Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献_第10页

Prevalence and risk of oral adverse outcomes in patients with COVID-19: a retrospective real-world cohort study. COVID-19患者口腔不良结局的患病率和风险：一项回顾性现实世界队列研究

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2026-01-16 DOI: 10.1016/j.oooo.2026.01.003

Stella O Oyewole, Adetokunbo B Olawuyi, Osariemen Okhuaihesuyi, Adepitan A Owosho

{"title":"Prevalence and risk of oral adverse outcomes in patients with COVID-19: a retrospective real-world cohort study.","authors":"Stella O Oyewole, Adetokunbo B Olawuyi, Osariemen Okhuaihesuyi, Adepitan A Owosho","doi":"10.1016/j.oooo.2026.01.003","DOIUrl":"https://doi.org/10.1016/j.oooo.2026.01.003","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, affects multiple systems, including the oral cavity, with ulcers, taste changes, and mucosal lesions. Existing studies are limited in scope, highlighting the need for large-scale studies to clarify the prevalence and clinical relevance of these oral outcomes.</p><p><strong>Materials and methods: </strong>We conducted a retrospective cohort study using the TriNetX Research Network to analyze COVID-19 patients from 2020 to 2025. Queried oral conditions, including ulcers, taste alterations, salivary disturbances, and mucosal lesions. Propensity score matching was used to balance age, sex, and comorbidities. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated, with significance set at P < .05.</p><p><strong>Results: </strong>Among 4,875,258 adults with COVID-19, the most common oral outcomes were taste alteration (0.588%), aphthous ulcers (0.106%), salivary disturbances (0.053%), and stomatitis (0.025%). Compared with age, sex, and co-morbid matched controls, COVID-19 was associated with a higher risk of taste alteration (OR = 10.11; P < .0001) and herpetic oral lesions (OR = 1.46; P < .0001), while other oral conditions were less frequent. Anti-COVID-19 medication use was associated with a lower incidence of taste alteration (0.14% vs 0.54%; P < .0001) and higher records of aphthous ulcers and herpetic lesions.</p><p><strong>Conclusion: </strong>COVID-19 is associated with a significantly increased risk of taste alteration and herpetic oral lesions, while anti-COVID-19 medication use is associated with lower odds of taste alteration.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contemporary strategies for active learning in oral and maxillofacial surgery education. 口腔颌面外科教学中主动学习的当代策略。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2026-01-15 DOI: 10.1016/j.oooo.2026.01.002

Eric R Carlson, Joshua Segal

引用次数: 0

Oral adverse events associated with anti-tumor necrosis factor-alpha therapies: using a large real-world dataset. 与抗肿瘤坏死因子- α治疗相关的口服不良事件：使用大型真实数据集

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2026-01-15 DOI: 10.1016/j.oooo.2026.01.001

Stella O Oyewole, Adetokunbo B Olawuyi, Osariemen Okhuaihesuyi, Adepitan A Owosho

{"title":"Oral adverse events associated with anti-tumor necrosis factor-alpha therapies: using a large real-world dataset.","authors":"Stella O Oyewole, Adetokunbo B Olawuyi, Osariemen Okhuaihesuyi, Adepitan A Owosho","doi":"10.1016/j.oooo.2026.01.001","DOIUrl":"https://doi.org/10.1016/j.oooo.2026.01.001","url":null,"abstract":"<p><strong>Background: </strong>Anti-tumor necrosis factor-alpha (anti-TNF-α) therapies are efficacious in managing immune-mediated inflammatory diseases, however, long-term use has been associated with notable adverse events. As patients use expands, understanding the spectrum of oral adverse events (OAEs) has become essential.</p><p><strong>Materials and methods: </strong>We conducted a retrospective cohort study using the TriNetX research network. A 5‑year observation window identified patients prescribed anti‑TNF-α therapies. Patients with prior oral conditions, concurrent cancer therapies, or antiresorptive exposure were excluded. OAEs were categorized into xerostomia, mucosal disorders, infectious disorders, gingival hyperplasia, medication-related osteonecrosis of the jaw (MRONJ), and oral squamous cell carcinoma (OSCC). Propensity score matching (1:1, age/sex) compared anti‑TNF-α users with unexposed controls.</p><p><strong>Results: </strong>In a cohort of 1,645,751 individuals receiving anti‑TNF‑α therapy, OAEs were frequent, with oral lichenoid lesions (1.27%, 20,135), candidiasis (1.09%, 17,475), xerostomia (0.87%, 14,024), stomatitis (0.68%, 10,904), and oral herpes (0.39%, 6,343) most commonly observed. Less frequent events included MRONJ (0.01%, 173), gingival hyperplasia (0.02%, 285), and OSCC (0.07%, 1,074). Compared with the general population, anti‑TNF‑α therapy significantly increased the odds of most mucosal and infectious conditions (P < .001), though oral lichen planus showed no association. Interestingly, OSCC exhibited an inverse association (OR = 0.75, P < .0001), suggesting a potential protective effect.</p><p><strong>Conclusion: </strong>These findings highlight the importance of routine oral health surveillance and robust pharmacovigilance amongst patients on anti‑TNF-α therapies.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraosseous (central) mucoepidermoid carcinoma: a case series and association with features of glandular odontogenic cyst. 骨内（中央）黏液表皮样癌：一个病例系列及其与腺性牙源性囊肿特征的关系。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2026-01-14 DOI: 10.1016/j.oooo.2026.01.006

Shravan Thiagarajan, Renee Reich, Paul Freedman

{"title":"Intraosseous (central) mucoepidermoid carcinoma: a case series and association with features of glandular odontogenic cyst.","authors":"Shravan Thiagarajan, Renee Reich, Paul Freedman","doi":"10.1016/j.oooo.2026.01.006","DOIUrl":"https://doi.org/10.1016/j.oooo.2026.01.006","url":null,"abstract":"<p><strong>Objective: </strong>Although mucoepidermoid carcinoma is one of the most common salivary gland malignancies, its involvement in the jaws is exceedingly rare. This report's purpose is to describe the histologic and demographic features of intraosseous mucoepidermoid carcinoma (IMEC) and to add evidence to support a potential relationship with glandular odontogenic cysts (GOCs).</p><p><strong>Study design: </strong>Cases of patients diagnosed with IMEC were obtained from Oral Pathology Laboratory, Inc, at New York-Presbyterian Queens from 1985 to 2024. Slides and clinical information were reviewed.</p><p><strong>Results: </strong>Fourteen patients with IMEC were identified who had an average age of 58.6 years and a slight female predilection. IMEC was equally present in both jaws. Twelve patients were classified as having low-grade tumors with cystic areas composed of an admixture of epidermoid and mucous cells, 6 cases of which had areas resembling GOCs. Two patients had high-grade tumors demonstrating anaplasia and perineural invasion. One high-grade tumor had areas that resembled a GOC. Four of the 7 presentations of IMEC (6 low-grade and 1 high-grade) with GOC features were from the mandible.</p><p><strong>Conclusions: </strong>We describe the common and uncommon histopathologic features of IMEC while also demonstrating that GOC-type areas often are seen as a component of these tumors. Therefore, all lesions identified as GOCs should be carefully analyzed to rule out the early development of an IMEC.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of bone repair using sticky bone in preradiotherapy extraction sockets of head and neck cancer patients: a pre- and postradiotherapy follow-up. 头颈癌患者放射治疗前拔牙槽中使用粘性骨进行骨修复的评价：放疗前后随访。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2026-01-06 DOI: 10.1016/j.oooo.2025.12.016

Jessica Ferreira Rodrigues, Dhiancarlo Rocha Macedo, Luiz Fernando Barbosa de Paulo, Gabriella Lopes de Rezende Barbosa, André Luís Faria E Silva, Carlos José Soares, Priscilla Barbosa Ferreira Soares

{"title":"Evaluation of bone repair using sticky bone in preradiotherapy extraction sockets of head and neck cancer patients: a pre- and postradiotherapy follow-up.","authors":"Jessica Ferreira Rodrigues, Dhiancarlo Rocha Macedo, Luiz Fernando Barbosa de Paulo, Gabriella Lopes de Rezende Barbosa, André Luís Faria E Silva, Carlos José Soares, Priscilla Barbosa Ferreira Soares","doi":"10.1016/j.oooo.2025.12.016","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.12.016","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of Sticky Bone-a biomaterial composed of Solid-PRF (S-PRF), a variant of platelet-rich fibrin (PRF), and deproteinized bovine bone-on bone formation after tooth extraction performed prior to radiotherapy, with follow-up during both the pre- and postradiotherapy phases.</p><p><strong>Methods: </strong>Fifteen patients were randomized to receive either a blood clot (control) or Sticky Bone (experimental) in each extraction socket. Six patients were followed for up to 60 days after radiotherapy. Clinical assessments included evaluation of the surgical site, whereas bone repair was qualitatively analyzed using radiographs reviewed by three blinded examiners. Data were analyzed using the Mann-Whitney U test, multilevel binary regression, and mixed-effects regression (α = 0.05).</p><p><strong>Results: </strong>Sticky Bone showed no significant effect on the evaluated clinical outcomes, regardless of the assessment period. Improved clinical scores were observed 7 days postoperatively; however, no meaningful differences in soft tissue healing or bone repair were detected within 60 days after radiotherapy.</p><p><strong>Conclusion: </strong>The null hypothesis was accepted: Sticky Bone had no significant effect on bone or soft tissue healing for up to 60 days after radiotherapy when applied to extraction sites prior to treatment.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteonecrosis of the jaw as a possible adverse effect of tocilizumab 托珠单抗可能导致颌骨骨坏死。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2026-01-01 Epub Date: 2025-08-20 DOI: 10.1016/j.oooo.2025.08.011

Hedyeh Samady DMD, MSD , Mark Drangsholt DDS, MPH, PhD , Gale Sebastian BDS, MDS, MSD , David Dean DDS, MSD

引用次数: 0

The incidence and role of EBV and HIV in head and neck lymphomas: an institutional study EBV和HIV在头颈部淋巴瘤中的发病率和作用：一项机构研究。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2026-01-01 Epub Date: 2025-08-30 DOI: 10.1016/j.oooo.2025.08.015

Buntu Xoki BChD, MChD, FCMFOS(SA) , Andries Masenge MSc , Tsholofelo Kungoane BDS, MDENT, FC SA (PATH) Oral

{"title":"The incidence and role of EBV and HIV in head and neck lymphomas: an institutional study","authors":"Buntu Xoki BChD, MChD, FCMFOS(SA) , Andries Masenge MSc , Tsholofelo Kungoane BDS, MDENT, FC SA (PATH) Oral","doi":"10.1016/j.oooo.2025.08.015","DOIUrl":"10.1016/j.oooo.2025.08.015","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine the prevalence of Epstein-Barr virus (EBV) positive lymphomas in a cohort of patients with head and neck lymphomas and to correlate these lymphomas with HIV status, CD4<sup>+</sup> cell count, clinical stage, and overall survival.</div></div><div><h3>Study Design</h3><div>This retrospective descriptive study sourced data from pathology reports and clinical records. Data collected included lymphoma type, HIV status, and medical information related to immunosuppression, CD4<sup>+</sup> T-cell counts, HIV viral load, Ann Arbor clinical stage, and follow-up data.</div></div><div><h3>Results</h3><div>We reviewed 228 lymphomas, comprising 9 Hodgkin lymphomas and 219 non-Hodgkin lymphomas (HIV-positive: 133; HIV-negative: 23, and unknown HIV status: 72). Diffuse large B-cell lymphoma and plasmablastic lymphoma (PBL) were common and associated with HIV immune suppression, male sex, and middle age. Seventy-four lymphomas were Epstein-Barr encoded RNA in situ hybridization (EBER-ISH) positive. PBL was the most common EBV-driven lymphoma (median CD4<sup>+</sup> count = 147 cells/mm<sup>3</sup>), with the highest Ann Arbor staging.</div></div><div><h3>Conclusion</h3><div>These findings suggest that EBV infection is among the primary factors contributing to PBL oncogenesis in HIV-positive patients. Patients with PBL presented with CD4<sup>+</sup> T-cell counts of <400 cells/mm<sup>3</sup>. Patients with HIV infection had a lower overall survival rate compared to HIV-negative patients, irrespective of lymphoma type.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 1","pages":"Pages 106-115"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AAE and AAOMR Joint Position Statement: Use of Cone-Beam Computed Tomography in Endodontics 2025 Update AAE和AAOMR联合立场声明：锥形束计算机断层扫描在牙髓学中的应用2025更新

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2026-01-01 Epub Date: 2025-12-15 DOI: 10.1016/j.oooo.2025.09.013

Saulo L. Sousa Melo DDS, MSD, PhD , Mohamed I. Fayad DDS, MS, PhD , Anita Gohel BDS, PhD , Bradford R. Johnson DDS, MHPE , Sajitha Kalathingal BDS, DDS, MS , Mina Mahdian DDS, MDSc , Madhu Nair BDS, DMD, MS, PhD , Frank C. Setzer DDS, DMD, MS, PhD , Scott R. Makins DDS, MS

引用次数: 0

Quantitative assessment of the temporomandibular joints in patients with osteogenesis imperfecta: a CBCT study 成骨不全患者颞下颌关节的定量评估：一项CBCT研究。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2026-01-01 Epub Date: 2025-09-17 DOI: 10.1016/j.oooo.2025.09.007

Michelle Briner DDS , Jean-Marc Retrouvey DMD, MSc , Members of BBDC

{"title":"Quantitative assessment of the temporomandibular joints in patients with osteogenesis imperfecta: a CBCT study","authors":"Michelle Briner DDS , Jean-Marc Retrouvey DMD, MSc , Members of BBDC","doi":"10.1016/j.oooo.2025.09.007","DOIUrl":"10.1016/j.oooo.2025.09.007","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate mandibular condylar volume and height in individuals with osteogenesis imperfecta (OI) compared to age- and sex-matched controls using CBCTs.</div></div><div><h3>Study Design</h3><div>This study included 48 OI patients and 48 matched controls. CBCTs were analyzed using 3DSlicer and Anatomage-InVivo6 software. Condylar volume and height were measured bilaterally. Data were analyzed using t-tests, ANOVA, and Tukey posthoc tests.</div></div><div><h3>Results</h3><div>No sex-based differences in condylar volume were found in either OI or control patients. Volumetric developmental stage differences were significant only in OI patients. In OI patients, condylar height was significantly associated with sex on the right side only. In controls, no sex-based differences were found, but developmental stage differences were significant in the left condyle. No significant differences in volume or height were observed between OI types.</div></div><div><h3>Conclusion</h3><div>Individuals with OI, show significantly reduced condylar volume and height, indicating impaired and delayed condylar development consistent with their overall skeletal maturation delay.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 1","pages":"Pages 116-125"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of the clinicopathologic characteristics and immunohistochemical expression of recurrent and nonrecurrent glandular odontogenic cysts: a retrospective longitudinal cohort multicenter study 复发性与非复发性腺性牙源性囊肿临床病理特征及免疫组织化学表达的比较研究：一项回顾性纵向队列多中心研究。

IF 1.9 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2026-01-01 Epub Date: 2025-08-22 DOI: 10.1016/j.oooo.2025.08.010

Alberto Peraza-Labrador MSc , John Wright , Victoria Woo , Monica Kowalski , Kittiphoj Tikkhanarak , Nidhi Q. Handoo , Wattawan Wongpattaraworakul , Elizabeth Bilodeau , Felipe Nor , Molly Housley Smith , Matthew Kesterke , Hua Zhang , Patricia Barros , Madhu Shrestha

{"title":"Comparative study of the clinicopathologic characteristics and immunohistochemical expression of recurrent and nonrecurrent glandular odontogenic cysts: a retrospective longitudinal cohort multicenter study","authors":"Alberto Peraza-Labrador MSc , John Wright , Victoria Woo , Monica Kowalski , Kittiphoj Tikkhanarak , Nidhi Q. Handoo , Wattawan Wongpattaraworakul , Elizabeth Bilodeau , Felipe Nor , Molly Housley Smith , Matthew Kesterke , Hua Zhang , Patricia Barros , Madhu Shrestha","doi":"10.1016/j.oooo.2025.08.010","DOIUrl":"10.1016/j.oooo.2025.08.010","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study was to analyze the clinicopathological profile of recurrent and non-recurrent glandular odontogenic cyst (GOC) through a longitudinal cohort multicenter study.</div></div><div><h3>Study Design</h3><div>This multicenter longitudinal cohort study investigates factors associated with GOC recurrence. Included in the study were patients with histologically confirmed GOC (per Fowler’s criteria), who experienced recurrence at least 1-year post-treatment. Controls were GOCs with a minimum of 5 years of recurrence-free follow-up. Histologic features, treatment rendered, and immunohistochemical staining results for CK13, CK19, and Ki-67 were documented.</div></div><div><h3>Results</h3><div>Eleven recurrent cases (6 men and 5 women; mean age = 56.09 years) were analyzed. The anterior mandible was the most frequently affected site (45.5%), followed by the posterior and anterior maxilla (27.1% each). The average follow-up time was 36.1 months. Recurrence was significantly associated with multiple compartments and the absence of apocrine snouting (<em>P</em> = .013, <em>P</em> = .034, respectively). The majority of the primary GOCs that later recurred were treated with enucleation (73%).</div></div><div><h3>Conclusions</h3><div>Multiple compartments and lack of apocrine snouting may be a histological predictor of recurrence. All recurrent cases were treated with enucleation and/or curettage, highlighting treatment approach as a key factor.</div><div>(Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 1","pages":"Pages 86-95"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0