Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献_第5页

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IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-27 DOI: 10.1016/S2212-4403(24)00418-8

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IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-27 DOI: 10.1016/S2212-4403(24)00419-X

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Letter to the editor regarding “Surgical management of naso-orbito-ethmoidal fractures: a systematic review” 致编辑的信，内容涉及 "鼻眶外侧骨折的手术治疗：系统综述

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-23 DOI: 10.1016/j.oooo.2024.07.015

Naji Naseef Pathoor MSc, Rajesh Kanna Gopal MPhil, PhD, Pitchaipillai Sankar Ganesh MPhil, PhD

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Differences in BRAF V600E mutation between the epithelium and mesenchyme in classic ameloblastoma 典型骨髓母细胞瘤上皮细胞和间充质的 BRAF V600E 突变差异

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-21 DOI: 10.1016/j.oooo.2024.08.001

Zhuoxuan Chen MD , Yingying Hong PhD , Zhenni Zhao MD , Ningxiang Wu MD , Xiaokun Ma MD , Linlin Chen PhD , Ran Zhang PhD

{"title":"Differences in BRAF V600E mutation between the epithelium and mesenchyme in classic ameloblastoma","authors":"Zhuoxuan Chen MD , Yingying Hong PhD , Zhenni Zhao MD , Ningxiang Wu MD , Xiaokun Ma MD , Linlin Chen PhD , Ran Zhang PhD","doi":"10.1016/j.oooo.2024.08.001","DOIUrl":"10.1016/j.oooo.2024.08.001","url":null,"abstract":"<div><h3>Objective</h3><div>Laser capture microdissection (LCM) was used to pinpoint the mutated tissue in ameloblastoma and investigate whether B-Raf proto-oncogene, serine/threonine kinase (<em>BRAF)</em> mutation is the main pathogenic gene in classic ameloblastoma.</div></div><div><h3>Study Design</h3><div>A total of 24 patients with ameloblastoma scheduled to undergo surgery between 2000 and 2024 were included in the study. LCM was used to isolate tumor cells. Oxford nanopore technology (ONT) was used to analyze the collected cells. GO and KEGG enrichment analyses were then performed on the 300 most highly expressed genes in the epithelial tissue and mesenchyme.</div></div><div><h3>Results</h3><div>Mandibular follicular ameloblastoma showed <em>BRAF</em> V600E mutations in all epithelial cells but not in the mesenchyme. The mutation rate was significantly higher in mandibular ameloblastomas compared to the maxilla (<em>P</em> < .05). RNA-seq showed that traditional follicular ameloblastoma epithelium was enriched in “growth factor receptor binding” and “angiogenesis regulation,” while the mesenchyme was enriched in “ECM receptor interaction.” KEGG enrichment analysis showed differential gene expression, mainly in MAPK and PI3K-AKT pathways.</div></div><div><h3>Conclusion</h3><div>Classical follicular ameloblastoma shows the presence of <em>BRAF</em> V600E mutation in epithelial tissue, with a higher mutation rate in the mandible than in the maxilla. The signaling pathways of MAPK and PI3K may be significantly involved in epithelial signal transduction.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 6","pages":"Pages 753-762"},"PeriodicalIF":2.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The oral medicine workforce and impact on access to care in the United States 美国口腔医学人才队伍及其对获得医疗服务的影响

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-20 DOI: 10.1016/j.oooo.2024.08.010

Petros Yoon DDS , Brittany Klein DDS , Lama Alabdulaaly BDS, DMSc , Abdulrahman Nakshabandi BDS , Mandlin Almousa DMD , Laurel Henderson DDS , Malak Al-Hadlaq BDS, DMSc , Amal Bajonaid BDS, DMSc , Piamkamon Vacharotayangul DDS, PhD , Nathaniel Treister DMD, DMSc , Stephen Sonis DMD, DMSc

{"title":"The oral medicine workforce and impact on access to care in the United States","authors":"Petros Yoon DDS , Brittany Klein DDS , Lama Alabdulaaly BDS, DMSc , Abdulrahman Nakshabandi BDS , Mandlin Almousa DMD , Laurel Henderson DDS , Malak Al-Hadlaq BDS, DMSc , Amal Bajonaid BDS, DMSc , Piamkamon Vacharotayangul DDS, PhD , Nathaniel Treister DMD, DMSc , Stephen Sonis DMD, DMSc","doi":"10.1016/j.oooo.2024.08.010","DOIUrl":"10.1016/j.oooo.2024.08.010","url":null,"abstract":"<div><h3>Objectives</h3><div>The objective of this study was to characterize the current oral medicine (OM) workforce by examining the distribution of OM diplomates (OMDs) across the Unites States and to determine the need for expanding access to care.</div></div><div><h3>Study Design</h3><div>The OMD access was calculated based on the OMDs per 10,000 state population from the 2020 US Census data as well as their distance from state capitals and most populated cities. OMD penetrance in hospitals and cancer centers was assessed at National Cancer Care Network (NCCN) cancer centers, and Best Hospitals as reported in the 2022 US News and World Report (USNWR).</div></div><div><h3>Results</h3><div>OMDs are present in 64% of the states with an uneven geographic distribution. Primary workplaces included dental schools (47%), hospitals (30%), and private practices (19%). Of the OMDs in private practice, 57% limited their practice to OM. OMDs were noted at 28% of NCCN cancer centers, 30% of USNWR Best Hospitals for Cancer, and 20% of USNWR Best Hospitals.</div></div><div><h3>Conclusions</h3><div>There is low density and uneven distribution of OMDs with approximately one-third of the population without access to an OMD in their state, thus limiting access to care. This suggests both vast opportunities for growth and expansion of OM, as well as challenges in developing and training the necessary workforce.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 6","pages":"Pages 745-752"},"PeriodicalIF":2.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-19 DOI: 10.1016/S2212-4403(24)00382-1

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Information for Readers 读者信息

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-19 DOI: 10.1016/S2212-4403(24)00383-3

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Oral manifestations of peripheral T cell lymphoma, not otherwise specified: case series and review of the current literature. 非特异性外周 T 细胞淋巴瘤的口腔表现：病例系列和现有文献综述。

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-17 DOI: 10.1016/j.oooo.2024.08.011

Eduardo Morato de Oliveira, Cinthia Veronica Bardález Lopéz de Cáceres, Carla Isabelly Fernandes-Rodrigues, Paulo Victor Mendes Penafort, Juan Manuel Arteaga Legarrea, Nathalia Rodrigues Gomes, Hélder Antônio Rebelo Pontes, Pablo Agustin Vargas, José Narciso Rosa Assunção Júnior, Ciro Dantas Soares, Felipe Paiva Fonseca

{"title":"Oral manifestations of peripheral T cell lymphoma, not otherwise specified: case series and review of the current literature.","authors":"Eduardo Morato de Oliveira, Cinthia Veronica Bardález Lopéz de Cáceres, Carla Isabelly Fernandes-Rodrigues, Paulo Victor Mendes Penafort, Juan Manuel Arteaga Legarrea, Nathalia Rodrigues Gomes, Hélder Antônio Rebelo Pontes, Pablo Agustin Vargas, José Narciso Rosa Assunção Júnior, Ciro Dantas Soares, Felipe Paiva Fonseca","doi":"10.1016/j.oooo.2024.08.011","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.011","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to describe a series of peripheral T-cell lymphoma, not otherwise specified (PTCL NOS) affecting the oral cavity and to review the available literature.</p><p><strong>Study design: </strong>Cases diagnosed as PTCL-NOS affecting the oral cavity were retrospectively retrieved from pathology files. Original hematoxylin and eosin-stained slides and immunohistochemical reactions were reviewed for microscopic confirmation. The presence of Epstein-Barr virus (EBV) was investigated by in situ hybridization. Clinical and follow-up data were retrieved from patients' pathology and medical files.</p><p><strong>Results: </strong>A total of 5 cases were obtained with a mean age of 51.8 years old, 3 male patients and 2 female patients. Three cases affected the palate and 2 cases affected the gingiva, whereas 1 case affected the maxillary bone. Tumors presented as destructive, infiltrative, and painful lesions causing swelling, ulceration, and tissue necrosis. All cases exhibited CD3 expression. GATA3 was expressed in 3 cases. Four patients were deceased of the disease during follow-up.</p><p><strong>Conclusions: </strong>PTCL NOS affecting the oral cavity is rare and usually present as a very aggressive disease, associated with a poor prognosis and dismal outcome. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Clinical factors associated with salivary flow rate in adults with acromegaly 与肢端肥大症成人唾液流量相关的临床因素

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-16 DOI: 10.1016/j.oooo.2024.08.009

Renata C. Campelo DDS, MSc , Bruno B. Benatti DDS, PhD , Joana A.B. de Sousa DDS, MSc , Gilvan C. Nascimento MD, PhD , Rossana S.S. Azulay MD, PhD , Manuel dos S. Faria MD, PhD , Marcelo Magalhães PhD , Vandilson P. Rodrigues DDS, PhD

{"title":"Clinical factors associated with salivary flow rate in adults with acromegaly","authors":"Renata C. Campelo DDS, MSc , Bruno B. Benatti DDS, PhD , Joana A.B. de Sousa DDS, MSc , Gilvan C. Nascimento MD, PhD , Rossana S.S. Azulay MD, PhD , Manuel dos S. Faria MD, PhD , Marcelo Magalhães PhD , Vandilson P. Rodrigues DDS, PhD","doi":"10.1016/j.oooo.2024.08.009","DOIUrl":"10.1016/j.oooo.2024.08.009","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the stimulated salivary flow (SSF) and unstimulated salivary flow (USF) in adults with acromegaly and to identify possible clinical factors associated with salivary flow.</div></div><div><h3>Study design</h3><div>A case-control study was conducted with a group composed of adults diagnosed with acromegaly (n = 29, mean age = 50.2 years) and a control group (n = 29, mean age = 54.3 years). Variables for socio-demographic characterization, lifestyle habits, and diabetes diagnosis, body mass index (BMI), cervical circumference (CC) and abdominal circumference (AC) were collected. USF and SSF variables were analyzed as outcomes. Unpaired t-test, Pearson's correlation, and multivariate regression models were used for statistical analysis.</div></div><div><h3>Results</h3><div>Both groups were 44.8% male and 55.2% female. Diabetes was present in 55.2% of the acromegaly group and in 51.7% of the controls (<em>P</em> = .792). The acromegaly group had a higher USF than the control group (0.50 mL/min versus 0.22 mL/min). SSF showed a direct correlation with CC (r = 0.470, <em>P</em> = .010). Acromegaly was associated with higher USF (standardized coefficient = 0.780, <em>P</em> = .039), and age was inversely related to USF (standardized coefficient = −0.333, <em>P</em> = .013).</div></div><div><h3>Conclusions</h3><div>The findings suggest that adults with acromegaly have an increased USF and that being older is associated with a decrease in USF.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 6","pages":"Pages 735-744"},"PeriodicalIF":2.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Oral and vulval disease: prevalence, associations, and management recommendations for the oral medicine clinician 口腔和外阴疾病：口腔和外阴疾病：发病率、关联性和管理建议，供口腔医学临床医生参考

IF 2 3区医学

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-16 DOI: 10.1016/j.oooo.2024.08.007

Sangeetha Yogarajah BDS , Fiona Tasker MBBS, IntBSc, MRCP, PGDip , Barbara Carey MB, BCh, BAO, BDS, FDS (OM), RCSI , Fiona Lewis MD, FRCP

{"title":"Oral and vulval disease: prevalence, associations, and management recommendations for the oral medicine clinician","authors":"Sangeetha Yogarajah BDS , Fiona Tasker MBBS, IntBSc, MRCP, PGDip , Barbara Carey MB, BCh, BAO, BDS, FDS (OM), RCSI , Fiona Lewis MD, FRCP","doi":"10.1016/j.oooo.2024.08.007","DOIUrl":"10.1016/j.oooo.2024.08.007","url":null,"abstract":"<div><h3>Objective</h3><div>The oral cavity is a common site for mucosal conditions which may be confined to the mouth, or may manifest as mucocutaneous involvement at other sites, including the anogenital region. This retrospective analysis aimed to assess the appropriateness of oral medicine referrals to a specialized vulval clinic and review the prevalence of oral disease associated with vulval involvement of the same condition.</div></div><div><h3>Study Design</h3><div>One hundred thirty-six patients referred from oral medicine to the vulval service at Guy's Hospital were analyzed. Retrospective data collated included: reason(s) for referral, onset of oral and genital symptoms, oral diagnosis, vulval diagnosis, correlation between the oral and vulval diagnosis, and discharge at first appointment.</div></div><div><h3>Results</h3><div>Forty-nine percent (n = 67) of the patients had oral and vulval manifestations of the same disease. The majority of these patients (n = 63) were diagnosed with vulval lichen planus, of whom 61 had concomitant oral lichen planus involvement (97%). Other associated oral and vulval diseases included aphthous ulceration, Behçet's disease, dryness secondary to Sjögren's disease, Crohn's disease, and mucous membrane pemphigoid. The remaining 51% (n = 69) of the patients presented with independent vulval conditions unrelated to their oral disease.</div></div><div><h3>Conclusion</h3><div>Clinicians should recognize the association between genital symptoms and oral disease and refer to specialist allied services, as appropriate.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 6","pages":"Pages 728-734"},"PeriodicalIF":2.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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