Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献

{"title":"Oral and maxillofacial clinical features of Ehlers-Danlos syndrome: a systematic review.","authors":"Antunes David, Nicot Romain, Bovis Marine, Ferri Joël","doi":"10.1016/j.oooo.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.05.010","url":null,"abstract":"<p><strong>Background: </strong>Ehlers-Danlos syndromes (EDS) are inherited connective tissue disorders with diverse clinical manifestations, complicating subtype classification. While joint hypermobility, skin hyperextensibility, and tissue fragility are key diagnostic features, oral and maxillofacial signs are often overlooked.</p><p><strong>Objective: </strong>This review compiles dental and maxillofacial manifestations in EDS patients and identifies subtype-specific features to assist diagnosis.</p><p><strong>Study design: </strong>This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered on PROSPERO (CRD42023410501). Studies published from 1969 to March 2023 were screened. Eligible studies included original articles, case series, and case reports involving human subjects with any EDS subtype reporting dental or maxillofacial features.</p><p><strong>Results: </strong>Subtype-specific maxillofacial features included nasal bridge depression in 80% of arthrochalasia EDS, downslanting palpebral fissures in 80% of kyphoscoliotic EDS, and deep-set eyes in 34% of classical EDS (cEDS). Oral anomalies comprised tooth agenesis in 50% of spondylodysplastic and 75% of dermatosparactic EDS cases. Dental malformations included pulpal calcifications (11/89 cEDS), root fusion (8/31 vascular EDS [vEDS]), and excessive root length (11/31 vEDS). Gingival hyperplasia was reported in 100% of dermatosparactic EDS cases. The absence of labial and/or lingual frenula remains debated.</p><p><strong>Conclusions: </strong>This review underscores the diagnostic value of a thorough oral and maxillofacial examination in identifying EDS subtypes.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional analysis of fibrosis-related gene expression in drug-induced gingival enlargement associated with periodontitis.","authors":"Jer-Haur Kuo, Li-Wen Lin","doi":"10.1016/j.oooo.2025.06.005","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.06.005","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to characterize the expression patterns of inflammation- and fibrosis-related genes in drug-induced gingival enlargement (DIGE) among patients with periodontitis.</p><p><strong>Study design: </strong>Gingival tissue samples from 44 patients were categorized into 4 groups: N (healthy controls), P (periodontitis), A (patients with periodontitis receiving amlodipine and valsartan without DIGE), and G (periodontitis patients with DIGE). All specimens were obtained during periodontal flap surgery at least 6 months following initial therapy. Histomorphometric analysis, immunohistochemistry, and immunofluorescence staining were used to assess protein expression levels.</p><p><strong>Results: </strong>Following initial therapy, no patient exhibited DIGE scores of 2 or 3. The expression levels of inflammation- and fibrosis-related markers, including cluster of differentiation 68, matrix metalloproteinase 12, a disintegrin and metalloproteinase 17, connective tissue growth factor, and cathepsin L, were elevated in group G compared with the other groups. Notably, group A demonstrated the highest expression of sirtuin 1 (SIRT1).</p><p><strong>Conclusions: </strong>Effective supragingival and subgingival plaque control remains essential for managing DIGE in patients with periodontitis. The observed upregulation of SIRT1 in non-DIGE cases might indicate a potential antifibrotic role for this molecule.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Submucosal nodule on the lower lip.","authors":"Kamile Leonardi Dutra-Horstmann, Daniele Março de Sousa Rocha, Mauricio Assunção Pereira, Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Elena Riet Correa Rivero","doi":"10.1016/j.oooo.2025.06.004","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.06.004","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TEK-related venous malformation of the orofacial region: report of a case with multidisciplinary treatment guided by molecular diagnosis.","authors":"Yi-Shing Lisa Cheng, Daniel Bustamante, David M Yates, Silvia Menendez, Angela C Chi","doi":"10.1016/j.oooo.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.05.009","url":null,"abstract":"<p><p>Vascular malformations (VMs) often affect the orofacial region, where they can markedly impact the quality of life. They frequently harbor mutations in TEK, PIK3CA, or other genes essential for angiogenesis. Alpelisib is a phosphatidylinositol 3-kinase inhibitor recently shown to be effective for treating VMs with PIK3CA or TEK mutations. Herein we describe a 13-year-old female with an orofacial VM present since birth. Based on clinical, histopathologic, and molecular findings, the final diagnosis was TEK-related venous malformation. She received multimodal therapy, consisting of sclerotherapy, surgical debulking, and systemic alpelisib. Ten months after surgery and 7 months after terminating systemic therapy, the buccal mucosal aspect of the lesion was barely apparent. Molecular diagnostics and targeted agents have ushered in a new era of precision medicine for VMs. It is important for pathologists and clinicians to be aware of molecular-guided therapy as delivered via a multidisciplinary team-based approach for optimal management of patients with VMs.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S2212-4403(25)01056-9","DOIUrl":"10.1016/S2212-4403(25)01056-9","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 2","pages":"Page A6"},"PeriodicalIF":2.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Pathologic Conference Case 6: An ulcerated lesion on the gingiva of an adolescent female","authors":"Madhu Shrestha ,&nbsp;Saja Alramadan ,&nbsp;Victoria Woo ,&nbsp;John Wright","doi":"10.1016/j.oooo.2025.03.012","DOIUrl":"10.1016/j.oooo.2025.03.012","url":null,"abstract":"&lt;div&gt;&lt;div&gt;&lt;strong&gt;Clinical Presentation&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;A 12-year-old female patient presented with a chief complaint of a non-healing ulcer in the anterior maxilla. The lesion had been present for 3 months, and there was a history of a slowly growing mass. Clinical examination revealed an approximately 1.5 × 1 cm ulcerated mass involving the left maxillary canine-lateral incisor area (Figure 1). The surface appeared to be ulcerated, with an overall erythroleukoplakic appearance. The patient experienced variable sensitivity, and the medical history was unremarkable. Further palpation revealed a firm, ulcerated mass with rolled borders. An incisional biopsy was performed, and the tissue was sent for histopathological examination.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Differential Diagnosis&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;The clinical differential diagnosis for a gingival lesion in an adolescent is broad, encompassing a range of possibilities from reactive and benign to malignant lesions. The patient's age makes a malignant lesion unlikely. However, the clinical presentation of a speckled and granular erythro-leukoplakic appearance, along with visible dilated blood vessels (telangiectasias), raises suspicion for a malignancy. Despite the patient's age, the primary considerations include malignant entities such as squamous cell carcinoma and rhabdomyosarcoma, intermediate conditions like Langerhans cell histiocytosis, and benign conditions such as myofibroma, although the latter is less likely.&lt;/div&gt;&lt;div&gt;Squamous cell carcinoma (SCC) is highly suspected in this case, despite the patient's age. The clinical presentation of an exophytic lesion with a granular and erythro-leukoplakic appearance telangiectasias is concerning. The presentation of erythro-leukoplakia suggests an epithelial neoplastic origin. SCC is the most common malignancy of the oral cavity.&lt;sup&gt;1&lt;/sup&gt; It typically exhibits a peak incidence in the elderly and is strongly associated with smoking and alcohol abuse.&lt;sup&gt;1&lt;/sup&gt; Whereas oral SCC (OSCC) is rare in individuals under 50, recent global epidemiological studies have shown a rising incidence, particularly among young adults.&lt;sup&gt;1-3&lt;/sup&gt; The etiopathogenesis of OSCC in younger patients remains unclear, and traditional risk factors like tobacco and alcohol use are thought to play a minimal role in these cases, since the duration of exposure to these factors is believed to be shorter in young individuals.&lt;sup&gt;1,4&lt;/sup&gt;&lt;/div&gt;&lt;div&gt;The gingival-alveolar ridge is a common site for OSCC in children without known genetic predisposition to cancer.&lt;sup&gt;4&lt;/sup&gt; However, the possibility of a genetic predisposition should be considered in such cases. Rare hereditary syndromes, such as Fanconi anemia, xeroderma pigmentosum, Bloom syndrome, Li-Fraumeni syndrome, and dyskeratosis congenita, have all been associated with an increased risk of developing OSCC, particularly in the tongue, as well as other head and neck neoplasms.&lt;sup&gt;4&lt;/sup&gt;&lt;/div&gt;&lt;div&gt;Rhabdomyosarcoma (RMS) wa","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 2","pages":"Pages e55-e57"},"PeriodicalIF":2.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Pathologic Conference Case 1: A reddish nodule on the midline hard palate","authors":"Ivan José Correia-Neto DDS, MSc ,&nbsp;Gabriela Anaya-Saavedra DDS, PhD ,&nbsp;Paulo Afonso de Oliveira Junior DDS, MSc ,&nbsp;Edgard Graner DDS, PhD ,&nbsp;Alan Roger Santos-Silva DDS, PhD ,&nbsp;Pablo Agustin Vargas DDS, PhD ,&nbsp;Marcio Ajudarte Lopes DDS, PhD","doi":"10.1016/j.oooo.2025.03.008","DOIUrl":"10.1016/j.oooo.2025.03.008","url":null,"abstract":"&lt;div&gt;&lt;div&gt;&lt;strong&gt;Clinical Presentation&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;A 13-year-old boy was referred for evaluation of an asymptomatic lesion on the midline hard palate with a 3-month history of evolution. The patient denied any history of trauma or injury to the area. Intraoral examination revealed a reddish sessile nodule, with well-defined borders, fibroelastic consistency, and measuring approximately 5 mm. Telangiectasia was also noticed on the surface (Figure 1A). Panoramic radiography showed complete permanent dentition and no bone alterations were observed in the area corresponding to the lesion (Figure 1B).&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Differential Diagnosis&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;Lesions on the hard palate in pediatric patients may represent a complex diagnostic challenge, encompassing a range of benign and malignant possibilities. Given the clinical and radiographic characteristics, several entities can be included in the differential diagnoses, such as cysts, benign mesenchymal neoplasms, salivary gland tumors, inflammatory processes of the salivary glands, and developmental entities such as choristomas, hamartomas, and vascular lesions.&lt;/div&gt;&lt;div&gt;Reactive and inflammatory processes represent a group of lesions that can be frequently observed in pediatric patients, such as pyogenic granuloma, follicular lymphoid hyperplasia, subacute sialadenitis, and atypical histiocytic granuloma. Pyogenic granuloma (PG) is a common benign lesion characterized by an overgrowth of granulation tissue that typically develops in response to chronic irritation or trauma.&lt;sup&gt;1&lt;/sup&gt; PG occurs more frequently in the gingiva and tongue. On the other hand, it is unusual on the hard palate, particularly in the middle region.&lt;sup&gt;1&lt;/sup&gt; Follicular lymphoid hyperplasia (FLH) is a non-neoplastic lymphoproliferative disease (also known as a nodular lymphoid lesion and pseudolymphoma) associated with persistent local irritation that commonly affects the hard palate. Notably, a third of palatal FLH cases are linked to denture wear, predominantly affecting elderly patients. The typical presentation is a painless, slowly growing, non-ulcerated nodule, measuring less than 3 cm, with a color ranging from normal mucosa to purple-reddish and a texture varying from soft to firm.&lt;sup&gt;2,3&lt;/sup&gt; Subacute sialadenitis (SAS) is a rare inflammatory condition affecting minor salivary glands. It is an uncommon and self-limiting necrotizing condition that often affects the minor salivary glands of the palate.&lt;sup&gt;4&lt;/sup&gt; This condition typically occurs in men over 45 years of age but can also appear in teenagers and young adults. The most common clinical appearance is an ulcerative lesion, usually 1 to 3 cm in size, which can mimic a malignant growth. On the other hand, in some cases, the mucosal surface remains undamaged.&lt;sup&gt;4&lt;/sup&gt; However, because of the absence of salivary glands in the midline of the hard palate, this diagnosis is unlikely. Atypical histiocytic granuloma is rarely reported in the pa","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 2","pages":"Pages e41-e43"},"PeriodicalIF":2.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Pathologic Conference Case 4: An adult male patient with a sellar mass","authors":"Wilfredo Alejandro González-Arriagada DDS, PhD ,&nbsp;Anne C. McLean DMD, MS","doi":"10.1016/j.oooo.2025.03.010","DOIUrl":"10.1016/j.oooo.2025.03.010","url":null,"abstract":"&lt;div&gt;&lt;div&gt;&lt;strong&gt;Clinical Presentation&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;A 62-year-old Black male patient presented to the emergency department in August of 2021 with muscle weakness and macroglossia. The patient's medical history included hypertension, osteoporosis, femoral and pubic bone fractures, muscle wasting, and generalized pain. He reported an unintentional loss of 100 pounds within the preceding 6-month period. Upon further questioning, the patient revealed that his muscle weakness began several years prior, in 2015. He also stated that a prior evaluation by a neurologist at an outside facility had been done, and that there was no concern for a neuropathic process. A physical examination and laboratory work-up were undertaken in the emergency department.&lt;/div&gt;&lt;div&gt;The patient demonstrated vocal changes including hoarseness and dysphagia, and examination revealed unilateral macroglossia with immobility (Fig. 1), and fullness of the base of tongue area. He exhibited extreme muscle weakness and spasmodic episodes and was unable to lift his legs off of the hospital bed. The patient had hypophosphatemia and hyperparathyroidism, indicative of electrolyte and endocrine derangement. Otolaryngology was consulted, and initial imaging studies were performed.&lt;/div&gt;&lt;div&gt;A computed tomography (CT) scan of the brain completed upon admission showed a 6.5-cm mass centered in the sellar region, which was eroding the left mastoid, clivus, and bilateral sphenoid sinuses (Fig. 2A, 2B). A mass effect was noted upon the posterior left orbit and medial rectus muscle. Magnetic resonance imaging (MRI) with and without contrast was then performed the next day, and this redemonstrated the heterogeneously enhancing mass extending anteriorly to the ethmoid sinus, abutting the bilateral optic nerves, and indenting the frontal lobes of the brain superiorly (Fig. 3A, 3B, 3C). The mass also encroached upon the posterior nasal cavity and nasopharynx. It was seen to displace the pituitary gland superiorly. The cavernous sinus was invaded by the mass, and the bilateral internal carotid artery cavernous segments were encased.&lt;/div&gt;&lt;div&gt;Based on these findings, the patient was taken to the operative room for bilateral nasal endoscopy and biopsy. At surgery, the mass was noted to be at least partially encapsulated. Several biopsies were taken, and intraoperative consultation was performed.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Differential Diagnosis&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;Considering the clinical presentation and the patient's medical history, a bone neoplasm associated with a systemic condition is postulated; furthermore, the differential diagnosis should include other sinonasal tumors, such as benign tumors of the base of the skull (pituitary adenoma or craniopharyngioma), or endocrine lesions involving bones (hyperparathyroidism-related bone tumor). In this particular case, the initial discussion also includes a quite broad number of lesions such as suprasellar teratoma, Rathke cleft cyst, multiple myeloma wit","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 2","pages":"Pages e46-e52"},"PeriodicalIF":2.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Pathologic Conference Case 3: A WELL-DEFINED OSTEOLYTIC LESION IN THE BODY OF THE MANDIBLE WITH SPECIAL EMPHASIS ON DIAGNOSTIC ALGORITHM USING IMMUNOHISTOCHEMICAL AND HORMONAL PROFILING","authors":"N. Sivakumar MDS ,&nbsp;Katya Pulido-Díaz DDS, MSc, PhD ,&nbsp;Kiran Jot MDS ,&nbsp;Sandeep R. Mathur MD ,&nbsp;Ongkila Bhutia MDS ,&nbsp;Varun Surya MDS ,&nbsp;Ajay Gogia MD, DM ,&nbsp;Deepika Mishra MDS","doi":"10.1016/j.oooo.2025.03.009","DOIUrl":"10.1016/j.oooo.2025.03.009","url":null,"abstract":"&lt;div&gt;&lt;div&gt;&lt;strong&gt;Case Presentation&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;A 56-year-old North Indian woman presented with heaviness in her right lower back teeth region for 3 months. On intraoral examination, root stumps were present in #18 and #25 regions (FDI numbering system). No visible soft tissue lesions were found in the oral cavity, but an orthopantomogram revealed an ill-defined unilocular osteolytic radiolucency in the right body of the mandible, corresponding to the periapical regions of #43, #44, and #45, with blunting of root apices (Fig. 1). The patient had a history of fine-needle aspiration biopsy from the left breast, which was suggestive of invasive breast carcinoma of no special type. The hormonal profile of the tumor was as follows: estrogen receptor (ER)–positive (Allred score = 8/8), progesterone receptor (PR)–positive (Allred score = 7/8), and Her2Neu–negative (0/8). The tumor cells retained E-cadherin expression, with a Ki67 labeling index of 10% in proliferating areas. Following histopathological diagnosis, the patient underwent neoadjuvant chemotherapy (6 cycles of doxorubicin at 84 mg, cyclophosphamide at 840 mg, and G-CSF at 300 mg) and radiotherapy (15 cycles of 2.67 gray whole breast irradiation). A follow-up positron emission tomography (PET) scan revealed metabolically active soft tissue enhancement in the upper outer quadrant of the left breast. Thus, a mastectomy was performed to excise the residual tumor, which showed similar histopathological and immunohistochemical features as the incisional biopsy, with ypT3ypN3ayMx staging; Miller Payne grade 3, residual cancer burden (RCB) score of 4.536, and RCB class III.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Differential Diagnosis&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;The clinical presentation of the lesion favored a range from a benign cystic lesion to a malignant neoplasm. The differential diagnosis included central giant cell granuloma, odontogenic keratocyst, odontogenic fibroma, unicystic ameloblastoma, osteosarcoma, solitary plasmacytoma, non-Hodgkin's lymphoma, Langerhans cell histiocytosis (LCH), intraosseous mucoepidermoid carcinoma, and metastatic disease.&lt;sup&gt;1&lt;/sup&gt;&lt;/div&gt;&lt;div&gt;Central giant cell granulomas are more common in the anterior portions of the jaw that frequently cross the midline and, radiographically, may appear as a unilocular radiolucency with well-delineated borders. In the case of an odontogenic keratocyst, the lesion shows anteroposterior growth within the medullary cavity without causing expansion of the medullary cavity.&lt;sup&gt;1&lt;/sup&gt; Odontogenic fibromas are rare lesions, and more than half of the tumors are located posterior to the first molar of the mandible. Solitary plasmacytoma of bone shows a preponderance in males and is most common in the spine, with the least occurrence in the mandible. It may also produce a well-delineated radiolucency.&lt;sup&gt;2&lt;/sup&gt; LCH most commonly occurs in children younger than 15 years old as multiple or solitary, sharply punched-out radiolucencies, with a characterist","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 2","pages":"Pages e44-e46"},"PeriodicalIF":2.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Society Page","authors":"","doi":"10.1016/S2212-4403(25)01055-7","DOIUrl":"10.1016/S2212-4403(25)01055-7","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 2","pages":"Page A5"},"PeriodicalIF":2.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}