Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献_第2页

Polypoid lump on the ventral tongue in a pediatric patient with discordant FISH and immunohistochemical studies.

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-11-17 DOI: 10.1016/j.oooo.2024.11.080

Brian Maloney, Rebecca Schembri Higgans, Esther O'Regan, Veronica Fisher

引用次数: 0

Analysis of genetic polymorphism and expression of SOX2 in oral leukoplakia: a case-control study.

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-11-15 DOI: 10.1016/j.oooo.2024.11.082

Suelen Teixeira Scheifer, Arieli Carini Michels, Filipe Modolo, Emanuela Carla Dos Santos, Rafaela Scariot, Maria Cassia Ferreira Aguiar, Sergio Aparecido Ignácio, Lucia de Noronha, Laysa Toschi Martins, Henrique Ravanhol Frigeri, Cleber Machado de Souza, Bruno Correia Jham, Mariana Hornung Marins, Aline Cristina Batista Rodrigues Johann

{"title":"Analysis of genetic polymorphism and expression of SOX2 in oral leukoplakia: a case-control study.","authors":"Suelen Teixeira Scheifer, Arieli Carini Michels, Filipe Modolo, Emanuela Carla Dos Santos, Rafaela Scariot, Maria Cassia Ferreira Aguiar, Sergio Aparecido Ignácio, Lucia de Noronha, Laysa Toschi Martins, Henrique Ravanhol Frigeri, Cleber Machado de Souza, Bruno Correia Jham, Mariana Hornung Marins, Aline Cristina Batista Rodrigues Johann","doi":"10.1016/j.oooo.2024.11.082","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.11.082","url":null,"abstract":"Purpose: To investigate the association of SOX2 polymorphisms with oral leukoplakia with dysplasia (OLD) and compare it with the immunohistochemical expression of SOX-2.Methods: The samples comprised 64 patients with oral leukoplakia and 20 with normal oral mucosa who were subjected to SOX2 polymorphism rs77677339 genotyping by real-time polymerase chain reaction and immunohistochemistry for SOX-2 (basal epithelium expression, suprabasal and total; nuclear area and intensity). Statistical tests included the Chi-square and Fisher's exact tests.Results: No significant difference was observed in genotype distribution between the OLD and control groups. The GG genotype (96.9%) was observed in the OLD group and 100% in the control group. The GA genotype was not observed in the control group. Statistical comparisons between the immunohistochemistry and genetic results were not statistically significant. No association was identified between rs77677339 and immunohistochemistry in OLD; however, the presence of allele A in heterozygotes with OLD suggests that this allele may serve as a risk marker.Conclusion: The variant rs77677339 is localized in a region that contains different micro-RNA-binding sites, which can lead to changes in gene expression, contributing to OLD development through unclear molecular mechanisms. This study presents the preliminary results for this single nucleotide polymorphism in the literature.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weight loss, nutritional aspects and quality of life in head and neck cancer survivors.

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-11-09 DOI: 10.1016/j.oooo.2024.10.255

Paolo Junior Fantozzi, Federica Bruno, Riccardo Pampena, Maegan Reilly, Beatrice Carta, Veronica Stendardo, Giorgia Cunicella, Marco Della Monaca, Gianluca Tenore, Francesca De Felice, Valentino Valentini, Antonella Polimeni, Umberto Romeo, Alessandro Villa

{"title":"Weight loss, nutritional aspects and quality of life in head and neck cancer survivors.","authors":"Paolo Junior Fantozzi, Federica Bruno, Riccardo Pampena, Maegan Reilly, Beatrice Carta, Veronica Stendardo, Giorgia Cunicella, Marco Della Monaca, Gianluca Tenore, Francesca De Felice, Valentino Valentini, Antonella Polimeni, Umberto Romeo, Alessandro Villa","doi":"10.1016/j.oooo.2024.10.255","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.10.255","url":null,"abstract":"Objectives: Comprehensive care is fundamental to cancer survivors enduring long-term side-effects of cancer treatment including nutrition impact symptoms and critical weight loss (CWL). The aim of our study was to address weight loss (WL), nutritional aspects, and quality of life (QoL) in head and neck cancer (HNC) survivors.Study design: This was a cross-sectional study of HNC patients treated at the Sapienza University-Hospital, 2018-2022. We administered a modified version of the EORTC-QLQ-H&N35, the National Health and Nutrition Examination Survey for taste disorders, and the Fox Questionnaire for dry mouth. WL was recorded at T0 (before cancer treatment), T1 (right after treatment), and (at follow-up) T2.Results: All patients (n = 63; 61.9% males) had a median WL of 16.7% (range: 1.4%-44.2%) at T1 and a median of 9.8% (range: 1.8%-45.6%) at T2. Patients with dysgeusia, poor dentition, and those who underwent major orofacial surgery had the highest WL (P < .05). Patients who received multiple treatment regimens had a higher WL compared to those receiving fewer regimens (P < .05). Patients with nutritional problems (71.4%) had a lower QoL throughout (P < .05).Conclusions: CWL is an important side effect of HNC treatment and may particularly affect survivors with xerostomia/dysgeusia, poor dentition, and those receiving multiple treatment regimens.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Society Page 社会网页

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-11-08 DOI: 10.1016/S2212-4403(24)00600-X

引用次数: 0

Information for Readers 读者信息

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-11-08 DOI: 10.1016/S2212-4403(24)00601-1

引用次数: 0

Acknowledgement to Reviewers 2024 致审稿人 2024

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-11-08 DOI: 10.1016/j.oooo.2024.10.114

引用次数: 0

Oral epithelial dysplasia with lichenoid features shares proteomic overlap with oral epithelial dysplasia without lymphocytic immune response.

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-11-07 DOI: 10.1016/j.oooo.2024.10.085

Alejandro I Lorenzo-Pouso, Elina Pérez-García, Susana B Bravo, Martina Coppini, Fábio França-Vieira-E-Silva, Cintia M Chamorro-Petronacci, Vito Carlo Alberto Caponio, María Elena Padín-Iruegas, Irene Lafuente-Ibañez-de-Mendoza, Pilar Gándara-Vila, Mario Pérez-Sayáns, Andrés Blanco-Carrión

{"title":"Oral epithelial dysplasia with lichenoid features shares proteomic overlap with oral epithelial dysplasia without lymphocytic immune response.","authors":"Alejandro I Lorenzo-Pouso, Elina Pérez-García, Susana B Bravo, Martina Coppini, Fábio França-Vieira-E-Silva, Cintia M Chamorro-Petronacci, Vito Carlo Alberto Caponio, María Elena Padín-Iruegas, Irene Lafuente-Ibañez-de-Mendoza, Pilar Gándara-Vila, Mario Pérez-Sayáns, Andrés Blanco-Carrión","doi":"10.1016/j.oooo.2024.10.085","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.10.085","url":null,"abstract":"Objective: This study investigates the proteomic profiles of oral epithelial dysplasia with lichenoid features (OEDwithLF) and evaluates its relevance as a histopathological feature for lichenoid mucositis (LM) through differential proteomic characterization.Study design: SWATH-MS proteomic profiling was conducted on FFPE samples from 6 OEDwithLF, 5 OED cases without associated lymphocytic infiltration, and 5 LM cases. Protein expression levels were quantified and compared. In silico analysis examined the biological and molecular functions of dysregulated proteins.Results: A total of 460 proteins were identified. Unsupervised clustering revealed significant differences between LM and OEDwithLF, with fewer differences observed between OEDwithLF and OED. Bioinformatic analysis indicated dysregulated proteins are involved in nucleic acid binding, ribosome function, and developmental biology. Key potential biomarkers include KRT17, LYSC, CAL5, and CRNN.Conclusions: The proteomic profile of OEDwithLF is similar to OED without associated lymphocytic infiltration, but significantly different from LM. OED is relevant in lichenoid tissues, and its proteomic changes can be detected. Although OED may coexist with interface mucositis, it is not a defining feature of LM. This challenges the exclusion of epithelial dysplasia from lichenoid diagnoses. Based on this hypothesis-generating study, further investigation is warranted.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenomatoid hyperplasia of minor salivary glands: a systematic review. 小唾液腺腺瘤样增生：系统综述。

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-10-30 DOI: 10.1016/j.oooo.2024.10.081

Gabriel Lima Braz, Ana Carolina Uchoa Vasconcelos, Ana Paula Neutzling Gomes, Camila Barcellos Calderipe, Alini Cardoso Soares

{"title":"Adenomatoid hyperplasia of minor salivary glands: a systematic review.","authors":"Gabriel Lima Braz, Ana Carolina Uchoa Vasconcelos, Ana Paula Neutzling Gomes, Camila Barcellos Calderipe, Alini Cardoso Soares","doi":"10.1016/j.oooo.2024.10.081","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.10.081","url":null,"abstract":"Objective: To systematically review available data regarding adenomatoid hyperplasia of minor salivary glands (AHMSG).Study design: Electronic searches were performed in six databases and gray literature. The risk of bias was assessed using the Joanna Briggs Institute tool.Results: Forty studies reporting 121 cases of AHMSG were included. There is a male predominance (n = 72/64.29%), with individuals in their fourth and fifth decade of life being the most affected. The palate was the main anatomical location (n = 90/74.39%), and most lesions presented as single, asymptomatic nodules. The mean size of AHMSGs was 1.48 ± 0.77 cm, and the mean evolution time was 16.84 ± 25.67 months. Immunohistochemical evaluation in three cases (2.48%) showed a low labeling index for Ki-67 (n = 2/66.67%) and proliferating cell nuclear antigen (n = 1/33.33%).Conclusions: AHMSG is an uncommon benign lesion with no tendency to recur after initial surgical removal. The main histological features include an abundant proliferation of glandular acini, occasional ductal dilation, and sometimes the presence of inflammatory infiltrate. Pathologists and clinicians should be aware of AHMSG, as it can closely resemble both benign and malignant salivary gland lesions.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of oral mucosal punch biopsy and other oral biospecimen collections in clinical research. 临床研究中口腔黏膜打孔活检和其他口腔生物样本采集的安全性。

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-10-30 DOI: 10.1016/j.oooo.2024.10.084

Aanish Puri, Beverly Wuertz, Nelson L Rhodus, Frank G Ondrey

{"title":"Safety of oral mucosal punch biopsy and other oral biospecimen collections in clinical research.","authors":"Aanish Puri, Beverly Wuertz, Nelson L Rhodus, Frank G Ondrey","doi":"10.1016/j.oooo.2024.10.084","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.10.084","url":null,"abstract":"Objective: Oral punch biopsies are frequently used for analysis of lesions since they are minimally invasive, easily performed, and assist in diagnosis. Despite broad usage, recent changes in risk classification characterize oral punch biopsies as \"greater than minimal risk\" for institutional review board purposes. We performed a retrospective review of oral sampling in clinical trials to determine the safety of punch biopsies and other biospecimen collection methods in our oral cancer surveillance program.Study design: Punch biopsies of 3- and 4-mm were collected following topical and local injection anesthetic. Hemostasis was achieved using pressure and silver nitrate cautery. Other specimens were collected according to standard collection guidelines. Safety and adverse events were determined through consultation with clinical investigator guidelines and were graded with the NCI Common Terminology Criteria for Adverse Events (CTCAE) v5.Results: In total, 579 samples were collected, 339 of which were oral punch biopsies. There were no adverse events above NCI CTCAE grade 1 for any biospecimen collection.Conclusions: These results support the safety profile of oral punch biopsies and saliva collection. Additionally, these results align with previous research on punch biopsy safety and demonstrate fewer bleeding events. Based on the results and prior research, we believe that punch biopsies should be considered a minimal-risk procedure.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human oncogenic viruses: a focus on head and neck carcinogenesis: a systematic review and meta-analysis. 人类致癌病毒：关注头颈部癌变：系统回顾和荟萃分析。

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-10-30 DOI: 10.1016/j.oooo.2024.10.082

Antonia Taiane Lopes de Moraes, Erison Santana Dos Santos, Caíque Mariano Pedroso, Rafael Tomaz Gomes, Renata Ferrarotto, Alan Roger Santos-Silva

{"title":"Human oncogenic viruses: a focus on head and neck carcinogenesis: a systematic review and meta-analysis.","authors":"Antonia Taiane Lopes de Moraes, Erison Santana Dos Santos, Caíque Mariano Pedroso, Rafael Tomaz Gomes, Renata Ferrarotto, Alan Roger Santos-Silva","doi":"10.1016/j.oooo.2024.10.082","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.10.082","url":null,"abstract":"Objective: This systematic review aimed at identifying oncoviruses associated with head and neck malignant neoplasms (HNC).Study design: Five databases and grey literature sources were searched following PRISMA guidelines. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist, and the certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation tool.Results: One hundred and 19 studies were included in the qualitative synthesis. Gathered results of 57 studies were combined in a meta-analysis revealing a significant link between oncoviruses and the development of head and neck cancer, with the most common viruses identified were human papillomavirus (HPV)-16, HPV-18, and Epstein-Barr virus. More studies are needed to clarify the association of human cytomegalovirus and Merkel Cell Polyomavirus with HNC.Conclusions: Although the role of viruses in cancer onset has been studied for years, our results demonstrated using a meta-analysis that these viruses are associated with HNC.","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0