{"title":"Corrigendum to \"Does the use of the levonorgestrel intrauterine system increase the prevalence of masticatory muscles tenderness?\" [Oral Surg Oral Med Oral Pathol Oral Radiol. 140/4 (2025) Pages 384-390].","authors":"Serhat Can, Sinem Büşra Kıraç Can, Sultan Seren Karakuş, Gülcan Berkel","doi":"10.1016/j.oooo.2025.09.001","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.09.001","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Information for Readers","authors":"","doi":"10.1016/S2212-4403(25)01180-0","DOIUrl":"10.1016/S2212-4403(25)01180-0","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 5","pages":"Page A6"},"PeriodicalIF":1.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145128377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole Lonni, Andressa Fernanda Paza Miguel, Elis Ângela Batistella, Daniella Serafin Couto Vieira, Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Rogério Oliveira Gondak, Elena Riet Correa Rivero
{"title":"Agreement of tumour budding, tumour-stroma ratio, and tumour thickness in oral squamous cell carcinoma biopsy and resection samples and their clinical implications.","authors":"Nicole Lonni, Andressa Fernanda Paza Miguel, Elis Ângela Batistella, Daniella Serafin Couto Vieira, Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Rogério Oliveira Gondak, Elena Riet Correa Rivero","doi":"10.1016/j.oooo.2025.09.002","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.09.002","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the concordance between preoperative biopsies and corresponding surgical resections in assessing tumour budding (TB), tumour/stroma ratio (TSR), and tumour thickness (TT) in oral squamous cell carcinoma (OSCC) samples, and to explore their potential as prognostic indicators.</p><p><strong>Study design: </strong>31 surgical resections and 30 diagnostic biopsies were analysed using cytokeratin-immunostained slides to assess TB, TSR, TT, and the BT score (integrating TB and TT).</p><p><strong>Results: </strong>Histopathological features were consistently underestimated in matched biopsies compared to resections in quantitative analysis, with resections showing higher TB counts, greater TT, and lower TSR (P < .007). However, when classified as categorical variables, no significant differences were observed in TB and TSR. In resections, TB was higher in poorly differentiated tumours, and TT was greater in cases with high TB (P < .049). A positive correlation was observed between TT and TB in biopsies (P < .034). Intermediate and high-risk BT score group had significantly worse disease-free survival (DFS) compared to the low-risk group (P < .02).</p><p><strong>Conclusion: </strong>Despite the underestimation of TB and TSR in biopsies, these parameters remain predictive of aggressive tumor behaviour. Additionally, integrating histopathological parameters into combined scores, such as BT, could optimize biopsy evaluation and complement clinical staging and treatment planning.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mary Papandreas, Alonso Carrasco-Labra, Michael Glick
{"title":"When did \"I don't know\" become a diagnosis? A conceptual review on diagnoses of exclusion.","authors":"Mary Papandreas, Alonso Carrasco-Labra, Michael Glick","doi":"10.1016/j.oooo.2025.08.020","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.020","url":null,"abstract":"<p><p>Diagnosis of exclusion (DOE) is a term used when a conclusive diagnosis of a condition cannot be reached after exhausting a list of differential diagnoses. A comprehensive search across multiple electronic databases and AI-assisted search platforms was conducted to identify published literature related to DOE. The search identified 29 conditions with a DOE and several articles discussing the concept of DOE. However, no publication reported specific criteria or frameworks to help clinicians reach a DOE. Deliberative, iterative discussions were held with clinical specialists and experts in oral medicine, clinical epidemiology, and probabilistic diagnostics, to discuss the identified publications. Once a consensus was reached, a DOE framework based on probabilistic diagnostics was proposed. This conceptual review proposes a decision-making framework that applies a probabilistic diagnostic approach to reaching a DOE. The proposed framework allows clinicians to establish a diagnostic workup to navigate decision-making thresholds that will guide clinicians in reaching a definitive diagnosis, or alternatively, a DOE with more certainty.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gavin Soppe, Jay Saepoo, Emily Lanzel, Sherry Timmons, Nidhi Handoo, John Hellstein, Amy Greenwood
{"title":"What's in your toothpaste? A review of toothpaste ingredients and rationale for their use or avoidance.","authors":"Gavin Soppe, Jay Saepoo, Emily Lanzel, Sherry Timmons, Nidhi Handoo, John Hellstein, Amy Greenwood","doi":"10.1016/j.oooo.2025.08.014","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.014","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahdi Zakeri, Jordan Manley, Patrick Louis, Brian Kinard
{"title":"Does preoperative antiresorptive medication affect total temporomandibular joint replacement outcomes?","authors":"Mahdi Zakeri, Jordan Manley, Patrick Louis, Brian Kinard","doi":"10.1016/j.oooo.2025.08.018","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.018","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical and radiographic outcomes of temporomandibular joint (TMJ) total joint replacement (TJR) in osteoporotic patients receiving preoperative antiresorptive therapy.</p><p><strong>Study design: </strong>This retrospective chart review included osteoporotic patients who underwent TMJ TJR at a single institution. Data collected included demographics, medical history, type and duration of antiresorptive therapy, surgical details, and postoperative outcomes. Clinical parameters included range of motion (ROM), joint noise, and dietary limitations. Radiographic assessment evaluated periprosthetic bone changes and implant stability. Descriptive statistics summarized outcomes.</p><p><strong>Results: </strong>Eight patients (62.5% female; mean age 61.5 ± 11.4 years) with osteoporosis and history of antiresorptive therapy were analyzed. The average therapy duration was 3.75 ± 3 years. Mean clinical and CBCT follow-up was 16 ± 9.6, and 6.5 ± 3.6 months respectively. No patients developed medication-related osteonecrosis of the jaw (MRONJ), prosthetic failure, hardware loosening, or periprosthetic osteolysis. Functional outcomes were favorable, with mean postoperative ROM of 35.1 ± 4.8 mm and no joint noise.</p><p><strong>Conclusion: </strong>Preoperative antiresorptive therapy in osteoporotic patients does not appear to increase the risk of complications or impair functional outcomes following TMJ TJR. Larger sample sizes, possibly through multicenter investigations, are critical to establishing high-level evidence regarding its safety and efficacy.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kuankuan Jia, Jingang An, Yi Zhang, Yang He, Shuo Chen
{"title":"Imaging evaluation of condylar remodeling after open reduction and internal fixation of unilateral mandibular condylar fracture in pediatric patients.","authors":"Kuankuan Jia, Jingang An, Yi Zhang, Yang He, Shuo Chen","doi":"10.1016/j.oooo.2025.08.017","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.017","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the radiographic changes in damaged condyles after open reduction and internal fixation (ORIF) in pediatric patients with unilateral condylar fractures.</p><p><strong>Study design: </strong>We retrospectively analyzed patients aged ≤ 18 years who underwent ORIF for unilateral condylar fractures. The study group comprised fractured condyles, while contralateral healthy condyles served as controls. We assessed post-ORIF condylar remodeling and analyzed the influencing factors. We also compared condylar remodeling before and after internal fixation hardware removal.</p><p><strong>Results: </strong>The study included 88 patients; for 16 of them, imaging data were obtained after hardware removal. All fractures healed without ankylosis. Patients aged <12 years showed greater susceptibility to irregular condylar morphology and condylar head resorption. Compared with long screw fixation, titanium plate fixation was associated with an increased propensity for condylar head resorption and condylar hyperplasia. Although significant differences in condylar height were observed, the mean difference remained within 2 mm. Postremoval imaging revealed progressive condylar morphological normalization, with no significant height discrepancies.</p><p><strong>Conclusions: </strong>ORIF restored condylar height but likely adversely affected bone remodeling, with younger children demonstrating greater susceptibility. Condylar morphology gradually normalized after hardware removal; earlier hardware removal was associated with reduced remodeling impact.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The incidence and role of EBV and HIV in head and neck lymphomas: an institutional study.","authors":"Buntu Xoki, Andries Masenge, Tsholofelo Kungoane","doi":"10.1016/j.oooo.2025.08.015","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.015","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the prevalence of Epstein-Barr virus (EBV) positive lymphomas in a cohort of patients with head and neck lymphomas and to correlate these lymphomas with HIV status, CD4<sup>+</sup> cell count, clinical stage, and overall survival.</p><p><strong>Study design: </strong>This retrospective descriptive study sourced data from pathology reports and clinical records. Data collected included lymphoma type, HIV status, and medical information related to immunosuppression, CD4<sup>+</sup> T-cell counts, HIV viral load, Ann Arbor clinical stage, and follow-up data.</p><p><strong>Results: </strong>We reviewed 228 lymphomas, comprising 9 Hodgkin lymphomas and 219 non-Hodgkin lymphomas (HIV-positive: 133; HIV-negative: 23, and unknown HIV status: 72). Diffuse large B-cell lymphoma and plasmablastic lymphoma (PBL) were common and associated with HIV immune suppression, male sex, and middle age. Seventy-four lymphomas were Epstein-Barr encoded RNA in situ hybridization (EBER-ISH) positive. PBL was the most common EBV-driven lymphoma (median CD4<sup>+</sup> count = 147 cells/mm<sup>3</sup>), with the highest Ann Arbor staging.</p><p><strong>Conclusion: </strong>These findings suggest that EBV infection is among the primary factors contributing to PBL oncogenesis in HIV-positive patients. Patients with PBL presented with CD4<sup>+</sup> T-cell counts of <400 cells/mm<sup>3</sup>. Patients with HIV infection had a lower overall survival rate compared to HIV-negative patients, irrespective of lymphoma type.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}