Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献

{"title":"Orofacial adverse events associated with immune checkpoint inhibitors: using a large real-world dataset","authors":"Stella O. Oyewole ,&nbsp;Adepitan A. Owosho","doi":"10.1016/j.oooo.2025.09.006","DOIUrl":"10.1016/j.oooo.2025.09.006","url":null,"abstract":"<div><h3>Background</h3><div>Immune checkpoint inhibitors (ICIs) represent a promising therapeutic class in oncology, increasingly utilized either alone or alongside chemotherapy/radiotherapy. As their use expands, understanding the spectrum of oral adverse events especially when administered as monotherapy has become critical.</div></div><div><h3>Method</h3><div>This retrospective study leveraged the TriNetX real-world healthcare dataset to identify patients treated solely with ICIs. We did not apply a specific time restriction for inclusion, to allow for the capture of all available patients who received ICIs. To identify patients on ICI monotherapy, we excluded those receiving concomitant chemotherapy or radiotherapy. Orofacial adverse events were categorized into xerostomia, oral mucosal disorders, and orofacial neural conditions.</div></div><div><h3>Result</h3><div>Out of 15,638 patients meeting the inclusion and exclusion criteria, 1,564 (10%) developed orofacial immune-related adverse events (irAEs) following ICI administration. Among these, orofacial neuropathies accounted for 56.97%, oral mucosal disorders accounted for 33.95%, and xerostomia for 9.07%. The most prevalent orofacial irAE was dysphagia (3.6%), followed by facial numbness/trigeminal neuralgia (1.63%), oral lichenoid drug reaction (1.4%), stomatitis (1.22%), and xerostomia (0.91%).</div></div><div><h3>Conclusions</h3><div>This study highlights the adverse events associated with ICIs affecting the orofacial region. Our findings suggest that ICIs, even when used as a monotherapy, may contribute significantly to oral complications. Increased awareness and early identification of these complications is essential for timely management and improved patient quality of life.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages 170-175"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral manifestations in leishmaniasis: a single-center experience from Venezuela","authors":"Carlos Sánchez-Ramírez DDS, MSc ,&nbsp;José Alcides Almeida de Arruda DDS, MSc, PhD ,&nbsp;Idalina Martínez-Da-Silva MD ,&nbsp;José Ramón Guevara MD ,&nbsp;Bruno Augusto Benevenuto de Andrade DDS, MSc, PhD ,&nbsp;Mariana Villarroel-Dorrego DDS, MSc, PhD","doi":"10.1016/j.oooo.2025.09.010","DOIUrl":"10.1016/j.oooo.2025.09.010","url":null,"abstract":"<div><h3>Objective</h3><div>Leishmaniasis is among the 10 most neglected tropical diseases worldwide. Because oral involvement is uncommon, diagnosis can be challenging. This study assessed the oral health status of individuals with leishmaniasis and described the clinicopathological features and treatment of its oral manifestations.</div></div><div><h3>Study Design</h3><div>A cross-sectional study was conducted from 2021 to 2022 at a dermatology center in Venezuela. Clinicopathological features and treatment of individuals with leishmaniasis were analyzed descriptively.</div></div><div><h3>Results</h3><div>Among 215 individuals diagnosed with leishmaniasis, 6 (2.8%) presented oral mucosal involvement. Males accounted for 83.4% of these cases, with a mean age of 53.4 years (range: 13-75). The mucocutaneous form was the most common (<em>n</em> = 5/83.3%). The hard/soft palate was the most frequently affected site (<em>n</em> = 4/66.7%). Clinically, lesions manifested as irregular, hemorrhagic ulcers, occasionally with nodular patterns. Microscopically, granulomatous inflammation with macrophages containing intracytoplasmic <em>Leishmania</em> inclusions was identified. Poor oral hygiene was present in 80.5% of patients, and tooth loss in 56.3%. Treatment with meglumine antimonate was effective in 86.5% of cases.</div></div><div><h3>Conclusion</h3><div>Oral leishmaniasis in endemic regions such as Venezuela requires enhanced surveillance and a multidisciplinary approach for early diagnosis and management. Public health strategies should prioritize the oral health needs of this venerable population.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages 187-196"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement of tumour budding, tumour-stroma ratio, and tumour thickness in oral squamous cell carcinoma biopsy and resection samples and their clinical implications","authors":"Nicole Lonni Msc ,&nbsp;Andressa Fernanda Paza Miguel PhD ,&nbsp;Elis Ângela Batistella PhD ,&nbsp;Daniella Serafin Couto Vieira PhD ,&nbsp;Ricardo Luiz Cavalcanti de Albuquerque-Júnior PhD ,&nbsp;Rogério Oliveira Gondak PhD ,&nbsp;Elena Riet Correa Rivero PhD","doi":"10.1016/j.oooo.2025.09.002","DOIUrl":"10.1016/j.oooo.2025.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the concordance between preoperative biopsies and corresponding surgical resections in assessing tumour budding (TB), tumour/stroma ratio (TSR), and tumour thickness (TT) in oral squamous cell carcinoma (OSCC) samples, and to explore their potential as prognostic indicators.</div></div><div><h3>Study design</h3><div>31 surgical resections and 30 diagnostic biopsies were analysed using cytokeratin-immunostained slides to assess TB, TSR, TT, and the BT score (integrating TB and TT).</div></div><div><h3>Results</h3><div>Histopathological features were consistently underestimated in matched biopsies compared to resections in quantitative analysis, with resections showing higher TB counts, greater TT, and lower TSR (<em>P &lt; .</em>007). However, when classified as categorical variables, no significant differences were observed in TB and TSR. In resections, TB was higher in poorly differentiated tumours, and TT was greater in cases with high TB (<em>P &lt; .</em>049). A positive correlation was observed between TT and TB in biopsies (<em>P &lt; .</em>034). Intermediate and high-risk BT score group had significantly worse disease-free survival (DFS) compared to the low-risk group (<em>P &lt; .</em>02).</div></div><div><h3>Conclusion</h3><div>Despite the underestimation of TB and TSR in biopsies, these parameters remain predictive of aggressive tumor behaviour. Additionally, integrating histopathological parameters into combined scores, such as BT, could optimize biopsy evaluation and complement clinical staging and treatment planning.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages 209-217"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral and intestinal histopathological alterations in inflammatory bowel disease: correlation with clinical activity and psychosocial factors–pilot study","authors":"Danielle Nobre Lopes DDS, PhD ,&nbsp;Noêmia Pereira de Oliveira DDS, MSc ,&nbsp;Letícia Côgo Marques DDS, PhD ,&nbsp;Karla Cristina de Campos Augusto DDS ,&nbsp;Júlia Severino Peres Vieira DDS ,&nbsp;Isabelle dos Santos Xavier Dias PhD ,&nbsp;Bernardo Acácio Santini Pereira PhD ,&nbsp;Ana Luiza Miguez MD, PhD ,&nbsp;Márcia Henriques Magalhães MD, MSc ,&nbsp;Anna Karoline Fausto da Silva PhD ,&nbsp;Karin Soares Cunha DDS, PhD ,&nbsp;Rafaela Elvira Rozza-de-Menezes DDS, PhD","doi":"10.1016/j.oooo.2025.08.019","DOIUrl":"10.1016/j.oooo.2025.08.019","url":null,"abstract":"<div><div>Inflammatory bowel diseases (IBD) are chronic gastrointestinal conditions that can also manifest in the \"oral mucosa\", affecting patients’ quality of life. This study aimed to assess histopathological alterations in the oral and intestinal mucosa of individuals with IBD and explore their correlation with psychometric measures and clinical disease activity. This pilot study included 20 IBD participants (10 with Crohn's disease [CD] and 10 with ulcerative colitis [UC]) and five control cases. Biopsies of the upper lip mucosa were obtained from all participants, and intestinal biopsies from the IBD group. Anxiety, depression, and stress levels were assessed using the Depression, Anxiety, and Stress Scale (DASS-21). Intestinal mucosa histopathology was evaluated using the IBD-DCA score (CD) and Geboes Score (UC). Clinical disease activity was observed in 60% of UC cases and 50% of CD cases. Histopathological disease activity was present in 95% of IBD participants, including those clinically in remission (<em>P</em> = .047) and they were correlated with the classification of intestinal segments according to histological activity in DC and UC (<em>P &lt; .</em>001). Chronic inflammatory cell infiltrates in the oral mucosa were more prevalent in IBD participants than controls (<em>P</em> = .002). A strong correlation was found between histopathological changes in the intestinal mucosa and stress levels in CD patients (<em>P &lt; .</em>001). Histological activity in IBD may persist despite clinical remission. Anxiety appears to influence \"(P = 0.047)\" clinical disease activity, while stress correlates with intestinal inflammation in CD patients. The presence of inflammatory infiltrates in the oral mucosa and their correlation with intestinal findings suggest a possible link between the two mucosae, reinforcing the importance of integrated and multidisciplinary approaches for disease monitoring and management.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages 197-208"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of neural networks to predict a potential osteoporotic metabolic condition based on the panoramic mandibular index","authors":"Philip Roebers MSc ,&nbsp;Ralf Schulze MD","doi":"10.1016/j.oooo.2025.09.022","DOIUrl":"10.1016/j.oooo.2025.09.022","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the use of neural networks to predict potential osteoporotic metabolic conditions using the Panoramic Mandibular Index (PMI) derived from panoramic radiographs.</div></div><div><h3>Study Design</h3><div>A total of n = 750 radiographs were collected and 1,500 regions of interest (ROIs) were analysed. Convolutional neural network (CNN), specifically ResNet-50, were used with transfer learning, achieving the highest accuracy. Three classification approaches were tested: binary classification (PMI &gt; 0.25 vs. PMI &lt; 0.25), 3-class classification (PMI &gt; 0.25, 0.2-0.25, PMI &lt; 0.2), and a modified 2-class classification (PMI &gt; 0.25 vs. PMI &lt; 0.2).</div></div><div><h3>Results</h3><div>The best classification, the modified 2-class classification, achieved an accuracy of 89.5%. Data augmentation techniques including rotation, reflection, and scaling, improved model robustness.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that a neural network can be trained to effectively classify PMI values in panoramic radiographs, providing an easy applicable and noninvasive method to identify patients at risk of osteoporosis.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages 245-254"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145589482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging evaluation of condylar remodeling after open reduction and internal fixation of unilateral mandibular condylar fracture in pediatric patients","authors":"Kuankuan Jia MD, DDS,&nbsp;Jingang An MD, DDS,&nbsp;Yi Zhang MD, PhD,&nbsp;Yang He MD, DDS,&nbsp;Shuo Chen MD, DDS","doi":"10.1016/j.oooo.2025.08.017","DOIUrl":"10.1016/j.oooo.2025.08.017","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the radiographic changes in damaged condyles after open reduction and internal fixation (ORIF) in pediatric patients with unilateral condylar fractures.</div></div><div><h3>Study Design</h3><div>We retrospectively analyzed patients aged ≤ 18 years who underwent ORIF for unilateral condylar fractures. The study group comprised fractured condyles, while contralateral healthy condyles served as controls. We assessed post-ORIF condylar remodeling and analyzed the influencing factors. We also compared condylar remodeling before and after internal fixation hardware removal.</div></div><div><h3>Results</h3><div>The study included 88 patients; for 16 of them, imaging data were obtained after hardware removal. All fractures healed without ankylosis. Patients aged &lt;12 years showed greater susceptibility to irregular condylar morphology and condylar head resorption. Compared with long screw fixation, titanium plate fixation was associated with an increased propensity for condylar head resorption and condylar hyperplasia. Although significant differences in condylar height were observed, the mean difference remained within 2 mm. Postremoval imaging revealed progressive condylar morphological normalization, with no significant height discrepancies.</div></div><div><h3>Conclusions</h3><div>ORIF restored condylar height but likely adversely affected bone remodeling, with younger children demonstrating greater susceptibility. Condylar morphology gradually normalized after hardware removal; earlier hardware removal was associated with reduced remodeling impact.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages 151-157"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From static to robotic: evolving navigation systems in oral and maxillofacial surgery","authors":"Abinav Sundar T MDS ,&nbsp;Pratiksha Shetty MDS ,&nbsp;Padmaraj Hegde MDS ,&nbsp;Shreya S MDS","doi":"10.1016/j.oooo.2025.10.015","DOIUrl":"10.1016/j.oooo.2025.10.015","url":null,"abstract":"<div><div>Navigation-assisted surgical systems in oral and maxillofacial surgery have evolved considerably over the past 5 years, with newer modifications aimed at improving surgical precision, accuracy, and patient outcomes. This narrative review summarizes recent advances in navigation technologies applied to trauma, orthognathic, oncologic, and reconstructive procedures. A comprehensive literature search was performed across PubMed, MEDLINE, Web of Science, Cochrane Library, and Scopus. Relevant articles published between 2019 and 2025 were identified using combinations of MeSH terms and keywords (“Maxillofacial Surgery,” “Computer-Assisted Surgery,” “Surgical Navigation”) linked by Boolean operators. Recent studies highlight developments in dynamic navigation, augmented reality–based platforms, robot-assisted navigation, and artificial intelligence–integrated systems. These technologies demonstrate potential benefits in improving intraoperative accuracy, anatomical reconstruction, and surgical training. Navigation-assisted approaches in oral and maxillofacial surgery reduce intraoperative errors and enhance procedural efficiency, though their impact is influenced by operator expertise and institutional resources. Emerging hybrid and AI-assisted platforms hold promise for further advancing precision and safety in complex maxillofacial interventions.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages e1-e9"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparisons of the reliability of airway measurements on cone beam computed tomography scans among human raters and a convolutional neural network","authors":"Steven Dorris DDS, MS ,&nbsp;Sindhura Anamali BDS, MS ,&nbsp;Juan P. Castro DDS, MS ,&nbsp;Shareef M. Dabdoub PhD ,&nbsp;Trishul Allareddy BDS, MS, MBA","doi":"10.1016/j.oooo.2025.10.001","DOIUrl":"10.1016/j.oooo.2025.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the performance of commercially available AI tools in airway evaluation in clinical conditions.</div></div><div><h3>Study Design</h3><div>100 anonymized cone beam computed tomography datasets obtained from the records of the University of Iowa were oriented and analyzed by 2 calibrated oral and maxillofacial radiology residents using InVivo software (InVivo6). Measurements made were total airway volume and minimum cross-sectional surface area of the airway. These measurements were then compared to those produced by uploading the same datasets to Diagnocat AI software (Diagnocat).</div></div><div><h3>Results</h3><div>The results indicate that all comparisons showed good to excellent reliability (ICC &gt; 0.75), suggesting high agreement between raters. Specifically: The intraclass correlation coefficients of 0.954 (CI: 0.757–0.983) and .944 (CI: 0.732–0.978) between the human and Diagnocat measurements indicate excellent reliability.</div></div><div><h3>Conclusion</h3><div>Diagnocat (Diagnocat) artificial intelligence software is capable of analyzing patients’ oropharyngeal airway volume and minimum cross-sectional area in cone beam computed tomography datasets with minimal to moderate motion artifact at a level comparable to qualified human practitioners.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages 255-264"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteopontin expression in oral potentially malignant disorders and squamous cell carcinoma: association with early invasion but not with dysplastic grade.","authors":"Marco Tulio Leandro Ribeiro, Teresa Cristina Ribeiro Bartholomeu Dos Santos, Alexandro Barbosa de Azevedo, Alan Roger Santos-Silva, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Lucio Souza Gonçalves, Fabio Ramoa Pires","doi":"10.1016/j.oooo.2026.01.013","DOIUrl":"https://doi.org/10.1016/j.oooo.2026.01.013","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate osteopontin (OPN) expression in oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) and explore its prognostic relevance.</p><p><strong>Study design: </strong>This cross-sectional study analyzed 120 cases from 2017 to 2022, including OPMD with varying degrees of epithelial dysplasia and OSCC. Immunohistochemical staining for OPN was performed, and clinicopathologic variables such as patient demographics, lesion site and size, clinical presentation, and histopathologic features were evaluated. Statistical analyses were conducted to assess associations between OPN expression and clinicopathologic parameters.</p><p><strong>Results: </strong>Patients ranged from 22-92 years (mean: 59.3), with a slight female predominance (54.2%). The lateral tongue was the most affected site, and leukoplakia was the predominant clinical presentation. Mean lesion size was 15.8 mm, with mean duration of 23.2 months. OPN expression was detected in 68.2% of cases, with high intensity staining in 46.7%. While stronger OPN expression was noted at OSCC invasion fronts, no significant association was found between OPN levels and epithelial dysplasia grade.</p><p><strong>Conclusions: </strong>OPN does not appear to correlate with epithelial dysplasia or malignant transformation in OPMD. However, its overexpression at OSCC invasion fronts compared to adjacent areas suggests a role in early invasion, potentially helping identify initial lesions with more aggressive behavior.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of computer-guided versus conventional arthrocentesis in the management of temporomandibular joint disorders: a systematic review of clinical studies.","authors":"Mohammed Elsaid, Maryam Altuhafy, Safwat Elwaseef, Khalid Qasim, Junad Khan","doi":"10.1016/j.oooo.2026.01.004","DOIUrl":"https://doi.org/10.1016/j.oooo.2026.01.004","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review aimed to evaluate the clinical effectiveness and procedural accuracy of computer-guided versus conventional freehand arthrocentesis in the management of temporomandibular joint disorders.</p><p><strong>Study design: </strong>A comprehensive electronic search was conducted across 6 databases (PubMed, Embase, Scopus, Web of Science, OVID, and Cochrane Library) up to August 2025, following PRISMA guidelines (PROSPERO registration no. CRD420251123995). Eligible studies included human clinical trials comparing computer-guided or patient-specific stent-assisted arthrocentesis or intra-articular injection with conventional techniques. Risk of bias was assessed using the Cochrane RoB 2 and ROBINS-I V2 tools.</p><p><strong>Results: </strong>Eight studies (5 randomized controlled trials and 3 prospective case series) involving 137 patients met the inclusion criteria. Computer-guided arthrocentesis demonstrated superior procedural accuracy, eliminated the need for needle relocation, and significantly reduced operative time. Guided approaches provided faster pain reduction and earlier improvement in maximum mouth opening during short-term follow-up, while long-term outcomes were comparable between guided and conventional methods. No significant complications were reported.</p><p><strong>Conclusions: </strong>Within the limitations of current evidence, computer-guided TMJ arthrocentesis offers enhanced precision, procedural efficiency, and early clinical recovery compared with conventional freehand methods, while maintaining similar long-term outcomes.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}