International Journal of Chronic Obstructive Pulmonary Disease最新文献

{"title":"Different Properties of the Erector Spinae and Multifidus Muscles on Physical Performance in Patients With Chronic Obstructive Pulmonary Disease.","authors":"Kyosuke Imashiro, Masanori Nakanishi, Yuta Minoshima, Ken Kouda, Seigo Sasaki, Koichiro Takahashi, Kazuhisa Asai, Tsunahiko Hirano, Kazuto Matsunaga, Yoshiaki Minakata","doi":"10.2147/COPD.S513153","DOIUrl":"https://doi.org/10.2147/COPD.S513153","url":null,"abstract":"<p><strong>Background: </strong>Muscle atrophy in the dorsal muscle group (DMG) is associated with physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD). However, no studies have separately evaluated the erector spinae muscle (ESM) and the multifidus muscle (MM) within the DMG, leaving the distinct impact of each muscle on PA unclear.</p><p><strong>Purpose: </strong>This study evaluated the differences in muscle characteristics between ESM and MM in stable patients with COPD.</p><p><strong>Patients and methods: </strong>In Study 1, we evaluated the relationship between the cross-sectional area of ESM (ESM_CSA) and MM (MM_CSA) on chest computed tomography and PA parameters. In Study 2, as a pilot study, we analyzed the muscle fatigue characteristics of ESM and MM using a trunk holding test and electromyographic (EMG) power spectrum analysis to evaluate the median frequency (MF) slope. We then evaluated the differences in the MF slopes of both muscles in patients with COPD compared with healthy subjects.</p><p><strong>Results: </strong>Of 77 patients with COPD, the MM_CSA was positively associated with the duration of PA at ≥3.0 metabolic equivalents (METs) (r=0.279, p=0.014), whereas the ESM_CSA was negatively associated with the duration of behavior at 1.0-1.5 METs (r=-0.429, p<0.001). The MF slopes of the MM were significantly lower in COPD patients (n=7) than in healthy subjects (n=28) (p<0.01), indicating greater fatigue, with no significant differences in MF slopes for ESM or trunk extension holding time.</p><p><strong>Conclusion: </strong>These results indicate that the functional characteristics of the ESM and MM differ in COPD patients. MM was mainly associated with moderate-to-vigorous PA and involved greater fatigue in COPD patients compared to healthy subjects, while the ESM was mainly associated with sedentary behavior.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1299-1308"},"PeriodicalIF":2.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Heterogenous Phenotypes of Chronic Obstructive Pulmonary Disease: Network Analysis and Penalized Generalized Linear Model.","authors":"Hyeon-Kyoung Koo, Sung Jun Chung, Dongil Park, Ho Cheol Kim, Hyewon Seo, Hyun Jung Kim, Hyoung Kyu Yoon, Chin Kook Rhee, Kwang Ha Yoo, Deog Kyeom Kim","doi":"10.2147/COPD.S496199","DOIUrl":"https://doi.org/10.2147/COPD.S496199","url":null,"abstract":"<p><strong>Background and objective: </strong>Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, with chronic bronchitis (CB) and emphysema phenotypes. The aim of our study was to compare the distinct patterns of correlation networks for respiratory symptoms and predictors of future exacerbations of different COPD phenotypes.</p><p><strong>Methods: </strong>CB and emphysema were identified using a questionnaire and computed tomography images, respectively, and also included patients with preserved ratio impaired spirometry (PRISm). We constructed separate correlation networks for each subgroup using Spearman correlation coefficients. Predictors of future exacerbations were selected via least absolute shrinkage and selection operation regression analyses in multivariable analysis.</p><p><strong>Results: </strong>Among the 3436 patients, 2232 were non-CB, 1131 were CB, 1116 were emphysema, and 73 were PRISm groups. The forced expiratory volume in one second (FEV1) and respiratory symptoms worsened in the following order: PRISm, non-CB, emphysema, and CB groups. During the 1-year follow-up, 17.3%, 21.3%, and 18.9% of patients in the non-CB, CB, and emphysema groups, respectively, experienced exacerbation. Each group showed a distinct correlation pattern between demographic characteristics, comorbidities, pulmonary function, blood biomarkers, respiratory symptoms, and exercise capacity. Across all groups, lower FEV1 (%), higher white blood cell count, higher erythrocyte sedimentation rate, and worse Saint George's Respiratory Questionnaire symptom and total scores were identified as common risk factors for future exacerbations. However, each group showed distinct predictors for future exacerbations.</p><p><strong>Conclusion: </strong>The correlation network patterns and predictors of future exacerbations varied significantly depending on the COPD phenotype. Further research is required to understand the heterogeneous COPD pathophysiology and facilitate personalized medicine.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1267-1277"},"PeriodicalIF":2.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Phenotypes Assessment by Using Quantitative Parameters for CT-Defined Subtypes of Chronic Obstructive Pulmonary Disease.","authors":"Wufei Chen, Jing Zhu, Jixiang Ni, Xiang Li, Yu Li, Wen Yin, Shan Zhu, Yang Xiao, Ying Wang, Hui Huang, Yi Hu","doi":"10.2147/COPD.S505092","DOIUrl":"https://doi.org/10.2147/COPD.S505092","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the quantitative imaging phenotype differences for CT-defined subtypes classified by the Fleischner Society in patients with chronic obstructive pulmonary disease (COPD).</p><p><strong>Patients and methods: </strong>A total of 228 COPD patients who underwent non-enhanced chest CT screening from 2018 to 2024 were included. All patients were divided into type-A (Absent emphysema that no or mild emphysema, Goddard score ≤8, regardless of bronchial wall thickening), type-E (Emphysema that significant emphysema, Goddard score >8, without bronchial wall thickening), and type-M (Mixed emphysema and bronchial wall thickening that both significant emphysema, Goddard score >8, and bronchial wall thickening ≥ grade 1 in ≥1 lung lobe). Imaging phenotype parameters included lung airspace analysis (LAA) and LAA size analysis (LAASA) in emphysema, airway wall, lung vessels and interstitial lung disease (ILD) extracted by a COPD-specific analysis software were analysis among three groups.</p><p><strong>Results: </strong>Quantitative assessment of emphysema among three image phenotypes showed significant differences in full emphysema and full emphysema ratio based on LAA among three groups (P < 0.05). The areas of consolidation, ground-glass opacity, and reticular patterns were significantly larger in type-M than the other two types (P < 0.05). Quantitative assessment of small airways disease and small vessel parameters found smaller lumen-volume and larger wall-volume in whole lung level in the emphysema phenotype of type-M (P < 0.05) were found in the small vessel count in distance of 6 mm and 9mm from the pleura were significant differences among three groups (P < 0.05). The multivariate logistic regression analysis showed that the higher proportion of full emphysema ratio and wall-volume, a proportion of smaller lumen-volume, and a more noticeable interstitial lung alterations were associated with type-M.</p><p><strong>Conclusion: </strong>A quantitative CT evaluation can further delineate the imaging phenotypes characteristics thereby in guiding to early diagnosis, severity assessment, and therapeutic recommendations in COPD patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1279-1286"},"PeriodicalIF":2.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mechanism of Traditional Chinese Medicine and Natural Medicine in Treating Chronic Obstructive Pulmonary Disease.","authors":"Lei Li, Xiao-Feng Liu, Zhi-Fang Cui, Heng Zou, Shu-Ling Liu, Hong-Wu Wang","doi":"10.2147/COPD.S518248","DOIUrl":"https://doi.org/10.2147/COPD.S518248","url":null,"abstract":"<p><strong>Ethnopharmacological relevance: </strong>Chronic obstructive pulmonary disease (COPD) is one of the crucial chronic diseases that seriously endangers the health of residents in China. There is a complex mechanism of the pathogenesis of COPD, and no specific drugs are currently available to reverse the progressive decline in lung function during the natural course of COPD. Traditional Chinese Medicine (TCM) not only alleviates clinical symptoms, but also leads to fewer adverse reactions. However, the mechanism of action of TCM in COPD treatment remains unclear.</p><p><strong>Aim: </strong>To summarize the mechanisms of action of Chinese herbal compounds and natural drugs in the treatment of COPD and identify potential signaling pathways and targets that can provide preclinical evidence for the treatment of COPD.</p><p><strong>Methods: </strong>Literature was retrieved from the scientific databases PubMed, Web of Science, and CNKI, Wanfang Data Knowledge Service Platform, and VIP Chinese Science and Technology Journal from July 2007 to December 2023.</p><p><strong>Results: </strong>This study introduced the specific pathways, targets and mechanisms of TCM in treating COPD from the perspectives of inhibiting inflammation, reducing oxidative stress, and regulating autophagy.</p><p><strong>Conclusion: </strong>This study provides a comprehensive summary of the theories of Chinese medicine in treating COPD, which utilize multiple targets and pathways to display the advantages of Chinese medicine. This lays the foundation for further exploration of pathways related to Chinese medicine for the treatment of COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1249-1266"},"PeriodicalIF":2.7,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Neutrophil Percentage to Serum Albumin Ratio and in-Hospital Mortality of Patients with Chronic Obstructive Pulmonary Disease in Intensive Care Unit: A Retrospective Cohort Study.","authors":"Yanfei Shi, Yushan Shi, Yongjuan Liu, Chunxiao Wang, Ming Qi, Chengwei Li","doi":"10.2147/COPD.S508964","DOIUrl":"https://doi.org/10.2147/COPD.S508964","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the potential correlation between the neutrophil percentage to serum albumin ratio(NPAR) and in-hospital mortality in critically ill patients with Chronic Obstructive Pulmonary Disease (COPD).</p><p><strong>Patients and methods: </strong>This study employed a retrospective cohort design. A total of 599 COPD patients were included in this research. Clinical data from the MIMIC-IV (Medical Information Mart for Intensive Care IV) database were utilized. To determine whether a correlation exists between NPAR and in-hospital mortality, a multivariable logistic regression analysis was conducted. Subgroup analyses were performed, taking into account factors such as age, sex, diabetes, congestive heart failure, and ventilator use.</p><p><strong>Results: </strong>Among the 599 patients studied, 114 (19.0%) experienced in-hospital mortality. In the multivariable logistic regression model, NPAR was positively correlated with in-hospital mortality; for each unit increase in NPAR, the in-hospital mortality rate increased by 5% (Odds Ratio [OR] = 1.05; 95% Confidence Interval [95% CI] = 1.02-1.09). Compared to the lowest NPAR group, the highest NPAR group had a significantly greater risk of in-hospital mortality (OR [95% CI] = 2.15 [1.11-4.17]). Furthermore, the results of the subgroup analyses were consistent across all groups.</p><p><strong>Conclusion: </strong>Our study reveals a correlation between NPAR levels and mortality in COPD patients. Further research is warranted to validate these findings.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1227-1237"},"PeriodicalIF":2.7,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Brief and Effective Questionnaire for COPD Screening in High-Altitude Areas.","authors":"Jia Cui, Yuxia Wang, Yaqi Tong, Yixuan Liao, Yan Liu, Di Chai, Zhenzhen Xing, Huanyu Long, Yanfei Guo","doi":"10.2147/COPD.S505941","DOIUrl":"https://doi.org/10.2147/COPD.S505941","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a reliable screening questionnaire for chronic obstructive pulmonary disease (COPD) for primary health care institutions in high-altitude areas.</p><p><strong>Patients and methods: </strong>This was a large cross-sectional study. The study included individuals who resided at an altitude of more than 2100 meters, were aged 35 years or older. The data were randomly divided into a development set and a validation set at a ratio of 7:3. Single-factor and multifactor logistic regression equations were employed to identify pertinent variables and construct a scoring system. The receiver operating characteristic (ROC) curve, area under the curve (AUC), positive predictive value (PPV) and negative predictive value (NPV) were used to evaluate the discriminative ability of the questionnaire.</p><p><strong>Results: </strong>A total of 2909 individuals were included in this study, including 1304 males (44.83%), with a median age of 47.00 (41.00-55.00) years. A multivariate analysis of the development set revealed that five variables (age, history of pulmonary tuberculosis, smoking status, household air pollution exposure and CPOD Assessment Test (CAT) score) were significantly correlated with COPD. A scoring system was constructed on the basis of these findings. The AUC for the model in the development set was 0.714, whereas that for the validation set was 0.726. ROC analysis indicated that the optimal diagnostic cutoff value for the score was 22 points, with a sensitivity of 85.0% and a specificity of 48.4%. The results indicated that the sensitivity of the model was the highest (87.3%) at altitudes between 2100 and 3000 meters, whereas the specificity was the highest (80.9%) at altitudes >4000 meters. The conclusions were essentially consistent when the lower limit of normal (LLN) was used to verify the values in different altitude areas.</p><p><strong>Conclusion: </strong>The COPD screening questionnaire effectively screens COPD in high-altitude primary healthcare settings.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1239-1248"},"PeriodicalIF":2.7,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Smoking and Airway Restriction on Subclinical Atherosclerosis.","authors":"Mihrican Yeşildağ, Zeynep Keskin, Durdu Mehmet Yavşan, Taha Tahir Bekci, Usame Omer Osmanoglu","doi":"10.2147/COPD.S512381","DOIUrl":"https://doi.org/10.2147/COPD.S512381","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic obstructive pulmonary disease (COPD) is a chronic disease associated with systemic inflammation that may accelerate the atherosclerotic process. Smoking is a common risk factor for COPD and atherosclerosis. The goal of this study was to investigate the effects of COPD and smoking on carotid intima-media thickness (CIMT), in order to emphasise their importance in terms of subclinical atherosclerosis.</p><p><strong>Materials and methods: </strong>The study involved 208 male patients aged 45-65 years and was designed as a prospective, observational case-control study. Patients were separated into three groups, as follows: Group 1-non-smokers without airway obstruction (control) (n= 70); Group 2-smokers without airway obstruction (n= 70); and Group 3-smokers with airway obstruction(COPD) (n= 68). They were also classified into thickened CIMT (≥0.8mm) and normal CIMT (<0.8mm) groups. Pulmonary function tests (PFT), carotid Doppler ultrasound, and biochemical and haematological tests were applied to all the participants.</p><p><strong>Results: </strong>CIMT values were markedly increased in the COPD group (1.00 [0.90-1.30] mm), compared to the smoker group without airway obstruction (0.70 [0.58-0.90] mm) and the non-smoker control group (0.60 [0.50-0.70] mm). The factors associated with CIMT were FEV₁/FVC ratio (Exp B 0.0952, p=0.003), age (Exp B 1.082, p<0.001), and cigarette pack-years (Exp B 1.030, p=0.020). In feature importance analysis, the most influential factor on CIMT was the FEV₁/FVC ratio (0.54) indicating COPD, followed by age (0.33) and cigarette pack-years (0.13).</p><p><strong>Conclusion: </strong>Among the factors influencing CIMT, the impact of a decreased FEV₁/FVC ratio was found to be the highest. Therefore, screening with carotid US should be considered for the early detection of subclinical atherosclerosis in patients with COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1217-1226"},"PeriodicalIF":2.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Stress Hyperglycemia Ratio Predicts Poor Clinical Outcome in Critically Ill COPD Patients: A Retrospective Study.","authors":"Mengyuan Qiao, Hui Yang, Mengzhen Qin, Yingyang Li, Haiyan Wang","doi":"10.2147/COPD.S520418","DOIUrl":"https://doi.org/10.2147/COPD.S520418","url":null,"abstract":"<p><strong>Objective: </strong>Stress hyperglycemia ratio (SHR) was introduced as an indicator of relative hyperglycaemia and is widely used for prognostic prediction in critically ill patients. The present study aimed to investigate the relationship between SHR and adverse clinical outcomes in critically ill COPD patients.</p><p><strong>Methods: </strong>A total of 1,580 patients diagnosed with COPD were included in this retrospective cohort study. SHR = ABG (mmol/L) / [1.59 × HbA1c (%) - 2.59]. Primary endpoints included ICU mortality and in-hospital mortality. Secondary endpoints were acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and acute respiratory failure (ARF). Logistic regression, Restricted Cubic Sample (RCS) and Receiver Operating Characteristic (ROC) were used to explore the relationship between SHR and prognosis of COPD patients. In addition, subgroup analyses and interaction tests were performed to investigate potential heterogeneity.</p><p><strong>Results: </strong>Multivariate logistic regression analysis showed that elevated SHR was not associated with ICU mortality and in-hospital mortality. In contrast, SHR quartiles were correlated with ICU mortality and in-hospital mortality. Restricted cubic spline regression models showed a nonlinear correlation between SHR and both ICU mortality and in-hospital mortality (all <i>P</i><0.001). In addition, a linear correlation was found between SHR and AECOPD and ARF, with elevated SHR associated with increased risk of AECOPD and ARF. <i>ROC</i> analyses showed that SHR was a more effective predictor of mortality and prognosis than admission blood glucose (ABG) and hemoglobin A1c (HbA1c) in patients with COPD, with the former being a better predictor of mortality and prognosis. In subgroup analyses, after adjusting for all covariates considered in the present study, the relationship between SHR and prognostic risk in patients with COPD remained stable across gender, age, BMI, smoking, drinking, history of hypertension, coronary heart disease, diabetes, and cerebrovascular disease.</p><p><strong>Conclusion: </strong>SHR is independently associated with an increased risk of adverse clinical outcomes in critically ill COPD patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1203-1215"},"PeriodicalIF":2.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatable Traits in Patients with Obstructive Lung Diseases in a Well-Established Asthma/COPD Service for Primary Care.","authors":"Lars Dijk, Yoran H Gerritsma, Thys Van der Molen, Ian Pavord, Ronald J Meijer, Huib Kerstjens, Janwillem Kocks","doi":"10.2147/COPD.S508281","DOIUrl":"https://doi.org/10.2147/COPD.S508281","url":null,"abstract":"<p><strong>Purpose: </strong>The primary objective of this study was to assess the prevalence of treatable traits (TTs) in patients with obstructive lung diseases in a primary care setting and how these TTs co-occur. The secondary objective was to assess the stability of TTs and the effect of management advice on changes in traits and health outcomes.</p><p><strong>Patients and methods: </strong>Data from the Dutch asthma/COPD service (2007-2023) were studied retrospectively. Patients ≥18 years with asthma, COPD, or Asthma-COPD overlap (ACO) were included. The prevalence of eight TTs were assessed: 1) insufficient inhaler technique, 2) poor medication adherence, 3) blood eosinophilia, 4) smoking, 5) obesity, 6) physical inactivity, 7) reversible airflow limitation, and 8) anxiety and/or depression. The effect of management advice on TTs was evaluated for patients with a follow-up visit scheduled within 1-2 years.</p><p><strong>Results: </strong>In total, 15246 patients (COPD n=4822; ACO n=1761, asthma n=8663) were included. The highest proportions of TTs were insufficient inhaler technique: 43.6% (95% CI: 42.9-44.4), followed by poor medication adherence: 40.3% (95% CI: 39.2-41.4) and blood eosinophilia: 36.9% (95% CI: 35.8-38.1). Overall, 83.3% of patients had ≥ 1 TTs, and 48.9% of patients ≥ 2 TTs. Among patients with blood eosinophilia, a significant reduction of the trait at follow-up (OR: 0.61, 95% CI: 0.39; 0.96) and improved health status were observed when the pulmonologist advised the general practitioner to initiate or increase the dose of ICS. No significant association was found between management advice and the exacerbation rate at follow-up.</p><p><strong>Conclusion: </strong>The TTs assessed in this study are common in primary care patients, with nearly half of the patients showing a combination of at least two TTs. These TTs coexist in many different combinations. A personalized approach targeting these traits may be effective in achieving better control of these heterogeneous diseases.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1189-1201"},"PeriodicalIF":2.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Physical Activity, Sedentary Behavior and Sleep Disorders in Chronic Obstructive Pulmonary Disease Patients: A Cross-Sectional Study.","authors":"Xianghui Ma, Qing Zhang, Xigang Gao, Mingxiang Sun","doi":"10.2147/COPD.S487616","DOIUrl":"https://doi.org/10.2147/COPD.S487616","url":null,"abstract":"<p><strong>Objective: </strong>Sleep disorder is a common comorbidity in chronic obstructive pulmonary disease (COPD). We aim to explore the potential association between daily sitting time (DST), leisure-time physical activity (LTPA) and sleep disorders in COPD patients.</p><p><strong>Methods: </strong>The sleep, LTPA, and DST data of participants with COPD were extracted from the National Health and Nutrition Examination Survey (NHANES) portal (2007-2012), basing on Global Physical Activity Questionnaire. The <i>t</i>-test, Mann-Whitney test, or chi-square test were employed to analyze the differences between two groups. The weighted binomial logistic regression model was used to estimate the odds ratio (OR) and 95% confidence interval (CI) of DST and LTPA on sleep disorders. The analyses were conducted from April 1 to July 1, 2023.</p><p><strong>Results: </strong>A total of 2063 COPD samples were included in this work, of which 58% had LTPA < 150 min/wk and 48% had DST > 6h. Patients with sleep disorders had longer sedentary time (DST > 6h: 151, DST > 8h: 105) and less physical activity (LTPA < 150min/wk: 185). Longer sedentary time was correlated with a higher risk of sleep disorders, while LTPA showed no significant correlation with sleep disorders. The conjoint analysis revealed that the risk of sleep disorders in patients with LTPA <150 min/wk and DST > 8h was 5.88 times (95% CI: 1.80-19.2) great than that of patients with LTPA≥150 min/wk and DST < 4h.</p><p><strong>Conclusion: </strong>COPD patients often lacked physical activity and exhibited sedentary behaviors. Long-term sedentary behavior was associated with elevated risk of sleep disorders in COPD patients. More light intensity physical activity and supervised exercise programs are probably good choices to prevent sleep disorders in COPD population.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1175-1187"},"PeriodicalIF":2.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}