Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献

{"title":"A rapidly growing nasal mass","authors":"Keyur Y. Naik DDS, MD , Daniel Bustamante MD , Arshad Kaleem MD, DMD, FACS , Hans C. Brockhoff DDS, MD, FACS","doi":"10.1016/j.oooo.2024.07.004","DOIUrl":"10.1016/j.oooo.2024.07.004","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 5","pages":"Pages 586-593"},"PeriodicalIF":2.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141707611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti–TNF-α induced mucous membrane pemphigoid-like disease","authors":"Giacomo Setti DDS, MSc, PhD ,&nbsp;Cristina Vaschieri BS ,&nbsp;Stefania Caramaschi MD ,&nbsp;Cristina Magnoni MD, PhD ,&nbsp;Ugo Consolo MD, DDS ,&nbsp;Pierantonio Bellini MD","doi":"10.1016/j.oooo.2024.07.002","DOIUrl":"10.1016/j.oooo.2024.07.002","url":null,"abstract":"<div><div>Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease affecting various mucous membranes, with rare skin involvement. We present a case of a 40-year-old woman with recurring desquamative gingivitis, implicating etanercept, an anti–TNF-α agent, in MMP-like lesions confined to the oral mucosa. Suspicion arose due to temporal correlation between drug administration and lesion onset, confirmed by recurrence upon resumption and resolution upon suspension. Laboratory findings supported MMP diagnosis. Notably, the patient had a history of autoimmune urticaria and axial spondylarthritis. A probable adverse drug reaction was established using the Naranjo scale. Possible mechanisms involve the role of TNF-α in MMP pathophysiology and its interaction with viral triggers, exemplified by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection. This case underscores the intricate relationship among autoimmune conditions, medications, and external factors in mucocutaneous disorders, advocating for comprehensive patient assessment and interdisciplinary collaboration for optimal management. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 5","pages":"Pages e95-e100"},"PeriodicalIF":2.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141700296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foreign body gingivitis as a possible contributor to oral carcinogenesis: a clinicopathologic study","authors":"Dr. Alberto Peraza Labrador ,&nbsp;Dr. Madhu Shrestha ,&nbsp;Dr. Victoria Woo ,&nbsp;Dr. John Wright ,&nbsp;Dr. Enrique ter Horst ,&nbsp;Dr. Letícia Cabido","doi":"10.1016/j.oooo.2024.04.052","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.04.052","url":null,"abstract":"<div><h3>Introduction</h3><p>Foreign body gingivitis (FBG) is an inflammatory reaction associated with the presence of foreign material in the gingival tissues. Si is the element most prevalent in the foreign particles and is typically found in nature as SiO2 (silica). Silica is a major component of toothpaste, pumice, polishing paste, and carborundum. We have previously reported a significant association between the presence of foreign particles and epithelial dysplasia. Herein, we aim to evaluate the clinical and histologic features of additional gingival lesions of FBG with significant epithelial changes to better characterize the histologic spectrum of the host response and epithelial findings.</p></div><div><h3>Materials and Methods</h3><p>Fourteen gingival lesions showing FBG and significant epithelial changes were retrieved from the archives of the Texas A&amp;M Oral Pathology Services. Clinical records and deidentified microscopic slides were reviewed.</p></div><div><h3>Results</h3><p>Both sexes were affected equally, with an average age of 68.7 years. There was a strong predilection for the posterior gingiva (92.9% of cases), and the lesions were clinically suspected to be leukoplakia, proliferative verrucous leukoplakia, or dysplasia in the majority of cases. Microscopically, the predominant inflammatory cell type was lymphocytes followed by plasma cells, and the pattern of inflammation was lichenoid in 64.2%. A verrucous architecture was seen in 57.1% of the cases and varying degrees of dysplasia in 71.4 %.</p></div><div><h3>Conclusion</h3><p>Although the effects of silica microparticles in oral tissues are poorly understood, they have been shown to cause significant changes such as silicosis and carcinoma in the lung. Given the recent increase in the prevalence of gingival carcinomas and the wide use of nano- and microparticles in dental and household products, the biological effects of these particles in oral epithelium need to be better elucidated. Further documentation and evidence are needed, and pathologists should evaluate and document all gingival premalignant lesions for foreign material.</p></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 2","pages":"Page e46"},"PeriodicalIF":2.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benign Fibro-Osseous Lesions of the Jawbones (BFOLJ): A Clinicopathologic Analysis of 518 Cases from a Single Institution","authors":"Mr. Quinn Saluan ,&nbsp;Ms. Anika Moffitt ,&nbsp;Dr. Kristin McNamara ,&nbsp;Dr. Prokopios Argyris ,&nbsp;Dr. John Kalmar","doi":"10.1016/j.oooo.2024.04.060","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.04.060","url":null,"abstract":"<div><h3>Introduction</h3><p>BFOLJ represent a heterogeneous group of conditions with overlapping clinico-radiographic and histopathologic features despite diverse etiopathogenesis and biologic behavior. Overall, BFOLJ are subclassified into cemento-osseous dysplasia (COD), (cemento-)ossifying fibroma (OF) and fibrous dysplasia (FD). Herein, we present our institutional experience regarding the epidemiologic and clinicopathologic characteristics of BFOLJ.</p></div><div><h3>Material and methods</h3><p>Archived BFOLJ cases diagnosed over a 22-year period (2000-2022) were retrieved from the electronic laboratory databases of Oral Pathology Consultants at The OSU. Available information regarding patient age and gender, anatomic location, lesion focality, radiographic appearance, and histopathologic diagnosis was recorded and used for analysis.</p></div><div><h3>Results</h3><p>A total of 518 BFOLJ cases were identified with 440 (85%) affecting women and 78 (15%) men (F:M=5.6:1; age range=4-92y, mean=40.5y). The mandible was involved in 86% and the maxilla in 14% of the cases with the posterior mandible being the most common site (304, 57%). Among 123 BFOLJ with available clinico-radiographic information, 101 (82%) appeared unifocal and 22 (18%) showed multifocality with 63% of the cases presenting as well-defined, mixed radiopacity/radiolucency, 23% as unilocular radiolucency and 14% as radiopacity. Most BFOLJ were diagnosed as COD (449, 86.7%; F:M=7.8:1; age range=11-92y, mean=43y) further subcategorized as focal (292, 65%), florid (46, 10.25%), periapical (19, 4.25%), and COD NOS (92, 20.5%). Other diagnoses included OF (33, 6.4%; F:M=1:1; age range=4-47y, mean=26y), FD (28, 5.4%; F:M 3:1, age range=8-66y, mean=31y), juvenile OF (7, 1.3%) and renal osteodystrophy (1, 0.2%). Thirty (5.8%) BFOLJ were associated with secondary lesions, chiefly traumatic bone cyst (18, 60%), followed by central giant cell lesion (4, 13.3%) and xanthoma of bone (3, 10%).</p></div><div><h3>Conclusions</h3><p>BFOLJ are relatively uncommon and largely represent forms of COD with a strong predilection for the posterior mandible of middle-aged women. Histopathologic examination and clinico-radiographic correlation are required for accurate diagnosis and proper management.</p></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 2","pages":"Page e49"},"PeriodicalIF":2.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cocamidopropyl betaine: another possible oral healthcare chemical associated with plasma cell lesions of the oral cavity.","authors":"Dr. Jay Saepoo ,&nbsp;Dr. Nidhi Handoo ,&nbsp;Dr. Emily Lanzel ,&nbsp;Dr. John Hellstein","doi":"10.1016/j.oooo.2024.04.092","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.04.092","url":null,"abstract":"<div><h3>Introduction</h3><p>Plasma cell gingivitis has been recognized and described for many decades and has generally been associated with sensitivity reactions to various oral healthcare products or food flavoring agents. Plasma cell gingivitis is recognized as clinical lesions that are flat to slightly raised, erythematous, and diffuse but confined to the attached gingival surfaces. Whereas plasma cell mucositis has been a term utilized when lesions extend beyond the attached gingival surfaces. 3 abstracts on plasma cell lesions of the oral cavity were presented at last year's meeting and anecdotal discussions amongst oral pathologists revealed a general sense that these lesions have been increasing in incidence.</p></div><div><h3>Materials and methods</h3><p>We will present a small case series where cases were associated with CAPB containing toothpastes. The rise of cocamidopropyl betaine containing dentifrices began approximately in 2008 as a result of trying to eliminate sodium lauryl sulfate from oral healthcare products. However, it is not well-known that CAPB was recognized as 2004 allergen of the year by dermatologists.</p></div><div><h3>Results</h3><p>Simply changing the CAPB containing toothpaste resulted in resolution of the gingival/mucosal phenotype in multiple patients. However, we also eliminated other substances which have been associated with plasma cell gingivitis such as cinnamon or herbal ingredients making a definitive association impossible.</p></div><div><h3>Conclusion</h3><p>This abstract discusses another possible oral healthcare chemical that clinicians should be aware of in the diagnosis and potential management of oral plasma cell lesions. We also wish to seek out more evidence of whether the association is real or possibly due to the synergistic effect of multiple oral healthcare product chemicals.</p></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 2","pages":"Pages e61-e62"},"PeriodicalIF":2.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLI1-altered epithelioid soft tissue tumor: a newly defined entity with characteristic genetic profile","authors":"Dr. Rana AlShagroud ,&nbsp;Dr. Rasha AlRasheed ,&nbsp;Dr. Bader AlDawsari ,&nbsp;Dr. Ioannis Koutlas","doi":"10.1016/j.oooo.2024.04.057","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.04.057","url":null,"abstract":"<div><h3>Introduction</h3><p>GLI1-altered epithelioid soft tissue tumor is a recently recognized entity featuring GLII-1 fusions or amplifications. It has a predilection for the head and neck area, particularly in the tongue, and appears to have a malignant potential. Herein we report an additional case of GLI1-altered soft tissue tumor of the tongue in a patient with growth retardation and epilepsy.</p></div><div><h3>Materials and Methods</h3><p>A 9-year-old boy presented with a lobulated sessile reddish nodule at the dorsum of the tongue of unknown duration. His medical history was significant for growth hormone insufficiency and epilepsy with centrotemporal spikes. Magnetic resonance imaging showed an avidly enhancing lesion at the midline dorsum of the tongue. An incisional biopsy of the lesion was performed.</p></div><div><h3>Results</h3><p>Microscopic examination of the lesion revealed a multilobulated submucosal mass of epitheloid to ovoid cell proliferation with a perivascular distribution around delicate and branching blood vessels. The tumor cells are small to medium with clear to amphophilic cytoplasm. They are arranged in fascicles, cords, and reticular patterns and separated by richly vascular stroma with frequent prominent capillary-sized vasculature. Protrusion of tumor cells into vascular spaces is focally seen. Immunohistochemistry showed cytoplasmic positivity of the tumor cells to GLUT-1 and B-Catenin and negativity to S100, GFAP, Pan-CK, SMA, WT-1, CD-31, CD-34, and HMB-45. Ki-67 is around 10-15%. RNA-sequencing confirmed the presence of ACTB::GLI1 fusion.</p></div><div><h3>Conclusion</h3><p>GLI1-altered epithelioid soft tissue tumor is a unique neoplasm with unknown lineage and variable immunoreactivity. Therefore, molecular testing is indicated to confirm the diagnosis. GLI1-altered epithelioid soft tissue tumors have the potential for local recurrence and distant metastases; thus, it is best regarded as low-grade sarcoma and warrants a long-term follow-up after surgical excision.</p></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 2","pages":"Page e48"},"PeriodicalIF":2.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report of Four Cases of Intraoral Lipomatous Neurofibroma","authors":"Dr. Carter Bruett ,&nbsp;Dr. Spencer Roark ,&nbsp;Dr. Renee Reich ,&nbsp;Dr. Paul Freedman","doi":"10.1016/j.oooo.2024.04.027","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.04.027","url":null,"abstract":"<div><h3>Introduction</h3><p>Neurofibroma is a benign tumor that originates from the peripheral nerve sheath. In its localized form, the tumor most often presents as a superficial, solitary lesion arising anywhere on the body. Oral localized neurofibromas are common. The diffuse and plexiform growth patterns of neurofibroma are associated with neurofibromatosis 1, while the localized form is not. Histologically, neurofibromas are widely variable. One rare form is the lipomatous neurofibroma. This more recently described variant is characterized by the presence of intratumoral fat in clear excess of entrapped adipose tissue. Typically, this variant is cutaneous and affects the head and neck- only a handful of cases have been reported in the oral cavity. Here, we report four cases of intraoral lipomatous neurofibromas.</p></div><div><h3>Materials and Methods</h3><p>Cases for this series were retrieved from the archives of Oral Pathology Laboratory, Inc.</p></div><div><h3>Results</h3><p>Four cases were identified, two of which our laboratory have previously presented. Age at presentation ranged from 18 to 62 with a median of 35. Two male patients and two female patients were affected, with three of the tumors presenting on the hard palate and one presenting on the dorsal tongue. All tumors presented as a raised mass. No patients had a history of neurofibromatosis type 1. Immunohistochemical studies completed on the cases reveal S100 positivity, and negativity for CD99, CD34, and BCL2. Clinically, these tumors were often biopsied under suspicion of a salivary gland neoplasm.</p></div><div><h3>Conclusion</h3><p>Five cases of intraoral lipomatous neurofibroma have been reported to date- one by Shimoyama et al. and the four present cases. The histologic features identified here are concordant with previously described cases, both intraoral and cutaneous. This case series expands the known spectrum of this lesion. Greater recognition of this variant may help to identify the driving forces behind this histopathologic finding.</p></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 2","pages":"Page e37"},"PeriodicalIF":2.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malakoplakia of the Maxilla","authors":"Dr. Spencer Roark ,&nbsp;Dr. Carter Bruett ,&nbsp;Dr. Martin Dominger ,&nbsp;Dr. Paul Freedman ,&nbsp;Dr. Renee Reich","doi":"10.1016/j.oooo.2024.04.031","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.04.031","url":null,"abstract":"<div><h3>Introduction</h3><p>Malakoplakia is a rare inflammatory disorder which typically occurs in immunocompromised patients secondary to impaired bactericidal activity of macrophages. Histopathologically, it is characterized by a dense infiltrate of histiocytes with eosinophilic cytoplasm and Michaelis-Gutmann bodies, which are basophilic, round inclusions within macrophages. Malakoplakia commonly affects the genitourinary and gastrointestinal tracts but has been reported in other organs. Oral cavity involvement, however, is exceptionally rare. Here we present the first reported case of maxillary malakoplakia in an immunosuppressed patient.</p></div><div><h3>Materials and Methods</h3><p>This case was submitted to the Oral Pathology Laboratory, Inc. at New York-Presbyterian Queens.</p></div><div><h3>Case Report</h3><p>A 66-year-old male with a history of lung transplant presented with a non-healing extraction site of the left maxilla. To rule out a diagnosis of malignant neoplasm, the submitting clinician performed an incisional biopsy. Multiple pieces of tan-brown soft tissue measuring 2.3 × 2.0cm in aggregate were submitted for histopathologic examination.</p><p>Microscopic examination revealed a lesion composed of diffuse sheets of ovoid to spindle cells containing foamy cytoplasm. Numerous round, basophilic inclusions, consistent with Michaelis-Gutmann bodies, were noted within the cells. The inclusions were positive with von Kossa stain, indicating the presence of calcium. Immunohistochemical studies for CD68 were strongly positive, confirming a dense macrophage infiltrate. GMS and PAS stains were negative for the presence of microorganisms.</p></div><div><h3>Conclusions</h3><p>This is the first reported case of malakoplakia affecting the maxilla. Forty-nine previous cases of malakoplakia affecting the head and neck region have been published, with only 9 intraoral cases reported. Malakoplakia should be considered in the differential diagnosis of patients presenting with non-healing surgical sites, especially in those with a history of immunosuppression. Early diagnosis and prompt treatment are essential for successful management of this rare disease.</p></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 2","pages":"Pages e38-e39"},"PeriodicalIF":2.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistical Overview of Patients within a Yearly Quarter of Private Practice Oral Pathology","authors":"Ms. Cricket Wuebker ,&nbsp;Mr. Alex Nash ,&nbsp;Dr. Christel Haberland ,&nbsp;Dr. Carl Allen ,&nbsp;Dr. Ashleigh Briody","doi":"10.1016/j.oooo.2024.04.058","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.04.058","url":null,"abstract":"<div><p>This study investigates the patterns of patient quantity to diagnostic trends within a private practice oral pathology setting over a three-month period. A comprehensive data collection approach involved the extraction and analysis of relevant statistics, including the distinction of new versus established patients, the distribution of different diagnoses among these groups, and the overall number of patients who underwent procedures. By examining the interventions, and recommendations provided to patients following diagnosis, the research aims to enhance our understanding of the longitudinal care strategies employed by oral pathologists. The study utilizes a retrospective observational design, utilizing electronic health records and patient databases to ensure accurate and completeness of the dataset. Over three months, 1,542 patients were clinically examined, with an average of 33 patients per day, or 132 patients per week. Of these, 82% presented with lichenoid mucositis, 63% with leukoplakia, 22% with candidiasis, 15% with no evidence of recurrent disease following treatment, and 11% with burning mouth syndrome. There were an additional 60 diagnoses examined in this time period in smaller increments. Patients were placed into multiple diagnostic categories as they presented with multiple different lesions. Of the 1,542 patients examined, 351 had a biopsy procedure performed. The findings of this research contribute valuable information for what one can expect to see within a busy clinical oral pathology practice in a major metropolitan area. Understanding variations in the diagnostic landscape can inform personalized patient treatment plans and resource allocation. Additionally, insights into biopsy frequency enhances the understanding of the diagnostic process and may guide improvements in patient care, practice efficiency, and long-term oral health outcomes.</p></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 2","pages":"Pages e48-e49"},"PeriodicalIF":2.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sebaceous Carcinoma with Involvement of the Oral Cavity: A Case Report of a Rare Occurrence","authors":"Dr. Hisham Alshuaibi ,&nbsp;Prof Mohammed Islam ,&nbsp;Dr. Sarah Fitzpatrick ,&nbsp;Prof. Indraneel Bhattacharyya","doi":"10.1016/j.oooo.2024.04.038","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.04.038","url":null,"abstract":"<div><h3>Introduction</h3><p>Sebaceous carcinoma (SC) is an aggressive, rare cutaneous malignancy. It shows striking predilection for the skin of the eyelid, face, neck, and scalp, but may arise on any cutaneous site.. Extraorbital sites overall account for only approximately 25% of SCl, and the head and neck region is involved in 70% of cases. Involvement of the oral cavity in SC is rare. Hereby we present a case of cutaneous SC with direct extension and involvement of the oral mucosa.</p></div><div><h3>Case presentation</h3><p>A 25-year-old male presented with a painless ulcerated lesion on the left commissure area persisting for a duration of 3 months. The past medical history was unremarkable. Extra-oral examination showed a markedly ulcerated, exophytic, irregularly shaped mass of the left commissure extending to the labial and buccal mucosa. The lesion straddled the point of transition between mucosa and skin. The clinical differential diagnosis included squamous cell carcinoma, basal cell carcinoma, and salivary gland malignancy. On histopathological examination, a poorly differentiated malignant epithelial neoplasm with sebaceous differentiation was identified. Upon immunohistochemical testing, the neoplastic cells were strongly reactive for AE1/3, EMA, and CD15. In addition, CAM 5.2 and Ber-EP4 were also focally positive toward the periphery of the neoplastic islands. SOX10 was negative. The final diagnosis of sebaceous carcinoma was rendered. The patient was referred for oncologic treatment but lost to follow-up.</p></div><div><h3>Conclusion</h3><p>This case illustrates a rare case of SC with extension beyond its typical cutaneous boundaries into the oral mucosa. The presentation of SC in this manner underscores the complexity of diagnosing and managing such uncommon manifestations of skin cancers. This case reinforces that SC should be included in the differential diagnosis of lesions involving both skin and oral cavity and careful evaluation of both histopathology as well as immunohistochemistry is essential for accurate diagnosis.</p></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"138 2","pages":"Page e41"},"PeriodicalIF":2.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}