Oral potentially malignant disorders: clinical-pathological correlations in a dental institution in North Carolina

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-04-18 DOI:10.1016/j.oooo.2025.04.003

Jarod Ruffing , Oscar Jaimes , David Paquette , Heather Khosa , Eric Holmes , Andres Flores-Hidalgo

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引用次数: 0

Abstract

Objective

To investigate the prevalence and diagnostic accuracy of oral potentially malignant disorders (OPMDs) in North Carolina, focusing on the agreement between clinical impressions and microscopic diagnoses.

Study Design

This retrospective study analyzed 76 patient records from the East Carolina University Oral Pathology Biopsy Service. Clinical impressions of OPMDs, including leukoplakia, erythroplakia, and chronic ulcers, were compared with histopathological diagnoses. Data were collected using HIPAA-compliant software, and Cohen’s Kappa was used to evaluate diagnostic agreement.

Results

The patient cohort had a mean age of 62.2 years, with 65.7% male and 60.5% identifying as Caucasian. The most common lesion locations were the lateral tongue (32.8%) and alveolar ridge mucosa (27.6%). Minimal agreement was observed between clinical impressions and microscopic diagnoses (Kappa: 0.0266 ± 0.0682, P = .6965). Smoking and alcohol use were significantly associated with higher grades of oral epithelial dysplasia.

Conclusion(s)

The study highlights significant diagnostic challenges in identifying OPMDs based on clinical impressions alone, emphasizing the need for histopathological evaluation. Improved diagnostic training and public health interventions are essential to enhance early detection and reduce the burden of oral cancer in North Carolina.

查看原文本刊更多论文

口腔潜在恶性疾病：临床病理相关性在北卡罗莱纳牙科机构。

目的：探讨北卡罗莱纳州口腔潜在恶性疾病（OPMDs）的患病率和诊断准确性，重点关注临床印象与显微镜诊断之间的一致性。研究设计：本回顾性研究分析了东卡罗莱纳大学口腔病理活检服务的76例患者记录。将opmd的临床表现，包括白斑、红斑和慢性溃疡，与组织病理学诊断进行比较。使用符合hipaa的软件收集数据，并使用Cohen's Kappa评估诊断一致性。结果：患者队列平均年龄为62.2岁，男性占65.7%，白种人占60.5%。最常见的病变部位为舌侧（32.8%）和牙槽嵴粘膜（27.6%）。临床印象与显微镜诊断之间的一致性极小（Kappa: 0.0266±0.0682,P = .6965）。吸烟和饮酒与较高程度的口腔上皮发育不良显著相关。结论：该研究强调了仅根据临床印象识别opmd的重大诊断挑战，强调了组织病理学评估的必要性。改进诊断培训和公共卫生干预措施对于加强北卡罗莱纳州口腔癌的早期发现和减轻口腔癌负担至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.