International Journal of Chronic Obstructive Pulmonary Disease最新文献

{"title":"Body Mass Index and Lung Function in Hospitalized Severe AECOPD Patients: Investigating Nonlinear Associations and the Role of Hemoglobin.","authors":"Cong Zhang, Wenhao Ling, He Pan, Rui Bai, Li He","doi":"10.2147/COPD.S521112","DOIUrl":"https://doi.org/10.2147/COPD.S521112","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and mortality. Patients hospitalized with severe acute exacerbations of COPD (AECOPD) represent a high-risk group with poor outcomes and accelerated lung function decline. Body mass index (BMI) shows inconsistent associations with lung function across populations, and its role in AECOPD remains unclear. Understanding this relationship may improve clinical management. Hemoglobin (Hb), essential for oxygen transport, may further influence this association through physiological mechanisms. This study aimed to explore the relationship between BMI and lung function in hospitalized patients with severe AECOPD and to assess whether BMI influences length of hospital stay (LOHS), while evaluating the potential modifying role of Hb.</p><p><strong>Methods: </strong>A retrospective, single-center cross-sectional study was conducted among 579 patients hospitalized for severe AECOPD from 2021 to 2023. Data on BMI, lung function, Hb levels, and LOHS were collected. Nonlinear and threshold effect analyses were used to explore associations between BMI and lung function or LOHS. Subgroup analyses assessed the modifying effect of Hb.</p><p><strong>Results: </strong>BMI exhibited a nonlinear positive association with FEV1, FVC, FEV1% predicted, and FVC% predicted. Thresholds were identified at 25.39 kg/m² for FEV1, 26.23 kg/m² for FEV1% predicted, 21.67 kg/m² for FVC, and 22.19 kg/m² for FVC% predicted. The association was more pronounced in patients with higher Hb levels. No significant association was found between BMI and LOHS, suggesting that other factors such as infection severity, comorbidities, or treatment strategies may may exert greater influence.</p><p><strong>Conclusion: </strong>A nonlinear, inverse L-shaped association was observed between BMI and lung function, further modified by Hb levels. These findings highlight the importance of individualized treatment and stratification strategies in severe AECOPD. Future longitudinal studies are needed to validate these observations.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1309-1320"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Laboratory-Derived Frailty Index on Clinical Outcomes in Critical Care Patients with COPD: A Retrospective Analysis Using the MIMIC-IV Database.","authors":"Zhihu Zhou, Yixing He, Qianqian Wang, Jian Li, Yi Yu","doi":"10.2147/COPD.S518633","DOIUrl":"https://doi.org/10.2147/COPD.S518633","url":null,"abstract":"<p><strong>Background and objective: </strong>Chronic obstructive pulmonary disease (COPD) is associated with high mortality and morbidity worldwide. Notably, 20% of COPD patients are admitted to the ICU, and among them, there is a 25% mortality rate. Therefore, identifying novel risk factors for effective intervention is crucial for managing COPD. This research aims to investigate the relationship between the physiological and laboratory - based frailty index (FI - Lab) and mortality among critical care patients with COPD.</p><p><strong>Methods: </strong>The FI-Lab was constructed using 33 items. This index was used to quantify the frailty level of critically ill patients with COPD in the ICU. We analyzed data from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. Our study group consisted of 6825 COPD patients with an average age of 65.8 ± 14.8 years, and 52.2% of them were male. The primary outcomes were 30-day and 90-day mortality rates. Multivariable Cox regression was used for statistical analysis. Propensity score matching (PSM) was applied to ensure robustness.</p><p><strong>Results: </strong>In total, 6825 patients were included in the study, and the PSM cohort had 1282 patients. Both continuous and categorical increases in the FI-Lab were significantly associated with higher mortality (<i>P</i> < 0.001). These results were further validated by PSM. Subgroup analyses corroborated these findings. Restricted cubic splines illustrated a linear relationship between the FI-Lab and mortality. Kaplan-Meier analysis revealed significantly reduced 90-day survival with increasing FI-Lab (Log rank test, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Elevated FI-Lab is an independent predictor of increased mortality in critical care patients with COPD. Further randomized controlled trials are required to confirm these results and refine patient management strategies.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1335-1346"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 12 weeks of Head-Down Strong Abdominal Breathing Training on Gait and Cognitive Function in Patients with Chronic Obstructive Pulmonary Disease.","authors":"Feiyun Song, Kexin Ding, Wen Sun, Qiong Huang, Ruichen Jiang, Heping Xiang, Mingyun Sun","doi":"10.2147/COPD.S514766","DOIUrl":"https://doi.org/10.2147/COPD.S514766","url":null,"abstract":"<p><strong>Background: </strong>As chronic obstructive pulmonary disease (COPD) progresses, it can limit physical activity, resulting in reduced mobility. And patients with COPD have a higher incidence of cognitive impairment compared to normal individuals. The aim of this study was to investigate the effect of breathing training in COPD patients' gait and cognitive function by changing the body position.</p><p><strong>Study design and methods: </strong>Eighty-three COPD patients were recruited and randomized (1:1:1) into a head-down strong abdominal breathing training group (HDBT), a head-down training group (HDT), and a strong abdominal breathing training group (BT). Cognitive function and gait performance were assessed after the intervention by comparing patients' stride frequency, stride length, step speed and Montreal cognitive assessment(MoCA) scores.</p><p><strong>Results: </strong>63 patients completed this study. After 12 weeks, in terms of Obstacle walking tasks gait, the HDBT group significantly improved the performance of COPD patients in obstacle walking tasks in terms of stride length (73.29±0.64, P<0.001), step speed (97.73±0.47, P=0.018) performance. At the same time, we also found that there was no statistical difference in the gait performance of each group in the walking task (P > 0.05). In terms of cognition, cognitive function scores(MoCA) were significantly higher in HDBT (P<0.001) HDT (P<0.001), and BT (P<0.001) compared to baseline.</p><p><strong>Conclusion: </strong>A 12-week HDBT program elevated cognitive function and improved stride length and speed metrics during an obstacle walking task in patients with stable COPD.</p><p><strong>Clinical trial registration number: </strong>chictr2400080452(30/01/2024).</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1347-1359"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Psychometric Evaluation of an Instrument to Assess Physical Activity Participation Behavior Among Chinese Patients with Chronic Obstructive Pulmonary Disease.","authors":"Yuanyu Liao, Huan Wang, Yuxin Zhan, Yunfang Liu, Weiwei Wang, Hui Ke, Fenfen Lan, Qiongge Zhi, Wang Li, Jiaohua Yu","doi":"10.2147/COPD.S511061","DOIUrl":"10.2147/COPD.S511061","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop and evaluate a psychometrically reliable tool specifically designed to assess physical activity participation behavior in COPD patients in China.</p><p><strong>Patients and methods: </strong>Using the Motivation-Opportunity-Ability (MOA) model as a framework, a scale was developed and evaluated through literature and guideline reviews, qualitative research, interdisciplinary expert consultations (n=21), and a pilot trial (n=50). A sample of COPD patients diagnosed over a year was randomly divided into two groups for exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) to test the factor structure. The scale's content validity, internal consistency and test-retest reliability were further assessed.</p><p><strong>Results: </strong>433 COPD patients from four hospitals in a city in China participated in this study. The final scale included 32 items and demonstrated good internal consistency, with a Cronbach's α of 0.956 and a test-retest reliability of 0.777. The EFA identified four dimensions, with factor loadings ranging from 0.530 to 0.799, explaining 60.338% of the total variance: Motivation (5 items), Opportunity (12 items), Ability (9 items), and Behavior (6 items). The CFA confirmed that the four-dimensional model fit the data well: χ²/df = 1.891, standardized root mean residual (SRMR) = 0.0497, root mean square error of approximation (RMSEA) = 0.064, comparative fit index (CFI) = 0.927, Tucker-Lewis index (TLI) = 0.921.</p><p><strong>Conclusion: </strong>The Physical Activity Participation Behavior Scale for COPD patients demonstrated good reliability and validity and can be used to assess physical activity participation in individuals with COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1321-1334"},"PeriodicalIF":2.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of and Attitudes Towards Standard Care in Patients with COPD.","authors":"Maximilian Zimmermann, Charlotte Maria von Plessen, Doreen Kroppen, Sarah B Stanzel, Melanie Berger, Maximilian Wollsching-Strobel, F Feldmeyer, Cornelius Kellner, Tim Mathes, Wolfram Windisch, Daniel S Majorski","doi":"10.2147/COPD.S489395","DOIUrl":"https://doi.org/10.2147/COPD.S489395","url":null,"abstract":"<p><strong>Objective: </strong>Health-related-quality-of-life is frequently reduced following intensive care treatment. Unwarranted or unwanted therapeutic interventions should be avoided at all costs. Since COPD patients are often faced with difficult decisions, an assessment was made of their desire for disease education. Our aim was to identify patients understanding of their disease and what their attitudes are towards different treatment options and whether this correlates to demographic factors.</p><p><strong>Methods: </strong>The COPD-Assessment-Test (CAT) was used to measure subjective disease burden. The COPD-Questionnaire (COPD-Q) was used to assess subjects' own knowledge of their disease. In addition, a specifically designed questionnaire was used to assess patient's subjective level of desire to be educated on COPD-specific topics. A multiple linear regression analysis was performed to identify the demographic factors associated with a greater desire for disease-specific information.</p><p><strong>Results: </strong>127 patients (67.2±8.8 years) were prospectively enrolled. Mean CAT score was 21.3±8.9 (95% CI:1-40). The desire for medical consultation was highly individual. In terms of vaccination, 31.5% of patients wished for more information while 34.6% wished for less. This also held true for information on long-term pharmacological therapy (29.1% vs 30.7%, respectively). Information on behaviour in case of emergencies as well as smoking cessation were wished for 38% and 42% of patients, respectively. Results of the COPD-Q showed that subjects were well-informed about specific topics (vaccination, etiology, emergency-inhaler) and less informed about long-term pharmacotherapy. In linear regression analyses, age (p=0.086), sex (p=0.906), education (p=0.833), health literacy (p=0.336) and burden of disease (p=0.296) did not influence patients´ desire for disease-specific information.</p><p><strong>Conclusion: </strong>Based on our cohort, COPD patients wish for more medical information related to behaviour in emergency situations and smoking cessation. The desire for education on disease-specific topics did not naturally correlate with demographic characteristics. The provision of medical information to patients remains a highly individualized and essential part of patient care.</p><p><strong>Trial registration: </strong>German Clinical Trials Registry (DRKS00022109).</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1287-1297"},"PeriodicalIF":2.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different Properties of the Erector Spinae and Multifidus Muscles on Physical Performance in Patients With Chronic Obstructive Pulmonary Disease.","authors":"Kyosuke Imashiro, Masanori Nakanishi, Yuta Minoshima, Ken Kouda, Seigo Sasaki, Koichiro Takahashi, Kazuhisa Asai, Tsunahiko Hirano, Kazuto Matsunaga, Yoshiaki Minakata","doi":"10.2147/COPD.S513153","DOIUrl":"https://doi.org/10.2147/COPD.S513153","url":null,"abstract":"<p><strong>Background: </strong>Muscle atrophy in the dorsal muscle group (DMG) is associated with physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD). However, no studies have separately evaluated the erector spinae muscle (ESM) and the multifidus muscle (MM) within the DMG, leaving the distinct impact of each muscle on PA unclear.</p><p><strong>Purpose: </strong>This study evaluated the differences in muscle characteristics between ESM and MM in stable patients with COPD.</p><p><strong>Patients and methods: </strong>In Study 1, we evaluated the relationship between the cross-sectional area of ESM (ESM_CSA) and MM (MM_CSA) on chest computed tomography and PA parameters. In Study 2, as a pilot study, we analyzed the muscle fatigue characteristics of ESM and MM using a trunk holding test and electromyographic (EMG) power spectrum analysis to evaluate the median frequency (MF) slope. We then evaluated the differences in the MF slopes of both muscles in patients with COPD compared with healthy subjects.</p><p><strong>Results: </strong>Of 77 patients with COPD, the MM_CSA was positively associated with the duration of PA at ≥3.0 metabolic equivalents (METs) (r=0.279, p=0.014), whereas the ESM_CSA was negatively associated with the duration of behavior at 1.0-1.5 METs (r=-0.429, p<0.001). The MF slopes of the MM were significantly lower in COPD patients (n=7) than in healthy subjects (n=28) (p<0.01), indicating greater fatigue, with no significant differences in MF slopes for ESM or trunk extension holding time.</p><p><strong>Conclusion: </strong>These results indicate that the functional characteristics of the ESM and MM differ in COPD patients. MM was mainly associated with moderate-to-vigorous PA and involved greater fatigue in COPD patients compared to healthy subjects, while the ESM was mainly associated with sedentary behavior.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1299-1308"},"PeriodicalIF":2.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Heterogenous Phenotypes of Chronic Obstructive Pulmonary Disease: Network Analysis and Penalized Generalized Linear Model.","authors":"Hyeon-Kyoung Koo, Sung Jun Chung, Dongil Park, Ho Cheol Kim, Hyewon Seo, Hyun Jung Kim, Hyoung Kyu Yoon, Chin Kook Rhee, Kwang Ha Yoo, Deog Kyeom Kim","doi":"10.2147/COPD.S496199","DOIUrl":"https://doi.org/10.2147/COPD.S496199","url":null,"abstract":"<p><strong>Background and objective: </strong>Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, with chronic bronchitis (CB) and emphysema phenotypes. The aim of our study was to compare the distinct patterns of correlation networks for respiratory symptoms and predictors of future exacerbations of different COPD phenotypes.</p><p><strong>Methods: </strong>CB and emphysema were identified using a questionnaire and computed tomography images, respectively, and also included patients with preserved ratio impaired spirometry (PRISm). We constructed separate correlation networks for each subgroup using Spearman correlation coefficients. Predictors of future exacerbations were selected via least absolute shrinkage and selection operation regression analyses in multivariable analysis.</p><p><strong>Results: </strong>Among the 3436 patients, 2232 were non-CB, 1131 were CB, 1116 were emphysema, and 73 were PRISm groups. The forced expiratory volume in one second (FEV1) and respiratory symptoms worsened in the following order: PRISm, non-CB, emphysema, and CB groups. During the 1-year follow-up, 17.3%, 21.3%, and 18.9% of patients in the non-CB, CB, and emphysema groups, respectively, experienced exacerbation. Each group showed a distinct correlation pattern between demographic characteristics, comorbidities, pulmonary function, blood biomarkers, respiratory symptoms, and exercise capacity. Across all groups, lower FEV1 (%), higher white blood cell count, higher erythrocyte sedimentation rate, and worse Saint George's Respiratory Questionnaire symptom and total scores were identified as common risk factors for future exacerbations. However, each group showed distinct predictors for future exacerbations.</p><p><strong>Conclusion: </strong>The correlation network patterns and predictors of future exacerbations varied significantly depending on the COPD phenotype. Further research is required to understand the heterogeneous COPD pathophysiology and facilitate personalized medicine.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1267-1277"},"PeriodicalIF":2.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Phenotypes Assessment by Using Quantitative Parameters for CT-Defined Subtypes of Chronic Obstructive Pulmonary Disease.","authors":"Wufei Chen, Jing Zhu, Jixiang Ni, Xiang Li, Yu Li, Wen Yin, Shan Zhu, Yang Xiao, Ying Wang, Hui Huang, Yi Hu","doi":"10.2147/COPD.S505092","DOIUrl":"https://doi.org/10.2147/COPD.S505092","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the quantitative imaging phenotype differences for CT-defined subtypes classified by the Fleischner Society in patients with chronic obstructive pulmonary disease (COPD).</p><p><strong>Patients and methods: </strong>A total of 228 COPD patients who underwent non-enhanced chest CT screening from 2018 to 2024 were included. All patients were divided into type-A (Absent emphysema that no or mild emphysema, Goddard score ≤8, regardless of bronchial wall thickening), type-E (Emphysema that significant emphysema, Goddard score >8, without bronchial wall thickening), and type-M (Mixed emphysema and bronchial wall thickening that both significant emphysema, Goddard score >8, and bronchial wall thickening ≥ grade 1 in ≥1 lung lobe). Imaging phenotype parameters included lung airspace analysis (LAA) and LAA size analysis (LAASA) in emphysema, airway wall, lung vessels and interstitial lung disease (ILD) extracted by a COPD-specific analysis software were analysis among three groups.</p><p><strong>Results: </strong>Quantitative assessment of emphysema among three image phenotypes showed significant differences in full emphysema and full emphysema ratio based on LAA among three groups (P < 0.05). The areas of consolidation, ground-glass opacity, and reticular patterns were significantly larger in type-M than the other two types (P < 0.05). Quantitative assessment of small airways disease and small vessel parameters found smaller lumen-volume and larger wall-volume in whole lung level in the emphysema phenotype of type-M (P < 0.05) were found in the small vessel count in distance of 6 mm and 9mm from the pleura were significant differences among three groups (P < 0.05). The multivariate logistic regression analysis showed that the higher proportion of full emphysema ratio and wall-volume, a proportion of smaller lumen-volume, and a more noticeable interstitial lung alterations were associated with type-M.</p><p><strong>Conclusion: </strong>A quantitative CT evaluation can further delineate the imaging phenotypes characteristics thereby in guiding to early diagnosis, severity assessment, and therapeutic recommendations in COPD patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1279-1286"},"PeriodicalIF":2.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mechanism of Traditional Chinese Medicine and Natural Medicine in Treating Chronic Obstructive Pulmonary Disease.","authors":"Lei Li, Xiao-Feng Liu, Zhi-Fang Cui, Heng Zou, Shu-Ling Liu, Hong-Wu Wang","doi":"10.2147/COPD.S518248","DOIUrl":"https://doi.org/10.2147/COPD.S518248","url":null,"abstract":"<p><strong>Ethnopharmacological relevance: </strong>Chronic obstructive pulmonary disease (COPD) is one of the crucial chronic diseases that seriously endangers the health of residents in China. There is a complex mechanism of the pathogenesis of COPD, and no specific drugs are currently available to reverse the progressive decline in lung function during the natural course of COPD. Traditional Chinese Medicine (TCM) not only alleviates clinical symptoms, but also leads to fewer adverse reactions. However, the mechanism of action of TCM in COPD treatment remains unclear.</p><p><strong>Aim: </strong>To summarize the mechanisms of action of Chinese herbal compounds and natural drugs in the treatment of COPD and identify potential signaling pathways and targets that can provide preclinical evidence for the treatment of COPD.</p><p><strong>Methods: </strong>Literature was retrieved from the scientific databases PubMed, Web of Science, and CNKI, Wanfang Data Knowledge Service Platform, and VIP Chinese Science and Technology Journal from July 2007 to December 2023.</p><p><strong>Results: </strong>This study introduced the specific pathways, targets and mechanisms of TCM in treating COPD from the perspectives of inhibiting inflammation, reducing oxidative stress, and regulating autophagy.</p><p><strong>Conclusion: </strong>This study provides a comprehensive summary of the theories of Chinese medicine in treating COPD, which utilize multiple targets and pathways to display the advantages of Chinese medicine. This lays the foundation for further exploration of pathways related to Chinese medicine for the treatment of COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1249-1266"},"PeriodicalIF":2.7,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Neutrophil Percentage to Serum Albumin Ratio and in-Hospital Mortality of Patients with Chronic Obstructive Pulmonary Disease in Intensive Care Unit: A Retrospective Cohort Study.","authors":"Yanfei Shi, Yushan Shi, Yongjuan Liu, Chunxiao Wang, Ming Qi, Chengwei Li","doi":"10.2147/COPD.S508964","DOIUrl":"https://doi.org/10.2147/COPD.S508964","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the potential correlation between the neutrophil percentage to serum albumin ratio(NPAR) and in-hospital mortality in critically ill patients with Chronic Obstructive Pulmonary Disease (COPD).</p><p><strong>Patients and methods: </strong>This study employed a retrospective cohort design. A total of 599 COPD patients were included in this research. Clinical data from the MIMIC-IV (Medical Information Mart for Intensive Care IV) database were utilized. To determine whether a correlation exists between NPAR and in-hospital mortality, a multivariable logistic regression analysis was conducted. Subgroup analyses were performed, taking into account factors such as age, sex, diabetes, congestive heart failure, and ventilator use.</p><p><strong>Results: </strong>Among the 599 patients studied, 114 (19.0%) experienced in-hospital mortality. In the multivariable logistic regression model, NPAR was positively correlated with in-hospital mortality; for each unit increase in NPAR, the in-hospital mortality rate increased by 5% (Odds Ratio [OR] = 1.05; 95% Confidence Interval [95% CI] = 1.02-1.09). Compared to the lowest NPAR group, the highest NPAR group had a significantly greater risk of in-hospital mortality (OR [95% CI] = 2.15 [1.11-4.17]). Furthermore, the results of the subgroup analyses were consistent across all groups.</p><p><strong>Conclusion: </strong>Our study reveals a correlation between NPAR levels and mortality in COPD patients. Further research is warranted to validate these findings.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1227-1237"},"PeriodicalIF":2.7,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}