International Journal of Chronic Obstructive Pulmonary Disease最新文献

{"title":"Association Between Platelet Indices and Risk of Chronic Obstructive Pulmonary Disease: A Bidirectional Mendelian Randomization Study.","authors":"Weifeng Liao, Xiaoxi Lin, Keyu Liu, Yitian Yang, Lianfang Du, Jingjing Pan, Feiju Chen, Weilong Ye, Bainian Chen, Riken Chen, Wenliang Chen, Weimin Yao","doi":"10.2147/COPD.S531797","DOIUrl":"10.2147/COPD.S531797","url":null,"abstract":"<p><strong>Introduction: </strong>Platelet indices are associated with chronic obstructive pulmonary disease (COPD), their causal relationship remains unclear. This study aims to explore the causal relationship between four common platelet indices and COPD using Mendelian randomization (MR), including platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW).</p><p><strong>Methods: </strong>We analyzed summary statistics from European-ancestry genome-wide association studies (GWAS) for platelet indices (UK Biobank, n=408,112) and COPD (FinnGen, n=433,208). MR analyses were performed using Inverse Variance Weighting (IVW), MR Egger (ME), Simple Mode (SM), Weighted Median (WMe), and Weighted Mode (WMo). Heterogeneity between SNPs was assessed using Cochran's Q test in combination with a random-effects IVW approach. MR-Egger intercept test and MR-PRESSO analysis demonstrate horizontal pleiotropy. Leave-one-out analysis to assess outlier-driven bias.</p><p><strong>Results: </strong>IVW analysis indicated that higher PLT was suggestively associated with increased COPD risk (OR = 1.054, 95% CI = 1.005-1.056, <i>p</i> = 0.029, FDR = 0.116). In the reverse direction, COPD was suggestively associated with increased PCT (OR = 1.025, 95% CI = 1.003-1.048, <i>p</i> = 0.024, FDR= 0.096). No significant associations were observed for MPV or PDW. Sensitivity analyses confirmed the robustness of results, with no signs of pleiotropy or reverse causality.</p><p><strong>Conclusion: </strong>Our bidirectional MR analysis found no definitive causal relationship between platelet indices and COPD, but observed suggestive associations between higher PLT/PCT and an increased risk of COPD. These findings warrant further investigation into the roles of platelet indices in COPD pathogenesis and their potential as biomarkers or therapeutic targets.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2967-2977"},"PeriodicalIF":3.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Abnormal Functional Performance in Chronic Obstructive Pulmonary Disease Using Respiratory Models: A Pilot Study.","authors":"Caroline Oliveira Ribeiro, Agnaldo José Lopes, Pedro Lopes de Melo","doi":"10.2147/COPD.S524591","DOIUrl":"https://doi.org/10.2147/COPD.S524591","url":null,"abstract":"<p><strong>Introduction: </strong>The contribution of respiratory models to understanding and predicting functional capacity abnormalities in chronic obstructive pulmonary disease (COPD) has not yet been investigated.</p><p><strong>Purpose: </strong>The aims of this study were: (1) To investigate the associations between the extended Resistance-Inertance-Compliance (eRIC) and the fractional-order (FrOr) models with changes in Glittre-ADL and handgrip tests and; (2) To evaluate the accuracy of these models in predicting abnormal functional capacity in COPD.</p><p><strong>Patients and methods: </strong>The study was carried out in a group of 40 adults with COPD and a control group of 40 healthy individuals, both evaluated by respiratory oscillometry, spirometry, Glittre-ADL test and handgrip test. eRIC and fractional order models were also used to quantify biomechanical changes and obtain physiological information. The ability of model parameters to predict abnormal functional performance was evaluated by investigating the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>Inverse relationships were observed between central airway resistance from the eRIC model and the handgrip test (p<0.005), while respiratory compliance (C) was directly related with handgrip strength test and inversely associated with the Glittre-ADL test time (p<0.05). The FrOr model showed direct associations among respiratory damping (G) and elastance with the Glittre-ADL test (p<0.02), while significant inverse relationships were observed with the handgrip test (p<0.05). Modeling parameters (peripheral resistance, total resistance and hysteresivity) achieved high prediction accuracy (AUC>0.90) in predicting non-normal functional capacity in COPD assessed by the Glittre-ADL test. Considering abnormal changes evaluated by the handgrip test as a reference, C (AUC=0.810) and G (AUC=0.786) obtained the highest predictive accuracies.</p><p><strong>Conclusion: </strong>Parameters obtained from the eRIC and the fractional order models are associated with non-normal exercise performance in COPD and may help predict poor functional performance in these patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2945-2965"},"PeriodicalIF":3.1,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Eosinophil Stability Predicts Clinical Outcomes in Hospitalized Patients with Acute Exacerbations of COPD.","authors":"Lujia Guan, Jiachen Li, Lirong Liang, Zhaohui Tong","doi":"10.2147/COPD.S536911","DOIUrl":"https://doi.org/10.2147/COPD.S536911","url":null,"abstract":"<p><strong>Background and objective: </strong>Blood eosinophil (EOS) levels are considered a potential biomarker for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) management, but the impact of EOS stability during hospitalization on outcomes is unclear. This study examined the relationship between EOS stability and clinical outcomes in these patients.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 2105 AECOPD patients hospitalized at Beijing Chao-Yang Hospital from 2013 to 2022. Patients were classified into four groups according to EOS counts (2%) at admission and discharge: persistent high, decreased, increased, and persistent low. Clinical characteristics and outcomes were compared between EOS stability groups. Multivariable logistic regression was used to evaluate the association between EOS stability and adverse hospital outcomes. Cox regression analysis was performed to assess the risk of AECOPD-related readmission within three years. Receiver operating characteristic (ROC) curves and nomograms were used to evaluate the predictive performance of the models.</p><p><strong>Results: </strong>There were 586 (27.8%), 154 (7.3%), 593 (28.2%), and 772 (36.7%) patients in the persistent high, decreased, increased, and persistent low groups, respectively. Multivariable logistic regression analysis showed that the persistent high EOS group had a significantly lower risk of adverse hospital outcomes compared to the persistent low EOS group (aOR: 0.77, 95% CI: 0.59-0.99, <i>P</i> = 0.040). The nomogram developed based on the multivariate model demonstrated good predictive accuracy for adverse hospital outcomes, with an AUC of 0.67, and was well-calibrated. Cox regression analysis revealed that the persistent high EOS group had a higher risk of AECOPD-related readmission within three years compared to the persistent low EOS group (aHR: 1.38, 95% CI: 1.13-1.68, <i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>Blood eosinophil stability during hospitalization is associated with AECOPD prognosis and may help guide inpatient treatment and identify patients at higher risk of future readmission.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2913-2923"},"PeriodicalIF":3.1,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic Cell in COPD: Mechanisms of Airway Remodeling, Immune Dysregulation, and Therapeutic Implications.","authors":"Kailin Zhou, Qianmei Wen, Yujie Zuo, Ge Bai, Ruiting Sun","doi":"10.2147/COPD.S523519","DOIUrl":"https://doi.org/10.2147/COPD.S523519","url":null,"abstract":"<p><p>The pathological alterations in COPD cells represent adaptive responses to COPD lesions, focusing on three primary pathological changes: abnormal repair and tissue remodeling, protease-antiprotease imbalance, and inflammatory amplification alongside immune disorder. These alterations ultimately result in a detrimental cycle of lung parenchymal destruction and airway structural remodeling. COPD manifests with diverse pathological phenotypes, pronounced heterogeneity, and a convoluted evolution process. However the role of pathological changes and mechanisms in pathological cells, as well as cellular senescence, metabolic reprogramming, and intercellular interaction networks in COPD, remains unclear. This review comprehensively encapsulates the most recent research advancements regarding the principal pathological cells in COPD, encompassing airway epithelial cells, fibroblasts, endothelial cells, and immune inflammatory cells. Elucidated the pathological alterations of these cells in relation to COPD, their influence on disease progression, and their clinical implications. Furthermore, Exosome-mediated miRNA transfer exacerbates inflammation and fibrosis, suggesting novel therapeutic targets. In summary, our work aims to provide a basic reference for research into the pathogenic mechanisms of this disease.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2925-2943"},"PeriodicalIF":3.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Sectional Survey of COPD Risk in Undiagnosed Adults in Saudi Arabia Using the Arabic COPD-PS.","authors":"Ayedh D Alahmari, Hams M Shrourou","doi":"10.2147/COPD.S530064","DOIUrl":"https://doi.org/10.2147/COPD.S530064","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic obstructive pulmonary disease (COPD) is a common disease and the third leading cause of death, although it remains misdiagnosed and untreated. Individuals at risk of developing COPD, when detected early, have a significant chance to alter the progression of the disease by prompt medical and non-medical care.</p><p><strong>Objective: </strong>To evaluate the risk level of COPD in Saudi Arabia regions by using an Arabic-translated COPD Population Screener (COPD-PS) questionnaire.</p><p><strong>Methods: </strong>This is a cross-sectional study conducted from October 12, 2023, to October 29, 2024. A convenience sampling method was used to recruit participants. This study utilized a self-administered Arabic-translated version of the COPD-PS, which evaluates various subjects related to COPD.</p><p><strong>Results: </strong>In this study of 2002 participants, a majority of them 74.39% (n = 1494) were from the Western region of Saudi Arabia. Most participants 76.72% (n = 1536) were below 35 years of age, and over half 57.39% (n = 1149) were non-smokers. The result of the COPD-PS scoring indicated 88.76% (n = 1777) of participants at low risk of COPD, while 11.24% (n = 225) participants were at high risk of COPD. Also, this study showed a statistically significant difference regarding the risk level of COPD among regions (p < 0.0001). In addition, the risk level of COPD and smoking status revealed a statistically significant difference (p ≤ 0.0001). Further analysis demonstrated that the risk level of COPD has an association with the existence of Diabetes/Hypertension (p = 0.0013).</p><p><strong>Conclusion: </strong>The Arabic-translated version of COPD-PS is an effective tool for screening the risk level of COPD among the Arabic responders in Saudi Arabia. There are various factors, including smoking status, the existence of Diabetes/ Hypertension, and regions associated with higher COPD-PS risk.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2905-2911"},"PeriodicalIF":3.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Geriatric Nutritional Risk Index for Readmission within 6-Months in Elderly Inpatients with Acute Exacerbation Chronic Obstructive Pulmonary Disease.","authors":"Huan Liu, Jingsi Song, Zhiqiang Wang, Xingyu Xiong, Zhi Li, Xiaofan Jing","doi":"10.2147/COPD.S533605","DOIUrl":"10.2147/COPD.S533605","url":null,"abstract":"<p><strong>Purpose: </strong>Elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) who are hospitalized have a higher incidence of nutritional risk. The geriatric nutritional risk index (GNRI) was applied to evaluate nutritional status in elderly AECOPD patients. Furthermore, its predictive value for 6-month readmission due to acute exacerbations was analyzed.</p><p><strong>Patients and methods: </strong>A total of 301 elderly AECOPD inpatients admitted to the Department of Respiratory and Critical Care Medicine from March 2023 to June 2024 were included. The demographic, clinical characteristics, smoking history, comorbidities, laboratory values, outcomes of all patients were collected. Evaluate the nutritional risk of patients using GNRI. Multivariate logistic regression model analysis was used to identify the influencing factors of readmission within 6-months.</p><p><strong>Results: </strong>According to the GNRI, 180 subjects (59.80%) had nutritional risk (GNRI ≤ 98). The readmission rate within 6-months was 32.56%. Single-factor logistic regression analysis showed that GNRI, Sex, BMI, length of hospital stay, heart failure, smoking and GOLD were significantly related to readmission within 6-months (p <0.05). Multivariate logistic regression analysis showed that the risk factors for readmission within 6- months included GNRI (OR = 2.439, p = 0.003, 95% CI: 1.348-4.413), Current smoking (OR = 8.297, p < 0.001, 95% CI: 4.158-16.557), GOLD II (OR = 4.045, p = 0.015, 95% CI: 1.316-12.435), GOLD III (OR = 5.725, p = 0.002, 95% CI: 1.878-17.451), and GOLD IV (OR = 19.063, p < 0.001, 95% CI: 4.504-80.674).</p><p><strong>Conclusion: </strong>The proportion of nutritional risk was higher in elderly AECOPD inpatients, and GNRI (GNRI ≤ 98) is an independent risk factor for readmission due to acute exacerbations within 6-months.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2893-2903"},"PeriodicalIF":3.1,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers in COPD-Associated PH/CCP: Circulating Molecules and Cell-Intrinsic Marker.","authors":"Juan Wang, Yankun Zhang, Huimin Liu, Lingling Liu, Chong Xu, Jing Zhang","doi":"10.2147/COPD.S521659","DOIUrl":"https://doi.org/10.2147/COPD.S521659","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is a chronic progressive disease of the airways and lungs characterized by persistent respiratory symptoms and airflow limitation. Under hypoxic conditions, endothelial cells and immune cells secrete inflammatory mediators and growth factors, promoting the proliferation of pulmonary vascular smooth muscle cells and fibroblasts, leading to vascular remodeling. Considering the high morbidity and mortality of pulmonary hypertension (PH) in patients with COPD, we investigated the molecular mechanisms underlying vascular remodeling in COPD-related PH. Neurohumoral factor N-terminal brain natriuretic peptide (NT-proBNP), inflammatory mediators, growth factors, and forkhead box M1 (FOXM1) were evaluated as auxiliary diagnostic markers for COPD with PH and chronic cor pulmonale (CCP), aiming to facilitate early PH screening, prevention, and improvement of patient survival and quality of life. Circulating biomarkers (NT-proBNP, inflammatory mediators, growth factors) can be detected via clinical blood sampling, offering non-invasive, convenient diagnostic approaches with high specificity and sensitivity-ideal tools for disease screening. Intracellular molecular marker FOXM1, requiring tissue or enriched cell detection, serves as a histopathological marker and potential target for liquid biopsy, positioning it as a promising future screening tool.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2869-2883"},"PeriodicalIF":3.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dual Threat Combined Pulmonary Fibrosis and Emphysema (CPFE): Two Cases.","authors":"Shan Peng, Fanqing Meng, Cheng Wu, Mengshu Cao, Wei Li, Xiaoyan Xin, Anning Feng","doi":"10.2147/COPD.S523597","DOIUrl":"https://doi.org/10.2147/COPD.S523597","url":null,"abstract":"<p><p>Emphysema is common in fibrotic interstitial lung diseases, and its combination with pulmonary fibrosis is known as \"Combined Pulmonary Fibrosis and Emphysema (CPFE) syndrome\". The diagnosis of CPFE significantly impacts treatment strategies and prognosis. In this article, we report the clinical, imaging, and especially the pathological features of two CPFE patients. <b>Case 1</b>: A 51-year-old male patient with a history of smoking. CT scans revealed interstitial lung disease combined with pulmonary bullae. Pathology showed extensive deposition of mononuclear cells in the alveolar spaces, with some cells phagocytosing pigment. Mild fibrous tissue hyperplasia was present in the lung interstitium, along with chronic inflammation and lymphoid nodule formation. The histological findings were consistent with desquamative interstitial pneumonia (DIP), and the clinical, imaging, and pathological correlation confirmed a diagnosis of CPFE. <b>Case 2</b>: A 58-year-old male, a driver with a history of dust exposure and smoking, was admitted due to chest tightness and a cough for 2 years. Chest CT revealed interstitial changes, emphysema, and bullae in both lungs. Histopathology showed fibrous widening of alveolar septa, mild chronic inflammation, and dust cell deposition, along with emphysematous changes and bulla formation, consistent with CPFE. The purpose of this report is to increase pathologists' awareness of this complex disease and emphasize the importance of multidisciplinary cooperation in the diagnosis and treatment of CPFE. Furthermore, this article encourages further research into CPFE.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2885-2891"},"PeriodicalIF":3.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Severity Assessment of COPD Based on Machine Learning of Chest CT Images.","authors":"He Sui, Zhanhao Mo, Ying Wei, Feng Shi, Kailiang Cheng, Lin Liu","doi":"10.2147/COPD.S528988","DOIUrl":"10.2147/COPD.S528988","url":null,"abstract":"<p><strong>Purpose: </strong>During the acute phase of obstructive pulmonary disease (COPD), completing a standard pulmonary function test may be challenging for some patients. The goal of this experiment is to develop a machine learning model that uses chest CT images for automated diagnosis and grading of COPD patients, aiming to enhance diagnostic efficiency and accuracy.</p><p><strong>Patients and methods: </strong>The study retrospectively included 173 COPD patients and 176 healthy controls from December 2017 to June 2023. Deep learning segmentation modules were used to automatically segment the obtained chest CT images for lung parenchyma, airway, pulmonary artery, and vein. Imaging features were extracted from these segmented regions. The most reliable and relevant features were selected using Mann-Whitney <i>U</i>-test with a significant p-value of 0.05 and the least absolute shrinkage and selection operator (LASSO) method. Machine learning models were established through support vector machine (SVM) classifier in the training set and further tested in the internal testing set. Additional tests were performed on an external testing set with 68 individuals.</p><p><strong>Results: </strong>In the machine learning model for COPD diagnosis, the image model achieved AUC values of 0.981 and 0.977 in the training and testing sets, with corresponding accuracies of 0.949 and 0.956 respectively. For COPD severity grading, the image model obtained AUC values of 0.889 and 0.796 in the training and testing sets, along with accuracies of 0.784 and 0.719.</p><p><strong>Conclusion: </strong>The machine learning model based on chest CT images can accurately predict lung function, which can assist in the diagnosis and severity grading of COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2853-2867"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Serum Inflammatory Markers and Chronic Obstructive Pulmonary Disease in Middle-Aged and Older Adults in the United States: A Cross-Sectional Study Based on NHANES 2013-2018.","authors":"Yefeng Chen, Yanmin Pei, Weiqiang Mo, Haiqin Wang","doi":"10.2147/COPD.S534504","DOIUrl":"10.2147/COPD.S534504","url":null,"abstract":"<p><strong>Objective: </strong>Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by increased inflammation, persistent decline in lung function, and extensive lung damage. Research has shown that inflammation plays a crucial role in the formation and progression of COPD. The systemic inflammation response index (SIRI) is an emerging inflammatory biomarker whose clinical significance in COPD remains undetermined. This study aims to explore the potential association between serum inflammatory marker SIRI levels and the prevalence of COPD.</p><p><strong>Methods: </strong>This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) database from 2013-2018. A total of 10,273 participants were analyzed and divided into two groups: COPD (n = 595) and non-COPD (n = 9678). Comparative analysis of demographic and clinical characteristics was performed between cohorts. The SIRI was calculated based on the counts of monocytes, neutrophils, and lymphocytes. Weighted logistic regression models were applied to assess the association between SIRI and COPD, while restricted cubic spline (RCS) curves were utilized to investigate potential non-linear relationships. Additionally, subgroup and interaction analyses were performed.</p><p><strong>Results: </strong>Our study included 10,273 participants, of whom 595 were diagnosed with COPD, while 9678 were diagnosed with non-COPD. In the fully adjusted logistic regression model, SIRI was significantly positively correlated with COPD (OR = 1.96, 95% CI = 1.34-2.87). The analysis of the RCS curve revealed a non-linear relationship between SIRI and COPD <i>(P</i> < 0.05). Subgroup and interaction analyses further confirmed the robustness of our findings.</p><p><strong>Conclusion: </strong>Serum inflammatory marker SIRI levels are positively correlated with the occurrence of COPD and exhibit a non-linear relationship.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2837-2846"},"PeriodicalIF":3.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}