特立帕肽作为治疗晚期药物相关性颌骨骨坏死的辅助疗法。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-04-10 DOI:10.1016/j.oooo.2025.04.001

Annu Singh BDS , Kevin Chung DDS, MSD , Joseph M. Huryn DDS, FAAMP , Cherry L. Estilo DMD , Azeez Farooki MD , SaeHee K. Yom DDS, MPH

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引用次数: 0

摘要

特立帕肽，重组人甲状旁腺激素，是美国食品和药物管理局（FDA）批准的用于治疗男性和绝经后妇女骨质疏松症的药物。最近的研究表明，它可以促进颌骨药物相关性骨坏死（MRONJ）的骨愈合。我们描述了一个成功的管理与特立帕肽治疗晚期MRONJ的案例，最初是为骨质疏松症规定的。该病例表明，对于伴有明显疼痛和频繁急性感染发作的进行性MRONJ患者，特立帕肽可能是治疗MRONJ的可行辅助药物，并有助于缓解症状和改善生活质量。（口腔外科、口腔医学、口腔病理、口腔放射学；年；卷：页范围）。

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Teriparatide as an adjuvant therapy in the management of advanced-stage medication-related osteonecrosis of the jaw

Teriparatide, recombinant human parathyroid hormone, is a US Food and Drug Administration (FDA)-approved drug used for the treatment of osteoporosis in men and postmenopausal women. Recent studies have shown that it may promote bone healing in medication-related osteonecrosis of the jaw (MRONJ). We describe a case of successful management of advanced-stage MRONJ with teriparatide therapy that was initially prescribed for osteoporosis. This case demonstrates that in patients with progressive MRONJ with significant pain and frequent flares of acute infection, teriparatide may be a viable adjunct in treating MRONJ, as well as helping alleviate symptoms and improve quality of life. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.