Salivary Th17-associated cytokines as potential biomarkers in primary Sjögren's Disease.

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-04-30 DOI:10.1016/j.oooo.2025.04.171

Giovanna P Florezi, Felippe P Barone, Cibele Pelissari, Muhammad Shahnawaz Soyfoo, Christine Delporte, Silvia V Lourenço

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引用次数: 0

Abstract

Objective: Primary Sjögren's disease (SjD) is a chronic autoimmune exocrinopathy characterized by focal lymphocytic infiltration in exocrine glands, leading to progressive secretory dysfunction. This study aimed to analyze salivary cytokines associated with the Th17 immune response to enhance understanding of SjD pathophysiology and identify potential diagnostic biomarkers, given that saliva reflects both the morphological and functional changes in glandular parenchyma.

Methods: Saliva samples from 27 patients with SjD, selected based on ACR-EULAR consensus criteria, and 15 healthy controls were analyzed using a multiplex assay to quantify cytokines linked to Th17 lymphocytes.

Results: Salivary analysis revealed significantly elevated levels of TNF-α (P = .006), IFN-γ (P = .028), IL-22 (P = .023), and IL-17 (P < .001) in patients with SjD compared with healthy controls. Conversely, IL-10 (P = .049), IL-21 (P < .001), and CD40L (P < .001) were significantly higher in the healthy controls than in patients with SjD.

Conclusions: These findings suggest that the identified cytokines play a critical role in the inflammatory processes of SjD and may serve as potential salivary biomarkers, reflecting the disease-associated alterations in salivary gland morphology and function.

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唾液th17相关细胞因子作为原发性Sjögren病的潜在生物标志物

目的：原发性Sjögren病（SjD）是一种慢性自身免疫性外分泌病，其特征是外分泌腺局灶性淋巴细胞浸润，导致进行性分泌功能障碍。鉴于唾液反映了腺实质的形态和功能变化，本研究旨在分析与Th17免疫反应相关的唾液细胞因子，以增强对SjD病理生理的理解，并确定潜在的诊断生物标志物。方法：根据ACR-EULAR共识标准选择27例SjD患者的唾液样本，以及15名健康对照，使用多重检测定量与Th17淋巴细胞相关的细胞因子。结果：唾液分析显示，与健康对照组相比，SjD患者的TNF-α (P = 0.006)、IFN-γ (P = 0.028)、IL-22 （P = 0.023）和IL-17 （P < 0.001）水平显著升高。相反，IL-10 （P = 0.049）、IL-21 （P < 0.001）和CD40L （P < 0.001）在健康对照组显著高于SjD患者。结论：这些研究结果表明，所鉴定的细胞因子在SjD的炎症过程中起着关键作用，可能作为潜在的唾液生物标志物，反映了唾液腺形态和功能的疾病相关改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.