Antimicrobial photodynamic therapy in the treatment of oral lesions: experience report and clinical protocol

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI:10.1016/j.oooo.2025.01.059

Giovanna Meneses, Maria Paula Siqueira de Melo Peres, Juliana Bertoldi Franco

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Abstract

Antimicrobial photodynamic therapy (aPDT) is based on the application of a photosensitizing agent on the injured tissue followed by low-level laser therapy (LLLT) emission on the region. The interaction generates free radicals and oxidation of the plasma membrane of microorganisms, providing antimicrobia, antiviral and antifungal activity without harming healthy host cells. Is considered a noninvasive, local, painless procedure, which has the advantage of tissue biostimulating, helping to reduce the administration of systemic medications in immunosuppressed patients. The photosensitizing agent (methylene blue 0.01%) was applied over all lesions and, after 5 minutes, LLLT was used at 660 nm, on contact mode, point by point, with 100 mW, 178 J/cm 2, 6J, and 60s per point, with sessions every 24 hours depending on clinical evolution. Widely used in the treatment of oral lesions in adult and pediatric patients, in herpetic lesions, candidiasis, Paracoccidioidomycosis, osteonecrosis of the jaws, and osteoradionecrosis, with success.

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抗菌光动力疗法治疗口腔病变：经验报告和临床方案

抗菌光动力疗法（aPDT）是基于在受伤组织上应用光敏剂，然后在该区域进行低水平激光治疗（LLLT）。这种相互作用产生自由基并氧化微生物的质膜，在不损害健康宿主细胞的情况下提供抗菌、抗病毒和抗真菌活性。被认为是一种无创、局部、无痛的手术，具有组织生物刺激的优点，有助于减少免疫抑制患者的全身药物管理。将光敏剂（亚甲基蓝0.01%）涂抹在所有病变上，5分钟后，在660 nm处使用LLLT，接触模式，逐点，100mw, 178 J/ cm2, 6J，每点60s，根据临床进展每24小时进行一次治疗。广泛应用于成人及儿童口腔病变、疱疹性病变、念珠菌病、副球孢子菌病、颌骨骨坏死、放射性骨坏死的治疗，均取得成功。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.