{"title":"Noncaseating granulomatous inflammation of the orofacial region and its potential association with underlying systemic disease: a clinicopathological analysis of 19 cases","authors":"Carter Milne, Bryan Trump","doi":"10.1016/j.oooo.2025.04.071","DOIUrl":"10.1016/j.oooo.2025.04.071","url":null,"abstract":"<div><h3>Introduction</h3><div>Noncaseating granulomatous inflammation can be an inconclusive finding in many cases involving the oral cavity that may steer clinicians toward forming a differential diagnosis including (1) Crohn’s disease, (2) sarcoidosis, (3) chronic oral infection, (4) foreign material, or (5) allergies. Nineteen clinical cases were identified from the biopsy database at the University of Utah between October 2021 and March 2023. The main objective was to compare the findings and diagnoses of these cases through the lens of similar studies in today’s literature to leave clinicians better informed about trends of both systemic involvement and the most common location of clinical presentation. Materials and Methods. Five parameters were chosen to be evaluated: (1) patient’s age, (2) gender, (3) diagnosis, (4) location differing from the most common site of the upper lip, and (5) the absence of any diagnostic tests performed to arrive at proper diagnosis.</div></div><div><h3>Results</h3><div>Ages ranged from 6 to 83 years old—median being 52—nine male, 10 female. None of the lesions were associated with Crohn’s or allergies. One specimen was associated with sarcoidosis, one tested positive for infection, two for foreign material contamination, and two that were consistent with lichen planus. The remaining 13 had no definitive diagnosis but were signed off less-specifically as orofacial granulomatosis. Only one case presented on the upper lip.</div></div><div><h3>Conclusions</h3><div>Although only six of the 19 specimens were determined to have a more definitive cause, the other 13 were only given a diagnosis of either noncaseating granulomatous inflammation or orofacial granulomatosis because further testing for systemic factors was not performed. The hope is that future studies will highlight how much more common systemic involvement proves to be when patients elect to follow through with further systemic testing—allowing clinicians to treatment plan better for patients with these conditions.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e90"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primordial odontogenic tumor: report of a rare case with a review of literature","authors":"Navneet Kaur Sehgal , Dwight Rice , Tsungju O-Lee , Mia Nepomuceno-Perez , Anupama Grandhi","doi":"10.1016/j.oooo.2025.04.049","DOIUrl":"10.1016/j.oooo.2025.04.049","url":null,"abstract":"<div><div>The primordial odontogenic tumor (POT) was first described in 2014. The term was used due to the histologic similarity of the tumor with the elements of the early stages of tooth development. It is a benign odontogenic tumor with epithelial and mesenchymal components. It occurs in the first and second decades of life. It is prevalent in the tooth-bearing areas of the mandible. Almost 18 cases have been published in peer-reviewed journals so far. It commonly presents as a well-defined pericoronal unilocular radiolucency. It is composed of fibromyxoid tissue with areas resembling the dental papilla and lined by epithelium that resembles the inner enamel epithelium of the enamel organ. Focal stellate reticulum-like cells can be seen external to the lining epithelium. A few cases in the literature have shown small focal calcifications. Treatment with conservative surgical excision appears to be curative, with no recurrence potential. Here we report a case of a primordial odontogenic tumor.</div></div><div><h3>Case</h3><div>An 8-year-old male patient presented to the Loma Linda University Ear, Nose, and Throat Surgery Department with a soft tissue mass in the right maxillary sinus along with a free-floating devitalized tooth. A clinical diagnosis of a maxillary cyst was made. A Caldwell-Luc (transantral) approach was utilized for enucleation of the lesion in the right maxillary sinus. A right maxillary antrostomy was also performed. The histopathology showed a biphasic tumor with an epithelial lining that was composed of columnar cells with focal stellate reticulum. A diagnosis of primordial odontogenic tumor was made based on the microscopic features. Upon a 2-year follow-up, the patient appears to have responded well to treatment with no evidence of recurrence.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e82"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prokopios P. Argyris , Gabrielle R. Dennis , Rajaram Gopalakrishnan , Ioannis Koutlas , John R. Kalmar , Kristin K. McNamara
{"title":"Oral soft tissue and jawbone sarcomas (OSTJS): a retrospective clinicopathologic analysis of 128 cases from two institutions","authors":"Prokopios P. Argyris , Gabrielle R. Dennis , Rajaram Gopalakrishnan , Ioannis Koutlas , John R. Kalmar , Kristin K. McNamara","doi":"10.1016/j.oooo.2025.04.053","DOIUrl":"10.1016/j.oooo.2025.04.053","url":null,"abstract":"<div><h3>Introduction</h3><div>Head/neck sarcomas comprise a heterogeneous group of malignant mesenchymal neoplasms accounting for 1%-2% of all head/neck cancers and 4%-10% of all sarcomas in adults. Head/neck sarcomas exhibit aggressive biologic behavior with 5-year survival of 46%-60%. Studies regarding OSTJS are scarce. We present the collaborative experience with OSTJS from two academic institutions.</div></div><div><h3>Materials and Methods</h3><div>Archived OSTJS cases (2000-2022) were retrieved from the electronic laboratory databases of the oral pathology services at Ohio State University and University of Minnesota. Patient age and gender, anatomic site, and histopathologic subtype were recorded. Cases with incomplete information and/or diagnosis of spindle cell carcinoma or myeloid sarcoma were excluded.</div></div><div><h3>Results</h3><div>From a total of 128 OSTJS cases, 123 (96.1%) were primary and 5 (3.9%) metastatic. Seventy-seven (60.2%) cases affected men and 51 (39.8%) women (age range: 4-102 years). Favored sites included the mandible (48, 37.5%), maxilla (39, 30.4%), gingiva (15, 11.7%), palate (13, 10.2%), and tongue (4, 3.1%). OSTJS showed a predilection for adults (113, 88.3%; mean age: 52.2 years) with only 15 pediatric examples (11.7%; age range: 4-18 years, mean: 12.8 years). All but one pediatric OSTJS were intraosseous (14, 93.3%). The pediatric OSTJS included osteosarcoma (8, 53.3%), Ewing sarcoma (4, 26.7%), and 1 each (6.7%) of mesenchymal chondrosarcoma, <em>TFCP2::EWSR1</em> rhabdomyosarcoma, and alveolar soft part sarcoma. In adults, the most frequent tumors were osteosarcoma (58, 51.3%), Kaposi sarcoma (KS; 18, 15.9%), leiomyosarcoma (7, 6.2%), chondrosarcoma (6, 5.3%), angiosarcoma (5, 4.4%), and 4 each (3.5%) of rhabdomyosarcoma and undifferentiated pleomorphic sarcoma. The most common oral soft tissue sarcoma was KS (18 of 39, 46.2%).</div></div><div><h3>Conclusions</h3><div>OSTJS are uncommon with a strong predilection for the jawbones of males in their 4th decade. Osteosarcoma is the predominant sarcoma in both the pediatric and adult populations. Although OSTJS are chiefly primary tumors, metastatic sarcomas to the oral cavity may infrequently occur.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e83"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Moni Ahmadian , Sonal Shah , Jean Shen , Joseph Lasky
{"title":"Dentoalveolar manifestations as the presenting sign of Gardner syndrome","authors":"Moni Ahmadian , Sonal Shah , Jean Shen , Joseph Lasky","doi":"10.1016/j.oooo.2025.04.009","DOIUrl":"10.1016/j.oooo.2025.04.009","url":null,"abstract":"<div><h3>Background</h3><div>Gardner syndrome (GS) is a rare variant of familial adenomatous polyposis (FAP) associated with highly penetrant mutations involving the <em>adenomatous polyposis coli (APC)</em> tumor suppressor gene. Although GS is typically inherited as an autosomal dominant trait, approximately 30% of cases may represent de novo mutations. GS is classically characterized by multiple premalignant gastrointestinal polyps, osteomas, epidermoid cysts, and both cutaneous and subcutaneous soft tissue tumors. However, in correlation with the specific position of the mutations within the <em>APC</em> gene, GS demonstrates variable clinical expressivity. Between 22% and 30% of patients with GS present with dental abnormalities consisting of multiple impacted teeth, supernumerary teeth, and odontomas. These dental abnormalities may precede the intestinal manifestations and may serve as a key feature in early diagnosis of this syndrome.</div></div><div><h3>Case Summary</h3><div>A 14-year-old, otherwise healthy and asymptomatic, female patient presented to the orthodontic clinic with complaint of over-retained primary teeth. Clinical and radiographic evaluation revealed multiple impacted permanent teeth, micro-odontomas, and areas of sclerotic dense bone without significant facial deformity. On further inquiry, no familial pattern is identified within the patient’s immediate family. Subsequent medical and imaging workup led to identification of multiple adenomatous and tubular gastrointestinal polyps and a paraspinal desmoid fibromatosis. Further genetic studies confirmed a diagnosis of GS.</div></div><div><h3>Conclusion</h3><div>This case highlights the significance of recognition of the dentoalveolar manifestations in the early diagnosis of GS emphasizing on the importance of interdisciplinary collaboration and maintaining open communication with other healthcare practitioners. Dental clinicians may serve a key role in the early diagnosis and instigation of adequate treatment of this life-threatening rare syndrome.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Pages e69-e70"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khadijah Bagazi, Reem Alrabiah, Jose Luis Tapia, Alfredo Aguirre
{"title":"Plasma cell myeloma of the mandible: a case report","authors":"Khadijah Bagazi, Reem Alrabiah, Jose Luis Tapia, Alfredo Aguirre","doi":"10.1016/j.oooo.2025.04.076","DOIUrl":"10.1016/j.oooo.2025.04.076","url":null,"abstract":"<div><div>Plasma cell myeloma (PCM, also known as multiple myeloma [MM]), is a bone marrow malignant proliferation of monoclonal plasma cells accompanied by serum or urine M protein. In contrast, solitary plasmacytoma of bone (SPB) is a localized monoclonal proliferation of plasma cells without bone marrow involvement. In the head and neck region, PCM and/or SPB present in the jaws, mostly in the posterior mandible. Typically, with nonspecific and ambiguous symptoms. Microscopically, these tumors have to be separated from florid inflammatory plasma cell-rich lesions. The aim of this report is to present a case of PCM of the mandible. A 59-year-old female was referred for evaluation of an asymptomatic mandibular lesion. Intraoral examination showed no expansion of the affected area. A panoramic radiograph revealed a circumscribed, noncorticated radiolucency in the left posterior body of the mandible. The patient’s medical history was noncontributory. A biopsy was obtained, and the tissue was fixed in 10% buffered formalin. Microscopic examination showed sheets of densely infiltrative atypical cells with eccentric nuclei and clockface chromatin displaying plasma cell morphology. Immunohistochemical examination showed CD138 and lambda light chain positivity. Kappa light chain, CD3, CD20, and MPO were negative. In view of the patient’s unremarkable past medical history, the diagnosis rendered was consistent with solitary plasmacytoma. However, the patient was referred to an oncological center for a complete work-up and a diagnosis of multiple myeloma was established. Clinical history, immunohistochemical stains, and laboratory studies are essential for the diagnosis of PCM.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e91"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spencer Roark, Leigh Griffin, Carter Bruett, Paul Freedman, Reneé Reich
{"title":"Oral malignant B-cell neoplasms: a retrospective study","authors":"Spencer Roark, Leigh Griffin, Carter Bruett, Paul Freedman, Reneé Reich","doi":"10.1016/j.oooo.2025.04.072","DOIUrl":"10.1016/j.oooo.2025.04.072","url":null,"abstract":"<div><h3>Introduction</h3><div>Non-Hodgkin lymphomas (NHL) are malignant neoplasms derived from lymphocyte progenitor cells, commonly B-lymphocytes. When present in the oral cavity, they typically arise as extranodal masses of soft tissues or gnathic bones. This diverse group of diseases comprises the second most common primary malignancy affecting the oral cavity. The objective of this study is to examine characteristics among patients diagnosed with intraoral malignant B-cell neoplasms by our laboratory.</div></div><div><h3>Materials and Methods</h3><div>Histologic, demographic, and clinical data were collected from 103 cases of malignant B-cell lymphoma from 2016 to 2022. Immunohistochemical staining was performed in all cases and molecular studies in some to confirm diagnoses and further classify the tumors.</div></div><div><h3>Results</h3><div>Malignant B-cell neoplasms comprised 7.2% of the malignancies diagnosed in our laboratory between 2016 and 2022. Diffuse large B-cell lymphoma (DLBCL) was the most common subtype of NHL diagnosed; of the 40 cases of DLBCL, 14 were of germinal center origin. A total of 2 double-hit NHLs and 2 triple-hit NHLs were diagnosed. Other subtypes included 31 cases of plasmacytoma, 14 follicular lymphomas, 6 plasmablastic lymphomas, and 5 marginal zone lymphomas. Mean age at diagnosis was 64 years old. Females were affected slightly more often. The most common location was within the mandible, with 25 NHLs occurring in this site, followed by the maxilla (14) and hard palate (14); of the 25 tumors noted within the mandible, 15 were plasmacytomas, which comprised roughly half of the plasmacytomas diagnosed at our institution from 2016 to 2022. Reported clinical symptoms included mild pain, paresthesia, and tooth mobility, while presentations ranged from boggy to firm masses or swellings.</div></div><div><h3>Conclusions</h3><div>Our review is consistent with previously published reports with respect to demographics and prevalence of DLBCL subtype. Although the occurrence of primary oral NHL is rare, differential diagnoses of potential intraoral malignancy should include B-cell neoplasms.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e90"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincent Lavoie, Ethan Lee, Deepika Chugh, Iona Leong, Justin Bubola, Grace Bradley, Marco Magalhaes
{"title":"Spatial transcriptomic analysis of oral epithelial dysplasia reveals unique differentially expressed genes and microenvironment changes","authors":"Vincent Lavoie, Ethan Lee, Deepika Chugh, Iona Leong, Justin Bubola, Grace Bradley, Marco Magalhaes","doi":"10.1016/j.oooo.2025.04.082","DOIUrl":"10.1016/j.oooo.2025.04.082","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral epithelial dysplasia (OED) may progress to oral squamous cell carcinoma (OSCC) but the genetic changes underlying progression are not well understood and the risk of progression cannot be accurately predicted. The purpose of this study was to use spatial transcriptomics to characterize the genetic signatures underlying OED progression to OSCC.</div></div><div><h3>Materials and Methods</h3><div>A 10-year retrospective analysis of OSCC cases with preceding biopsy specimens of OED was conducted. A total of 27 pairs of OSCC with previous OED and matching 28 pairs of sequential biopsies showing nonprogressing OED were selected based on clinicopathologic characteristics. All cases were assessed by three oral pathologists to confirm the diagnosis and evaluate the inflammatory response. A tissue microarray containing 126 patient samples was constructed. Spatial transcriptomic analysis was performed using Nanostring GeoMx DSP® in pan-cytokeratin positive (dysplastic epithelium or OSCC) and negative (stroma) areas. Differential gene expression (DE), cell abundance, and pathway enrichment analysis were performed.</div></div><div><h3>Results</h3><div>A total of 3 genes were differentially expressed in the epithelial component of progressing OED specimens (log<sub>2</sub>fold change >0.7, <em>P</em> < .01), while 41 genes were differentially expressed in OSCC compared to the corresponding premalignant sample (log<sub>2</sub>fold change >1.0, <em>P</em> < .01). Pathways involved in extracellular matrix organization, immune system response, and cell migration were enriched during malignant transformation. Cell deconvolution revealed an increase in fibroblasts (<em>P</em> = .013) and neutrophils (<em>P</em> = .005) in OSCC.</div></div><div><h3>Conclusion</h3><div>Spatial profiling of progressing OED revealed unique DE and microenvironment changes detectable before malignant transformation and highlights the critical role of immune responses in progression. Further studies will validate potential prognostic biomarkers and dissect the role of biological pathways involved in oral cancer progression.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Pages e93-e94"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Abdolrahmani , Neda Kardouni Khoozestani , Mehrdad Jafari
{"title":"Microcystic adnexal carcinoma of the nose: report of a challenging case","authors":"Ali Abdolrahmani , Neda Kardouni Khoozestani , Mehrdad Jafari","doi":"10.1016/j.oooo.2025.04.033","DOIUrl":"10.1016/j.oooo.2025.04.033","url":null,"abstract":"<div><h3>Introduction</h3><div>Microcystic adnexal carcinoma (MAC), also known as sclerosing sweat duct carcinoma and syringomatous carcinoma, is a rare and slow-growing cutaneous malignancy that primarily affects the head and neck region. MAC is locally aggressive and deeply infiltrative tumor with a high risk of local recurrence. Its margins can invade significantly beyond the extent clinically suspected, making it difficult to completely remove the tumor cells.</div></div><div><h3>Materials and Methods</h3><div>A 70-year-old male patient presented to our clinic with an extensive lesion involving the nose, provisionally diagnosed as a malignant adnexal tumor with foci suspicious of basal cell carcinoma based on the incisional biopsy. Under general anesthesia, surgical excision of the tumor was performed.</div></div><div><h3>Results</h3><div>Histologic examination confirmed the diagnosis of MAC, with a tumor size of 3.5 × 3 cm. As the surgical margins were microscopically involved with the tumor, the patient underwent radiotherapy.</div></div><div><h3>Conclusions</h3><div>In some cases of MAC, the lesion may not be diagnosed before advanced stages. Due to the tumor’s locally aggressive behavior and high risk of recurrence, achieving free margins may require a large surgical defect, which poses a significant challenge in the head and neck region, the most common site of involvement. Therefore, close follow-up of suspected lesions and performing a deep biopsy for early diagnosis can significantly reduce postoperative complications.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Pages e77-e78"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carter Bruett, Spencer Roark, Reneé Reich, Paul Freedman
{"title":"Dysgenetic polycystic disease of the minor salivary glands of the tongue","authors":"Carter Bruett, Spencer Roark, Reneé Reich, Paul Freedman","doi":"10.1016/j.oooo.2025.04.040","DOIUrl":"10.1016/j.oooo.2025.04.040","url":null,"abstract":"<div><div>Here we present a case of a 55-year-old male who presented with a 0.5 × 0.5 mm tissue-colored nodule of the lateral tongue. After histopathologic analysis, a diagnosis of dysgenetic polycystic disease was made. Dysgenetic polycystic disease, which has also been called “polycystic disease” or “polycystic parotid disease,” is a very rare developmental abnormality affecting the salivary gland duct system. The histology is distinct, showing numerous closely-packed cystic spaces lined by a bilayer of salivary-type epithelial cells and myoepithelial cells with occasional spherolith-like calcifications. This entity has been reported in only 20 patients previously. In previously reported cases, this lesion presents bilaterally affecting the parotid gland or rarely the submandibular gland. The present case report details the first time dysgenetic polycystic disease is found affecting the minor salivary glands of the tongue. Immunohistochemical findings are presented and include positivity for AE1/AE3 in luminal cells, positive p63 in the abluminal cells, scattered positive SMA in the abluminal cells, PAS-positive diastase resistant spheroliths, and negativity for Congo red, progesterone receptor, mammaglobin, S100.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Page e80"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Distant metastases to the submandibular gland—WHO, WHEN and WHAT","authors":"Irit Allon","doi":"10.1016/j.oooo.2025.04.015","DOIUrl":"10.1016/j.oooo.2025.04.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Metastases to the salivary glands mostly originate from squamous cell carcinomas of the head and neck region, followed by melanomas, and they comprise 5% of all salivary gland tumors. In this study, we present a case of metastatic renal cell carcinoma to the submandibular gland parenchyma and aim at characterizing metastatic tumors of the submandibular gland.</div></div><div><h3>Materials and methods</h3><div>An online search was conducted through the PubMed, MEsH, and PMC databases. Included were studies and case reports that presented metastases of nonhead and neck cancers to the submandibular gland.</div></div><div><h3>Results</h3><div>A total of 42 cases of submandibular gland metastases were found. The majority (13, 30.9%) originated from a primary kidney tumor, followed by Lung (7, 16.6%) and breast (6, 14.2%) tumors. There was a strong female predilection with 1.8: 1 F:M ratio. The average age was 60.7+ years that ranged from 28 to 97 years. 26 (61.9%) of the patients were treated by excision of the affected gland. Twenty-six (61.9%) had follow-up survival data, with average survival of 19.48+ months post-treatment of the submandibular metastases. The submandibular metastases were the first sign of malignancy in 10 (23.8%) of the cases and first sign of diagnosed metastatic disease in 25 (59.5%) patients. Additional metastases were reported in 24 (57.1%) of the patients, while 4 (9.5%) patients presented with solitary submandibular metastases, and the rest (14, 33.3%) had no data regarding additional metastases.</div></div><div><h3>Conclusion</h3><div>Submandibular salivary gland metastases are rare. There is a non-negligible percentage of cases in which these metastases are the first signs of an undiagnosed distal malignancy and/or an undiagnosed metastatic disease.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 3","pages":"Pages e71-e72"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}