International Journal of Chronic Obstructive Pulmonary Disease最新文献

{"title":"Are Smart Watches Really Smart? Comparison of Blood Oxygen Saturation Values Measured by Smart Watch, Pulse Oximetry and Arterial Blood Gases in Patients with Chronic Obstructive Pulmonary Diseases.","authors":"Ümran Toru Erbay, Şebnem Emine Parspur, İnci Arikan, Zeynep Yaren Yılmaz, Havva Koçak, Feride Marim, İlknur Kaya, Mehmet Doğan","doi":"10.2147/COPD.S500643","DOIUrl":"10.2147/COPD.S500643","url":null,"abstract":"<p><strong>Objective: </strong>Oxygen saturation is an important parameter for the follow-up of Chronic Obstructive Pulmonary Disease (COPD) patients. Pulse oximeters are the most common non-invasive way to assess peripheral blood saturation. Invasive way for this is blood gas analyses. Smart watches are actually developed as sports and physical activity watches in order to be used in daily routine by assessing vital parameters such as heart rate, blood pressure and oxygen saturation. In this sense, they can help better monitoring for patients with COPD on the other hand accuracy of these devices is the major concern.</p><p><strong>Background: </strong>This study aims to evaluate the correlation of oxygen saturation assessed by smart watch, pulse oximetry and blood gas analyses in COPD patients.</p><p><strong>Methods: </strong>This is a cross-sectional study evaluating the pulse oximetry technology of smart watch by comparing it real time oxygen saturation measurements of conventional pulse device and arterial blood gas (ABG) analysis in 100 patients with COPD.</p><p><strong>Results: </strong>A moderate correlation was found between oxygen saturation levels obtained by smart watch, pulse oximetry and ABG.</p><p><strong>Conclusion: </strong>Smart watches are really smart. Thus, COPD patients can use smart watches to measure oxygen saturation levels in their daily lives. However, SpO2 measurements should be tested in other patient groups and also different degrees of COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1457-1463"},"PeriodicalIF":2.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Albuterol Digihaler in COPD Disease Management: A Real-World Study to Assess Digihaler Inhalation Parameters, Thresholds and Their Use to Identify Deterioration in Clinical Practice.","authors":"Gary T Ferguson, Amanda Boe, Tanisha D Hill, Daisy Yu, Meena Krishnamony","doi":"10.2147/COPD.S519963","DOIUrl":"10.2147/COPD.S519963","url":null,"abstract":"<p><strong>Purpose: </strong>Despite increasing awareness, chronic obstructive pulmonary disease (COPD) exacerbations are often unrecognized, not reported or not treated. Assisting patients and caregivers to better identify deteriorations in COPD can help improve care. This study was designed to collect usage and inhalation parameters from albuterol Digihaler devices and its associated Digihaler dashboard, to identify potential inhalation parameters and alerts that might predict worsening COPD.</p><p><strong>Patients and methods: </strong>Real-time rescue albuterol Digihaler (albuterol sulfate) results for peak inspiratory flow (PIF), rescue inhaler usage and inhalation volume (InV) were assessed in 20 COPD patients over 6 months. Alert thresholds from device measurements were analyzed for 14 days prior to all COPD deteriorations defined by a COPD exacerbation or an acute worsening in COPD assessment test (CAT) score.</p><p><strong>Results: </strong>Eleven subjects experienced 22 COPD exacerbations, and 16 subjects experienced 40 CAT score worsening over 6 months' time. No demographic or physiologic differences were identified comparing patients with or without exacerbations or CAT score worsening. Falls in PIF and increases in rescue inhaler usage were weak predictors of impending exacerbations, while a higher percentage (36%) of subjects had a fall in InV prior to an exacerbation. No notable changes in inhaler parameters were associated with deteriorating CAT scores, and no changes in lung function were observed over the study. A combination of 3 alert thresholds was present in 59% of patients within the 2 weeks prior to a COPD exacerbation.</p><p><strong>Conclusion: </strong>Our study suggests that alert thresholds based on Digihaler device-measured physiologic parameters may have value in a predictive model for clinical deterioration in COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1465-1476"},"PeriodicalIF":2.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstructive Airway Disease is Associated with Increased Cardiovascular Disease Risk Independent of Phenotype: Evidence from Two Nationwide Population-Based Studies.","authors":"Kaifang Meng, Xinran Zhang, Huaping Dai","doi":"10.2147/COPD.S522367","DOIUrl":"10.2147/COPD.S522367","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD), as the most common comorbidity of chronic obstructive pulmonary disease (COPD), has received much attention. However, robust evidence of the relationship between other obstructive airway disease (OAD) phenotypes, such as asthma, asthma-COPD overlap (ACO), and CVD risk is limited. We aimed to compare the magnitude of CVD risk across different OAD phenotypes using two nationwide population-based studies.</p><p><strong>Methods: </strong>We analyzed cross-sectional data from the National Health and Nutrition Examination Survey 1999-2018 (N=44,972, representing 183,508,900 adults). Survey-weighted descriptive analysis and logistic regression were used to investigate the prevalence of CVD (including heart failure, coronary heart disease, angina pectoris, and myocardial infarction) across OAD phenotypes and calculate odds ratios (ORs) with 95% confidence intervals (CIs). Additionally, longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS) (N=13,533) were analyzed to validate these findings and calculate hazard ratios (HRs) with 95% CIs for new-onset CVD using Cox proportional hazards models.</p><p><strong>Results: </strong>The weighted prevalence of at least one CVD in asthma, COPD, and ACO was 6.21%, 16.82%, and 20.75%, respectively. Individuals with asthma, COPD, and ACO had a significantly higher prevalence of CVD than those without OAD, with ORs of 1.55 (95% CI: 1.34-1.78), 1.76 (95% CI: 1.50-2.07), and 2.99 (95% CI: 2.47-3.61), respectively. During the 9-year follow-up, 2,444 (18.1%) individuals developed CVD in CHARLS. The incidence of CVD was significantly higher in individuals with asthma (HR=1.67, 95% CI: 1.26-2.21), COPD (HR=1.71, 95% CI: 1.48-1.97), and ACO (HR=2.67, 95% CI: 2.21-3.24) than those without OAD.</p><p><strong>Conclusion: </strong>Individuals with OAD have a higher prevalence of comorbid CVD and an increased risk of developing CVD independent of phenotype, especially in those with ACO. These findings emphasize the need for awareness and appropriate cardiovascular screening in OAD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1435-1446"},"PeriodicalIF":2.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Rate Recovery After Cardiopulmonary Exercise Test Predicts Acute Exacerbations in Patients with Moderate Chronic Obstructive Pulmonary Disease.","authors":"Shan Nie, Ailin Yang, Wei Yuan, Nan Jia, Yunxiao Li, Yue Yu, Bo Xu, Qiufen Xu, Haoyan Wang, Xin He","doi":"10.2147/COPD.S509504","DOIUrl":"10.2147/COPD.S509504","url":null,"abstract":"<p><strong>Background: </strong>Automatic dysfunction is present in patients with Chronic Obstructive Pulmonary Disease (COPD). Heart rate recovery at 1 min (HRR1) after Cardiopulmonary Exercise Testing (CPET) serves an indicator of automatic function. Despite its potential significance, this primary method is still not well understood or widely utilized in predicting the progression of COPD. This study aimed to determine whether this indicator predicts acute exacerbations of COPD (AECOPD).</p><p><strong>Methods: </strong>In this prospective cohort study, 62 patients with COPD were recruited from 2013 to 2017. All participants underwent CPET test and followed up for 5 years thereafter. Univariate and multivariate linear regression, as well as Cox regression, were utilized to identify the abnormal HRR1 and the variables influencing AECOPD.</p><p><strong>Results: </strong>HRR1 after CPET was a significant correlation of COPD progression. According to the Receiver Operating Characteristic curve, 14 beats/min for HRR1 was optimally used to measure the characteristics of COPD patients. HRR1≤14 beats/min significantly predicted the time to the first AECOPD (<i>p</i>=0.00032, Log rank test). In the Cox proportional hazard models, HRR1≤14 beats/min was also consistently correlated with AECOPD occurrence (Hazards ratio=8.30, <i>p</i>=0.001).</p><p><strong>Conclusion: </strong>HRR1 after CPET was an independent predictor of AECOPD. Thus, this index can be applied to observe the conditions and treatment results of COPD patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1447-1456"},"PeriodicalIF":2.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Lactate-to-Albumin Ratio and 28-Day All-Cause Mortality in Critical Care Patients with COPD: Can Both Arterial and Peripheral Venous Lactate Serve as Predictors?","authors":"Kelan Zhao, Linshui Zhou, Yeling Ni, Jieying Tao, Ziyu Yu, Xiaojuan Li, Lu Wang","doi":"10.2147/COPD.S503625","DOIUrl":"https://doi.org/10.2147/COPD.S503625","url":null,"abstract":"<p><strong>Background: </strong>Lactate-to-albumin ratio (LAR) has been reported as a useful predictor for multiple critical illnesses. However, the association between LAR and mortality in patients with chronic obstructive pulmonary disease (COPD) remains unclear. This study aims to clarify the correlation between LAR and 28-day all-cause mortality in patients with COPD and to investigate whether LAR calculated using arterial lactate (AL) or peripheral venous lactate (PVL) can serve as predictive indicators.</p><p><strong>Methods: </strong>A total of 1428 patients from the Medical Information Mart for Intensive Care (MIMIC) IV database (version 2.2) and 2467 patients from the eICU Collaborative Research Database (eICU-CRD, version 2.0) were included in this study. Propensity score matching (PSM) method was conducted to control confounders. Cox proportional hazards model, Kaplan-Meier survival method, subgroup analysis and receiver operating characteristic (ROC) analysis were performed to assess the predictive ability of LAR. To verify our hypothesis, data from the two databases were analyzed individually.</p><p><strong>Results: </strong>After adjusting for covariates, LAR calculated using either AL (MIMIC IV, HR = 1.254, 95% CI, 1.013-1.552, P = 0.038) or PVL (eICU-CRD, HR = 1.442, 95% CI, 1.272-1.634, P < 0.001) was independently associated with 28-day all-cause mortality in COPD patients. Kaplan-Meier analysis showed that patients with higher LAR value had significantly higher all-cause mortality (all P < 0.05). This association was consistent across subgroup analyses. In addition, the ROC analysis suggested that LAR calculated using PVL may have better predictive performance compared to using AL.</p><p><strong>Conclusion: </strong>LAR calculated using both AL and PVL can independently predict the 28-day all-cause mortality after ICU admission in patients with COPD and higher level of LAR is related to higher mortality risk.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1419-1434"},"PeriodicalIF":2.7,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Case Management on Elderly Patients with Chronic Obstructive Pulmonary Disease.","authors":"Na Li, Wenjing Wang, Yinyin Lv, Caihong Li, Xiangdong Mu","doi":"10.2147/COPD.S517564","DOIUrl":"https://doi.org/10.2147/COPD.S517564","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the effects of case management on elderly patients with chronic obstructive pulmonary disease (COPD) and compare changes in pulmonary function indicators, quality of life, dyspnea, and inhaled medication adherence before and after case management.</p><p><strong>Patients and methods: </strong>A total of 199 elderly COPD patients were enrolled from Beijing Tsinghua Changgung Hospital between January 2020 and November 2023. We implemented case management programs including regular patient education, personalized interventions, continuous support systems, and timely feedback mechanisms, and subsequently collected patient data at 1, 3, 6, and 12 months after initiating case management.</p><p><strong>Results: </strong>After one year of case management, pulmonary function indicators (FEV₁/FVC, FEV₁, FEV₁%pred, MMEF75/25 and MMEF75/25%) in elderly patients with COPD showed significant improvement (P < 0.001). The CAT score decreased from 17.96±6.57 (mean ± standard deviation) to 11.80±6.50, and mMRC score decreased from 2.35±0.66 to 1.14±0.92 (p<0.001). Additionally, 77.9% (155/199) of patients were able to maintain their use of the inhaler for 1 year.</p><p><strong>Conclusion: </strong>This study confirmed the significant role of case management in improving respiratory function, quality of life, and dyspnea in elderly patients with COPD. These findings not only provide a valuable reference for clinicians and patients, but also provide a strong foundation for further optimization of management strategies for elderly patients with COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1407-1417"},"PeriodicalIF":2.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long Term Efficacy and Safety of Bronchoscopic Thermal Vapor Ablation in Patients with COPD: A Retrospective Study of 50 Patients.","authors":"Barak Pertzov, Merav Ben Avraham, Eldar Priel, Lev Freidkin, Dror Rosengarten, Mordechai Reuven Kramer","doi":"10.2147/COPD.S518270","DOIUrl":"https://doi.org/10.2147/COPD.S518270","url":null,"abstract":"<p><strong>Background: </strong>Bronchoscopic Thermal Vapor Ablation (BTVA) has demonstrated improvements in FEV1 and quality of life in clinical trials. However, the long-term benefits and overall efficacy of this procedure remain uncertain and are not yet fully established.</p><p><strong>Methods: </strong>We conducted a retrospective observational study of all patients who underwent BTVA at Rabin Medical Center, Israel. The primary outcome was the change in FEV₁ from baseline. Secondary outcomes included other pulmonary function parameters and procedural adverse events.</p><p><strong>Results: </strong>A total of 50 patients were included in the study. The mean FEV1 values at baseline, 6 months, and 12 months post-procedure (n=31) were 0.74±0.21 L, 0.93±0.32 L, and 0.85±0.25 L, respectively (overall P<0.001; pairwise comparisons: baseline to 6 months, P<0.001; baseline to 12 months, P=0.016). The mean FVC values at baseline, 6 months, and 12 months post-procedure (n=31) were 1.97±0.56 L, 2.27±0.71 L, and 2.14±0.68 L, respectively (overall P=0.003; pairwise comparisons: baseline to 6 months, P=0.002; baseline to 12 months, P=0.125). Post-procedural complications included pneumonia in 5 patients (11%), of whom 3 developed necrotizing pneumonia and subsequently died, resulting in a 6% post-procedural mortality rate in the entire cohort. Hemoptysis was reported in 1 patient (2%).</p><p><strong>Conclusion: </strong>Bronchoscopic thermal vapor ablation is a minimally invasive bronchoscopic intervention for lung volume reduction. The procedure was associated with significant improvements in FEV₁ at 6 to 12 months and in FVC at 6 months, followed by a gradual decline over 12 to 24 months. Further research is warranted to optimize patient selection, enhance procedural safety, and assess long-term efficacy.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1387-1394"},"PeriodicalIF":2.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and Validation of an Early Warning Model for Predicting the 28-Day Mortality in Sepsis Patients with Chronic Obstructive Pulmonary Disease.","authors":"Xiaoyuan Yu, Zihan Jiao, Fan Yang, Qi Xin","doi":"10.2147/COPD.S521816","DOIUrl":"https://doi.org/10.2147/COPD.S521816","url":null,"abstract":"<p><strong>Background: </strong>In the intensive care unit (ICU), approximately 45.6% of patients diagnosed with chronic obstructive pulmonary disease (COPD) also presented with sepsis, and this cohort exhibited a significantly higher 28-day mortality rate compared to sepsis patients without COPD (23.6% versus 16.4%). A novel nomogram is necessary to predict the risk of mortality within 28 days for sepsis patients with COPD.</p><p><strong>Methods: </strong>Clinical data from 501 sepsis patients with COPD were sourced from the MIMIC-IV database. These data were randomly allocated into a training cohort and a validation cohort in a 3:1 ratio. Independent predictors of 28-day mortality were identified through both univariate and multivariate logistic regression analyses. Subsequently, a nomogram model was developed, and its performance was assessed using receiver operating characteristic (ROC) curve analysis, calibration plots, and decision curve analysis.</p><p><strong>Results: </strong>The 28-day mortality rates in the training and validation cohorts were 32.7% and 27.2%, respectively. Multivariate regression analysis identified age, heart rate (HR), respiratory rate (RR), blood urea nitrogen (BUN), creatinine (Cr), lactate levels, pH, and urine output as independent risk factors for 28-day mortality in sepsis patients with COPD. Furthermore, the nomogram demonstrated superior predictive performance, with an area under the curve (AUC) of 0.784 for the training group and 0.689 for the validation group.</p><p><strong>Conclusion: </strong>This nomogram integrates laboratory indicators pertinent to the patient's metabolic status, hypoxia status, and organ function, thereby enhancing the accuracy of early prediction of 28-day mortality in sepsis patients with COPD. Additionally, the model's comparative advantage over existing scoring systems (eg, SOFA) would enhance its impact. Our findings hold substantial implications for early prognostic assessment and clinical decision-making in this patient population. Therefore, earlier diagnosis within 24 hours of admission and proper identification of high-risk patients may reduce disease-related mortality by promoting timely treatment.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1373-1385"},"PeriodicalIF":2.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Computed Tomography and Artificial Intelligence in Evaluating the Comorbidities of Chronic Obstructive Pulmonary Disease: A One-Stop CT Scanning for Lung Cancer Screening.","authors":"Xiaoqing Lin, Ziwei Zhang, Taohu Zhou, Jie Li, Qianxi Jin, Yueze Li, Yu Guan, Yi Xia, Xiuxiu Zhou, Li Fan","doi":"10.2147/COPD.S508775","DOIUrl":"https://doi.org/10.2147/COPD.S508775","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Comorbidities in patients with COPD significantly increase morbidity, mortality, and healthcare costs, posing a significant burden on the management of COPD. Given the complex clinical manifestations and varying severity of COPD comorbidities, accurate diagnosis and evaluation are particularly important in selecting appropriate treatment options. With the development of medical imaging technology, AI-based chest CT, as a noninvasive imaging modality, provides a detailed assessment of COPD comorbidities. Recent studies have shown that certain radiographic features on chest CT can be used as alternative markers of comorbidities in COPD patients. CT-based radiomics features provided incremental predictive value than clinical risk factors only, predicting an AUC of 0.73 for COPD combined with CVD. However, AI has inherent limitations such as lack of interpretability, and further research is needed to improve them. This review evaluates the progress of AI technology combined with chest CT imaging in COPD comorbidities, including lung cancer, cardiovascular disease, osteoporosis, sarcopenia, excess adipose depots, and pulmonary hypertension, with the aim of improving the understanding of imaging and the management of COPD comorbidities for the purpose of improving disease screening, efficacy assessment, and prognostic evaluation.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1395-1406"},"PeriodicalIF":2.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Causal Relationship between Chronic Obstructive Pulmonary Disease and Tuberculosis: A Mendelian Randomization Study.","authors":"Zhuo Wang, Shuang Zhao, Yiwu Zhou, Yanqi He","doi":"10.2147/COPD.S511734","DOIUrl":"https://doi.org/10.2147/COPD.S511734","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) and tuberculosis are both significant global public health challenges. The co-occurrence of these two diseases is frequently observed in clinical settings. However, their causal relationship remains unclear.</p><p><strong>Methods: </strong>We utilized genome-wide association study (GWAS) datasets to conduct bidirectional two-sample Mendelian randomization and multivariable Mendelian randomization analyses. We first analyzed COPD data from the FinnGen consortium (n = 193,638) and tuberculosis data from a genetic association study (n = 484,598). In the second phase, we stratified COPD patients by age into the EARLY COPD group (Event_Age < 65) and the LATER COPD group (Event_Age ≥ 65) to explore their causal relationships with tuberculosis separately. We then validated these results using tuberculosis data from MRC-IEU (n = 462,933). Finally, smoking and COPD-related SNPs as instrumental variables were analyzed by multivariable Mendelian randomization to further investigate the association between COPD and tuberculosis. Multiple methods were used in the Mendelian analyses to ensure a comprehensive and rigorous investigation.</p><p><strong>Results: </strong>In the initial analysis phase utilizing the inverse variance weighting (IVW) method, tuberculosis showed no significant contribution to the incidence of COPD (IVW odds ratio (OR) = 0.9961; 95% confidence interval (CI) = 0.9828-1.0095; P = 0.564). Conversely, COPD appeared to significantly increase the risk of developing tuberculosis (IVW OR = 1.0008; 95% CI = 1.0001-1.0014; P = 0.015), particularly in patients under 65 (IVW OR = 1.0008; P = 0.011).</p><p><strong>Conclusion: </strong>This Mendelian randomization analysis found that COPD may increase the risk of tuberculosis, while tuberculosis does not increase the risk of COPD, suggesting the necessity of enhancing prevention and screening efforts for tuberculosis among COPD patients, especially younger individuals.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1361-1371"},"PeriodicalIF":2.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}