for 1.88% and 1.54%, respectively, sharing features like similar age of onset and high dysplasia rates (57.58% vs 55.56%). However, significant differences still existed. Gender ratios were 1:2 in PVL and 2.34:1 in UVL. PVL had lower diagnostic accuracy due to lichenoid lesions in 69.70% of patients and higher biopsy counts (2.19 vs 1.19). Malignant transformation rates were higher in PVL (27.27% vs 11.11%), occurring on the gingiva, while in UVL, it was on the buccal mucosa and tongue.Conclusions: PVL and UVL are distinct clinical entities, highlighting the critical need for clinicians to differentiate and closely monitor both.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of structured orofacial muscle rehabilitation training on the recovery of facial expression muscles in patients with skeletal class II malocclusion after orthognathic surgery. 结构化口面肌康复训练对骨ⅱ类错颌正颌术后面部表情肌恢复的影响。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-06 DOI: 10.1016/j.oooo.2025.07.018

Ting Zeng, Mingjun Ren, Maolan Wang, Xiaoqin Bi

{"title":"Effects of structured orofacial muscle rehabilitation training on the recovery of facial expression muscles in patients with skeletal class II malocclusion after orthognathic surgery.","authors":"Ting Zeng, Mingjun Ren, Maolan Wang, Xiaoqin Bi","doi":"10.1016/j.oooo.2025.07.018","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.07.018","url":null,"abstract":"Objective: This study aimed to investigate the effects of structured orofacial muscle rehabilitation training (OMRT) on the recovery of facial expression muscles in patients with skeletal Class II malocclusion after orthognathic surgery.Study design: This randomized controlled trial enrolled 56 skeletal Class II malocclusion patients who underwent orthognathic surgery. The intervention group received structured OMRT, while the control group received standard postoperative care. Preoperative and postoperative assessments were performed at postoperative day 2, 14, 1 month, and 3 months, including linear angle measurements and relevant recovery indices. Data were analyzed using IBM SPSS 25.0 and R 4.1.2 software.Results: The OMRT group exhibited significant improvements in facial function indices, specifically ChL-ChR, Ls-Li, and ∠ChL-Sn-ChR at one month postsurgery, with values either close to or aligned with preoperative levels. The recovery curve demonstrated rapid improvement from postoperative day two to one month, indicating that early structured training was associated with enhanced facial expression recovery, improved self-image, and faster psychological and functional restoration.Conclusion: Structured OMRT significantly improves the recovery of facial expression muscles in skeletal Class II malocclusion patients following orthognathic surgery. These findings provide valuable clinical insights and may inform rehabilitation strategies for this patient population.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-05 DOI: 10.1016/j.oooo.2025.07.014

Elodie Pallois, Nathalie Pham Dang, Eva Chenu, Laurent Devoize

{"title":"Medication-Related Osteonecrosis of the Jaw induced by a CDK 4/6 inhibitor (Palbociclib) in a patient who was naïve to Antiresorptive Bone Therapy: A Case Report.","authors":"Elodie Pallois, Nathalie Pham Dang, Eva Chenu, Laurent Devoize","doi":"10.1016/j.oooo.2025.07.014","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.07.014","url":null,"abstract":"Medication-related osteonecrosis of the jaw (MRONJ) is a well-documented adverse effect initially linked to antiresorptive agents such as bisphosphonates. Over time, other drug classes have been associated with MRONJ: monoclonal antibodies targeting RANK ligand, monoclonal antibodies targeting VEGF, tyrosine kinase inhibitors, and mammalian target of rapamycin (mTOR) inhibitors. This article presents the case of an 83-year-old female patient referred to the maxillofacial surgery department due to a submental cutaneous fistula with purulent discharge and localized pain. Her notable medical history includes treatment with palbociclib and exemestane for breast cancer. Palbociclib (cyclin-dependent kinase [CDK] 4/6 inhibitors) are commonly used in combination with hormone therapy for the treatment of HR+/HER2- metastatic breast cancer. Whereas its efficacy in prolonging progression-free survival is well established, its potential impact on bone remodeling and the risk of MRONJ remain under investigation. This case highlights a potential new etiology of MRONJ associated with palbociclib. As CDK 4/6 inhibitors gain widespread use in oncology, clinicians should be aware of this possible complication and closely monitor patients for signs of jaw osteonecrosis.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is dental clearance necessary before antiresorptive treatment in pediatric patients? 儿科患者抗吸收治疗前是否有必要清除牙齿？

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-05 DOI: 10.1016/j.oooo.2025.07.015

Timothy W Neal, Sayyed Mohseni, Victoria Ratcliffe, Thomas Schlieve

{"title":"Is dental clearance necessary before antiresorptive treatment in pediatric patients?","authors":"Timothy W Neal, Sayyed Mohseni, Victoria Ratcliffe, Thomas Schlieve","doi":"10.1016/j.oooo.2025.07.015","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.07.015","url":null,"abstract":"Introduction: This study aimed to determine if there was a difference in the frequency of medication-related osteonecrosis of the jaws (MRONJ) between pediatric patients who obtained dental clearance and those who didn't obtain dental clearance before the start of antiresorptive therapy. The secondary aim was to assess the effect of dental clearance on future dental follow-up after the start of antiresorptive treatment.Materials and methods: The study population was composed of patients less than 18 years of age who received antiresorptive treatment from 2010 to 2024 at Children's Medical Center Dallas.Results: There were 88 subjects in the clearance group and 48 in the no-clearance group. No cases of MRONJ were observed in either group. The clearance group mean dental visits per year after the start of antiresorptive therapy was 1.21 (SD 0.96), and 0.55 (0.65) for the no-clearance group. There was a significant difference between the two groups (P = .0002).Discussion: No cases of MRONJ were observed in the present study. In pediatric patients who receive dental clearance prior to the start of antiresorptive medications, there is an association with continued routine dental follow-up.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malt lymphoma affecting the oral cavity: a clinical, pathologic and genetic study of malt 1 gene translocation. 影响口腔的麦芽淋巴瘤：麦芽1基因易位的临床、病理和遗传学研究。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-05 DOI: 10.1016/j.oooo.2025.07.016

Juan Manuel Arteaga Legarrea, Mauro Lima Dos Santos, Nathalia Gomes Rodrigues, Ricardo Santiago Gomez, Ricardo Alves Mesquita, Silvia Ferreira de Sousa, Cinthia Verónica Bardález López de Cáceres, Hélder Antônio Rebelo Pontes, Pablo Agustin Vargas, Luiz Alexandre Viana Magno, Felipe Paiva Fonseca

{"title":"Malt lymphoma affecting the oral cavity: a clinical, pathologic and genetic study of malt 1 gene translocation.","authors":"Juan Manuel Arteaga Legarrea, Mauro Lima Dos Santos, Nathalia Gomes Rodrigues, Ricardo Santiago Gomez, Ricardo Alves Mesquita, Silvia Ferreira de Sousa, Cinthia Verónica Bardález López de Cáceres, Hélder Antônio Rebelo Pontes, Pablo Agustin Vargas, Luiz Alexandre Viana Magno, Felipe Paiva Fonseca","doi":"10.1016/j.oooo.2025.07.016","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.07.016","url":null,"abstract":"Objective: To investigate the clinicopathological, immunohistochemical and molecular features of MALT Lymphoma affecting the oral cavity.Methods: Oral pathology files of a Brazilian institution were searched for cases of oral MALT lymphoma. New H&E-stained slides and immunohistochemistry reactions were evaluated for diagnosis confirmation. Molecular screening for MALT1 gene translocation was performed using fluorescent in-situ hybridization (FISH). Clinical data regarding sex, age, tumor location, clinical presentation, treatment and status at last follow-up were collected from patients' pathology files.Results: Eleven cases were retrieved, comprising three females and four males (four unknown). Cases presented a wide age range of 35 to 75 years with a mean of 58 years, involving the hard palate (3 cases), soft palate (2 cases) and floor of mouth (3 cases). Microscopically, all cases demonstrated a diffuse proliferation of small to medium sized neoplastic cells that infiltrated normal structures. All tumors demonstrated a predominance of CD20-positive cells, but with many CD3-positive reactive T lymphocytes. BCL2 expression was positive in all cases, and negative to CD5, BCL6 and CD10, with a low Ki67 proliferation index. Five cases were investigated for genetic translocation in MALT1 gene, all of them resulted negative. All patients were treated with surgery.Conclusion: Oral MALT lymphoma is an indolent neoplasm with a favorable prognosis. The occurrence of MALT1 translocation was not observed in the sample evaluated.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0