Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献_第9页

Deformed mandibular posterior border 下颌后缘变形。

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-14 DOI: 10.1016/j.oooo.2024.08.003

Neeraj Bansal MDS , Zainab Chaudhary MDS , Pankaj Sharma MDS , Jeyaseelan Augustine MDS, MBA, DipFHID , Jahangir Irfan Dar MDS , Harshita Joshi

引用次数: 0

Predictive value of early dynamic changes of NLR and PLR for the efficacy of immune checkpoint inhibitor in head and neck squamous cell carcinoma NLR和PLR的早期动态变化对头颈部鳞状细胞癌免疫检查点抑制剂疗效的预测价值

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-10 DOI: 10.1016/j.oooo.2024.07.014

Dong Hyun Kim MD, MS , Seo Yoon Jang MD , Bhumsuk Keam MD, PhD

{"title":"Predictive value of early dynamic changes of NLR and PLR for the efficacy of immune checkpoint inhibitor in head and neck squamous cell carcinoma","authors":"Dong Hyun Kim MD, MS , Seo Yoon Jang MD , Bhumsuk Keam MD, PhD","doi":"10.1016/j.oooo.2024.07.014","DOIUrl":"10.1016/j.oooo.2024.07.014","url":null,"abstract":"<div><h3>Objective</h3><div>We analyzed the predictive value of dynamic changes in neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) treated with immune checkpoint inhibitors (ICIs).</div></div><div><h3>Study Design</h3><div>A total of 104 patients with R/M HNSCC treated with ICIs during August 2018 to June 2023 were included. Dynamic changes were defined as the difference between NLR and PLR on day 1 of cycles 1 and 2.</div></div><div><h3>Results</h3><div>Patients with increased NLR or PLR had an independently increased risk of disease progression at the first response evaluation (odds ratio [OR] 5.26, <em>P</em> = .005; OR 2.29, <em>P</em> = .042), disease progression (hazard ratio [HR] 2.29, <em>P</em> = .003; HR 1.68, <em>P</em> = .027), and death (HR 1.86, <em>P</em> = .027; HR 1.68, <em>P</em> = .037). Furthermore, patients with a decrease in NLR showed longer progression-free survival, with HRs of 0.36 (<em>P</em> < .001) for those with low pre-ICI NLR and 0.52 (<em>P</em> = .041) for those with high pre-ICI NLR, compared to those with increased NLR.</div></div><div><h3>Conclusions</h3><div>Increased NLR or PLR was associated with adverse outcomes after ICI treatment in patients with R/M HNSCC.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 6","pages":"Pages 763-771"},"PeriodicalIF":2.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of a blooming artifact reduction filter on the dimensional analysis of implants 减少模糊伪影过滤器对植入物尺寸分析的影响

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-09 DOI: 10.1016/j.oooo.2024.08.004

Matheus Akira Sakurada DDS, MSc , Luiz Eduardo Gregoris Rabelo DDS, MSc, PhD , Ivonete Barreto Haagsma DDS , Luis Carlos do Carmo Filho DDS, MSc, PhD , Carlos Estrela DDS, MSc, PhD , Isabela Reginaldo DDS , Thais Marques Simek Vega Gonçalves DDS, MSc, PhD

{"title":"The effect of a blooming artifact reduction filter on the dimensional analysis of implants","authors":"Matheus Akira Sakurada DDS, MSc , Luiz Eduardo Gregoris Rabelo DDS, MSc, PhD , Ivonete Barreto Haagsma DDS , Luis Carlos do Carmo Filho DDS, MSc, PhD , Carlos Estrela DDS, MSc, PhD , Isabela Reginaldo DDS , Thais Marques Simek Vega Gonçalves DDS, MSc, PhD","doi":"10.1016/j.oooo.2024.08.004","DOIUrl":"10.1016/j.oooo.2024.08.004","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the effect of a blooming artifact reduction (BAR) filter on cone beam computed tomography (CBCT) images in the dimensional analysis of dental implants.</div></div><div><h3>Study Design</h3><div>Six types of implants (<em>n</em> = 5 for each type) composed of titanium (3 types), titanium-zirconia alloy, zirconium oxide, and titanium-aluminum-vanadium alloy, and made with 2 manufacturing processes (milled and printed) were individually installed in a bovine rib block according to the manufacturer's protocol. CBCT images were acquired with i-CAT and Carestream scanners, randomized, and analyzed without and with the e-Vol DX BAR filter (60 images for each scanner). Implant length, diameter, and thread-to-thread distance were measured by two radiologists, with a stereomicroscopic image of each implant as the reference standard for calculation of distortion in measurements. Repeated measures ANOVA with Bonferroni corrections and intraclass correlation coefficients (ICC) were applied (α = 0.05).</div></div><div><h3>Results</h3><div>The BAR filter significantly reduced distortion in various parameters for specific implants, aligning closely with stereomicroscopic measurements. Titanium and printed implants showed reduced dimensional distortion regardless of BAR filter use. Carestream measurements presented smaller dimensional differences than i-CAT for most implants and parameters, especially without BAR (<em>P</em> < .05). Interexaminer reliability was good to excellent, with ICC ranging from 0.80 to 0.95.</div></div><div><h3>Conclusions</h3><div>The BAR filter can enhance implant dimensional analysis, although variations based on implant material and manufacturing process were observed.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 6","pages":"Pages 813-822"},"PeriodicalIF":2.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraosseous mandibular clear cell odontogenic carcinoma with predominant small round blue cells: a potential diagnostic pitfall 以小圆形蓝细胞为主的下颌骨透明细胞牙源性癌：潜在的诊断陷阱。

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-05 DOI: 10.1016/j.oooo.2024.07.009

Shunsuke Koga MD, PhD , James C. Gates DMD, MD , Scott M. Peters DDS , Kumarasen Cooper MBChB, Dphil

{"title":"Intraosseous mandibular clear cell odontogenic carcinoma with predominant small round blue cells: a potential diagnostic pitfall","authors":"Shunsuke Koga MD, PhD , James C. Gates DMD, MD , Scott M. Peters DDS , Kumarasen Cooper MBChB, Dphil","doi":"10.1016/j.oooo.2024.07.009","DOIUrl":"10.1016/j.oooo.2024.07.009","url":null,"abstract":"<div><h3>Objective</h3><div>Clear cell odontogenic carcinoma (CCOC) is a rare malignancy of the jaw, presenting significant diagnostic challenges. This report aims to highlight the complexities associated with biopsy-based diagnoses of oral and maxillofacial lesions, as demonstrated in a case of intraosseous mandibular CCOC initially suggestive of Ewing's sarcoma due to its presentation with small round blue cells.</div></div><div><h3>Results</h3><div>The patient, a 37-year-old male, presented with a mandibular lesion that on incisional biopsy was suggestive of Ewing's sarcoma. Subsequent, comprehensive histologic evaluation after definitive resection via mandibulectomy revealed a CCOC, characterized by a biphasic pattern of clear and basaloid cells. Histological examination confirmed the presence of glycogen-rich clear cells, supported by periodic acid-Schiff (PAS) staining and confirmed by PAS diastase staining, which demonstrated glycogen digestion. Immunohistochemistry was positive for AE1/AE3, p40, and p63, while negative for c-kit and CD34, confirming CCOC and excluding other malignancies such as Ewing's sarcoma, which would have been treated with neoadjuvant chemotherapy instead of primary surgical treatment as in CCOC.</div></div><div><h3>Conclusion</h3><div>This case highlights the essential need for thorough histopathological evaluation and the value of a second opinion via additional histologic consultation, particularly due to the diagnostic challenges of heterogeneous lesions in the oral and maxillofacial region.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 6","pages":"Pages e120-e124"},"PeriodicalIF":2.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated detection and classification of mandibular fractures on multislice spiral computed tomography using modified convolutional neural networks 利用修正的卷积神经网络在多层螺旋计算机断层扫描上对下颌骨骨折进行自动检测和分类

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-05 DOI: 10.1016/j.oooo.2024.07.010

Jingjing Mao MDS, RES , Yuhu Du BCS , Jiawen Xue BDS, RES , Jingjing Hu MDS, RES , Qian Mai MDS, ATP , Tao Zhou PhD , Zhongwei Zhou DDS, PhD

{"title":"Automated detection and classification of mandibular fractures on multislice spiral computed tomography using modified convolutional neural networks","authors":"Jingjing Mao MDS, RES , Yuhu Du BCS , Jiawen Xue BDS, RES , Jingjing Hu MDS, RES , Qian Mai MDS, ATP , Tao Zhou PhD , Zhongwei Zhou DDS, PhD","doi":"10.1016/j.oooo.2024.07.010","DOIUrl":"10.1016/j.oooo.2024.07.010","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the performance of convolutional neural networks (CNNs) for the automated detection and classification of mandibular fractures on multislice spiral computed tomography (MSCT).</div></div><div><h3>Study Design</h3><div>MSCT data from 361 patients with mandibular fractures were retrospectively collected. Two experienced maxillofacial surgeons annotated the images as ground truth. Fractures were detected utilizing the following models: YOLOv3, YOLOv4, Faster R-CNN, CenterNet, and YOLOv5-TRS. Fracture sites were classified by the following models: AlexNet, GoogLeNet, ResNet50, original DenseNet-121, and modified DenseNet-121. The performance was evaluated for accuracy, sensitivity, specificity, and area under the curve (AUC). AUC values were compared using the <em>Z</em>-test and <em>P</em> values <.05 were considered to be statistically significant.</div></div><div><h3>Results</h3><div>Of all of the detection models, YOLOv5-TRS obtained the greatest mean accuracy (96.68%). Among all of the fracture subregions, body fractures were the most reliably detected (with accuracies of 88.59%-99.01%). For classification models, the AUCs for body fractures were higher than those of condyle and angle fractures, and they were all above 0.75, with the highest AUC at 0.903. Modified DenseNet-121 had the best overall classification performance with a mean AUC of 0.814.</div></div><div><h3>Conclusions</h3><div>The modified CNN-based models demonstrated high reliability for the diagnosis of mandibular fractures on MSCT.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 6","pages":"Pages 803-812"},"PeriodicalIF":2.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression and clinical significance of U2AF homology motif kinase 1 in oral squamous cell carcinoma U2AF 同源结构激酶 1 在口腔鳞状细胞癌中的表达及其临床意义

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-07-22 DOI: 10.1016/j.oooo.2024.07.005

Xuan Zhang , Yuanyong Feng , Fei Gao , Tongtong Li , Yan Guo , Shengyou Ge , Ning Wang

{"title":"Expression and clinical significance of U2AF homology motif kinase 1 in oral squamous cell carcinoma","authors":"Xuan Zhang , Yuanyong Feng , Fei Gao , Tongtong Li , Yan Guo , Shengyou Ge , Ning Wang","doi":"10.1016/j.oooo.2024.07.005","DOIUrl":"10.1016/j.oooo.2024.07.005","url":null,"abstract":"<div><h3>Objective</h3><div>U2AF homology motif kinase 1 (UHMK1) is a newly discovered molecule that may have multiple functions. Recent studies have revealed that UHMK1 had aberrant expression in many tumors and was associated with tumor progression. However, UHMK1 was rarely reported in oral squamous cell carcinoma (OSCC).</div></div><div><h3>Study Design</h3><div>In this study, Western blot, quantitative real-time polymerase chain reaction (PCR), and immunohistochemistry were used to detect the expression of UHMK1 in OSCC and peritumoral non-neoplastic tissues. Then, its relationship with clinicopathologic parameters was analyzed. The Kaplan–Meier method and Cox regression model were used to analyze the effects of UHMK1 expression on the prognosis and survival of OSCC patients.</div></div><div><h3>Results</h3><div>Our results showed that UHMK1 had higher expression in OSCC tissues compared with in peritumoral non-neoplastic tissues, and its high expression was associated with high TNM stage and lymph node metastasis. High UHMK1 expression was related to short overall and disease-free survival times. Moreover, UHMK1 expression was identified as an independent prognostic factor that influences overall and disease-free survival of OSCC patients.</div></div><div><h3>Conclusions</h3><div>High expression of UHMK1 is associated with the poor prognosis of patients, and it can be used as a potential prognostic molecule for OSCC.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 5","pages":"Pages 626-634"},"PeriodicalIF":2.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141779873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First report on parotid tissue choristomas within and adjacent to TMJ ligaments 首次报告--颞下颌关节韧带内和颞下颌关节韧带附近的腮腺组织瘤

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-07-22 DOI: 10.1016/j.oooo.2024.07.006

Scotty Bolding DDS , S. Bryan Whitaker DDS , R. Constance Wiener DMD, PhD , Jerry E. Bouquot DDS, MSD

{"title":"First report on parotid tissue choristomas within and adjacent to TMJ ligaments","authors":"Scotty Bolding DDS , S. Bryan Whitaker DDS , R. Constance Wiener DMD, PhD , Jerry E. Bouquot DDS, MSD","doi":"10.1016/j.oooo.2024.07.006","DOIUrl":"10.1016/j.oooo.2024.07.006","url":null,"abstract":"<div><h3>Objective</h3><div>To report the first examples of ectopic salivary glands of TMJ ligaments & capsules.</div></div><div><h3>Methods and Materials</h3><div>Nine subjects with chronic TMJ disorders were found incidentally to have ectopic salivary glands (choristomas) within or near damaged TMJ ligaments and capsules. Clinicopathologic characteristics of 12 TMJs are summarized.</div></div><div><h3>Results</h3><div>The 9 subjects were ages 22-64 years (average = 43.0); 6 were female. Microscopic examination revealed major, almost complete ligament replacement by dense, avascular fibrous scar tissue in all but 1 sample. Chronic inflammatory cells were present in the stroma of 3 samples. A total of 33 lobular, independent salivary structures of variable sizes were embedded in or near ligaments and/or capsules. Half were multiple in the same joint; 13 were bilaterally located in the joints of a single subject, with 8 small glandular lobules in one TMJ. All glands consisted of histologically normal serous acini except 1 which showed a focal lobule of mucus acini and another comprised only of mucus acini. Serial sections showed no connection to parotid glands. Some choristomas showed the aging phenomena of fatty infiltrates (<em>n</em> = 7) and oncocytosis (<em>n</em> = 7). Additionally, 3 of the 12 TMJ samples contained preauricular lymph nodes, with 3 nodes in 1 joint and bilateral involvement in 1 subject. Of the 5 identified nodes, all but one was hyperplastic, with nonspecific inflammatory histiocytosis.</div></div><div><h3>Conclusions</h3><div>We report, for the first time, independent salivary gland choristomas (<em>n</em> = 33) within the soft tissues of the TMJ (<em>n</em> = 12), with one joint containing 8 such choristomas. All consisted of normal serous tissue except one, a mucus gland. Additionally, a fourth of TMJ surgical samples contained hyperplastic preauricular lymph nodes.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 6","pages":"Pages 719-727"},"PeriodicalIF":2.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141779963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local anesthesia nerve block for managing burning mouth syndrome: a scoping review 局部麻醉神经阻滞治疗烧灼口腔综合征：范围综述

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-07-22 DOI: 10.1016/j.oooo.2024.07.007

Camila Barcellos Calderipe DDS , Laura Borges Kirschnick DDS, MSc , Thaís Cristina Esteves-Pereira DDS , Erison Santana dos Santos DDS, MSc , Ana Carolina Uchoa Vasconcelos DDS, MSc, PhD , Marcio Ajudarte Lopes DDS, MSc, PhD , Nathaniel Simon Treister DMD, DMSc , Alan Roger Santos-Silva DDS, MSc, PhD, FAAOM

{"title":"Local anesthesia nerve block for managing burning mouth syndrome: a scoping review","authors":"Camila Barcellos Calderipe DDS , Laura Borges Kirschnick DDS, MSc , Thaís Cristina Esteves-Pereira DDS , Erison Santana dos Santos DDS, MSc , Ana Carolina Uchoa Vasconcelos DDS, MSc, PhD , Marcio Ajudarte Lopes DDS, MSc, PhD , Nathaniel Simon Treister DMD, DMSc , Alan Roger Santos-Silva DDS, MSc, PhD, FAAOM","doi":"10.1016/j.oooo.2024.07.007","DOIUrl":"10.1016/j.oooo.2024.07.007","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the clinical scenarios in which nerve blocks are employed in the context of burning mouth syndrome (BMS).</div></div><div><h3>Study Design</h3><div>This scoping review followed the PRISMA-ScR. A protocol was generated on Open Science Framework. Electronic searches were performed in the following databases: PubMed, Scopus, EMBASE, Web of Science, LILACS, and Cochrane, in addition to the grey literature and citations from Grémeau-Richard et al. (2010).</div></div><div><h3>Results</h3><div>Nerve blocks were used for treatment purposes in all cases. The mandibular nerve and the stellate ganglion were both blocked in 50% studies, while the maxillary nerve and lingual nerve were blocked in 25% study each. The anesthetics used were lidocaine (50%) and bupivacaine (50%). Relief was generally reported after immediate block, and at a mean follow-up of 4.5 weeks, there was considerable improvement compared to the initial conditions when the mandibular and/or maxillary nerve were targeted.</div></div><div><h3>Conclusions</h3><div>The use of nerve blocks has been employed in the treatment of patients with refractory BMS. Clinical studies with standardized methodology are necessary to validate and understand the potential role of mandibular and maxillary nerve block in this setting.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 5","pages":"Pages 619-625"},"PeriodicalIF":2.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141779872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review and meta-analysis on the use of regenerative graft materials for socket preservation in randomized clinical trials 关于在随机临床试验中使用再生植骨材料进行牙槽窝保存的系统回顾和荟萃分析

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-07-18 DOI: 10.1016/j.oooo.2024.07.003

Seyed Abdolhojeh Alavi DDS , Mahsa Imanian DDS , Salem Alkaabi DDS, MSc, MOMS, RCS Ed , Ghamdan Al-sabri DDS, MSc , Tim Forouzanfar MD, PhD , Marco Helder PhD

{"title":"A systematic review and meta-analysis on the use of regenerative graft materials for socket preservation in randomized clinical trials","authors":"Seyed Abdolhojeh Alavi DDS , Mahsa Imanian DDS , Salem Alkaabi DDS, MSc, MOMS, RCS Ed , Ghamdan Al-sabri DDS, MSc , Tim Forouzanfar MD, PhD , Marco Helder PhD","doi":"10.1016/j.oooo.2024.07.003","DOIUrl":"10.1016/j.oooo.2024.07.003","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate if regenerative materials with/without scaffold deployed in dental socket preservation led to reduced radiographic height and width bone resorption.</div></div><div><h3>Study design</h3><div>English-written human studies from January 2010 to December 2023 were selected from PubMed, EMBASE, MEDLINE, Cochrane CENTRAL, Google Scholar and manually searched journals. Six meta-analyses were conducted, addressing treatments with all blood-derived growth factor preparations as well as L-platelet-rich fibrin (L-PRF) separately, and recombinant human BMP-2 (rhBMP-2). An unpaired t-test on L-PRF and rhBMP-2 determined the clinically best preservation treatment. Cochrane risk of bias in all studies was analyzed.</div></div><div><h3>Results</h3><div>Twenty-nine articles (1068 participants) were included. Meta-analyses on blood-derived preparations demonstrated nonsignificant alveolar width, but significant (<em>p</em> = .001) height preservation. L-PRF vs. natural healing demonstrated nonsignificant changes in both dimensions. RhBMP-2 caused highly significant reduced horizontal (<em>p</em> = .01) and vertical (<em>p</em> < .0008) bone resorptions. When comparing mean resorption rates, significant benefits of rhBMP-2 over L-PRF were observed for width but not height preservation (<em>p</em> < .0001 and <em>p</em> = .057, respectively). Six studies recorded low, 8 moderate, and 15 high net risks.</div></div><div><h3>Conclusions</h3><div>Regenerative materials appear beneficial for radiographic bone width and height preservation after tooth extraction. Although rhBMP-2 performed better in alveolar width preservation, L-PRF can be an autologous and cost-effective alternative.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 6","pages":"Pages 702-718"},"PeriodicalIF":2.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141881933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rapidly growing nasal mass 鼻腔肿块迅速增大

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-07-15 DOI: 10.1016/j.oooo.2024.07.004

Keyur Y. Naik DDS, MD , Daniel Bustamante MD , Arshad Kaleem MD, DMD, FACS , Hans C. Brockhoff DDS, MD, FACS

引用次数: 0