LED-based low-level light therapy for oral mucositis in cancer patients: a systematic review and GRADE analysis

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-04-22 DOI:10.1016/j.oooo.2025.04.095

Betsy Joseph PhD , Matti Mauramo PhD , Timo Sorsa PhD , Sukumaran Anil PhD , Tuomas Waltimo PhD

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引用次数: 0

Abstract

Objective

This systematic review aimed to evaluate the efficacy of light-emitting diode (LED) therapy in reducing oral mucositis (OM) severity, pain, and healing time in cancer patients and compare it to standard care or sham light.

Materials and methods

A comprehensive search of major databases was conducted using relevant MeSH terms and keywords. Two authors independently screened studies meeting the eligibility criteria. The Cochrane Risk-of-Bias tool for randomized controlled trials (RoB-2) and the Risk of Bias in Non-Randomized Studies - of Interventions (ROBINS-I) were used to assess the methodological quality of included studies. The certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.

Results

The review included five studies (256 participants). Four studies reported significant improvements in OM severity and pain with LED therapy while only one study suggested improved healing time. The risk of bias was moderate among the included studies. Due to heterogeneous data, a meta-analysis could not be performed. The GRADE assessment indicated low certainty of evidence, highlighting the need for further clinical research.

Conclusion

LED therapy may effectively manage cancer therapy-induced OM by reducing patient-reported pain and OM duration. However, the low certainty of evidence warrants more well-designed, longitudinal studies with larger sample sizes to confirm these findings and establish optimal treatment protocols.

查看原文本刊更多论文

基于led的低强度光治疗癌症患者口腔黏膜炎：系统回顾和GRADE分析。

目的：本系统综述旨在评估发光二极管（LED）治疗在减轻癌症患者口腔黏膜炎（OM）严重程度、疼痛和愈合时间方面的疗效，并将其与标准治疗或假光进行比较。材料和方法：利用相关MeSH术语和关键词对各大数据库进行全面检索。两位作者独立筛选了符合资格标准的研究。采用Cochrane随机对照试验的偏倚风险工具（rob2）和非随机干预研究的偏倚风险工具（ROBINS-I）来评估纳入研究的方法学质量。采用推荐、评估、发展和评价分级（GRADE）方法评估证据的确定性。结果：纳入5项研究（256名受试者）。四项研究报告了LED治疗对OM严重程度和疼痛的显著改善，而只有一项研究表明改善了愈合时间。在纳入的研究中，偏倚风险为中等。由于数据异构，不能进行meta分析。GRADE评估表明证据的确定性较低，强调需要进一步的临床研究。结论：LED疗法可通过减少患者报告的疼痛和OM持续时间来有效管理癌症治疗诱导的OM。然而，证据的低确定性需要更多精心设计的、更大样本量的纵向研究来证实这些发现并建立最佳治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.