口腔恶性b细胞肿瘤的回顾性研究

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-07-21 DOI:10.1016/j.oooo.2025.04.072

Spencer Roark, Leigh Griffin, Carter Bruett, Paul Freedman, Reneé Reich

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引用次数: 0

摘要

非霍奇金淋巴瘤（NHL）是源于淋巴细胞祖细胞的恶性肿瘤，通常是b淋巴细胞。当出现在口腔时，它们通常以结外软组织或颌骨肿块的形式出现。这一种类繁多的疾病是影响口腔的第二常见的原发性恶性肿瘤。本研究的目的是检查经我们实验室诊断为口腔内恶性b细胞肿瘤的患者的特征。材料与方法收集2016 - 2022年103例恶性b细胞淋巴瘤的组织学、人口学和临床资料。所有病例均行免疫组化染色，部分病例行分子研究，以确认诊断和进一步分类肿瘤。结果2016 - 2022年，恶性肿瘤诊断中，恶性b细胞肿瘤占7.2%。弥漫性大b细胞淋巴瘤（DLBCL）是NHL最常见的亚型；40例DLBCL中，生发中心起源14例。共诊断出2例双打型NHLs和2例三打型NHLs。其他亚型包括浆细胞瘤31例，滤泡性淋巴瘤14例，浆母细胞淋巴瘤6例，边缘区淋巴瘤5例。确诊时的平均年龄为64岁。女性受影响的几率略高。最常见的位置是下颌骨，25例nhl发生在该部位，其次是上颌骨（14例）和硬腭（14例）；在下颌骨发现的25个肿瘤中，有15个是浆细胞瘤，约占我院2016年至2022年诊断出的浆细胞瘤的一半。报告的临床症状包括轻度疼痛、感觉异常和牙齿活动，而表现从沼泽到坚固的肿块或肿胀不等。结论我们的回顾与先前发表的关于DLBCL亚型的人口统计学和患病率的报告是一致的。虽然原发性口腔非霍奇金淋巴瘤的发生是罕见的，潜在的口腔内恶性肿瘤的鉴别诊断应包括b细胞肿瘤。

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Oral malignant B-cell neoplasms: a retrospective study

Introduction

Non-Hodgkin lymphomas (NHL) are malignant neoplasms derived from lymphocyte progenitor cells, commonly B-lymphocytes. When present in the oral cavity, they typically arise as extranodal masses of soft tissues or gnathic bones. This diverse group of diseases comprises the second most common primary malignancy affecting the oral cavity. The objective of this study is to examine characteristics among patients diagnosed with intraoral malignant B-cell neoplasms by our laboratory.

Materials and Methods

Histologic, demographic, and clinical data were collected from 103 cases of malignant B-cell lymphoma from 2016 to 2022. Immunohistochemical staining was performed in all cases and molecular studies in some to confirm diagnoses and further classify the tumors.

Results

Malignant B-cell neoplasms comprised 7.2% of the malignancies diagnosed in our laboratory between 2016 and 2022. Diffuse large B-cell lymphoma (DLBCL) was the most common subtype of NHL diagnosed; of the 40 cases of DLBCL, 14 were of germinal center origin. A total of 2 double-hit NHLs and 2 triple-hit NHLs were diagnosed. Other subtypes included 31 cases of plasmacytoma, 14 follicular lymphomas, 6 plasmablastic lymphomas, and 5 marginal zone lymphomas. Mean age at diagnosis was 64 years old. Females were affected slightly more often. The most common location was within the mandible, with 25 NHLs occurring in this site, followed by the maxilla (14) and hard palate (14); of the 25 tumors noted within the mandible, 15 were plasmacytomas, which comprised roughly half of the plasmacytomas diagnosed at our institution from 2016 to 2022. Reported clinical symptoms included mild pain, paresthesia, and tooth mobility, while presentations ranged from boggy to firm masses or swellings.

Conclusions

Our review is consistent with previously published reports with respect to demographics and prevalence of DLBCL subtype. Although the occurrence of primary oral NHL is rare, differential diagnoses of potential intraoral malignancy should include B-cell neoplasms.

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.