Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献

{"title":"Spongiotic gingival hyperplasia: identifying new mechanisms and a survey of clinical approach.","authors":"Justin Lin, Will Jeong, Laura Dempster, Deepika Chugh, James Posluns, Marco Magalhaes","doi":"10.1016/j.oooo.2025.08.001","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.001","url":null,"abstract":"<p><strong>Objective: </strong>Spongiotic gingival hyperplasia (SGH) or localized juvenile spongiotic gingival hyperplasia (LJSGH) is a rare, benign, soft tissue oral lesion that shares overlapping clinical characteristics with more common reactive gingival lesions found in adolescents. SGH is clinically unrelated to the accumulation of plaque, and treatment by periodontal debridement and improved oral hygiene measures are ineffective. Currently, the etiology and pathogenesis of SGH are unknown. The objectives of this study are: (1) to assess the ability of clinicians to recognize and manage SGH compared with other gingival lesions, and (2) to identify the underlying mechanisms of SGH pathogenesis using messenger RNA (mRNA) sequencing.</p><p><strong>Study design: </strong>Orthodontic clinicians were surveyed using 4 representative clinical images (SGH, pyogenic granuloma, plaque-induced gingivitis, and squamous cell carcinoma). RNA was extracted from 3 cases of SGH and 2 cases of gingival inflamed fibromas (control), followed by differential gene expression analyses.</p><p><strong>Results: </strong>There is limited awareness among clinicians regarding SGH. Expression analyses revealed that SGH is characterized by overexpression of members of the IL-17 and TNF pathways, among others. Pathway analyses revealed upregulation of genes associated with angiogenesis, neutrophil activation, cell proliferation, and apoptosis, along with downregulation of pathways associated with keratinization.</p><p><strong>Conclusions: </strong>Increased education focused on oral pathology may be beneficial and bring more awareness to this unique entity. Genetic analyses suggest a reactive origin, with unique IL-17 and TNF activation and proliferative pathways driving SGH growth even in the absence of plaque, and further studies are needed to generate specific treatments targeting these immune pathways.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S2212-4403(25)01134-4","DOIUrl":"10.1016/S2212-4403(25)01134-4","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 4","pages":"Page A6"},"PeriodicalIF":1.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of autologous platelet-rich plasma therapy in the management of oral submucous fibrosis: an exploratory case series.","authors":"W J Wijesingha, Sandya Abeyrathne, Dileetha Kuruppu, Nilantha Liyanage, Sandeep Jayasekera, Sachinthani I Karunarathne, Nadisha Piyarathne","doi":"10.1016/j.oooo.2025.08.016","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.016","url":null,"abstract":"<p><strong>Objective: </strong>Oral submucous fibrosis (OSF) is a progressive disease with an increased risk of developing oral cancer. There exists a notable scarcity of evidence on treatments that can promote tissue regeneration in OSF. Autologous platelet-rich plasma (PRP) is an emerging therapy with limited applications in OSF.</p><p><strong>Study design: </strong>A prospective case-series was conducted in 10 patients with a histopathologically confirmed diagnosis of OSF. Baseline data included sociodemographic and risk habits, self-reported burning sensation to food was recorded using a visual analogue scale, and inter incisor distance at maximum mouth opening was measured in cm. Autologous PRP was infiltrated into bilateral buccal mucosa, once a month, and measurements were repeated at 6 months. Thresholds for clinically significant improvement were defined at ≥ 50% change in burning sensation, and ≥ 25% change in mouth opening. Data analysis was done using a paired sample T test and effect size (Cohen's D).</p><p><strong>Results: </strong>Patients were aged 31 to 69 years, female to male ratio was 1:4 with mild to moderate disease severity. Clinically significant change in mouth opening was reported in 60% of patients, whereas 100% reported significant reduction in burning sensation, no side effects were reported. There were statistically significant differences (P < .05) on mouth opening and burning sensation following PRP therapy.</p><p><strong>Conclusions: </strong>Based on this exploratory evidence, we propose intralesional PRP therapy as a safe and clinically effective treatment for mild to moderate OSF. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long noncoding RNA DQ786243 and miRNA146a as potential salivary biomarkers for selected oral potentially malignant disorders: a diagnostic accuracy study.","authors":"Salsabeel Afifi, Sally Ibrahim, Ali Aw Kotb, Sahar ElRefai, Layla Hafed, Olfat Shaker, Safaa Baz, Rania Shalaby","doi":"10.1016/j.oooo.2025.08.013","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.013","url":null,"abstract":"<p><strong>Objective: </strong>Assess the diagnostic accuracy of salivary long noncoding RNA (lncRNA) DQ786243 and miRNA-146a as potential biomarkers for differentiating oral lichen planus (OLP) and oral leukoplakia (OL), both belonging to oral potentially malignant disorders (OPMDs), from healthy controls.</p><p><strong>Study design: </strong>Forty-five subjects were enrolled in a consecutive manner and allocated into 3 groups. Group I: 20 participants suffering from OLP. Group II: 15 patients with OL. Group III: 10 healthy controls. Expression of DQ786243 and miRNA146a in saliva was measured using quantitative real-time polymerase chain reaction. Reference standard was histopathological examination of OLP and OL.</p><p><strong>Results: </strong>The greatest elevation of DQ8786243 and miRNA146a fold change (FC) occurred in OLP patients, especially erosive type, followed by OL group, whereas it was the lowest in healthy controls. Sensitivity and specificity of salivary DQ8786243 were 97.14% and 100%, respectively, at a cut point of 1.8 FC, delineating the difference between disease and control. Concerning miRNA146a, at a cut point of 1.4 FC, sensitivity and specificity were 94.29% and 100%, respectively.</p><p><strong>Conclusions: </strong>LncRNA DQ786243 and miRNA146a could be promising salivary biomarkers in the detection of OPMDs, especially OLP and OL. Salivary expression of both markers was the highest in erosive OLP.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of the clinicopathologic characteristics and immunohistochemical expression of recurrent and nonrecurrent glandular odontogenic cysts: a retrospective longitudinal cohort multicenter study.","authors":"Alberto Peraza-Labrador, John Wright, Victoria Woo, Monica Kowalski, Kittiphoj Tikkhanarak, Nidhi Q Handoo, Wattawan Wongpattaraworakul, Elizabeth Bilodeau, Felipe Nor, Molly Housley Smith, Matthew Kesterke, Hua Zhang, Patricia Barros, Madhu Shrestha","doi":"10.1016/j.oooo.2025.08.010","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.010","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to analyze the clinicopathological profile of recurrent and non-recurrent glandular odontogenic cyst (GOC) through a longitudinal cohort multicenter study.</p><p><strong>Study design: </strong>This multicenter longitudinal cohort study investigates factors associated with GOC recurrence. Included in the study were patients with histologically confirmed GOC (per Fowler's criteria), who experienced recurrence at least 1-year post-treatment. Controls were GOCs with a minimum of 5 years of recurrence-free follow-up. Histologic features, treatment rendered, and immunohistochemical staining results for CK13, CK19, and Ki-67 were documented.</p><p><strong>Results: </strong>Eleven recurrent cases (6 men and 5 women; mean age = 56.09 years) were analyzed. The anterior mandible was the most frequently affected site (45.5%), followed by the posterior and anterior maxilla (27.1% each). The average follow-up time was 36.1 months. Recurrence was significantly associated with multiple compartments and the absence of apocrine snouting (P = .013, P = .034, respectively). The majority of the primary GOCs that later recurred were treated with enucleation (73%).</p><p><strong>Conclusions: </strong>Multiple compartments and lack of apocrine snouting may be a histological predictor of recurrence. All recurrent cases were treated with enucleation and/or curettage, highlighting treatment approach as a key factor. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct expression profiles of hsa-miR-31, hsa-miR-29c, hsa-miR-17, and hsa-miR-10a in oral epithelial dysplasia and squamous cell carcinoma.","authors":"Ana Paula Negreiros Nunes Alves, Carolina Rodrigues Teófilo, Mario Rogerio Lima Mota, Fabricio Bitu Sousa, Camile de Barros Lopes, Ândrea Kely Campos Ribeiro Dos Santos, Felipe Pantoja Mesquisa, Paulo Goberlânio Barros Silva, Raquel Carvalho Montenegro","doi":"10.1016/j.oooo.2025.08.007","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.007","url":null,"abstract":"<p><strong>Objective: </strong>This research aimed to evaluate the expression of microRNAs-31, 29c, 17, and 10a and the biomarkers signal transducers and activators of transcription 3 and interleukin-6 in oral epithelial dysplasia and oral squamous cell carcinoma (OSCC).</p><p><strong>Study design: </strong>This research analyzed samples collected from patients with oral lesions and a control group consisting of individuals with no history of smoking or alcohol consumption. The tissues were histologically analyzed to classify oral epithelial dysplasia and OSCC and assessed by immunohistochemistry for signal transducers and activators of transcription 3 and interleukin-6 expression. In addition, molecular analysis involved total RNA extraction, cDNA synthesis, and microRNA quantification by real-time polymerase chain reaction. Statistical analysis was performed using SPSS to compare the expression of biomarkers and microRNAs between groups.</p><p><strong>Results: </strong>miR-17 (P = .005) and miR-29c (P = .014) increased in OSCC and miR-17 (P = .024) increased in perilesional dysplasia. In dysplasia, only miR-31 and miR-17 (P = .030), miR-10a and miR-17 (P = .003), and miR-10a and mir-29c (P = .001) but in OSCC all miRs were directly correlated (P < .05) and miR-10a and IL-6 were also directly correlated (P = .046). In perilesional OSCC, miR-17 was directly correlated with miR-31 (P = .008) and miR-31 with miR-10a (P = .039). In perilesional dysplasia, only miR-10a and miR-29c were directly correlated (P = .023).</p><p><strong>Conclusions: </strong>miR-17 is increased in perilesional oral dysplasia and OSCC, miR-29c is increased in OSCC and miR-10 appears to be the initiator of the tumor progression process. The increase in the interactions of microRNAs was a strong predictor of OSCC progression.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteonecrosis of the jaw as a possible adverse effect of tocilizumab.","authors":"Hedyeh Samady, Mark Drangsholt, Gale Sebastian, David Dean","doi":"10.1016/j.oooo.2025.08.011","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.011","url":null,"abstract":"<p><p>We report the case of a 79-year-old female with a complex medical history, presenting with recurrent gingival swelling, progressive gingival hyperplasia, and osteonecrosis of the jaw potentially associated with tocilizumab. Oral complications developed in close proximity to diagnosis of chronic myelomonocytic leukemia, complicating diagnosis and management.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperparathyroidism: more than just brown tumors.","authors":"Poramate Pitak-Arnnop","doi":"10.1016/j.oooo.2025.07.019","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.07.019","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical examination of intraparotid lymph nodes in various tumors of parotid gland using magnetic resonance imaging.","authors":"Mehmet Selcuk, Nadire Unver Dogan, Merih Onal, Abdussamet Batur, Ahmet Kagan Karabulut, Zeliha Fazliogullari","doi":"10.1016/j.oooo.2025.08.004","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.004","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study aimed to anatomically compare the morphometric measurements of intraparotid lymph nodes across different parotid gland tumors and a control group.</p><p><strong>Study design: </strong>The study used retrospective images of patients admitted to the Department of Otorhinolaryngology over the past 10 years from the Radiology Department archive at Selçuk University Medical Faculty Hospital. A total of 160 individuals were included in our study.Long-axis diameter (LAD) and short-axis diameter (SAD) were measured in axial section on magnetic resonance images.</p><p><strong>Results: </strong>In all patients, the mean SAD and LAD were significantly higher on the lesion (+) side compared to the lesion (-) side (P < .05). The mean SAD and LAD were significantly larger on the lesion (+) side compared to the control group (P < .05).</p><p><strong>Conclusions: </strong>In our findings, if the SAD exceeded 3.51 mm and the LAD exceeded 4.85 mm in the control group, it can be considered suspicious in terms of lymph node abnormality, potential pathologic evaluation, and indications for further examination.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conservative management of unicystic ameloblastoma: long-term outcomes from a 26-year retrospective study.","authors":"Gustavo Luiz Alkmin Paiva, Alan Roger Santos-Silva, André Caroli Rocha","doi":"10.1016/j.oooo.2025.08.002","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.08.002","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the long-term clinical outcomes of patients with unicystic ameloblastoma (UA) managed with conservative surgical approaches, with a particular focus on recurrence rates.</p><p><strong>Materials and methods: </strong>A retrospective review was conducted over a 26-year period to analyze the clinicopathological data of patients diagnosed with UA. Initial management consisted of incisional biopsy, followed by marsupialization when clinically indicated. Definitive treatment involves enucleation with peripheral ostectomy or cryotherapy. The primary outcome measure was disease recurrence.</p><p><strong>Results: </strong>A total of 26 patients were included. The mean follow-up duration was 8 years (range, up to 26 years). Initial marsupialization was performed in 23 patients and was effective in 89% of cases. Enucleation with peripheral ostectomy was employed as the definitive treatment in 24 patients. Recurrence was observed in one case, occurring 8 months after treatment in a patient who had initially undergone marsupialization followed by peripheral ostectomy.</p><p><strong>Conclusions: </strong>Marsupialization is effective in reducing the size of UA while minimizing surgical morbidity. Enucleation with peripheral ostectomy or cryotherapy has proven successful in the definitive management of UAs, with a low recurrence rate. These findings underscore the value of conservative treatment strategies, particularly in young patients who require long-term follow-up.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}