Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献

{"title":"Society Page","authors":"","doi":"10.1016/S2212-4403(25)01104-6","DOIUrl":"10.1016/S2212-4403(25)01104-6","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page A5"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding and targeting genes regulating the malignant potential of oral proliferative leukoplakia through a sequential computational approach","authors":"Manmeet Sandhu,&nbsp;Kamran Awan,&nbsp;Shilpa Bhandi,&nbsp;Frank Licari,&nbsp;Shankargouda Patil","doi":"10.1016/j.oooo.2025.04.060","DOIUrl":"10.1016/j.oooo.2025.04.060","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral proliferative leukoplakia (OPL) is a multifocal aggressive form of oral potentially malignant disorders (OPMD), carrying a higher malignant potential than solitary oral leukoplakia (OL).</div></div><div><h3>Materials and Methods</h3><div>The present study used a sequential computational approach to compare the molecular profile of OPL and OL to decode the genes responsible for augmenting the malignant potential of OPL. The analysis included integrated gene expression profiling, protein interaction network, molecular interconnectivity, survival assessment, and molecular docking with the existing anti-cancer drugs.</div></div><div><h3>Results</h3><div>OPL showed 159 genes that were distinctly upregulated compared to OL. Among these 13 genes were found to be associated with oral squamous carcinoma (OSCC). Further construction of a protein network from the 13 gene-encoded proteins activated diverse cancer-related pathways. Simultaneously, the expression of these 13 genes altered the survival rate in OSCC patients. Screening of 241 anti-cancer drugs against these 13 regulators, revealed the 3 most effective inhibitors.</div></div><div><h3>Conclusion</h3><div>The study decoded the key regulatory genes responsible for augmenting the malignant potential of OPL. Further, a significant association was observed between the decoded genes and the survival of OSCC patients. Anti-cancer medications capable of inhibiting these key regulators were identified. The application of the 3 most effective inhibitors could potentially prevent the malignant transformation of OPL.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e86"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraosseous schwannoma of the jaws: a case report and systematic review","authors":"Alberto Peraza Labrador ,&nbsp;Luciano Matos ,&nbsp;Victoria Woo","doi":"10.1016/j.oooo.2025.04.065","DOIUrl":"10.1016/j.oooo.2025.04.065","url":null,"abstract":"<div><h3>Introduction</h3><div>Intraosseous schwannoma (IS), also known as intraosseous neurilemoma, is a benign peripheral nerve sheath tumor postulated to arise de novo or from nerve fibers in pre-existing nutrient canals. ISs are uncommon and comprise less than 1% of neoplasms originating in bone. We herein describe a 66-year-old female who presented with a 4-month history of mandibular pain and pressure. A panoramic radiograph and cone beam computer tomography (CBCT) imaging revealed a well-defined, unilocular radiolucency of the anterior mandible that caused cortical thinning but no evidence of perforation. An incisional biopsy showed a benign spindle cell neoplasm with histologic features of a schwannoma. The tumor cells were strongly reactive for S-100. Complete enucleation was subsequently performed, and the patient is without evidence of disease at 8 months.</div></div><div><h3>Materials and Methods</h3><div>A systematic review of reported cases was undertaken to evaluate the demographics, clinical features, and treatment of ISs. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligibility criteria included publications having sufficient clinical and histological information to confirm the diagnosis.</div></div><div><h3>Results and Conclusions</h3><div>A total of 83 publications and 93 cases were included in the review with the following findings: predominance in females (57%); average age of occurrence of 37.3 years (range of 8-77 years); mean size of 3.6 cm; sites of involvement—mandibular body (37.6%), mandibular body and ramus (18.3%), and anterior mandible (18.3%). The predominant clinical sign was swelling (69.9%), and the majority of patients were asymptomatic (53.8%). The most common radiographic presentation was a radiolucency (94.6%) with well-defined borders (72%). All cases were treated surgically, with the average follow-up interval of 22.9 months. A 5.4% recurrence rate was reported, and recurrence as late as 6 years post-treatment has been documented, suggesting the need for long-term follow-up.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Pages e87-e88"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chondromyxoid fibroma of the mandible: report of a case","authors":"Jennie Ison","doi":"10.1016/j.oooo.2025.04.032","DOIUrl":"10.1016/j.oooo.2025.04.032","url":null,"abstract":"<div><h3>Introduction</h3><div>The chondromyxoid fibroma is an exceedingly rare benign tumor, representing less than 1% of all bone tumors. It has a slight male preponderance; males are affected approximately 1.5 times more often than females. Though typically affecting patients during the second and third decades of life, reports of patients who are 50 years and older do exist. With a distinct predilection for the metaphyseal regions of the long bones of the lower extremities, the chondromyxoid fibroma has also commonly been reported in the small bones of the feet and the ilium. Much less common are lesions of the craniofacial bones, ribs, spine, and short tubular bones of the hands and feet. Herein, a case of chondromyxoid fibroma of the mandible is reported.</div></div><div><h3>Case Report</h3><div>A multilocular radiolucent lesion was noted in the left mandible of a 48-year-old male, and submitted to the UKCD Oral Pathology Biopsy service with a clinico-radiographic differential diagnosis including ameloblastoma and odontogenic keratocyst. Upon histopathologic examination, a fragmented, but pseudolobulated mass composed of myxomatous and chondroid areas with intervening zones of hypercellular mononuclear tissue containing sparse multinucleated giant cells, was appreciated. The myxoid areas contained both plump and stellate spindled cells at the periphery. Immunohistochemistry for MDM2 was negative, essentially excluding the possibility of a low-grade central osteosarcoma.</div></div><div><h3>Conclusions</h3><div>Presentation of this case represents a significant addition to the literature of this rare entity occurring in a distinctly uncommon location, and highlights this entity as a consideration in the histopathological differential diagnosis of myxoid lesions of the craniofacial bones.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e77"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple bone cyst with unusual root resorption: a case report","authors":"Mark Mintline ,&nbsp;Jeffrey Elo ,&nbsp;Nickan Zarrabi ,&nbsp;Sahar Mirfarsi ,&nbsp;Sevin Barghan ,&nbsp;Setareh Lavasani","doi":"10.1016/j.oooo.2025.04.047","DOIUrl":"10.1016/j.oooo.2025.04.047","url":null,"abstract":"<div><div>This case report presents an unusual case of a gnathic simple bone cyst (SBC) with significant tooth resorption of a mandibular second molar. A 30-year-old male presented to the dental school clinic for further evaluation of an incidental periapical radiographic finding of a radiolucent lesion in the left mandibular second molar region. The lesion was not identifiable on his panoramic radiographic imaging 1 year prior. Plain films and cone-beam computed tomography (CBCT) images demonstrated a relatively well-demarcated radiolucent lesion in the left posterior body of the mandible with substantial resorption of the second molar. Based on the aggressive behavior of the lesion, a biopsy was immediately performed. Surgical exploration revealed a bone cavity containing sanguineous fluid with no evidence of a cystic lining or mass lesion consistent with an SBC. Sparse soft tissue fragments were curetted, and pieces of the bone cavity walls were submitted for histopathologic analysis. Histopathologic examination revealed a thin layer of fibrous tissue without an epithelial lining and lamellar bone consistent with an SBC. SBCs of the jaws commonly extend between the roots of teeth without resorption, and a minority of cases show bone expansion. Rarely, gnathic SBCs substantially resorb tooth roots.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Pages e81-e82"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary fibrous tumor of the buccal mucosa: case presentation and review of the literature","authors":"Eduard Munarov ,&nbsp;Tzvi Krupka ,&nbsp;Aryeh Mahana ,&nbsp;Aaron Yancoskie","doi":"10.1016/j.oooo.2025.04.020","DOIUrl":"10.1016/j.oooo.2025.04.020","url":null,"abstract":"<div><h3>Introduction</h3><div>Solitary fibrous tumor (SFT) occurs primarily in adults and is considered an entity of intermediate potential. Most cases follow a benign clinical course, with select tumors exhibiting malignant features. While SFT can occur at any site, the pleural lining of the thorax is the most common. Occurrence in the oral cavity is infrequent. Although histopathology is diverse from case to case, consistent characteristics include a monomorphic spindle cell population in a fibrous stroma with endothelial-lined channels of differing caliber that may show a stag-horn appearance. Treatment is dependent upon the clinical and microscopic features with complete excision and clinical follow-up being appropriate in most cases. We report an SFT of the right buccal mucosa in a female of 29 years and review the literature.</div></div><div><h3>Materials and Methods</h3><div>A 29-year-old female presented with an oral lesion that had gradually increased in size over 6 months. A nonpainful 1.5 × 1.5 cm spherical mass was identified on the right buccal mucosa.</div></div><div><h3>Results</h3><div>Incisional biopsy was performed under local anesthesia and the tissue was submitted to pathology. Microscopic features included an intact surface mucosa and underlying moderately-dense proliferation of monomorphic spindle cells possessing inconspicuous cytoplasmic borders arranged haphazardly in a fibrovascular stroma. The spindle cells stained strongly positive for CD-34 and STAT-6 and were negative for S-100 protein, confirming a diagnosis of SFT. The patient underwent excision under general anesthesia. Final histopathology showed tumor-free margins. The patient is free of disease 4-months postoperatively. The overall features of this case (patient age of less than 55 years, tumor size less than five cm, and few mitotic figures), predict a favorable clinical course based on Demiccio and colleagues’ criteria.</div></div><div><h3>Conclusion</h3><div>The clinical, histopathological, and immunohistochemical features of an SFT in a 29-year-old female are presented and the literature is reviewed. Management and follow-up are discussed.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e73"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of PD-L1 expression in oral squamous cell carcinoma","authors":"Wattawan Wongpattaraworakul,&nbsp;Allen Choi,&nbsp;Marisa Buchakjia,&nbsp;Emily Lanzel,&nbsp;Andrean Simons-Burnett,&nbsp;Anand Rajan","doi":"10.1016/j.oooo.2025.04.021","DOIUrl":"10.1016/j.oooo.2025.04.021","url":null,"abstract":"<div><h3>Background</h3><div>Programmed cell death protein ligand-1 (PD-L1) is an immune checkpoint protein. In cancer, PD-L1 expression inhibits immunological control leading to tumor cells avoiding immune destruction. In oral squamous cell carcinoma (OSCC), previous literature showed conflicting prognostic value of PD-L1 among studies potentially due to different clones of antibody, differences in scoring methods, and definitions of positive expression. Additionally, PDL1 could be expressed both on immune cells and cancer cells. The distribution of the cell positivity is different across different OSCC cases. Here, we aim to evaluate the prognostic role of PD-L1 expression in OSCC using an FDA-approved antibody and the associated recommended scoring criteria. We also evaluated prognostic significant of PDL1 based on the localization of positive cells.</div></div><div><h3>Methods</h3><div>We analyzed PD-L1 expression by immunohistochemistry in tissue microarrays containing 347 OSCC using antibody clone 22C3 pharmDx and combined positive score (CPS) criteria. Different cutoff points of PD-L1 expression were used to assess progression-free (PFS) and overall patient survival (OS). Survival outcomes were analyzed using Kaplan–Meier plots and log-rank tests.</div></div><div><h3>Results</h3><div>PD-L1 expression had no impact on survival in patients treated with surgery and radiation. However, in OSCC treated with surgery alone, OSCC with CPS ≥ 70 was associated with worse PFS. Interestingly, regardless of CPS, OSCC with PDL1 positivity exclusively/mostly on cancer cells was also associated with poor PFS. Even in cases with PDL1 &lt; 70, if the PDL1 positivity exclusively/mostly expressed on cancer cells, the PFS is as worse as OSCC with CPS ≥ 70.</div></div><div><h3>Conclusion</h3><div>PD-L1 expression using anti-PD-L1 antibody (22C3) with the associated CPS scoring criteria can predict PFS in OSCC patients who received surgery alone. Additionally, the cellular localization of PD-L1 levels appears to influence PFS: high levels of expression in cancer cells alone appear to portend a worse prognosis.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Pages e73-e74"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subacute necrotizing sialadenitis: 3 new cases with review of literature","authors":"Nagamani Narayana","doi":"10.1016/j.oooo.2025.04.017","DOIUrl":"10.1016/j.oooo.2025.04.017","url":null,"abstract":"<div><div>The main objective of this poster is to inform clinical dentists regarding subacute necrotizing sialadenitis (SAN). It was first described in 1985 as an unusual inflammatory condition affecting minor salivary glands primarily seen in the palate. It has also shown to present in the buccal mucosa, upper lip, and ventral tongue. SANs present as a symptomatic mass of few days duration, resolving in a week in contrast to necrotizing sialometaplasia which presents with ulceration and takes about 3 weeks to heal. Though there is no consensus regarding the etiology of SAN, all cases resolve without therapy. On searching UNMC College of Dentistry oral pathology service for cases of SANs from 1990 to 2021 (31 years) three cases were found. The age ranged from 16 to 77 years and presented in two males and a female. Two cases were from the palate while one case was from the upper lip. All cases presented with painful palpable masses with no ulceration. Two cases of the palate had a clinical diagnosis of lipoma and adenoma, while the case from the upper lip was called a fibroma. All cases microscopically presented with focal acinar degeneration with a mixed inflammatory infiltrate. No metaplasia of the ductal epithelium was noted. In conclusion, if an erythematous, painful, nonulcerated, palpable palatal mass is noted clinicians should consider SAN in the differential diagnosis.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e72"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical and molecular analysis of the inflammatory microenvironment of oral mucosal potentially malignant disorders","authors":"Andres Flores-Hidalgo ,&nbsp;Fatima Zahra Aly ,&nbsp;Megumi Williamson ,&nbsp;Ricardo Padilla","doi":"10.1016/j.oooo.2025.04.010","DOIUrl":"10.1016/j.oooo.2025.04.010","url":null,"abstract":"<div><h3>Introduction</h3><div>Recent studies have shown that the nature of the tumor microenvironment and infiltrating immune cells can significantly modify the outcome of genetic aberration in the oral epithelium. Although their role in cancer progression is not fully understood, these infiltrating cells have been strongly correlated with a poor or better prognosis for the patient in many solid tumors. This study analyzes the phenotypic and molecular expression of immune infiltrating cells in OPMD and known histopathologic mimickers.</div></div><div><h3>Materials and Methods</h3><div>Twenty archived tissue samples were selected from ECU, and UNC Oral and Maxillofacial Pathology Laboratories diagnosed with moderate to severe oral epithelial dysplasia (OED). Dual IHC/DIF staining was carried out on each case with CD4/CD8 and CD163/STAT1 antibodies, and automated histomorphometric digital analysis was performed. The second part of the study involves spatial transcriptomics to identify genes and cell types in FFPE tissue. Bulk RNA sequencing (Illumina, CA) is currently being performed to measure the average gene expression across the population of cells and identify differences between the study groups.</div></div><div><h3>Results</h3><div>Preliminary results show that STAT1/CD163+ macrophages were mainly found underlying the epithelium in OED with similar distribution to CD4+ cells in the same compartment. Intraepithelial CD8+ lymphocyte distribution correlated with the degree of dysplasia in high-grade OED, and that finding correlates with a small presence of STAT1/CD163+ cells. Compared with OLP, an increased presence of inflammatory intraepithelial cells in OED (CD8+ cells and STAT1/CD163+ macrophages) was observed. A significant increase in transcriptional signals appears in OED, specifically from cytotoxic cells.</div></div><div><h3>Conclusions</h3><div>The preliminary results of our study suggest that the inflammation elicited by premalignant conditions could be used as a surrogate indicator of malignant transformation and its microscopic separation from other mucosal inflammatory diseases.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e70"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human papillomavirus genotype distribution in head and neck cancer as a function of human Immunodeficiency virus status","authors":"Soo-Yeon Sohn ,&nbsp;Brandon Gold ,&nbsp;Janine Westra ,&nbsp;William Westra","doi":"10.1016/j.oooo.2025.04.077","DOIUrl":"10.1016/j.oooo.2025.04.077","url":null,"abstract":"<div><h3>Introduction</h3><div>Among the most transformative events in head and neck oncology over the past two decades has been the recognition that a significant fraction of head and neck squamous cell carcinoma (HNSCC) is caused by the human papillomavirus (HPV). The distribution of HPV genotypes in these HPV-HNSCCs diverges from patterns observed in anogenital cancers, but little is known about how complex interactions between viral exposures, modes of transmission, tissue susceptibilities, and other factors such as immunosuppression impact on genotype distribution. For example, patients who are human immunodeficiency virus (HIV) positive are at increased risk of developing HPV-HNSCC, but it is not known if these tumors are infected with different HPV genotypes compared to patients without HIV.</div></div><div><h3>Methods</h3><div>Data was collected for all patients with HNSCCs that had undergone HPV testing at an academic hospital as part of clinical care (2012-2019). Screening was performed using real-time PCR targeting L1 of low and high-risk HPV types, followed by genotyping of positive cases. Genotype status was correlated with HIV status. For HPV-HNSCCs, genotype distribution was compared for patients with and without HIV<em>.</em></div></div><div><h3>Results</h3><div>HPV testing had been performed on HNSCCs from 29 patients who were HIV positive. A total of 28 of 29 (97%) tumors were HPV positive. Of these, 18 (64%) harbored HPV16 and 10 (36%) harbored a non-16 variant. Compared to HPV-HNSCCs from patients who were HIV-negative, those from patients with HIV were more likely to be related to a non-16 variant.</div></div><div><h3>Conclusion</h3><div>For patients with HPV-HNSCCs, HPV genotypes are unevenly distributed across different patient populations as a function of HIV status. The finding challenges a prevailing assumption that HPV16 eclipses non-16 subtypes as the prevailing etiologic agent for all HPV-HNSCCs, and may inform developing therapeutic and surveillance strategies that depend on precise delineation of HPV genotype distribution across specific patient populations.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Pages e91-e92"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}