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Management of medication-induced gingival overgrowth in a hypertensive patient: a case report 高血压患者药物性牙龈增生的处理：1例报告
IF 2 3区 医学
Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.041
Leticia Beatriz da Cruz Santos, Amanda Feitoza da Silva, Claudia Rebecca Costa Cavalcante Silva, Matheus Santos Mafra Barbosa, Mariana Bitu Ramos-Pinto, Lais Christina Pontes de Espindola, Thalwylla Reiler Moratodos Reis Moreira
{"title":"Management of medication-induced gingival overgrowth in a hypertensive patient: a case report","authors":"Leticia Beatriz da Cruz Santos,&nbsp;Amanda Feitoza da Silva,&nbsp;Claudia Rebecca Costa Cavalcante Silva,&nbsp;Matheus Santos Mafra Barbosa,&nbsp;Mariana Bitu Ramos-Pinto,&nbsp;Lais Christina Pontes de Espindola,&nbsp;Thalwylla Reiler Moratodos Reis Moreira","doi":"10.1016/j.oooo.2025.01.041","DOIUrl":"10.1016/j.oooo.2025.01.041","url":null,"abstract":"<div><div>Gingival overgrowth can arise from inflammatory factors related to biofilm or specific medications, including anticonvulsants, immunosuppressants, and calcium channel blockers. We present a case of medication-induced gingival overgrowth associated with amlodipine. A 40-year-old male patient presented with complaints of altered gingival contour after 8 months of initiating amlodipine treatment for hypertension. Upon clinical examination, increased growth of gingival interdental papillae was observed, along with the presence of pseudopockets upon periodontal probing. Initial periodontal treatment was followed by gingivectomy and gingivoplasty. Post-treatment, the patient was referred to a cardiologist to evaluate the possibility of changing medication to prevent recurrence. After 60 days of follow-up, the periodontal condition was deemed satisfactory. Medication-induced gingival overgrowth is a common adverse effect in certain medication groups, and gingival plastic surgery may be necessary to restore physiological gingival contour, thereby improving patient function and aesthetics.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e8"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral carcinoma cuniculatum a rare entity: report of 3 cases 口腔癌是一种罕见的疾病：附3例报告
IF 2 3区 医学
Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.018
Javier Ignacio Gimenez, Maria de los Angeles Castrillo, Gabriela Acosta Haab, Gloria Irunigarro, Claudia Giacco, Verónica Flück
{"title":"Oral carcinoma cuniculatum a rare entity: report of 3 cases","authors":"Javier Ignacio Gimenez,&nbsp;Maria de los Angeles Castrillo,&nbsp;Gabriela Acosta Haab,&nbsp;Gloria Irunigarro,&nbsp;Claudia Giacco,&nbsp;Verónica Flück","doi":"10.1016/j.oooo.2025.01.018","DOIUrl":"10.1016/j.oooo.2025.01.018","url":null,"abstract":"<div><div>Carcinoma cuniculatum (CC) is a rare epithelial neoplasm, representing an unusual variety of squamous cell carcinoma (SCC). Histologically it is characterized by deep penetrating sinuses containing keratotic debris, making it susceptible to underdiagnosis. We present 3 cases seen during 2017-2023. They presented clinically as tumor lesions, fistulizing, and superficial blood vessels. The ages of the patients were 13, 70, and 80 years and the locations were jaw, upper maxilla, and trigone respectively. Multiple partial biopsies were performed, with CC not being the initial diagnosis. The definitive diagnosis was reached based on data collected from the anamnesis, clinical examination, histopathological and imaging analysis. The infrequency and the absence of cytological anaplasia, make CC susceptible to multiple negative biopsies and misdiagnosis. We emphasize clinical examination and anamnesis, together with the need to form work teams as a facilitating tool to establish the diagnosis.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e3"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral fibromyxoma: a case report focusing on differential diagnosis 外周纤维黏液瘤：1例鉴别诊断报告
IF 2 3区 医学
Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.082
Victor Samuel de Almeida Lopes, Maria Renata Caballero Lettieri Pinto, Cláudia Roberta Leite Vieira de Figueiredo, Keila Martha Amorim Barroso, Ricardo Villar Beltrão, Paulo Rogerio Ferreti Bonan
{"title":"Peripheral fibromyxoma: a case report focusing on differential diagnosis","authors":"Victor Samuel de Almeida Lopes,&nbsp;Maria Renata Caballero Lettieri Pinto,&nbsp;Cláudia Roberta Leite Vieira de Figueiredo,&nbsp;Keila Martha Amorim Barroso,&nbsp;Ricardo Villar Beltrão,&nbsp;Paulo Rogerio Ferreti Bonan","doi":"10.1016/j.oooo.2025.01.082","DOIUrl":"10.1016/j.oooo.2025.01.082","url":null,"abstract":"<div><div>Myxomas can be categorized as benign odontogenic lesion of ectomesenchyme, with the central and peripheral variants, being the last one much more uncommon. This case reported a nodular asymptomatic growth affecting a 35-year-old black female, causing facial asymmetry and difficulty in occlusion on anterior maxilla. The lesion was peripheral confirmed by periapical X-ray and cone beam tomography. Differential diagnosis included non-neoplastic proliferative processes. An excisional biopsy was taken, and histopathological analysis indicated a neoplasm with intermediate myxoid and fibrous stroma and with stellate and ovoid cells associated with focal mineralization without odontogenic epithelium. Alcian Blue staining revealed myxoid composition. The final diagnosis was peripheral fibromyxoma. The patient is following up without recurrence after 6 months.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e16"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical clinical presentation of oral erosive lichen planus: case report 口腔糜烂性扁平苔藓的不典型临床表现1例
IF 2 3区 医学
Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.057
Gustavo Rocha Vita, Guilherme Ribeiro de Queiroz, Tessa de Lucena Botelho, Claudio Maranhão Pereira
{"title":"Atypical clinical presentation of oral erosive lichen planus: case report","authors":"Gustavo Rocha Vita,&nbsp;Guilherme Ribeiro de Queiroz,&nbsp;Tessa de Lucena Botelho,&nbsp;Claudio Maranhão Pereira","doi":"10.1016/j.oooo.2025.01.057","DOIUrl":"10.1016/j.oooo.2025.01.057","url":null,"abstract":"<div><div>Lichen planus is a mucocutaneous disease that often affects the oral cavity (OLP). Its etiology is still unclear, but it has been considered an autoimmune disease. OLP can manifest in various forms, with the most common being the reticular. This is characterized by the presence of white lines on the buccal mucosa bilaterally. The erosive variant presents symptomatic debilitating lesions. Treatment is primarily carried out with systemic corticosteroids. The present case reports a 23-year-old patient with erosive OLP, with a 6-month evolution. For 5 months, the patient underwent various therapeutic protocols with corticosteroids and immunosuppressants, but without any resolution. In the reported case, despite the patient not presenting skin lesions, she was referred to a dermatologist due to the side effects that the medication was causing, combined with the morbidity of the OLP lesions affecting her quality of life. As of the present moment, despite medical follow-up, the patient remains uncontrolled.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e11"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pigmented Intradermal Melanocytic Nevus: A Case Report 色素沉着皮内黑色素细胞痣1例报告
IF 2 3区 医学
Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.047
Maria Sofia Schreiber Peralta, Fabián Junior Mendéz Colmán, María Eugenia Ayala Pereira, María Cristina Gómez Amarilla, Elisa Noemi Oviedo, Rosvita Estefania Cantero Eisenkolbl, Maria Alejandra Portillo Martinez
{"title":"Pigmented Intradermal Melanocytic Nevus: A Case Report","authors":"Maria Sofia Schreiber Peralta,&nbsp;Fabián Junior Mendéz Colmán,&nbsp;María Eugenia Ayala Pereira,&nbsp;María Cristina Gómez Amarilla,&nbsp;Elisa Noemi Oviedo,&nbsp;Rosvita Estefania Cantero Eisenkolbl,&nbsp;Maria Alejandra Portillo Martinez","doi":"10.1016/j.oooo.2025.01.047","DOIUrl":"10.1016/j.oooo.2025.01.047","url":null,"abstract":"<div><div>Nevi or Moles are raised, localized lesions that are mostly dark in color, mainly due to sunlight. They have a high risk of malignant transformation, due to sun exposure or chronic trauma. We present a male patient, 42 years old, who comes for dental treatment. During the oral and facial evaluation, a raised lesion is observed in the frontal region to the right of the midline, with a slight increase in pigmentation, and slight discomfort upon exposure. Solar, at the patient's request, the excisional biopsy was performed and sent for histopathological analysis, the result was a pigmented intradermal melanocytic nevus with significant activity in the dermo-epidermal junction where atypical melanocytes arranged in isolation were noted. This demonstrates the importance of performing an oral and facial checkup looking for dermal alterations in addition to mucosal alterations, fulfilling the purpose that corresponds to the health area.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e9"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An unusual case: malignant melanoma in the oral cavity 一个不寻常的病例：口腔恶性黑色素瘤
IF 2 3区 医学
Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.033
Bárbara Campo DallOrto Martins, Sergio Lins de-Azevedo-Vaz, Rossiene Motta Bertollo, Daniela Nascimento Silva, Águida Cristina Gomes Henriques Leitão, Danielle Resende Camisasca, Liliana Aparecida Pimenta de Barros
{"title":"An unusual case: malignant melanoma in the oral cavity","authors":"Bárbara Campo DallOrto Martins,&nbsp;Sergio Lins de-Azevedo-Vaz,&nbsp;Rossiene Motta Bertollo,&nbsp;Daniela Nascimento Silva,&nbsp;Águida Cristina Gomes Henriques Leitão,&nbsp;Danielle Resende Camisasca,&nbsp;Liliana Aparecida Pimenta de Barros","doi":"10.1016/j.oooo.2025.01.033","DOIUrl":"10.1016/j.oooo.2025.01.033","url":null,"abstract":"<div><div>Malignant melanoma in the oral cavity is rare, with uncertain etiology, possibly associated with pre-existing melanosis, dental irritation, cigarette smoking, alcohol use, and formaldehyde exposure. A 59-year-old white female complained of a darkened lesion that appeared 7 years ago, which increased after the lower first molar extraction. Intraorally, a 2 cm darkened lesion with irregular borders and irregular surface was identified on the lower right alveolar ridge. Radiographically, a radiolucent image compatible with a tooth socket after extraction was observed. The incisional biopsy and microscopic analysis revealed the proliferation of atypical melanocytes with neoplastic characteristics invading the connective tissue arranged in sheets and cords depositing brownish pigment, consistent with melanin. The final diagnosis was malignant melanoma. The patient underwent surgical treatment with follow-up. Although rare, malignant oral melanoma should be considered as a differential diagnosis for blackened patches in the oral cavity.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e6"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual radiographic aspects of conventional ossifying fibroma: 2 cases reported 常规骨化性纤维瘤的异常影像学表现：附2例报告
IF 2 3区 医学
Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.021
Camila Dayla Melo Oliveira, Erika Martins Pereira, Raísa Sales de Sá, Jennifer Sanzya Silva de Araújo, Aluísio Cruz de Sousa Neto, Milena Daniela Freire Corsini, Thalita Santana
{"title":"Unusual radiographic aspects of conventional ossifying fibroma: 2 cases reported","authors":"Camila Dayla Melo Oliveira,&nbsp;Erika Martins Pereira,&nbsp;Raísa Sales de Sá,&nbsp;Jennifer Sanzya Silva de Araújo,&nbsp;Aluísio Cruz de Sousa Neto,&nbsp;Milena Daniela Freire Corsini,&nbsp;Thalita Santana","doi":"10.1016/j.oooo.2025.01.021","DOIUrl":"10.1016/j.oooo.2025.01.021","url":null,"abstract":"<div><div>Conventional ossifying fibroma (COF) is a benign bone neoplasm that predominantly affects the jawbones. We report 2 cases of COF arising in the mandible that radiographically resembled odontogenic cysts. The first case is from a female 15-year-old patient presenting an expansive radiolucent lesion in the mandible, between the left second premolar e and first molar (vital teeth). The clinical hypothesis was a periodontal lateral cyst. The second case presented as a radiolucent lesion mimicking a periapical cyst in a 23-year-old male patient. The lesion was associated with the canine and first lower left premolar, both teeth were vital, however, the second premolar had undergone endodontic therapy. Clinical hypotheses included inflammatory lesions and central giant cell granuloma. Both lesions underwent surgical excision and microscopic analyses revealed cellular fibrous tissue with mineralized product, including osteoid, bone, and basophilic acellular spherules, with a final diagnosis of COF. Both patients are under follow-up with no recurrences.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e4"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of sclerosant solution for treatment of intraoral hemangioma: a case report 硬化剂溶液治疗口内血管瘤1例
IF 2 3区 医学
Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.022
Aline Martins Candido de Oliveira, Luigi Lucas Rentes, Rodrigo dos Santos Pereira, Fabrizio Albieri
{"title":"Use of sclerosant solution for treatment of intraoral hemangioma: a case report","authors":"Aline Martins Candido de Oliveira,&nbsp;Luigi Lucas Rentes,&nbsp;Rodrigo dos Santos Pereira,&nbsp;Fabrizio Albieri","doi":"10.1016/j.oooo.2025.01.022","DOIUrl":"10.1016/j.oooo.2025.01.022","url":null,"abstract":"<div><div>Hemangioma is considered the most common benign vascular tumor during childhood, primarily affecting fair-skinned female patients. The aim of this study is to describe a case of hemangioma in a 29-year-old male patient with fair skin, evolving over 8 years on the right lateral border of the tongue. The intraoral clinical examination revealed a purplish stain with increased volume. The diagnosis was made through diascopy, and the treatment elected was local infiltration of sclerosing solution Ethamoline oleate in association with dexamethasone. In this case, it is noteworthy to emphasize the importance of considering this entity in the differential diagnosis of indolent intraoral stains of some duration, and it is vital that dentists maintain a high degree of clinical attention, given its potential for malignancy.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e4"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mandibular venolymphatic malformation identified with infrared thermography: a case report 红外线热像仪鉴定下颌骨毒淋巴畸形1例
IF 2 3区 医学
Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.025
Reuber Mendes Rocha, Alessah Carolyna de Andrade Fernandes, Angela Natalia Garnica Hilarión, Eleazar Mezaiko, Larissa Rosa Santana Rodrigues, Fernanda Paula Yamamoto-Silva, Brunno Santos de Freitas Silva
{"title":"Mandibular venolymphatic malformation identified with infrared thermography: a case report","authors":"Reuber Mendes Rocha,&nbsp;Alessah Carolyna de Andrade Fernandes,&nbsp;Angela Natalia Garnica Hilarión,&nbsp;Eleazar Mezaiko,&nbsp;Larissa Rosa Santana Rodrigues,&nbsp;Fernanda Paula Yamamoto-Silva,&nbsp;Brunno Santos de Freitas Silva","doi":"10.1016/j.oooo.2025.01.025","DOIUrl":"10.1016/j.oooo.2025.01.025","url":null,"abstract":"<div><div>This report describes an unusual case of venolymphatic malformation in the left mandibular angle of a 38-year-old male. The patient sought specialized attention due to a “facial growth upon physical exertion,” present for 2 years, painless, and static. During periods of rest, there was no facial asymmetry, but exertion revealed a normochromic, elastic, well-defined volumetric increase in the left mandible. Initially, ambulatory thermographic imaging was performed using an infrared thermography device, which showed a significant temperature alteration in that region after exertion. Magnetic resonance imaging confirmed an infiltrative lesion in the left masseter muscle, with subcutaneous extension and possible venous origin. The clinical diagnosis of venolymphatic malformation was established, and the patient was referred for follow-up with a vascular surgeon, remaining stable for the past 12 months. This report suggests that infrared thermography may represent an important adjunct in the diagnosis of maxillofacial vascular lesions.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e4"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multisystemic presentation of langerhans cell histiocytosis in pediatric patient: a case report of letterer-siwe disease 小儿朗格汉斯细胞组织细胞增多症的多系统表现：letter -siwe病1例报告
IF 2 3区 医学
Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI: 10.1016/j.oooo.2025.01.008
Larissa Santos Amaral Rolim, Helder Domiciano Dantas Martins, Eduarda Gomes Onofre de Araújo, Keila Martha Amorim Barroso, Ana Carolina Lyra de Albuquerque, Alexandre Rolim da Paz, Paulo Rogério Ferreti Bonan
{"title":"Multisystemic presentation of langerhans cell histiocytosis in pediatric patient: a case report of letterer-siwe disease","authors":"Larissa Santos Amaral Rolim,&nbsp;Helder Domiciano Dantas Martins,&nbsp;Eduarda Gomes Onofre de Araújo,&nbsp;Keila Martha Amorim Barroso,&nbsp;Ana Carolina Lyra de Albuquerque,&nbsp;Alexandre Rolim da Paz,&nbsp;Paulo Rogério Ferreti Bonan","doi":"10.1016/j.oooo.2025.01.008","DOIUrl":"10.1016/j.oooo.2025.01.008","url":null,"abstract":"<div><div>Letterer-Siwe disease is the most common and serious of these entities, affecting mainly infants up to 2 years of age. Here we report a case affecting a 1-year-old white male, presented with a complaint of nonhealing gingival lesion. Medical history revealed a supposed milk protein allergy, gastric reflux, anorexia, recent fever, and seborrheic dermatitis. On extraoral physical examination, palpable bilateral anterior and postauricular cervical lymph nodes were noted, along with abdominal distension, fever, and seborrheic dermatitis. Intraoral examination revealed bilateral gingival enlargement in the posterior tooth region. Subsequently, an incisional biopsy of the gingival lesion revealed ulcerative areas with intense mixed inflammatory infiltrate. Immunohistochemical evaluation confirmed positivity for CD1a, CD68, S100, Myeloperoxidase, CD20, and CD3, confirming the diagnosis of Langerhans cell histiocytosis. Due to multisystemic presentation, the diagnosis of Letterer-Siwe disease was confirmed, and the patient was referred for chemotherapeutic treatment under follow-up.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e1"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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