Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献

{"title":"Aggressive (epithelioid) osteoblastoma camouflaged by pain associated with erupting third molars—case report and literature review","authors":"Dr. Yashaswini Jagadeesh ,&nbsp;Dr. Todd Kovach ,&nbsp;Dr. Lisa Yi- Shing Cheng ,&nbsp;Dr. Hui Liang","doi":"10.1016/j.oooo.2024.11.022","DOIUrl":"10.1016/j.oooo.2024.11.022","url":null,"abstract":"<div><h3>Clinical Presentation</h3><div>A 16-year-old patient was referred for extraction of third molars and supernumerary tooth distal of #17, as he had been experiencing pain in the left mandible. The pain persisted for more than 2 weeks after extraction of #17. Although the extraction site demonstrated good initial healing, there was evidence of significant bony expansion lingually with mobile #18 and 19. This had shown significant progression since the preoperative examination. A panoramic study showed resorption of distal root #19. Cone beam computed tomography scan was performed and showed a large, expansile, ill-defined, mixed density but predominantly radiolucent lesion. In addition, disruption of the lingual cortex and superior border of inferior alveolar canal was observed with no signs of paresthesia clinically.</div></div><div><h3>Differential Diagnosis</h3><div>Expansile bone tumors of jaw with resorption would include cemento-ossifying fibroma, osteoblastoma and osteosarcoma.</div></div><div><h3>Diagnosis and Management</h3><div>Histopathologic examination revealed an epithelioid neoplasm consisting of clusters of round epithelioid cells surrounding blue lace-like bony trabeculae (osteoid). Cytomorphology was bland and mitoses were occasionally seen. A diagnosis of aggressive (epithelioid) osteoblastoma was rendered. Management involved en-bloc resection with wide margins as epithelioid osteoblastoma has a high recurrence rate of almost 50%.</div></div><div><h3>Conclusions</h3><div>Aggressive (epithelioid) osteoblastoma, a rare histological subtype of osteoblastoma, shows a tendency for local invasion and high recurrence rate. Few cases have been reported in the jaws, with the mandible more commonly affected than the maxilla. The presence of pain from the emerging third molar and subtle clinical and radiologic evidence before extraction were the culprits which the lesion was not initially detected. Otherwise, the intense clinical expansion following extraction, location, and radiographic characteristics of this case appear to be consistent with the cases reported in the literature. Closely follow-up is recommended to monitor possible recurrence.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e75"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and type of exaggerated external occipital protuberances in a wide-age population","authors":"Mr. Brandon Crowther ,&nbsp;Dr. Anita Gohel ,&nbsp;Dr. Jennie Caldwell","doi":"10.1016/j.oooo.2024.11.071","DOIUrl":"10.1016/j.oooo.2024.11.071","url":null,"abstract":"<div><h3>Objective</h3><div>Exaggerated external occipital protuberances, also known as occipital spurs or chignon hooks, are a commonly found anatomical variant in large field-of-view cone beam computed tomography (CBCT) images and have been shown to correlate with clinical neck pain. Occipital spurs present in 3 types: type I, smooth; type II, sharp; type III, hooked (curved). A recent study by Shahar et al. characterizes the incidence of this finding in the 18-86 age group, but limited data exist to describe the type of spur found based on sex in wide-age populations. This study aims to provide data on the incidence of occipital spurs in a wide-age population (9-54 years) characterized by sex and type of spur present.</div></div><div><h3>Study Design</h3><div>In total, 100 large field-of-view CBCT scans taken between February 2021 and January 2023 were assessed by an oral radiology resident and a calibrated dental student. The image was properly oriented and the presence of an occipital spur, spur type, patient age, and sex were recorded. From this, incidence based on sex and type of spur present was obtained.</div></div><div><h3>Results</h3><div>The data revealed that 76% of male patients and 67% of female patients in the sample had occipital spurs present. Type I spurs were present in 38.5% of females and 21.9% of males. Type II spurs were present in 46% of females and 62.5% of males. Type III spurs were found in 15.3% of females and 15.6% of males.</div></div><div><h3>Conclusions</h3><div>Occipital spurs present similarly between sexes, with males showing a predilection for type II spurs. Females display a similar predilection for both type I and type II spurs, and both sexes display similar incidence of type III spurs. Occipital spurs are a frequent variant that can be observed in CBCT studies taken for orthodontic planning, which is important to note, as it may have clinical implications.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Pages e94-e95"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of pleomorphic adenoma","authors":"Dr. Priyanka Agarwal ,&nbsp;Dr. Adriana Creanga ,&nbsp;Dr. Steven Singer","doi":"10.1016/j.oooo.2024.11.038","DOIUrl":"10.1016/j.oooo.2024.11.038","url":null,"abstract":"<div><div>Pleomorphic adenoma (PA) is a benign salivary gland neoplasm. It represents 45% to 74% of all salivary gland tumors and is associated with recurrence, malignant transformation, and metastasis. The risk of malignant transformation in PA increases from around 1.6% in tumors with less than 5 years of evolution to 9.5% for those presenting for more than 15 years. Malignancies arising in PA encompass 3 entities: (1) carcinoma ex-pleomorphic adenoma (CXPA), (2) carcinosarcoma, and (3) metastasizing benign pleomorphic adenoma. CXPA is a rare, aggressive, poorly understood malignancy that usually develops in a primary or recurrent PA.</div><div><strong>Case Description:</strong> A 65-year-old female patient reported a chief complaint of pain and swelling below the lower jaw and around her ears, for 2 years. The patient had a history of swelling at the same site 20 years prior, which was operated on 2 years ago. On clinical examination, the swelling was present on the mandibular left posterior region, extending anteriorly from the lobule of the ear, and posteriorly along the length of the neck down to the supraclavicular notch. Upon palpation, the mass was soft to firm, lobulated, and nodular.</div><div><strong>Radiographic Imaging.</strong> Computed tomographic imaging of soft tissue windows reveals a well-defined predominantly cystic mass. The chest radiographs demonstrate a cannonball appearance. Multiple variable radiolucencies, seen in both lungs, are suggestive of metastasis.</div><div><strong>Differential Diagnosis.</strong> On the basis of clinical and radiographic imaging, the differential diagnosis includes metastasis, Wegner's granulomatosis, and CXPA.</div><div><strong>Diagnosis and Management:</strong> Fine needle aspiration was done, and was reported as CXPA. An excisional biopsy was then taken, and tissue was sent for histopathology, confirming the fine-needle aspiration diagnosis.</div><div><strong>Clinical Implication.</strong> Understanding the underlining complications of pleomorphic adenoma makes us better equipped to render an earlier diagnosis and optimal treatment to the patient.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Pages e81-e82"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal patient-reported oral health outcomes among patients who have received allogeneic hematopoietic stem cell transplantation","authors":"Leah Leinbach ,&nbsp;Shahdokht Boroumand ,&nbsp;Joe Nguyen ,&nbsp;Jacqueline Mays","doi":"10.1016/j.oooo.2024.10.093","DOIUrl":"10.1016/j.oooo.2024.10.093","url":null,"abstract":"<div><h3>Objective</h3><div>To describe longitudinal patient-reported oral health outcomes in the domains of oral health-related quality-of-life (OHRQoL) and performance status through 24 months postallogeneic hematopoietic stem cell transplantation (allo-HSCT).</div></div><div><h3>Methods</h3><div>This is an interim analysis using data from an ongoing National Institutes of Health natural history study (NCT03602599) of patients 18 years or older who have undergone allo-HSCT. Data were captured using the Oral Health Impact Profile-14 (OHIP-14) and standard performance status questionnaires. Means and standard deviations were calculated for continuous variables and frequencies and percentages for categorical variables. Lower OHIP-14 scores indicated better OHRQoL. All analyses were conducted using SAS 9.4.</div></div><div><h3>Results</h3><div>In total, 117 participants were screened for inclusion, 8 were not transplanted, and 2 withdrew consent, yielding a final study population of 107 participants at baseline, 95 at 3 months, 79 at 6 months, 72 at 12 months, 59 at 18 months, and 55 at 24 months after allo-HSCT. A total of 50.5% received a transplant for cancer, 49.5% for other reasons. 13% developed chronic graft-versus-host (cGVHD) during the study period. At time of transplant, the mean OHIP score was 3.7 (± 5.7), less than 10% of patients reported moderate-to-severe pain or dryness within the last month, 9% reported reduced oral health status compared with the previous month, and nearly all were on a full diet. Moderate-to-severe dry mouth was worst after 3 months (19% of patients), moderate-to-severe pain and dietary changes at 6 months (14% and nearly 20% of patients respectively), mean OHIP scores were worst at 12 months (4.8 ± 7.3). By 24 months, the mean OHIP was 4.1 (± 7.1), moderate-to-severe pain was reported by 9% of patients, moderate-to-severe dry mouth by 7% of patients, and nearly all were at a full diet. In cGVHD, mean OHIP was 16.8 (± 12.2), 50% reported moderate-to-severe pain, 17% reported moderate-to-severe dry mouth, 17% reported decline in oral health status, 60% were at a full diet at 24 months.</div></div><div><h3>Conclusions</h3><div>Data show that OHRQoL and performance status decline after allo-HSCT, with certain issues persisting through 24 months, particularly in cGVHD. Continued consideration for long-term, specialized oral health care among this patient population is indicated. Funding: NIH Intramural Research Program</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 2","pages":"Page e49"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-dependent modulation of a B-cell protein signature by ianalumab in patients with Sjögren disease","authors":"Athena S. Papas ,&nbsp;Andrea Grioni ,&nbsp;Benjamin A. Fisher ,&nbsp;Stephanie Finzel ,&nbsp;Alexandre Avrameas ,&nbsp;Danny Tuckwell ,&nbsp;Jonas Zierer ,&nbsp;Celine Rauld ,&nbsp;Valeria De Luca ,&nbsp;Enrico Ferrero ,&nbsp;Andre Nogueira da Costa ,&nbsp;Rainer Hillenbrand ,&nbsp;Isabelle Isnardi ,&nbsp;Wolfgang Hueber","doi":"10.1016/j.oooo.2024.10.097","DOIUrl":"10.1016/j.oooo.2024.10.097","url":null,"abstract":"<div><h3>Objective</h3><div>Ianalumab, an afuscosylated monoclonal antibody, depletes B cells and blocks survival signals mediated by the B-cell activating factor receptor (BAFFR). Sjögren disease (SjD) is an autoimmune disorder with exocrine glandular and extraglandular manifestations, elevated BAFF, and autoantibodies to nuclear antigens. A phase 2b dose-finding trial of ianalumab (NCT02962895) in 190 patients with active SjD met its primary endpoint; 300 mg was clinically efficacious and improved whole salivary flow. Here, we explored changes in autoantibody and proteomic signatures with ianalumab treatment to characterize biomarkers associated with SjD disease activity.</div></div><div><h3>Methods</h3><div>Patients with active SjD (N = 190) were randomized (1:1:1:1) to receive placebo or ianalumab (5/50/300 mg). Serum samples collected at baseline and week 24 were used for protein profiling and delineation of interferon protein signatures using the SomaScan(R) v4.1 platform. Autoantibodies and BAFF levels were assessed by Luminex-based enzyme-linked immunoassay assays. A linear mixed-effect model was used to identify longitudinal changes in protein concentration at week 24 versus baseline. Results were visualized using heatmaps and hierarchical clustering.</div></div><div><h3>Results</h3><div>At baseline, cluster analysis did not reveal significant correlations between European League Against Rheumatism Sjögren's Syndrome Disease Activity Index scores (including subdomains) and levels of autoantibodies or proteins of interest. Ianalumab led to marked changes in autoantibody and serum protein levels. The 300-mg dose showed increased numbers of significantly modulated serum proteins (42) with more pronounced expression modulation versus the 5-mg (9) and 50-mg (20) dose groups. Several B-cell surface proteins were consistently downregulated by ianalumab, including FcRL4, plausibly involved in the pathogenicity of SjD. The 50-mg and 300-mg doses induced downregulation of additional proteins: B-cell maturation antigen, specifically expressed by antibody-producing cells, or the chemokines CXCL13 and CCL21, associated with immune infiltration of glandular tissues. A trend for downregulation of interferon protein signatures was seen with 50-mg and 300-mg doses.</div></div><div><h3>Conclusions</h3><div>No differential proteomic signatures related to baseline disease activity were identified. The dose response in clinical efficacy of ianalumab in patients with SjD observed in the phase 2b trial is also reflected at the protein level, with increased depth and breadth of proteomic changes by week 24, correlating with increasing dose.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 2","pages":"Pages e50-e51"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of biological information in the diagnostic process: a glance into the future of dentistry","authors":"Katherine France DMD, MBE ,&nbsp;Craig S. Miller DMD, MS","doi":"10.1016/j.oooo.2024.09.009","DOIUrl":"10.1016/j.oooo.2024.09.009","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 2","pages":"Pages 131-133"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcifying odontogenic cyst: A detailed international multicentric study.","authors":"Hélen Kaline Farias Bezerra, Mateus José Dutra, Ana Luiza Oliveira Corrêa Roza, Stephanie Vargas de Freitas, Estela Kaminagakura, Ana Lia Anbinder, Marcela Vazquez-Garduño, Gonzalo Rojas-Alcayaga, Iris Lucia Espinoza-Santander, Ana Verónica Ortega Pinto, Danielle Machado Farias, Elaine Judite de Amorim Carvalho, Jurema Freire Lisboa de Castro, Márcio Ajudarte Lopes, Alan Roger Santos-Silva, Liam Robinson, Aline Corrêa Abrahão, Mário José Romañach, Willie van Heerden, Adalberto Mosqueda-Taylor, Pablo Agustin Vargas, Danyel Elias da Cruz Perez","doi":"10.1016/j.oooo.2025.01.731","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.01.731","url":null,"abstract":"<p><strong>Objective: </strong>To elucidate the histopathological, immunohistochemical, and ultrastructural characteristics of a large series of calcifying odontogenic cysts (COCs).</p><p><strong>Study design: </strong>This was a multicenter cross-sectional retrospective study of seven oral pathology department laboratories from four countries. Clinical, demographic, and radiographic data of the patients were collected. Histopathological, immunohistochemical, and microstructural analyses were based on formalin-fixed, paraffin-embedded tissues. All variables were described, and associations were analyzed using Pearson's chi-square and Fisher's exact tests.</p><p><strong>Results: </strong>A total of 146 cases of COC were analyzed, including 141 central and 5 peripheral cases. Male patients were most involved, with a mean age of 27.8 years. The main clinical presentation was an asymptomatic swelling in the anterior maxilla. Radiographically, most cases appeared as a single well-defined unilocular radiolucency. Forty cases of COC were associated with other odontogenic lesions, including odontoma, ameloblastic fibroma, and odontogenic keratocyst. Immunohistochemical study showed cytoplasmic positivity for CK AE1/AE3, CK14, CK19, and Bcl-2 protein. Nuclear expression of β-catenin was observed in most cases.</p><p><strong>Conclusions: </strong>COC mainly affects adult males between the second and third decades of life. Asymptomatic maxillary swellings with diverse radiographic and histopathological presentations were noted. Moreover, COC may present associations with other odontogenic lesions, particularly odontomas in younger patients.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Society Page","authors":"","doi":"10.1016/S2212-4403(24)00913-1","DOIUrl":"10.1016/S2212-4403(24)00913-1","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 2","pages":"Page A5"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe odontogenic infections in patients with mental disorders: the challenge of ineffective initial treatment","authors":"Satu Manninen BDS,&nbsp;Johanna Snäll MD, DDS, PhD,&nbsp;Tero Puolakkainen DDS, PhD,&nbsp;Aleksi Haapanen DDS, PhD","doi":"10.1016/j.oooo.2024.08.002","DOIUrl":"10.1016/j.oooo.2024.08.002","url":null,"abstract":"<div><h3>Objectives</h3><div>This study clarified possible delays and deficiencies in severe odontogenic infection (OI) treatment in patients with mental disorders.</div></div><div><h3>Study design</h3><div>Data of hospitalized patients with severe OI were evaluated retrospectively. The outcome variable was preceding health care visits prior to hospitalization. The primary predictor was patient's mental disorder. Explanatory variables were age, sex, smoking, heavy alcohol use, immunocompromised disease or medication, and time span from beginning of symptoms to hospitalization. Also, factors leading to intensive care unit (ICU) care were evaluated.</div></div><div><h3>Results</h3><div>Preceding visits prior to hospitalization were found in 61 (35.5%) out of 172 patients with OI. In total, 27 patients (15.7%) had a current mental disorder, more commonly in women (26.0%) than in men (8.1%) (<em>P</em> = .001). Patients with mental disorders had preceding health care visits related to the current infection notably more often than patients without recent psychiatric history (51.9% vs. 32.4%), <em>P</em> = .053. Patient-related treatment delay remained nonsignificant. Heavy alcohol use (<em>P</em> = .010) and smoking (<em>P</em> = .025) predicted ICU treatment, but no association with patient's mental disorder was found.</div></div><div><h3>Conclusions</h3><div>A patient's mental disorder can complicate diagnosis of OI. Effective and timely treatment requires the professional's ability to simultaneously identify the patient's mental health challenges and progressing OI.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 2","pages":"Pages 139-145"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ulcerated mass and radiolucency of the left mandible","authors":"Petra Pandurevic ,&nbsp;Ian Furst DDS, MSc ,&nbsp;Mark Roger Darling BChD, MSc (Dent), MSc (Med), MChD","doi":"10.1016/j.oooo.2024.08.023","DOIUrl":"10.1016/j.oooo.2024.08.023","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 2","pages":"Pages 134-138"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}