Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献

{"title":"Society Page","authors":"","doi":"10.1016/S2212-4403(25)00728-X","DOIUrl":"10.1016/S2212-4403(25)00728-X","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 4","pages":"Page A5"},"PeriodicalIF":2.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S2212-4403(25)00729-1","DOIUrl":"10.1016/S2212-4403(25)00729-1","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 4","pages":"Page A6"},"PeriodicalIF":2.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A painful mass of the midface.","authors":"Kenneth Chang Chien, Anthony Bejjani, Jacob Pilley, Jeffrey Tsai","doi":"10.1016/j.oooo.2025.02.010","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.02.010","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overexpression of inflammatory human caspase-4 in relation to clinical severity of oral lichen planus.","authors":"Darussakorn Maneerat, Anupong Jeerachaipansakul, Chanipa Atijit, Chavanya Tangjarroenphakdee, Panatda Tipsirisakun, Nattapat Hengsanankul, Warisara Krisanaprakornkit, Suttichai Krisanaprakornkit, Anupong Makeudom","doi":"10.1016/j.oooo.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.02.003","url":null,"abstract":"<p><strong>Objective: </strong>Involvement of non-canonical inflammasome, comprising inflammatory human caspase-4, caspase-5, and Gasdermin D, in the pathogenesis of oral lichen planus (OLP) has never been demonstrated. We aimed to determine human caspase-4, caspase-5, and Gasdermin D expressions in OLP, to correlate their expressions with OLP severity, and to measure salivary interleukin (IL)-1β levels.</p><p><strong>Study design: </strong>OLP and normal oral mucosal specimens (n = 42 each) were processed for immunohistochemistry or immunoblotting. The clinical score for OLP severity was assessed at the most severe site. The immunohistochemical (IHC) score was a summation of intensity and positive cell scores. Salivary IL-1β levels were measured by enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>Median IHC scores of caspase-4 and Gasdermin D in OLP group were significantly greater than those in normal mucosal group (P < .01), consistent with significantly upregulated expressions by immunoblotting (P < .05). The IHC scores of caspase-4 and Gasdermin D were positively correlated with the clinical scores (P < .05). Salivary IL-1β levels in the OLP group were significantly greater than those in the normal mucosal group (P < .001).</p><p><strong>Conclusions: </strong>Our study demonstrates enhanced human caspase-4 and Gasdermin D expressions in relation to increased OLP severity with elevated salivary IL-1β levels, proposing clinical applications of these biomolecules as potential prognostic markers and/or new therapeutic intervention for OLP.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of two fluorescence detectors in flow cytometry to predict malignant transformation of oral leukoplakia from cell cycle fractions.","authors":"Caroline Gennari Stevão, Matheus Henrique Lopes Dominguete, Paulo de Camargo Moraes, Victor Angelo Martins Montalli, André Luis Santana de Freitas, Marcelo Sperandio","doi":"10.1016/j.oooo.2025.01.726","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.01.726","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this paper was to compare the accuracy of predicting malignant transformation of oral leukoplakia using the 585-620 nm detector when compared with data obtained with the 661-683 nm detector.</p><p><strong>Study design: </strong>This was a single-factor retrospective longitudinal experimental study, whose factor will be DNA content (DNA ploidy) at 4 levels, G1 phase, S phase, mitosis phase (G2), and DNA excess (4cER). The sample is a cohort of individuals diagnosed with oral leukoplakia (N = 97) where 18 cases evolved into cancer and 79 did not.</p><p><strong>Results: </strong>The DNA content parameters 4cER, G2, and G1/G2 ratios were associated with malignant transformation (P < .05). Two analog algorithms of these findings generated positive predictive values (PPVs) of 38% (67% sensitivity and 76% specificity) and 40% (61% sensitivity and 80% specificity). DNA content by flow cytometry can achieve a PPV of 40% in high-risk lesions and negative predictive value (NPV) of 90% in low-risk lesions.</p><p><strong>Conclusions: </strong>There was no significant difference among the percentages of nuclei in the G1, S, G2, and excess G2 (4cER) phases comparing the 661-683 nm and 585-620 nm detectors. The 585-620 nm detector achieved PPV and NPV equivalent to those observed with the 661-683 nm detector.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral plasmacytoma in multiple myeloma patients: report of 18 cases.","authors":"Lama Alabdulaaly, Maryam Jessri, Nathaniel Treister, Tiffany Tavares, Efstathios Pettas, Sook-Bin Woo, Jacob Laubach, Alessandro Villa","doi":"10.1016/j.oooo.2025.02.002","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.02.002","url":null,"abstract":"<p><strong>Objectives: </strong>Plasmacytoma is a malignant neoplasm of plasma cells with or without an underlying multiple myeloma (MM). Plasmacytoma rarely involves the oral mucosa and jaw bones. We aimed to describe oral plasmacytoma in MM patients.</p><p><strong>Study design: </strong>Patients with oral plasmacytoma seen at the Oral Medicine clinic from 2007 to 2024 were included in this study.</p><p><strong>Results: </strong>There were 18 patients (26 oral plasmacytomas). The median age was 60.5 years (72.3% females). The most common symptoms were pain and bleeding. Ten patients had gnathic involvement, and 8 patients had soft tissue disease without bony involvement. The gingiva was the most common site (50.0%) and buccolingual involvement was seen in 38.5% of cases. Treatment directed at the oral disease was rendered in 11 patients. Over 90% of patients died with a median of 5 months.</p><p><strong>Conclusions: </strong>MM patients may present with oral involvement most commonly on the gingiva with frequent buccal and lingual involvement.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S2212-4403(24)00959-3","DOIUrl":"10.1016/S2212-4403(24)00959-3","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page A6"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities and diagnostic delays: multiple myeloma","authors":"Dr. Almas Binnal ,&nbsp;Dr. Ghaidaa Badabaan ,&nbsp;Dr. Anita Gohel","doi":"10.1016/j.oooo.2024.11.026","DOIUrl":"10.1016/j.oooo.2024.11.026","url":null,"abstract":"<div><h3>Clinical Presentation</h3><div>Multiple myeloma is an uncommon yet well-known hematological malignancy. The present case reports highlight the diagnostic delay encountered in 2 female patients aged 76 and 70 years. The first patient had pain in the right mandible for several months; however, the source of pain could not be established and was referred to a physician. Physical therapy was recommended, which aggravated her pain. Cone beam computed tomography images revealed a large, fairly well-defined, irregular radiolucency in right posterior mandible with effacement of cortices and a pathological fracture. Multiple, discrete, well-defined radiolucencies also were noted in other anatomical regions. The second patient noticed numbness of lower left jaw whenever she applied a gel on her knees for arthritic pain. The source of the pain could not be established for several months. Cone beam computed tomography images revealed multiple, well-defined radiolucencies distributed in entire mandible with 2 large lesions with effacement of the lingual cortex on left posterior region. Both the patients had paresthesia of the lower lip.</div></div><div><h3>Differential Diagnosis</h3><div>A radiographic diagnosis of multiple myeloma with plasmacytoma was made in both cases.</div></div><div><h3>Diagnosis and Management</h3><div>Histopathologic evaluation confirmed multiple myeloma. Positron emission tomography imaging and other investigations in the first patient showed metabolically active soft-tissue lesion with presence of 80% kappa restricted, predominantly CD27 plasma cells with monosomy 13 and t(11; 14). Patients were referred for appropriate management.</div></div><div><h3>Conclusions</h3><div>Multiple myeloma remains to be a diagnostic challenge owing to its diverse clinical presentations. Patients with multiple myeloma often experience long diagnostic delay, with 50% of the patients’ experience delay longer than 3 months. Prompt establishment of the source of pain and paresthesia is crucial. Early diagnosis and management limit the disease process, help to reduce the associated morbidities, improve prognosis and subsequent survival and quality of life.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e77"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of dental artificial intelligence (AI) platform for caries detection and its potential role in dental education","authors":"Dr. Somyung Ji ,&nbsp;Dr. Kumar Shah ,&nbsp;Dr. Vinodh Bhoopathi ,&nbsp;Dr. Sanjay Mallya","doi":"10.1016/j.oooo.2024.11.060","DOIUrl":"10.1016/j.oooo.2024.11.060","url":null,"abstract":"<div><div>Teaching and evaluating caries detection skills in dental education can be a time-consuming process that requires careful case selection and faculty calibration. We have developed an online caries detection competency assessment that evaluates students' ability to detect caries. The assessment involves scoring radiographs by a panel of 5 UCLA faculty members, with the consensus score considered the correct answer. This study examined the use of the Second Opinion® dental artificial intelligence (AI) platform for caries diagnosis and its potential to enhance student detection skills without faculty intervention.</div><div>The caries detection examination included 47 tooth surfaces, encompassing both proximal and occlusal surfaces. Radiographs were assessed using the AI platform to determine its diagnostic accuracy compared to the faculty consensus score. Student performance on the competency exam was also measured and compared with the AI platform.</div><div>The AI platform exhibited successful caries detection for interproximal surfaces, although it showed limitations in detecting occlusal caries. Of the 19 carious lesions, the platform correctly identified 17, with 1 false positive and 2 false negatives. The platform accurately identified the absence of caries in 27 out of 28 non-carious lesions, resulting in a sensitivity of 89% and a specificity of 96%. Overall, the AI platform correctly scored 44 of the 47 surfaces. In contrast, only 24 of the 47 surfaces were correctly scored by 100% of the students (<em>P</em> &lt; .001). The AI platform provided accurate diagnoses for 21 of the 23 surfaces that some students scored incorrectly. Interestingly, the 3 surfaces incorrectly scored by the AI platform were correctly identified by more than 90% of the students.</div><div>The Second Opinion® dental AI platform holds promise as an effective educational tool, particularly for diagnosing interproximal caries. The platform has the potential to guide accurate diagnoses and improve student performance in caries detection.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e90"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential usefulness of ChatGPT in the queries related to radiation biology and radiation protection","authors":"Dr. Jyoti Mago","doi":"10.1016/j.oooo.2024.11.075","DOIUrl":"10.1016/j.oooo.2024.11.075","url":null,"abstract":"<div><h3>Aim</h3><div>This current research aimed to evaluate the potential usefulness of ChatGPT in queries related to radiation biology and radiation protection. The study also aimed to evaluate recommendations for its usage in oral and maxillofacial radiology training.</div></div><div><h3>Materials and Methods</h3><div>A 40-question questionnaire was queried to the open-AI app ChatGPT3 application. There was an equal distribution of random questions on the basis of 2 categories; related to radiation biology and radiation protection. One oral and maxillofacial radiologist evaluated those queries that were answered by ChatGPT 3 model and rated them on a 4-point modified Likert scale. The post-survey analysis for its performance of ChatGPT was based on Strength Weakness Opportunity and threat analysis and its application in oral and maxillofacial radiology training and its recommendation of use.</div></div><div><h3>Results</h3><div>The mean scores for the queries related to radiation biology and radiation protection were 3.7 and 3.45, respectively. However, the median and mode scores were 4 and were similar to both categories. Of 40 queries, 2 abbreviations were queried from the segment of radiation protection, and none of them was answered correctly. The queries need to be very specific to get an appropriate response.</div></div><div><h3>Conclusion</h3><div>The study showed that ChatGPT-3 being a descriptive model is quite competent in answering queries related to radiation biology and radiation protection. ChatGPT can be used as an adjunct when an oral radiologist needs a piece of supplementary information; however, the data have a possibility of errors and high risk of infodemics. The information provided by ChatGPT is more advantageous for the queries of the general public, supplemented by the confirmatory responses from the oral and maxillofacial radiologists of that state.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e96"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}