Nicole Lonni, Andressa Fernanda Paza Miguel, Elis Ângela Batistella, Daniella Serafin Couto Vieira, Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Rogério Oliveira Gondak, Elena Riet Correa Rivero
{"title":"口腔鳞状细胞癌活检和切除标本中肿瘤出芽、瘤间质比和肿瘤厚度的一致性及其临床意义。","authors":"Nicole Lonni, Andressa Fernanda Paza Miguel, Elis Ângela Batistella, Daniella Serafin Couto Vieira, Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Rogério Oliveira Gondak, Elena Riet Correa Rivero","doi":"10.1016/j.oooo.2025.09.002","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the concordance between preoperative biopsies and corresponding surgical resections in assessing tumour budding (TB), tumour/stroma ratio (TSR), and tumour thickness (TT) in oral squamous cell carcinoma (OSCC) samples, and to explore their potential as prognostic indicators.</p><p><strong>Study design: </strong>31 surgical resections and 30 diagnostic biopsies were analysed using cytokeratin-immunostained slides to assess TB, TSR, TT, and the BT score (integrating TB and TT).</p><p><strong>Results: </strong>Histopathological features were consistently underestimated in matched biopsies compared to resections in quantitative analysis, with resections showing higher TB counts, greater TT, and lower TSR (P < .007). However, when classified as categorical variables, no significant differences were observed in TB and TSR. In resections, TB was higher in poorly differentiated tumours, and TT was greater in cases with high TB (P < .049). A positive correlation was observed between TT and TB in biopsies (P < .034). Intermediate and high-risk BT score group had significantly worse disease-free survival (DFS) compared to the low-risk group (P < .02).</p><p><strong>Conclusion: </strong>Despite the underestimation of TB and TSR in biopsies, these parameters remain predictive of aggressive tumor behaviour. Additionally, integrating histopathological parameters into combined scores, such as BT, could optimize biopsy evaluation and complement clinical staging and treatment planning.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Agreement of tumour budding, tumour-stroma ratio, and tumour thickness in oral squamous cell carcinoma biopsy and resection samples and their clinical implications.\",\"authors\":\"Nicole Lonni, Andressa Fernanda Paza Miguel, Elis Ângela Batistella, Daniella Serafin Couto Vieira, Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Rogério Oliveira Gondak, Elena Riet Correa Rivero\",\"doi\":\"10.1016/j.oooo.2025.09.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate the concordance between preoperative biopsies and corresponding surgical resections in assessing tumour budding (TB), tumour/stroma ratio (TSR), and tumour thickness (TT) in oral squamous cell carcinoma (OSCC) samples, and to explore their potential as prognostic indicators.</p><p><strong>Study design: </strong>31 surgical resections and 30 diagnostic biopsies were analysed using cytokeratin-immunostained slides to assess TB, TSR, TT, and the BT score (integrating TB and TT).</p><p><strong>Results: </strong>Histopathological features were consistently underestimated in matched biopsies compared to resections in quantitative analysis, with resections showing higher TB counts, greater TT, and lower TSR (P < .007). However, when classified as categorical variables, no significant differences were observed in TB and TSR. In resections, TB was higher in poorly differentiated tumours, and TT was greater in cases with high TB (P < .049). A positive correlation was observed between TT and TB in biopsies (P < .034). Intermediate and high-risk BT score group had significantly worse disease-free survival (DFS) compared to the low-risk group (P < .02).</p><p><strong>Conclusion: </strong>Despite the underestimation of TB and TSR in biopsies, these parameters remain predictive of aggressive tumor behaviour. Additionally, integrating histopathological parameters into combined scores, such as BT, could optimize biopsy evaluation and complement clinical staging and treatment planning.</p>\",\"PeriodicalId\":49010,\"journal\":{\"name\":\"Oral Surgery Oral Medicine Oral Pathology Oral Radiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral Surgery Oral Medicine Oral Pathology Oral Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.oooo.2025.09.002\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.oooo.2025.09.002","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Agreement of tumour budding, tumour-stroma ratio, and tumour thickness in oral squamous cell carcinoma biopsy and resection samples and their clinical implications.
Objective: To evaluate the concordance between preoperative biopsies and corresponding surgical resections in assessing tumour budding (TB), tumour/stroma ratio (TSR), and tumour thickness (TT) in oral squamous cell carcinoma (OSCC) samples, and to explore their potential as prognostic indicators.
Study design: 31 surgical resections and 30 diagnostic biopsies were analysed using cytokeratin-immunostained slides to assess TB, TSR, TT, and the BT score (integrating TB and TT).
Results: Histopathological features were consistently underestimated in matched biopsies compared to resections in quantitative analysis, with resections showing higher TB counts, greater TT, and lower TSR (P < .007). However, when classified as categorical variables, no significant differences were observed in TB and TSR. In resections, TB was higher in poorly differentiated tumours, and TT was greater in cases with high TB (P < .049). A positive correlation was observed between TT and TB in biopsies (P < .034). Intermediate and high-risk BT score group had significantly worse disease-free survival (DFS) compared to the low-risk group (P < .02).
Conclusion: Despite the underestimation of TB and TSR in biopsies, these parameters remain predictive of aggressive tumor behaviour. Additionally, integrating histopathological parameters into combined scores, such as BT, could optimize biopsy evaluation and complement clinical staging and treatment planning.
期刊介绍：
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.
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