Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献

{"title":"Improving CBCT diagnosis with pathological descriptors in radiology training.","authors":"Anthony R Mecham, Tyler Peterson, Yeji Lee, Emily Chung, Peggy P Lee","doi":"10.1016/j.oooo.2025.06.011","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.06.011","url":null,"abstract":"<p><strong>Objectives: </strong>This study assessed (1) CBCT interpretation improvement in Oral Radiology residents, (2) whether accurate pathological descriptor selection improved differential diagnosis, and (3) which descriptor categories best predicted diagnostic accuracy.</p><p><strong>Study design: </strong>Three residents interpreted 200 CBCTs with known pathologies during a 24-month residency (2013-2015) at the University of Washington. Sixty-seven cases were preselected based on confirmed pathology and diversity. Residents selected descriptors from 101 options and provided up to 5 differential diagnoses, compared to a senior radiologist's gold standard. Spearman's Rho and Kruskal-Wallis tests evaluated correlations (P < .05).</p><p><strong>Results: </strong>Residents significantly improved in selecting accurate descriptors and diagnoses (P < .05). Key predictors of correct diagnoses-location, size, and dentoalveolar involvement-correlated consistently across all residents (Rho > 0.6), while shape and border showed weaker associations.</p><p><strong>Conclusion: </strong>Training with pathological descriptors enhances CBCT diagnostic accuracy. Identifying strengths and weaknesses in descriptor use can guide targeted training, improving diagnostic skills. This approach offers a scalable method for radiology education and clinical application.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and imaging evaluation and therapeutic approach of 42 cases of odontogenic myxomas.","authors":"Ana Luiza Lima Medeiros Paz, Cristhiane Almeida Leite, Luiz Evaristo Ricci Volpato, André Caroli Rocha","doi":"10.1016/j.oooo.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.06.010","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the clinical and imaging characteristics and therapeutic approach of odontogenic myxomas (OMs).</p><p><strong>Study design: </strong>A retrospective multicenter study was conducted using data from medical records of patients treated at three hospitals in São Paulo, Brazil, between 1996 and 2021. Demographic, clinical, imaging (panoramic radiography and/or computed tomography, CT), and histopathological data were collected.</p><p><strong>Results: </strong>Forty-two cases were evaluated. The mean age of patients was 27.43 years (±10.39), and 64.3% were female. Most lesions were asymptomatic (83.3%) and located in the posterior mandible (40.5%). Multilocular radiolucency was the predominant pattern on panoramic radiographs (61.9%), whereas unilocular appearance prevailed on CT scans (45.2%). Ill-defined margins were observed in 52.4% of cases. Conservative treatment (excision with peripheral ostectomy) was employed in 95.2% of patients. The recurrence rate was 7.1%, with no statistically significant correlation between lesion characteristics and recurrence.</p><p><strong>Conclusions: </strong>OMs primarily affects young female patients and show variable radiographic patterns. Conservative surgical treatment appears effective, with low recurrence rates.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral and maxillofacial clinical features of Ehlers-Danlos syndrome: a systematic review.","authors":"Antunes David, Nicot Romain, Bovis Marine, Ferri Joël","doi":"10.1016/j.oooo.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.05.010","url":null,"abstract":"<p><strong>Background: </strong>Ehlers-Danlos syndromes (EDS) are inherited connective tissue disorders with diverse clinical manifestations, complicating subtype classification. While joint hypermobility, skin hyperextensibility, and tissue fragility are key diagnostic features, oral and maxillofacial signs are often overlooked.</p><p><strong>Objective: </strong>This review compiles dental and maxillofacial manifestations in EDS patients and identifies subtype-specific features to assist diagnosis.</p><p><strong>Study design: </strong>This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered on PROSPERO (CRD42023410501). Studies published from 1969 to March 2023 were screened. Eligible studies included original articles, case series, and case reports involving human subjects with any EDS subtype reporting dental or maxillofacial features.</p><p><strong>Results: </strong>Subtype-specific maxillofacial features included nasal bridge depression in 80% of arthrochalasia EDS, downslanting palpebral fissures in 80% of kyphoscoliotic EDS, and deep-set eyes in 34% of classical EDS (cEDS). Oral anomalies comprised tooth agenesis in 50% of spondylodysplastic and 75% of dermatosparactic EDS cases. Dental malformations included pulpal calcifications (11/89 cEDS), root fusion (8/31 vascular EDS [vEDS]), and excessive root length (11/31 vEDS). Gingival hyperplasia was reported in 100% of dermatosparactic EDS cases. The absence of labial and/or lingual frenula remains debated.</p><p><strong>Conclusions: </strong>This review underscores the diagnostic value of a thorough oral and maxillofacial examination in identifying EDS subtypes.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional analysis of fibrosis-related gene expression in drug-induced gingival enlargement associated with periodontitis.","authors":"Jer-Haur Kuo, Li-Wen Lin","doi":"10.1016/j.oooo.2025.06.005","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.06.005","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to characterize the expression patterns of inflammation- and fibrosis-related genes in drug-induced gingival enlargement (DIGE) among patients with periodontitis.</p><p><strong>Study design: </strong>Gingival tissue samples from 44 patients were categorized into 4 groups: N (healthy controls), P (periodontitis), A (patients with periodontitis receiving amlodipine and valsartan without DIGE), and G (periodontitis patients with DIGE). All specimens were obtained during periodontal flap surgery at least 6 months following initial therapy. Histomorphometric analysis, immunohistochemistry, and immunofluorescence staining were used to assess protein expression levels.</p><p><strong>Results: </strong>Following initial therapy, no patient exhibited DIGE scores of 2 or 3. The expression levels of inflammation- and fibrosis-related markers, including cluster of differentiation 68, matrix metalloproteinase 12, a disintegrin and metalloproteinase 17, connective tissue growth factor, and cathepsin L, were elevated in group G compared with the other groups. Notably, group A demonstrated the highest expression of sirtuin 1 (SIRT1).</p><p><strong>Conclusions: </strong>Effective supragingival and subgingival plaque control remains essential for managing DIGE in patients with periodontitis. The observed upregulation of SIRT1 in non-DIGE cases might indicate a potential antifibrotic role for this molecule.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High insertional torque and early implant failure.","authors":"Wyatt J Spresser, Brian R Carr, Emily M Duhon, Timothy W Neal, Richard A Finn","doi":"10.1016/j.oooo.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.06.006","url":null,"abstract":"<p><p>In implant surgery literature, there is a lack of agreement with regard to the ideal insertional torque at which an endosseous implant is placed. Some believe lower torque values permit increased success, whereas others suggest the same for higher torque. This prospective observational study investigated the association between high insertional torque and early dental implant failure. A total of 207 implants were placed in 95 patients at the Veterans Affairs North Texas Health Care System in Dallas, TX, and were categorized into 2 groups: those placed with insertional torque ≥ 60 Newton-Centimeter (N-cm) and a control group with torque between 30 and 59 N-cm. The primary outcome was early implant failure, defined as exfoliation, mobility during stage 2 surgery, or the need for explantation prior to prosthetic loading. Results demonstrated a statistically significant 9-fold increased risk of early failure in the high torque group (odds ratio [OR] = 9.00, 95% confidence interval [CI] = 1.06-76.18, P = .043). These findings suggest that although higher torque values may offer greater primary stability, they may also contribute to bone resorption, impaired osseointegration, and soft tissue loss, thereby increasing the risk of early implant failure. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis-related facial trauma: a 10-year review of facial trauma in Victoria, Australia.","authors":"Vincent Tran, Michael Qiu, Santosh Kumar Tadakamadla, Kai Lee","doi":"10.1016/j.oooo.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.06.007","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine whether cannabis use in facial trauma influenced the cause of injury, injury severity, or management.</p><p><strong>Study design: </strong>A retrospective cohort study was performed using records from a state-wide database of all patients who presented to a Victorian hospital with a facial fracture between 2004 and 2014. Data collected included demographics, concomitant cannabis use, mechanism of injury, facial injuries, and management. Statistical analysis was done using the chi square test, t test, binary logistic regression analysis, and multivariable linear regression analysis. Results were considered statistically significant if P < .05.</p><p><strong>Results: </strong>A total of 54,613 patient presentations for facial trauma were analyzed with 174 patients in the cannabis group, and 54,439 in the non-cannabis group. Those affected by cannabis are more likely to have their injuries be caused by motor vehicle accidents (odds ratio [OR] = 1.59, P < .05) when compared with non-cannabis users. When controlling for confounding variables, such as alcohol and other drug use, cannabis users had, on average, 0.22 more facial fractures and 0.11 more facial lacerations per presentation (P < .05). Cannabis-affected patients also required 0.11 more open reduction and internal fixation (ORIF) procedures and 1.0 more allied health inputs in their management (P < .05).</p><p><strong>Conclusions: </strong>Cannabis may be a potential comorbid risk factor in facial trauma that may result in an increased risk of vehicle-related injuries, more facial fractures, and a higher need for surgery and allied health inputs as part of management. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Submucosal nodule on the lower lip.","authors":"Kamile Leonardi Dutra-Horstmann, Daniele Março de Sousa Rocha, Mauricio Assunção Pereira, Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Elena Riet Correa Rivero","doi":"10.1016/j.oooo.2025.06.004","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.06.004","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TEK-related venous malformation of the orofacial region: report of a case with multidisciplinary treatment guided by molecular diagnosis.","authors":"Yi-Shing Lisa Cheng, Daniel Bustamante, David M Yates, Silvia Menendez, Angela C Chi","doi":"10.1016/j.oooo.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.05.009","url":null,"abstract":"<p><p>Vascular malformations (VMs) often affect the orofacial region, where they can markedly impact the quality of life. They frequently harbor mutations in TEK, PIK3CA, or other genes essential for angiogenesis. Alpelisib is a phosphatidylinositol 3-kinase inhibitor recently shown to be effective for treating VMs with PIK3CA or TEK mutations. Herein we describe a 13-year-old female with an orofacial VM present since birth. Based on clinical, histopathologic, and molecular findings, the final diagnosis was TEK-related venous malformation. She received multimodal therapy, consisting of sclerotherapy, surgical debulking, and systemic alpelisib. Ten months after surgery and 7 months after terminating systemic therapy, the buccal mucosal aspect of the lesion was barely apparent. Molecular diagnostics and targeted agents have ushered in a new era of precision medicine for VMs. It is important for pathologists and clinicians to be aware of molecular-guided therapy as delivered via a multidisciplinary team-based approach for optimal management of patients with VMs.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S2212-4403(25)01056-9","DOIUrl":"10.1016/S2212-4403(25)01056-9","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 2","pages":"Page A6"},"PeriodicalIF":2.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Pathologic Conference Case 6: An ulcerated lesion on the gingiva of an adolescent female","authors":"Madhu Shrestha ,&nbsp;Saja Alramadan ,&nbsp;Victoria Woo ,&nbsp;John Wright","doi":"10.1016/j.oooo.2025.03.012","DOIUrl":"10.1016/j.oooo.2025.03.012","url":null,"abstract":"&lt;div&gt;&lt;div&gt;&lt;strong&gt;Clinical Presentation&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;A 12-year-old female patient presented with a chief complaint of a non-healing ulcer in the anterior maxilla. The lesion had been present for 3 months, and there was a history of a slowly growing mass. Clinical examination revealed an approximately 1.5 × 1 cm ulcerated mass involving the left maxillary canine-lateral incisor area (Figure 1). The surface appeared to be ulcerated, with an overall erythroleukoplakic appearance. The patient experienced variable sensitivity, and the medical history was unremarkable. Further palpation revealed a firm, ulcerated mass with rolled borders. An incisional biopsy was performed, and the tissue was sent for histopathological examination.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Differential Diagnosis&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;The clinical differential diagnosis for a gingival lesion in an adolescent is broad, encompassing a range of possibilities from reactive and benign to malignant lesions. The patient's age makes a malignant lesion unlikely. However, the clinical presentation of a speckled and granular erythro-leukoplakic appearance, along with visible dilated blood vessels (telangiectasias), raises suspicion for a malignancy. Despite the patient's age, the primary considerations include malignant entities such as squamous cell carcinoma and rhabdomyosarcoma, intermediate conditions like Langerhans cell histiocytosis, and benign conditions such as myofibroma, although the latter is less likely.&lt;/div&gt;&lt;div&gt;Squamous cell carcinoma (SCC) is highly suspected in this case, despite the patient's age. The clinical presentation of an exophytic lesion with a granular and erythro-leukoplakic appearance telangiectasias is concerning. The presentation of erythro-leukoplakia suggests an epithelial neoplastic origin. SCC is the most common malignancy of the oral cavity.&lt;sup&gt;1&lt;/sup&gt; It typically exhibits a peak incidence in the elderly and is strongly associated with smoking and alcohol abuse.&lt;sup&gt;1&lt;/sup&gt; Whereas oral SCC (OSCC) is rare in individuals under 50, recent global epidemiological studies have shown a rising incidence, particularly among young adults.&lt;sup&gt;1-3&lt;/sup&gt; The etiopathogenesis of OSCC in younger patients remains unclear, and traditional risk factors like tobacco and alcohol use are thought to play a minimal role in these cases, since the duration of exposure to these factors is believed to be shorter in young individuals.&lt;sup&gt;1,4&lt;/sup&gt;&lt;/div&gt;&lt;div&gt;The gingival-alveolar ridge is a common site for OSCC in children without known genetic predisposition to cancer.&lt;sup&gt;4&lt;/sup&gt; However, the possibility of a genetic predisposition should be considered in such cases. Rare hereditary syndromes, such as Fanconi anemia, xeroderma pigmentosum, Bloom syndrome, Li-Fraumeni syndrome, and dyskeratosis congenita, have all been associated with an increased risk of developing OSCC, particularly in the tongue, as well as other head and neck neoplasms.&lt;sup&gt;4&lt;/sup&gt;&lt;/div&gt;&lt;div&gt;Rhabdomyosarcoma (RMS) wa","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 2","pages":"Pages e55-e57"},"PeriodicalIF":2.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}