International Journal of Chronic Obstructive Pulmonary Disease最新文献

{"title":"A Nomogram for Predicting 5-Year Risk of New-Onset Type 2 Diabetes in Patients with COPD: A Two-Center Retrospective Cohort Study.","authors":"Jingjing Pan, Feiju Chen, Weifeng Liao, Weilong Ye, Bainian Chen, Tong Lu, Kunning Li, Fang Liu, Xuyu Deng, Ting Sun, Riken Chen, Weimin Yao","doi":"10.2147/COPD.S590822","DOIUrl":"10.2147/COPD.S590822","url":null,"abstract":"<p><strong>Purpose: </strong>Type 2 diabetes mellitus (T2DM) often coexists with chronic obstructive pulmonary disease (COPD) and is accompanied by adverse outcomes, including high mortality. We developed and externally validated a nomogram to predict the 5-year new-onset T2DM risk in COPD patients without prior diabetes.</p><p><strong>Patients and methods: </strong>Patients hospitalized for COPD between May 2018 and December 2019 were enrolled and followed until December 2024. The development cohort was randomly divided into training and internal validation sets at a 7:3 ratio. In the training set, predictors were selected via least absolute shrinkage and selection operator (LASSO) regression and used to construct a nomogram. Model discrimination was evaluated by the receiver operating characteristic (ROC) curve with the area under the curve (AUC). Calibration curves and decision curve analysis (DCA) were used to assess calibration and clinical utility.</p><p><strong>Results: </strong>A total of 998 patients in our development cohort, 153 (15.3%) developed new-onset T2DM during follow-up. The final nomogram contained four predictors: Triglyceride-glucose index (TyG), hypertension (HTN), cardiovascular disease (CVD), and high-density lipoprotein (HDL). The AUCs in the training and internal validation sets were 0.749 and 0.758. External validation in an independent cohort of 1,018 patients, including 132 incident T2DM cases, produced an AUC of 0.798. DCA plots showed net clinical benefit across clinically relevant thresholds.</p><p><strong>Conclusion: </strong>This nomogram demonstrated good discrimination and calibration, and may facilitate risk stratification for T2DM among COPD patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"590822"},"PeriodicalIF":3.1,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Proposed Checklist for Optimizing COPD Patient Discharge Processes in Italian Internal Medicine Wards.","authors":"Alberto Benetti, Elisa Maria Fiorelli, Davide Grassi, Nicola Montano","doi":"10.2147/COPD.S571480","DOIUrl":"https://doi.org/10.2147/COPD.S571480","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is a major cause of hospital admissions and readmissions, particularly following acute exacerbations. The immediate post-discharge period is a vulnerable phase, often marked by clinical instability, poor adherence, and unaddressed needs related to inhaler use, comorbidities and rehabilitation. Despite guideline recommendations, key evidence-based interventions are often overlooked in hospital discharge processes, particularly in internal medicine wards where COPD may not be the primary focus. We conducted a targeted literature search using Medline/PubMed, screening approximately 240 relevant articles that support interventions across key domains of COPD discharge care. Building on this evidence, this narrative review and expert opinion aims to raise awareness and prompt systematic implementation of essential post-discharge care components and propose a structured COPD discharge checklist aimed at standardizing care and improving post-discharge outcomes. These include initiation of smoking cessation support, optimization of maintenance therapy, assessment and correction of inhaler technique, evaluation of vaccination status, referral to pulmonary rehabilitation, scheduling of early follow-up visits, and structured patient education on self-management strategies. The checklist is grounded in current evidence demonstrating that comprehensive discharge bundles reduce 30-day readmissions, enhance quality of life, and prevent further clinical deterioration. Early pulmonary rehabilitation, particularly within 3 weeks post-discharge, and timely initiation of appropriate pharmacotherapy, including triple inhaled therapy when indicated, further reduce exacerbation risk and healthcare utilization. By integrating these elements into a concise and actionable format, the checklist aims to support internists in delivering high-quality, standardized COPD care during hospital discharge. Broad adoption may improve care transitions, promote adherence to best practices, and ultimately enhance outcomes for patients with COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"571480"},"PeriodicalIF":3.1,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary-Intestinal Axis: Shared Genetic Basis and Mediating Factors Identified Through Multi-Omics Analysis.","authors":"Zhenzhu Zhang, Haoyue Liu, Yihang Su, Chengwen Wang, Wei Wang, Yinglin Li, Xiaobao Zhang, Chenguang Gao, Xue Tian, Chunqing Zhao","doi":"10.2147/COPD.S561645","DOIUrl":"https://doi.org/10.2147/COPD.S561645","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a systemic condition with comorbidities beyond the lung (eg, cardiovascular and metabolic disorders), and gastrointestinal (GI) disorders are also common. The shared genetic basis of COPD-GI comorbidity and its mediating factors remain unclear. We hypothesized that COPD and GI diseases share pleiotropic genetic architecture implicating lipid-metabolic pathways, with smoking mediating part of the association.</p><p><strong>Methods: </strong>We analyzed publicly available European-ancestry GWAS summary statistics for COPD (Global Biobank Meta-analysis Initiative), 15 GI diseases (FinnGen), and smoking phenotypes (UK Biobank). Genetic correlation was estimated using linkage disequilibrium score regression (LDSC) and high-definition likelihood (HDL). Multi-trait analysis of GWAS (MTAG) boosted COPD discovery by leveraging genetically correlated GI traits. We integrated locus-to-gene mapping with multi-tissue expression quantitative trait loci (eQTL) and plasma protein quantitative trait loci (pQTL) evidence to prioritize shared loci, genes, and proteins. Bidirectional two-sample Mendelian randomization (MR) tested causal directions, and two-step mediation MR evaluated smoking.</p><p><strong>Results: </strong>COPD showed significant genetic correlation with nine GI diseases. We identified six comorbidity-associated loci (three with CADD > 12.37) and 13 unique candidate pleiotropic genes; APOE was supported by proteomic evidence. Enrichment analyses highlighted lipid-metabolism pathways. MR suggested COPD increases risk of gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), acute appendicitis, and gastric ulcer, while diverticular disease showed reverse causality toward COPD. Smoking partially mediated the COPD effect on GERD, acute appendicitis, and gastric ulcer.</p><p><strong>Conclusion: </strong>COPD and multiple GI disorders share a distributed pleiotropic genetic basis within the broader systemic comorbidity spectrum of COPD. Multi-omics evidence supports a genomic pulmonary-intestinal axis in which lipid metabolism and smoking-related mechanisms contribute to COPD and GI comorbidity, providing targets for risk stratification and potential intervention.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"561645"},"PeriodicalIF":3.1,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participation of miRNA-23a-3p in Pulmonary Tuberculosis Through Macrophages via the JAK-STAT Pathway.","authors":"Wenjun Chang, Zheng Li, Qianqian Liang, Tao Liu, Fengsen Li","doi":"10.2147/COPD.S529070","DOIUrl":"https://doi.org/10.2147/COPD.S529070","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the role of miR-23a-3p in the pathogenesis of tuberculosis (TB)-associated obstructive pulmonary disease (TOPD) and its regulatory impact on THP-1 macrophages via the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway.</p><p><strong>Methods: </strong>Patients with TOPD, TB patients without airflow obstruction (only TB), and healthy controls were recruited. Peripheral blood mononuclear cells were isolated, followed by RNA-seq analysis to identify differentially expressed microRNAs. Gene set enrichment analysis was used to identify enriched biological pathways. Additionally, enzyme-linked immunosorbent assays, Western blot, and flow cytometry were used to explore the miR-23a-3p-mediated modulation in macrophages (such as apoptosis and polarization) via the JAK-STAT pathway.</p><p><strong>Results: </strong>RNA-seq analysis identified miR-23a-3p as being significantly upregulated in TOPD patients. Bioinformatics analysis indicated that miR-23a-3p targets regulation of the JAK-STAT pathway. Overexpression of miR-23a-3p in macrophages led to decreased JAK1 protein expression and reduced levels of phosphorylated JAK1 and STAT1. Functional assays revealed that miR-23a-3p mitigates macrophage apoptosis and macrophage polarization as well as influences inflammatory cytokine production.</p><p><strong>Conclusion: </strong>miR-23a-3p regulates TOPD pathogenesis by modulating macrophage inflammation, apoptosis, and differentiation via the JAK-STAT pathway, making it a promising immunotherapeutic target for future treatments.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"529070"},"PeriodicalIF":3.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13052251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Impaired Spirometry in Patients with Myocardial Infarction: A Longitudinal Study of Two European Cohorts.","authors":"Josefin Sundh, William A E Parker, Jonas Oldgren, Pontus Andell, Christian Reitan, Tomas Jernberg, Robin Hofmann, Moman A Mohammad, David Erlinge, Axel Åkerblom, Sofia Sederholm Lawesson, Kyriakos V Konstantinidis, Johan Lindbäck, Christer Janson, Anna Björkenheim, Nadir Elamin, Hannah McMellon, Bethany Moyle, Mehul Patel, Jad El Khoury, Raulin Surujbally, Stefan James, Robert F Storey","doi":"10.2147/COPD.S580301","DOIUrl":"https://doi.org/10.2147/COPD.S580301","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to investigate the associations between impaired spirometry such as obstructive pattern and preserved ratio impaired spirometry (PRISm) and occurrent cardiovascular events and deaths in patients with acute myocardial infarction.</p><p><strong>Patients and methods: </strong>Cohort study of 517 patients with age ≥40 years and ≥10 pack-years of smoking, hospitalized for myocardial infarction at eight sites in Sweden and the United Kingdom. The Vitalograph^® COPD-6 device was used to assess the ratio of forced expiratory volume in 1 and 6 seconds (FEV₁/FEV₆) and FEV₁ as a percentage of the predicted value (FEV₁%pred). Obstructive pattern was defined as FEV₁/FEV₆ <0.7, PRISm as FEV₁/FEV₆ >0.7 and FEV₁%pred <80, and normal findings as FEV₁/FEV₆ ≥0.7 and FEV₁%pred ≥80. Follow-up data were obtained from national registers or follow-up visits. Multivariable Cox regression was used to analyze the associations of obstructive pattern and PRISm with the incidence of acute ischemic cardiovascular events or major adverse cardiovascular events (MACE), respectively, within one year.</p><p><strong>Results: </strong>Obstructive pattern was found in 95 (18%), PRISm in 192 (37%) and normal spirometry in 230 (45%) patients. A cardiovascular event occurred in 21 (4%) and MACE in 28 (5%). Compared with normal spirometry, PRISm was independently associated with both new cardiovascular events (HR (95% CI) 3.44 (1.07-11.0)) and MACE (4.94 (1.63 to 15.0)), and obstructive pattern with MACE (3.87 (1.08-13.8)). Further adjustment for cardiac or COPD treatment did not substantially change the results.</p><p><strong>Conclusion: </strong>About half of patients with acute myocardial infarction and a ≥10 pack-year smoking history have abnormal spirometry findings. Both obstructive pattern and PRISm are independently associated with increased risk for MACE within one year. We suggest that spirometry should be considered as a routine assessment in patients with smoking history and recent myocardial infarction.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"580301"},"PeriodicalIF":3.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13052249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiopulmonary Exercise Testing for Prognostic Assessment of Clinical Outcomes in COPD: A Systematic Review and Meta-Analysis.","authors":"Michaël Staes, Jonas Dong, Iwein Gyselinck, Stephanie Everaerts, Wim Janssens","doi":"10.2147/COPD.S560342","DOIUrl":"https://doi.org/10.2147/COPD.S560342","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is a heterogeneous, progressive lung disorder. Despite its high prevalence, predicting clinical outcomes remains challenging. Various cardiopulmonary exercise testing (CPET) variables have been suggested as prognostic markers in COPD, but their role in clinical practice remains unclear. After registration in PROSPERO (ID CRD42024569879), a literature search of the Pubmed, Embase, Web of Science, Cochrane library and Scopus databases was carried out in August 2024. Study selection followed the PRISMA guidelines. Prospective and retrospective cohort studies evaluating associations between CPET variables and clinical outcomes in patients with COPD were included. Risk of bias was evaluated using the QUIPS tool. Data were extracted and synthesized narratively. A random-effects meta-analysis was planned if multiple studies reported comparable CPET variables, outcomes, and effect measures. Sixteen articles were included, three of which had an overall high risk of bias. Peak oxygen uptake (VO₂peak) was consistently associated with mortality in univariate analyses, but its independent prognostic value in multivariable models was inconsistent. A random-effects meta-analysis of three studies evaluating VO₂peak expressed as mL/kg/min did not demonstrate a statistically significant independent association with mortality (pooled HR 0.94, 95% CI 0.87-1.00; I² = 63%). Ventilatory efficiency (VE/VCO₂) was identified as a significant prognostic marker in multiple studies. Other CPET-derived variables failed to show an independent association with mortality, although heterogeneity in metrics and adjustment strategies limited comparability. Evidence for other CPET-derived variables and for predicting severe acute exacerbations of COPD (AECOPD) or hospitalization was limited and inconsistent. CPET-derived variables, particularly VO₂peak and VE/VCO₂, are associated with mortality in COPD, but evidence for their independent prognostic value and incremental benefit over established composite indices remains limited. Current data do not support routine use of CPET variables for prognostic stratification in COPD, apart from VO₂peak as a marker of exercise capacity within the modified BODE index.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"560342"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Rehabilitation with Airway Clearance Techniques Improves Mucus Hypersecretion and Clinical Outcomes in COPD: A Retrospective Study.","authors":"Huiyan Li, Miao Li, Wei Liu, Danxin Wang","doi":"10.2147/COPD.S576128","DOIUrl":"https://doi.org/10.2147/COPD.S576128","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of a pulmonary rehabilitation (PR) program incorporating airway clearance techniques Active Cycle of Breathing Technique (ACBT) and Oscillatory Positive Expiratory Pressure (OPEP) on mucus hypersecretion, pulmonary function, and quality of life in patients with chronic obstructive pulmonary disease (COPD).</p><p><strong>Methods: </strong>This single-center, retrospective observational study included 118 hospitalized patients with stable moderate COPD and sputum hypersecretion between April 2024 and July 2025. Patients received either PR combined with ACBT and OPEP (PR+ACBT/OPEP, n = 56) or conventional PR with basic breathing training (n = 62). Primary outcomes were sputum volume, sputum viscosity, and responder rate (≥20% viscosity reduction). Secondary outcomes included pulmonary function parameters, symptom burden assessed by the COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) scale, and treatment adherence.</p><p><strong>Results: </strong>Baseline characteristics were comparable between groups. Adherence was high in both groups, and no serious adverse events were observed. At discharge, the PR+ACBT/OPEP group demonstrated significantly greater reductions in sputum volume (-6.8 mL; P < 0.001) and viscosity (-46 mPa·s; P < 0.001) than controls, with a higher responder rate (69.6% vs. 29.0%). Improvements in pulmonary function were more pronounced in the PR+ACBT/OPEP group, including FEV₁, FEV₁%pred, and small-airway indices. Symptom burden was also reduced, with greater declines in CAT scores and a higher proportion of patients achieving the minimal clinically important difference. The mMRC grade improved in the PR+ACBT/OPEP group but remained unchanged in controls.</p><p><strong>Conclusion: </strong>In this retrospective, single-center study, the integration of ACBT and OPEP into pulmonary rehabilitation was associated with improved mucus clearance, lung function parameters, and patient-reported outcomes in COPD patients with chronic sputum hypersecretion. These findings should be interpreted as exploratory and hypothesis-generating, supporting the potential role of airway clearance techniques within pulmonary rehabilitation and warranting confirmation in prospective, multicenter studies.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"576128"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarker-Defined Iron Deficiency in Heavy Smokers with and without COPD and/or Emphysema.","authors":"Ingrid Marie Hardang, Kirill Neumann, Geir Tormod Gjønnes, Trond-Eirik Strand, Haseem Ashraf, Gunnar Einvik","doi":"10.2147/COPD.S573503","DOIUrl":"https://doi.org/10.2147/COPD.S573503","url":null,"abstract":"<p><strong>Purpose: </strong>Assess whether iron deficiency prevalence in heavy smokers is higher in presence of COPD and/or emphysema, how the prevalence of iron deficiency is impacted by the biomarker used to define it, and examine the prevalence of anemia and polycythemia in heavy smokers with or without COPD.</p><p><strong>Patients and methods: </strong>A cross-sectional analysis was conducted on 1002 participants from the Norwegian Early Lung Cancer Screening study. All participants underwent chest CT scans, spirometry, and venous blood sampling to analyze iron-related parameters, C-reactive protein (CRP), and hemoglobin. Iron deficiency was defined using transferrin saturation (TSat) <20%, ferritin < cutoff (CRP-dependent), or a combination of both.</p><p><strong>Results: </strong>The prevalence of iron deficiency varied from 3% to 30%, being highest when defined by TSat <20%, and was more prevalent in participants with COPD. Emphysema was not associated with iron deficiency. Decreasing hemoglobin, increasing soluble transferrin receptor (sTfR) and CRP were associated with TSat <20%. COPD was not independently associated with iron deficiency. Increasing age and sTfR, along with female sex, were associated with ferritin < cutoff. Anemia was more common than polycythemia, with approximately one-third of anemia cases attributable to iron deficiency.</p><p><strong>Conclusion: </strong>Iron deficiency was more prevalent in heavy smokers with COPD than in those without, but not in individuals with emphysema. TSat <20% identified significantly more cases of iron deficiency than ferritin < cutoff. Eight percent of participants had anemia, while four percent had polycythemia, with neither condition related to COPD or emphysema.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"573503"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation Levels and the Health Impact of Anti-Inflammatory Diets on Chronic Obstructive Pulmonary Disease: An NHANES Study.","authors":"Tingting Feng, Weikai Yu","doi":"10.2147/COPD.S535829","DOIUrl":"https://doi.org/10.2147/COPD.S535829","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD), the third leading cause of death globally, is closely associated with systemic inflammation in its pathophysiological mechanisms. Previous studies have primarily focused on localized airway inflammation, while the relationship between systemic inflammation markers such as the systemic immune-inflammation index (SII) and the systemic inflammation response index (SIRI)and COPD remains controversial. Additionally, the role of the composite dietary antioxidant index (CDAI) in modulating COPD risk requires further investigation.</p><p><strong>Methods: </strong>This cross-sectional study used data from NHANES (2007-2012) to investigate the association between systemic inflammation levels and COPD prevalence. SII and SIRI levels were stratified by interquartile range (IQR). Generalized linear models (GLM) combined with logistic regression models were used to analyze the association between SII, SIRI, and COPD risk. Interaction analysis was used to evaluate the modulating effects of CDAI on inflammation levels and COPD risk.</p><p><strong>Results: </strong>A total of 8,601 participants were included in the study, among whom 881 were COPD patients. The analysis revealed that for each 1 IQR increase in SII and SIRI, the OR for COPD prevalence significantly increased by 1.28 (95% CI: 1.12-1.47) and 1.45 (95% CI: 1.26-1.67), respectively. Compared to the lowest SII group (Q1), the prevalence of COPD in the other groups increased by 1.01%, 1.43%, and 3.53%, respectively. Similarly, compared to the lowest SIRI group (Q1), the prevalence of COPD in the other groups increased by 1.54%, 4.08%, and 7.42%, respectively. In the low CDAI population, the risk of COPD associated with SII and SIRI was even higher, with ORs of 1.24 (95% CI: 1.01-1.52) and 1.34 (95% CI: 1.09-1.64), respectively.</p><p><strong>Conclusion: </strong>SII and SIRI, as systemic inflammation markers, are closely associated with the risk of COPD. Adjusting dietary patterns may have significant potential to slow the onset and progression of COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"535829"},"PeriodicalIF":3.1,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Lifestyle Goal Setting in Patients with COPD.","authors":"Charlotte D C Born, Rosanne J H C G Beijers, Lieke E J van Iersel, Imke H M J E Muijrers, Lisanne T Schuurman, Sanne M P L Gerards, Sami O Simons, Harry R Gosker, Ardy van Helvoort, Annemie M W J Schols, Rik Crutzen","doi":"10.2147/COPD.S579191","DOIUrl":"https://doi.org/10.2147/COPD.S579191","url":null,"abstract":"<p><strong>Purpose: </strong>Healthy lifestyle changes can reduce symptoms and slow disease progression in patients with chronic obstructive pulmonary disease (COPD). To tailor strategies supporting long-term behavior change, this study investigated patients' willingness to set lifestyle goals during personalized counseling. Goal focus and content, goal adjustments over time, reasons for unwillingness, barriers and facilitators, and differences between goal setters and non-goal setters were also examined.</p><p><strong>Patients and methods: </strong>As part of an ongoing randomized controlled trial (NCT03807310), patients received monthly phone calls over 12 months, offering lifestyle counseling on diet and physical activity (PA) using motivational interviewing. Data were analyzed for a subset of patients who had completed the trial by 12 February 2025. Baseline trial data were used for patient characterization, and counseling notes were analyzed to assess willingness and factors affecting goal setting.</p><p><strong>Results: </strong>Data from 103 patients (61.2% male, mean age 68.3±6.5 years, body mass index 26.3±4.9 kg/m², FEV1 56.6±18.1% predicted), were analyzed. Overall, 71% were willing to set lifestyle goals, most often focused on PA. About one-quarter adjusted their goals during follow-up due to achievement or health complaints (PA) and previous unsuccessful attempts (diet). Patients unwilling to set goals mainly reported satisfaction with current habits or no perceived need for change. Experienced facilitators included accountability and favorable weather (PA) and visual reminders, social support, and seasonal influences (diet). Barriers were mainly health complaints (PA) and low motivation (diet). No differences were found between goal setters and non-goal setters in demographic, physiological, lifestyle or motivational characteristics.</p><p><strong>Conclusion: </strong>A majority of patients with COPD were willing to set lifestyle goals, particularly related to PA, but satisfaction with current behaviors and health-related barriers often limited engagement. These findings provide input for the design of future interventions to support sustainable lifestyle change in COPD care.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"21 ","pages":"579191"},"PeriodicalIF":3.1,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}