International Journal of Chronic Obstructive Pulmonary Disease最新文献

{"title":"Level of Awareness About Chronic Obstructive Pulmonary Disease Among Active Smokers.","authors":"Hajed M Al-Otaibi, Mazen M Homoud, Manal M Alqarni, Ghadeer J Alsobhi, Ghala Zaam Al-Otaibi, Nehal A Alnahdi","doi":"10.2147/COPD.S580239","DOIUrl":"https://doi.org/10.2147/COPD.S580239","url":null,"abstract":"<p><strong>Background: </strong>Smoking is considered the primary cause of chronic obstructive pulmonary disease (COPD). It has been shown that approximately half of smokers develop COPD at some point in their lives. Several studies have examined COPD awareness in the general population. However, data on awareness among active smokers remain limited. This study aims to assess the level of COPD awareness among current smokers.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among active smokers. Recruitment was performed via non-probability convenience sampling through commonly used social media platforms. An online survey was utilized to collect data on sociodemographic characteristics, health status, COPD awareness levels, and smokers' perceptions after learning about COPD. Multivariable logistic regression was performed to identify determinants of COPD awareness.</p><p><strong>Results: </strong>The total number of respondents was 455 active smokers. Of those, 342 (75%) were male. The mean age of participants was 35 ± 11 years. Although COPD-related symptoms were reported by 324 participants (71.2% of the total sample), only 91 participants (20%) indicated being aware of COPD. The most common symptoms reported were sputum production (209 participants, 46%), shortness of breath (167 participants, 36.7%), and cough (166 participants, 36.4%). Multivariable logistic regression analysis for determinants of COPD awareness showed that none of the predictors (sex, years of smoking, level of education, and COPD-related symptoms) were statistically significant. Among COPD-related symptoms, coughing (adjusted odds ratio (aOR) = 0.62, 95% confidence interval (CI): 0.35-1.08, p = 0.089) and sputum production (aOR = 1.48, 95% CI: 0.86-2.55, p = 0.160) showed trends toward association with COPD awareness but were still not statistically significant. The most common sources of knowledge about COPD were healthcare providers (34%) and social media platforms (31.8%).</p><p><strong>Conclusion: </strong>The level of COPD awareness is low among active smokers, which might hinder early diagnosis and delay timely interventions. Healthcare providers and social media may promote awareness. Therefore, the advocacy role of healthcare providers may need encouragement, and Social media platforms may support culturally tailored COPD awareness campaigns.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"580239"},"PeriodicalIF":3.1,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13045730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VE-VCO2 Slope During Cardiopulmonary Exercise Test Predicts Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.","authors":"Xiaona Li, Fang Lin, Jingxuan Wu, Jianxiong Zhang, Siqi Liu, Mengmeng Qiu, Wei Yuan, Shan Nie, Fugui Yan, Bo Xu, Yunxiao Li","doi":"10.2147/COPD.S581813","DOIUrl":"https://doi.org/10.2147/COPD.S581813","url":null,"abstract":"<p><strong>Background: </strong>Cardiopulmonary Exercise Test (CPET) serves as an integrative assessment tool to evaluate cardiac function, respiratory responses, and neuromuscular capacity in patients with chronic obstructive pulmonary disease (COPD) during incremental cycling exercise. VE-VCO2 slope during CPET was not fully understood in predicting acute exacerbations of COPD (AECOPD). This study aims to establish a predictive model for AECOPD based on the VE-VCO2 slope.</p><p><strong>Methods: </strong>In total, 79 patients with COPD were recruited between 2013 and 2019. All participants underwent baseline pulmonary function tests and CPET and were followed up for 5 years thereafter. Independent two-sample <i>t</i>-tests and Chi-square tests were used to compare AECOPD and Non-AECOPD groups. Univariate and multivariate Cox regression analyses were utilized to identify predictive factors for AECOPD. The diagnostic performance of these variables was evaluated by receiver operating characteristic (ROC) curve analysis. The optimal cutoff values calculated by Youden's index. Kaplan-Meier survival analysis between subgroups was based on the optimal cutoff values. Generating Forest plots to visualize Cox regression analysis results.</p><p><strong>Results: </strong>The AECOPD group contains 62 participants and the Non-AECOPD group contains 17 participants. Groups comparisons revealed significant differences in VE-VCO2 slope, age, BMI, FEV1%predicted, FEV1/FVC ratio, and EqCO2. Multivariate Cox regression analysis identified VE-VCO2 slope (OR = 1.19, 95% CI: 1.09-1.29, p < 0.001), age (OR = 1.05, 95% CI: 1.02-1.09, p = 0.005), and FEV1%predicted (OR = 0.96, 95% CI : 0.94-0.99, p = 0.015) as significant predictors of AECOPD. The ROC curve analysis results about the above predictors found that the AUC of VE-VCO2 slope is highest independently in 1 year, 3 years and 5 years, with the optimal cutoff values = 28.42 in 5 years (hazard ratio = 3.18, 95% CI: 1.639-6.2, p < 0.001).</p><p><strong>Conclusion: </strong>The stratification of VE-VCO2 slope ≥28.42 was an independent predictor of AECOPD. Our study established VE-VCO2 slope as a novel stratified clinical biomarker for predicting AECOPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"581813"},"PeriodicalIF":3.1,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13041537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LAMC2 Drives Airway Remodeling in COPD via EMT Regulation Through the AKT Pathway.","authors":"Zihan Wang, Jun Shi, Yue Zhang, Ying Luo, Yafei Rao, Jingge Qu, Xiaoyan Gai, Yongchang Sun","doi":"10.2147/COPD.S580964","DOIUrl":"https://doi.org/10.2147/COPD.S580964","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation, largely driven by airway remodeling. Epithelial-mesenchymal transition (EMT) is a key mechanism underlying this process. Laminin subunit gamma-2 (LAMC2) is implicated in fibrosis and EMT, but its role in COPD-associated airway remodeling remains unclear.</p><p><strong>Methods: </strong>Differential expression analysis was performed using airway epithelial cell datasets from COPD patients and TGF-β1-induced EMT models. Findings were validated in COPD patient lung tissues, smoke-exposed mice, and in vitro experiments. In vivo, chronic smoke-exposed mice were pre-treated intratracheally with adeno-associated virus (AAV)-shLAMC2. Functional assays involved siRNA knockdown or plasmid overexpression of LAMC2 in bronchial epithelial cells. RNA sequencing and pathway analyses were conducted to explore underlying mechanisms.</p><p><strong>Results: </strong>LAMC2 was significantly upregulated in COPD patient and murine airway epithelia. AAV-shLAMC2 administration alleviated airway remodeling and restored epithelial E-cadherin while reducing mesenchymal markers (N-cadherin, fibronectin), indicating attenuation of EMT. In vitro, LAMC2 was upregulated in TGF-β1-stimulated epithelial cells, and its modulation significantly influenced EMT progression. Transcriptomic analysis suggested that AKT signaling as a potential downstream of LAMC2, supported by functional assays.</p><p><strong>Conclusion: </strong>LAMC2 is upregulated in COPD airway epithelium and promotes airway remodeling by regulating EMT, potentially through AKT signaling. These findings suggest that targeting LAMC2 may represent a potential strategy for mitigating COPD-associated airway remodeling.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"580964"},"PeriodicalIF":3.1,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13037650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Clinical Nomogram for Predicting Densitometric Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease Based on NHANES Data.","authors":"Peng Jiang, Tingting Chen","doi":"10.2147/COPD.S571149","DOIUrl":"10.2147/COPD.S571149","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify factors associated with densitometric osteoporosis (OP) in patients with Chronic Obstructive Pulmonary Disease (COPD) and develop a predictive model for OP.</p><p><strong>Methods: </strong>Retrospective analysis was conducted using data from COPD patients in the National Health and Nutrition Examination Survey database. OP was defined with a T-score of ≤ -2.5 at the lumbar spine or femoral neck. Variables with more than 25% missing values were excluded, while others were imputed. Collinearity analysis was performed, and data were randomly divided into a 7:3 train-test set ratio. The Least Absolute Shrinkage and Selection Operator and Boruta algorithms were used for feature selection. The selected variables were evaluated with Receiver Operating Characteristic (ROC) analysis to identify the optimal predictive model, which was then used to construct a nomogram. The nomogram's efficacy and stability were validated in the test set.</p><p><strong>Results: </strong>Data from 1351 COPD patients were included. Age, weight, height, OP history of self-report, hemoglobin, and high-density lipoprotein cholesterol were identified as significant factors for OP. Those variables were combined into 7 different models. The ROC analysis results revealed that among the seven models, the model containing four variables was the optimal model. The nomogram, based on four variables (age, weight, height, and OP history of self-report), demonstrated good calibration and predictive performance (areas under curve: 0.841 in the train set, 0.833 in the test set). The nomogram showed high clinical net benefit and stability in subgroup analysis.</p><p><strong>Conclusion: </strong>Age, weight, height, and OP history of self-report are significantly associated with densitometric OP in COPD patients. The constructed nomogram, based on these factors, provides an effective and stable tool for early identification of high-risk OP patients in clinical practice.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"571149"},"PeriodicalIF":3.1,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Observational Study Evaluating the PRogression Of BronchiEctasis in COPD Patients - Results from the PROBE - COPD Study.","authors":"Rajesh Venkitakrishnan, Athulya Sudheendranath, Anand Vijay, Divya Ramachandran, Melcy Cleetus, Hasha Thankam Somson, Susan John","doi":"10.2147/COPD.S571906","DOIUrl":"10.2147/COPD.S571906","url":null,"abstract":"<p><strong>Background: </strong>Bronchiectasis is increasingly recognised in individuals suffering from chronic obstructive pulmonary disease (COPD) and is associated with adverse outcomes. However, data on its temporal course and risk factors for progression in advanced COPD remain limited.</p><p><strong>Objective: </strong>The study aimed to assess the progression of bronchiectasis in stage E COPD patients over one-year, identify factors contributing to its advancement, and compare clinical outcomes between patients diagnosed with bronchiectasis and those without the condition.</p><p><strong>Methods: </strong>Patients with stage E COPD underwent high-resolution CT (HRCT) and were classified according to whether bronchiectasis present or absent at baseline. All participants were followed for 12 months, with quarterly clinical evaluation, six-monthly sputum culture, spirometry, and repeat HRCT at one-year. Progression of bronchiectasis, decline in lung function, exacerbations, hospitalisations, and mortality were assessed. Predictors of progression were explored using univariate analysis.</p><p><strong>Results: </strong>Of the 104 patients, 33 (31.7%) had bronchiectasis at baseline. At one-year, 22 of these (66.67%) showed radiological progression and 8 (24.2%) remained stable Among the 71 without bronchiectasis, new bronchiectasis developed in 37 (52.1%). Frequent exacerbations (≥2/year) occurred more often in patients with bronchiectasis compared to those without (84.8% vs. 75.8%, P=0.023). Hospitalisation rates were also higher in the bronchiectasis group (60.6% vs. 35.2%, P<0.001).</p><p><strong>Conclusion: </strong>Bronchiectasis was present in one-third of stage E COPD patients at baseline, and more than half of those without bronchiectasis developed new lesions during follow-up. COPD patients with bronchiectasis had higher exacerbation frequency, hospitalisations, and greater progression of disease, underscoring its role as a poor prognostic marker in advanced COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"571906"},"PeriodicalIF":3.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13032755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Controlled Study on the Effects of Four-Limb Linkage Training on Clinical Efficacy and Antioxidative Mechanisms in Patients with Chronic Obstructive Pulmonary Disease.","authors":"Xijiao Liu, Li Chen, Zonghui Wei, Jinshan Jiang, Yunyan Yu, Zhishan Wang","doi":"10.2147/COPD.S576646","DOIUrl":"10.2147/COPD.S576646","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of systematic four-limb linkage training on pulmonary function, exercise capacity, dyspnea, and quality of life in patients with chronic obstructive pulmonary disease (COPD), and to explore its potential antioxidative mechanisms.</p><p><strong>Methods: </strong>This retrospective controlled study included 114 patients with COPD admitted between August 2023 and April 2025. Patients were divided into a control group (n=57), receiving lower-limb cycling training, and an observation group (n=57), receiving four-limb linkage training. Both groups underwent continuous rehabilitation intervention for 8 weeks. Pulmonary function indices (FEV1, FVC, FEV1/FVC, FEV1%pred), dyspnea scores (modified Medical Research Council and Borg scales), exercise capacity (6-minute walking distance, 6MWD), disease severity (BODE index), quality of life (St. George's Respiratory Questionnaire, SGRQ), and oxidative stress markers [thioredoxin (TRX) and thioredoxin-interacting protein (TXNIP) at mRNA and protein levels] were assessed at Pre-intervention and Post 8-week intervention.</p><p><strong>Results: </strong>At Post 8-week intervention, pulmonary function indices, exercise capacity, and quality-of-life scores were significantly improved, while dyspnea scores and BODE index were significantly reduced in both groups compared with Pre-intervention (P<0.05). The magnitude of improvement was significantly greater in the four-limb linkage training group than in the control group (P<0.05). In addition, TRX mRNA and protein expression levels were significantly increased, whereas TXNIP mRNA and protein expression levels were significantly decreased at Post 8-week intervention compared with Pre-intervention, with more pronounced changes observed in the observation group (P<0.05).</p><p><strong>Conclusion: </strong>Four-limb linkage training significantly improves pulmonary function, exercise capacity, dyspnea, and quality of life in patients with COPD. These benefits may be mediated, at least in part, by enhanced antioxidative activity through upregulation of TRX and suppression of TXNIP. Compared with lower-limb training alone, four-limb linkage training provides a more comprehensive rehabilitation strategy for COPD management.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"576646"},"PeriodicalIF":3.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomal miR-2110 from PM2.5-Exposed Lung Epithelial Cells Targets SRSF1 to Promote M1 Macrophage Polarization and Inflammatory Responses in COPD.","authors":"Yehong Miao, Jianjun Gu, Juan Li, Danye Sheng","doi":"10.2147/COPD.S584536","DOIUrl":"10.2147/COPD.S584536","url":null,"abstract":"<p><strong>Purpose: </strong>Exposure to PM2.5 is a known contributor to the development of chronic obstructive pulmonary disease (COPD). As direct targets of PM2.5, bronchial epithelial cells participate in intercellular communication with macrophages and induce phenotypic changes in these immune cells. This study aimed to investigate the role and underly mechanism of epithelial cell-derived exosomes in regulating macrophage polarization.</p><p><strong>Methods: </strong>Following PM2.5 exposure, exosomes were isolated from BEAS-2B cells and subsequently co-cultured with M0 macrophages. We measured the production of inflammatory cytokines and macrophage markers. The phenotypic effect of miR-2110 on macrophage polarization was examined in a COPD murine model, with subsequent exploration of relevant molecular pathways. The binding specificity of miR-2110 was assessed utilizing a luciferase reporter assay.</p><p><strong>Results: </strong>In vitro analyses confirmed that P-Exo (PM2.5-exposed BEAS-2B cells exosomes) triggered M1 polarization, as evidenced by elevated expression of IL-6, TNF-α, and iNOS-2. Additionally, miR-2110 expression was upregulated in P-Exo. Inhibition of miR-2110 reduced M1 polarization and decreased inflammatory cytokine production both in vitro and in vivo. Luciferase assays confirmed that miR-2110 targeted SRSF1 expression. Overexpression of SRSF1 mitigated the regulatory role of miR-2110 in promoting M1 phenotype transition and pro-inflammatory cytokine production.</p><p><strong>Conclusion: </strong>This work clarifies that exosomal miR-2110, which is produced from lung epithelial cells treated with PM2.5, exacerbates COPD and might be a viable target for COPD prevention and therapy.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"584536"},"PeriodicalIF":3.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13032734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Severe Vitamin D Deficiency on Antibiotic Use in Hospitalized COPD Patients with Exacerbations: A Retrospective Analysis.","authors":"Boyu Li, Meishan Liu, Bingqing Ren, Han Wu, Yi Zhang, Zhuoling An, Kewu Huang","doi":"10.2147/COPD.S568072","DOIUrl":"10.2147/COPD.S568072","url":null,"abstract":"<p><strong>Background: </strong>Exacerbations of chronic obstructive pulmonary disease (ECOPD) often require antibiotic treatment. Vitamin D deficiency has been implicated in influencing the outcomes of ECOPD; however, its role in antibiotic usage during hospitalization remains unclear.</p><p><strong>Patients and methods: </strong>We conducted a retrospective analysis of 125 hospitalized ECOPD patients, stratified into two groups based on the presence of severe vitamin D deficiency (SVDD, 25-hydroxyvitamin D < 10 ng/mL) and non-severe vitamin D deficiency (NSVDD). Clinical outcomes, including duration of antibiotic treatment, cumulative defined daily doses (cDDDs), hospital length of stay (LOS) and associated costs, were compared between subgroups. Multivariate linear regression was used to assess the association between 25-hydroxyvitamin D levels and antibiotic use, adjusting for demographic and clinical variables.</p><p><strong>Results: </strong>Patients with SVDD exhibited significantly longer durations of antibiotic use (13.50 <i>vs</i>. 11.00 days, <i>P</i>=0.023), higher cDDDs (16.16 vs. 12.00, <i>P</i>=0.012) and longer LOS (15.00 <i>vs</i>.12.00, <i>P</i>=0.026) compared to those with NSVDD. Patients with SVDD and pneumonia had more antibiotics use, longer LOS and higher cost than those with NSVDD and AECOPD (<i>P</i><0.05). Multivariate linear regression analysis revealed that lower 25-hydroxyvitamin D levels were independently associated with increased antibiotic duration (coefficient -0.20, 95% CI -0.32, -0.08, <i>P</i><0.001) and higher cDDDs (coefficient -0.24, 95% CI -0.46, -0.01, <i>P</i>=0.041) after adjustment, although the magnitude was smaller than that observed for some other variables.</p><p><strong>Conclusion: </strong>SVDD is independently associated with antibiotic burden in hospitalized COPD patients with exacerbation. Prospective studies are warranted to further explore this potential relationship and its clinical implications.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"568072"},"PeriodicalIF":3.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13032757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease Burden and Unmet Needs in Chinese Patients with Symptomatic and Exacerbating COPD While on Triple Inhaled Therapy: A Cross-Sectional Real-World Study.","authors":"Yongchang Sun, Tia Pennant, Fraser R Barrable","doi":"10.2147/COPD.S580726","DOIUrl":"10.2147/COPD.S580726","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a common respiratory disease and a major cause of mortality and morbidity in China. Global studies have revealed a subgroup of patients who had COPD symptoms and frequent exacerbations while receiving triple inhaled therapy. This study aimed to describe the clinical characteristics and disease burden of this patient population in China.</p><p><strong>Methods: </strong>This cross-sectional, real-world study drew data from the Adelphi COPD Disease Specific Programme (DSP)™ from July to November 2022 in China. Adult patients with a diagnosis of COPD and receiving triple therapy at survey date were included; among them, patients who had frequent productive cough and sputum, a history of smoking, ≥2 moderate or ≥1 severe exacerbation(s) in the prior 12 months and were receiving triple therapy were identified as the symptomatic SET cohort; all other patients were categorized as the triple therapy cohort. Disease-related characteristics and perceptions of disease control were described for both cohorts.</p><p><strong>Results: </strong>Of the 135 patients receiving triple therapy, 39 (28.9%) were categorized into the symptomatic SET cohort and 96 (71.1%) into the triple therapy cohort. In the triple therapy and symptomatic SET cohorts, mean (SD) age was 65.9 (9.0) and 69.2 (8.7), respectively; mean (SD) number of exacerbations during the last 12 months was 1.3 (1.4) and 2.3 (1.3), respectively; mean (SD) CAT score was 21.0 (8.3) and 25.7 (7.1), respectively. According to physicians' perception, around 70% of patients in the symptomatic SET cohort had, at the minimum, somewhat controlled COPD (completely controlled: 2.6%; well controlled: 28.2%; somewhat controlled: 38.5%). Satisfactory COPD control was achieved in 33.3% and 38.5% of patients in the symptomatic SET cohort as perceived by physicians and patients, respectively.</p><p><strong>Conclusion: </strong>Substantial disease burden and large unmet needs existed among patients with symptomatic and exacerbating COPD while receiving triple inhaled therapy in clinical settings in China. Novel therapeutic options and improved guideline-directed disease management are needed.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"580726"},"PeriodicalIF":3.1,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Phenomenological Qualitative Study of Primary Informal Caregiver of Chinese Patients with Advanced Stage COPD: An In-Depth Exploration of Experiences and Needs.","authors":"Xingshuai Ren, Fang Li, Tao Gao, Xilin Xu, Liyuan Sun, Shuangqi Liu, Yanhong Liu, Fei Wang","doi":"10.2147/COPD.S514685","DOIUrl":"10.2147/COPD.S514685","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder. It poses significant challenges in its advanced stages and requires frequent hospitalizations and complex care strategies. The burden on informal caregivers, who play a crucial role in managing the disease, is profound and multifaceted, involving physical, emotional, and social challenges.</p><p><strong>Objective: </strong>This study aimed to explore the lived experiences and needs of primary informal caregivers for patients with advanced COPD in China, with a focus on their emotional, physical, and social challenges and coping strategies.</p><p><strong>Methods: </strong>A phenomenological qualitative approach was employed to provide an in-depth understanding of caregiver experiences. Data were collected through face-to-face semi-structured interviews with 15 primary informal caregivers of advanced COPD patients from Central China. The interviews were analyzed using Colaizzi's method to extract key themes.</p><p><strong>Results: </strong>Caregivers reported significant emotional burdens, including anxiety and fear related to the patient's health and future. Physical challenges were prevalent, with many caregivers experiencing fatigue and health deterioration due to the demands of caregiving. Social isolation was also a critical issue, as caregiving responsibilities limited personal time and social interactions. Despite these challenges, caregivers employed various coping strategies, though these were often insufficient to fully mitigate the stress of caregiving.</p><p><strong>Conclusion: </strong>Informal caregivers of patients with advanced COPD often face intense physical and psychological burdens and need comprehensive support systems. Enhancements in caregiver education, the development of targeted psychological supports, and the integration of caregivers into formal care plans are essential to improve the health outcomes of both caregivers and patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"514685"},"PeriodicalIF":3.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}