Assessment of salivary biomarkers in psoriasis: a comprehensive scoping review

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-28 DOI:10.1016/j.oooo.2025.03.013

Larissa Conrado da Silva DDS , Luana Côrtes Amorim Guimarães DDS , Diego Belmiro do Nascimento Santos DDS , Lucas Alves Jural DDS , Sílvia Paula de Oliveira DDS, MSc, PhD , Bruno Augusto Benevenuto de Andrade DDS, MSc, PhD , Jefferson R. Tenório DDS, MSc, PhD

{"title":"Assessment of salivary biomarkers in psoriasis: a comprehensive scoping review","authors":"Larissa Conrado da Silva DDS , Luana Côrtes Amorim Guimarães DDS , Diego Belmiro do Nascimento Santos DDS , Lucas Alves Jural DDS , Sílvia Paula de Oliveira DDS, MSc, PhD , Bruno Augusto Benevenuto de Andrade DDS, MSc, PhD , Jefferson R. Tenório DDS, MSc, PhD","doi":"10.1016/j.oooo.2025.03.013","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To map the evidence on altered salivary biomarkers in individuals with psoriasis.</div></div><div><h3>Study design</h3><div>A comprehensive literature search was conducted across six databases and gray literature sources using keywords related to psoriasis and salivary biomarkers, with no restrictions on time or language, up to November 2024. Studies evaluating salivary biomarkers in humans with psoriasis were considered eligible. Identified outcomes were categorized based on biomarker type and analyzed descriptively.</div></div><div><h3>Results</h3><div>A total of 661 studies were initially identified, of which 22 met the inclusion criteria. These comprised 15 cross-sectional studies, 6 cohort studies, and 1 randomized clinical trial, collectively involving 987 individuals with psoriasis. The primary altered salivary biomarkers identified included inflammatory cytokines (IL-1β, IL-2, IL-6, IL-10, TNF-α, INF-γ), oxidative stress mediators (nitric oxide, nitrotyrosine), antioxidant enzymes (catalase, superoxide dismutase), immunological markers (salivary alpha-amylase, secretory immunoglobulin A), and stress-related hormones. Many of these biomarkers were significantly associated with disease severity and therapeutic response.</div></div><div><h3>Conclusion</h3><div>Cortisol, inflammatory cytokines and oxidative stress mediators are the most frequently altered salivary biomarkers in individuals with psoriasis. However, the methodological heterogeneity among the studies highlights the need for well-designed prospective studies with representative sample sizes to validate these findings.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 2","pages":"Pages 186-197"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212440325008454","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

To map the evidence on altered salivary biomarkers in individuals with psoriasis.

Study design

A comprehensive literature search was conducted across six databases and gray literature sources using keywords related to psoriasis and salivary biomarkers, with no restrictions on time or language, up to November 2024. Studies evaluating salivary biomarkers in humans with psoriasis were considered eligible. Identified outcomes were categorized based on biomarker type and analyzed descriptively.

Results

A total of 661 studies were initially identified, of which 22 met the inclusion criteria. These comprised 15 cross-sectional studies, 6 cohort studies, and 1 randomized clinical trial, collectively involving 987 individuals with psoriasis. The primary altered salivary biomarkers identified included inflammatory cytokines (IL-1β, IL-2, IL-6, IL-10, TNF-α, INF-γ), oxidative stress mediators (nitric oxide, nitrotyrosine), antioxidant enzymes (catalase, superoxide dismutase), immunological markers (salivary alpha-amylase, secretory immunoglobulin A), and stress-related hormones. Many of these biomarkers were significantly associated with disease severity and therapeutic response.

Conclusion

Cortisol, inflammatory cytokines and oxidative stress mediators are the most frequently altered salivary biomarkers in individuals with psoriasis. However, the methodological heterogeneity among the studies highlights the need for well-designed prospective studies with representative sample sizes to validate these findings.

查看原文本刊更多论文

银屑病唾液生物标志物的评估：一项全面的范围审查。

目的：寻找银屑病患者唾液生物标志物改变的证据。研究设计：使用与银屑病和唾液生物标志物相关的关键词，在没有时间和语言限制的情况下，对6个数据库和灰色文献来源进行全面的文献检索，截止到2024年11月。评估牛皮癣患者唾液生物标志物的研究被认为是合格的。确定的结果根据生物标志物类型进行分类，并进行描述性分析。结果：共纳入661项研究，其中22项符合纳入标准。这些研究包括15项横断面研究、6项队列研究和1项随机临床试验，共涉及987例牛皮癣患者。鉴定的主要改变的唾液生物标志物包括炎症因子（IL-1β、IL-2、IL-6、IL-10、TNF-α、INF-γ）、氧化应激介质（一氧化氮、硝基酪氨酸）、抗氧化酶（过氧化氢酶、超氧化物歧化酶）、免疫标志物（唾液α -淀粉酶、分泌免疫球蛋白A）和应激相关激素。许多这些生物标志物与疾病严重程度和治疗反应显著相关。结论：皮质醇、炎症因子和氧化应激介质是银屑病患者最常改变的唾液生物标志物。然而，研究方法的异质性突出表明需要设计良好的前瞻性研究，具有代表性的样本量来验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.