International Journal of Chronic Obstructive Pulmonary Disease最新文献

{"title":"Bibliometric Analysis of the Current Landscape of Chronic Obstructive Pulmonary Disease (COPD) Nursing Interventions and Research.","authors":"Sujuan Xu, Qian Jin, Jing Xia","doi":"10.2147/COPD.S543869","DOIUrl":"10.2147/COPD.S543869","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic Obstructive Pulmonary Disease (COPD) is a major global health issue, significantly impacting healthcare systems. Effective nursing interventions are crucial for improving patient outcomes and reducing hospitalizations. This study conducts a bibliometric analysis of nursing interventions and research in the management of COPD to identify key trends, contributors, and emerging research directions.</p><p><strong>Material and methods: </strong>We analyzed 1390 articles published before 2024, sourced from the Web of Science Core Collection (SCI-Expanded). Using R Bibliometrix, VOSviewer, and CiteSpace, we assessed publication trends, identified influential authors and institutions, and mapped research hotspots and collaborations. The analysis included quantitative metrics such as citation counts and co-citation networks, as well as qualitative assessments of thematic evolution.</p><p><strong>Results: </strong>The analysis revealed a significant increase in research output on COPD nursing interventions, particularly after 2001, with a peak in publications around 2021, likely due to the COVID-19 pandemic. The United States, the United Kingdom, and China were the top contributors, accounting for over 45% of the total publications. Key research hotspots included acute exacerbations, quality of life, evidence-based nursing, and pulmonary rehabilitation. The study highlighted a shift from symptom management to more holistic, patient-centered care models.</p><p><strong>Conclusion: </strong>This study emphasizes the critical role of nursing interventions in managing COPD and reducing its global burden. The identified research trends and emerging topics offer valuable insights for future research, underscoring the need for innovation in nursing practices and interdisciplinary collaboration. These findings aim to inform the development of more effective COPD nursing strategies and enhance clinical practice.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"3255-3268"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian Randomization Evidence for Relationship and Mediation of Educational Attainment on Chronic Obstructive Pulmonary Disease.","authors":"Xinyu Yang, Xiaomei Luo, Yan Wang, Meng Tang, Junhui Gong, Shaopan Lian, Ying Zhou, Xin Li, Jia Deng, Guoqiang Cao, Li Li","doi":"10.2147/COPD.S523785","DOIUrl":"10.2147/COPD.S523785","url":null,"abstract":"<p><strong>Background: </strong>Previous epidemiological studies revealed a potential correlation between educational imbalance and chronic obstructive pulmonary disease (COPD) incidence and hospitalization. However, such studies were susceptible to confounding factors and lacked strong causal evidence. The purpose of this study was to utilize Mendelian randomization (MR) to explore the causal relationship between educational attainment (EA) and the onset and hospitalization of COPD, as well as the mediating mechanism of EA on COPD through multivariable MR (MVMR) and two-step MR.</p><p><strong>Methods: </strong>Based on data from genome-wide association studies (GWASs), this study used single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for EA and COPD. Two-sample MR, MVMR and two-step MR analysis were conducted. The impact of each variable on the outcome was analysed, and the overall mediating effects of smoking, body mass index (BMI) and generalized allergic reactions were assessed.</p><p><strong>Results: </strong>MR analysis suggested that greater EA significantly reduced the incidence (OR = 0.22, 95% CI = 0.12-0.41) and hospitalization (OR = 0.28, 95% CI = 0.18-0.44) of COPD. The MVMR findings suggested that the impact of EA (OR = 0.53, 95% CI = 0.29-0.99) on COPD still existed after adjusting mediators. Combined MVMR and two-step MR analysis revealed that smoking, BMI and allergies mediate 47.9% of the relationship between EA and COPD.</p><p><strong>Conclusion: </strong>High levels of education may have potentially causal protective effect on the onset and hospitalization of COPD. Reducing smoking, obesity and preventing allergic reactions are candidate approaches to prevent COPD, especially in individuals with lower levels of education.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"3229-3240"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Body Roundness Index and Chronic Obstructive Pulmonary Disease in US Adults: Data from NHANES 2013-2018.","authors":"Weibo Zheng, Liandong Chen, Haojie Ying, Jiawei Lv, Binzhe Zhou, Chendong Tian, Yuchen Wu, Qihui Shao, Hanyu Xu, Bowen Jin","doi":"10.2147/COPD.S545770","DOIUrl":"10.2147/COPD.S545770","url":null,"abstract":"<p><strong>Background: </strong>The association between the body roundness index (BRI) and the prevalence of chronic obstructive pulmonary disease (COPD) in US adults remains unclear. This study aims to investigate the association between BRI and the likelihood of developing COPD.</p><p><strong>Methods: </strong>This study was conducted based on data from the 2013-2018 National Health and Nutrition Examination Survey. Participants were classified as having COPD if they met any of the following criteria: (i) self-reported physician diagnosis of COPD; (ii) physician-confirmed diagnosis of emphysema; or (iii) physician-confirmed diagnosis of chronic bronchitis. Those who responded \"no\" to all of the above were categorized as non-COPD. To assess the association between BRI and COPD, weighted logistic regression models, subgroup analyses, and interaction tests were employed. The dose-response relationship was investigated using a restricted cubic spline (RCS) model.</p><p><strong>Results: </strong>A total of 14,254 individuals were included. The overall weighted prevalence of COPD was 8.3%. After adjusting for multiple confounders, continuous BRI was found to be positively associated with COPD (odds ratio [OR] = 1.140, 95% confidence interval [CI]: 1.033-1.259, P = 0.012). The RCS analysis confirmed a linear dose-response relationship between BRI and COPD. Subgroup analyses demonstrated substantial heterogeneity across sex, hypertension, and cardiovascular disease subgroups, indicating that the association between BRI and COPD may be impacted by these factors.</p><p><strong>Conclusion: </strong>Higher BRI levels were positively associated with an increased likelihood of developing COPD among US adults. Our study suggests that BRI holds promise as a tool for assessing the odds of having COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"3217-3228"},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TET1 Alleviates Cigarette Smoke Induced Bronchial Epithelial Cell Apoptosis Through Upregulating Nrf2.","authors":"Zi-Xiao Zhang, Hao-Da Yu, Xiao-Yan Sai, Chu Qin, Yu Ding, Tao Bian","doi":"10.2147/COPD.S524465","DOIUrl":"10.2147/COPD.S524465","url":null,"abstract":"<p><strong>Introduction: </strong>Nuclear factor erythroid 2-related factor 2 (Nrf2), a key regulator of oxidative stress responses, is downregulated in patients with GOLD stage III-IV chronic obstructive pulmonary disease (COPD). However, the mechanisms underlying the epigenetic regulation of Nrf2 in COPD remain poorly understood.</p><p><strong>Methods: </strong>Protein levels of Nrf2, heme oxygenase-1 (HO-1), ten-eleven translocation methylcytosine dioxygenase 1 (TET1), and DNA methyltransferase 1 (DNMT1) were assessed by Western blotting in peripheral lung tissue and primary bronchial epithelial cells obtained from patients with COPD, never-smokers (control-NS), and smokers without COPD (control-S). CSE-treated human bronchial epithelial (HBE) cells were used as an in vitro model. Nrf2 promoter methylation was evaluated using bisulfite sequencing. Apoptosis of HBE cells was measured by flow cytometry. Chromatin immunoprecipitation (ChIP) was performed to assess the binding of TET1 to the Nrf2 promoter. Malondialdehyde (MDA) and superoxide dismutase (SOD) activity assays were used to quantify oxidative stress and antioxidant capacity.</p><p><strong>Results: </strong>Nrf2 and HO-1 expression was significantly reduced in both lung tissue and primary epithelial cells from patients with COPD. In vitro, CSE exposure increased Nrf2 promoter methylation in HBE cells. Overexpression of Nrf2 mitigated oxidative stress, increased SOD activity, and reduced apoptosis in response to CSE. TET1 expression was decreased in COPD lungs, and TET1 was shown to bind the Nrf2 promoter and enhance its transcription. TET1 overexpression reduced oxidative damage and apoptosis via Nrf2 upregulation.</p><p><strong>Conclusion: </strong>Reduced Nrf2 expression in COPD may result from promoter hypermethylation. TET1 directly binds and demethylates the Nrf2 promoter, restoring its expression and attenuating CSE-induced HBE cells apoptosis. These findings identify a potential epigenetic mechanism contributing to COPD pathogenesis and suggest TET1 as a novel therapeutic target.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"3203-3215"},"PeriodicalIF":3.1,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Mendelian Randomization and Machine Learning to Identify Hypoxia-Related Diagnostic Biomarkers and Causal Relationship in COPD.","authors":"Wenhui Fu, Yangli Liu, Renjie Li, Haiying Jin","doi":"10.2147/COPD.S524381","DOIUrl":"10.2147/COPD.S524381","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) involves progressive lung function decline, with hypoxia playing a key pathogenic role. However, systematic investigations focusing on hypoxia-related genes (HRGs) in COPD remain limited.</p><p><strong>Methods: </strong>We applied machine learning to identify HRG-associated diagnostic biomarkers and evaluated their performance via Receiver Operating Characteristic (ROC) analysis. Mendelian randomization (MR) was conducted to assess causal relationships between candidate genes and COPD. A nomogram model was constructed to evaluate clinical utility, and a ceRNA network was developed using ENCORI database.</p><p><strong>Results: </strong>Six HRG-based diagnostic biomarkers were identified, including <i>SLC2A1</i>, which demonstrated strong diagnostic value (AUC > 0.8). MR analysis revealed a significant causal effect of <i>SLC2A1</i> expression on COPD risk (OR = 1.32, 95% CI: 1.02-1.71, P < 0.05). Functional evidence suggests <i>SLC2A1</i> promotes hypoxia-induced metabolic reprogramming in airway epithelial cells. The constructed nomogram showed good clinical applicability. ceRNA analysis highlighted <i>MALAT1</i>, <i>NEAT1</i>, and <i>XIST</i> as potential upstream regulators.</p><p><strong>Conclusion: </strong>Our findings identify <i>SLC2A1</i> as a causal and diagnostically relevant gene in COPD, offering novel insight into hypoxia-driven disease mechanisms and supporting future personalized therapeutic strategies.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"3187-3202"},"PeriodicalIF":3.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing Fall Risk in Older Adults with COPD: Pilot Study to Test the Efficacy of a Home-Based Exercise Program with Virtual Care Support.","authors":"Amanda Bates, Susan Furber, Heidi Gilchrist, Catherine Sherrington, Nicola R Jones, Michelle Kershaw, Lisa Franco, Kristi-Lee Muir, Anne Tiedemann","doi":"10.2147/COPD.S502082","DOIUrl":"10.2147/COPD.S502082","url":null,"abstract":"<p><strong>Purpose: </strong>Older adults with chronic obstructive pulmonary disease (COPD) have a higher risk of falls than their peers without COPD. Home-based exercise programs can improve balance and strength and reduce falls in older adults and could be an option for older adults with COPD who access virtual care. We pilot tested a 6-month home-based balance and strength exercise program with virtual care support aimed at improving strength and balance in people with COPD aged 50 years and over.</p><p><strong>Patients and methods: </strong>Adults aged 50 years and over with COPD who access a virtual care service were invited to participate in an exercise program designed to improve balance and strength and reduce fall risk.</p><p><strong>Results: </strong>Thirteen people enrolled in the pilot program (mean age 72 ± SD 7 years, 9 females). Six participants (46%) reported having one or more falls in the 12-months prior to the study. A mixed model for repeated measures and Bonferroni correction for post hoc pairwise comparisons showed significant improvement in the Short Physical Performance Battery (SPPB) score between baseline and 6-months, effect size of 2.01; 95% CI [0.45-3.58], and between 3-months and 6-months, effect size of 1.65; 95% CI [0.48 to 2.81]. The alternate step test improved by more than 3 seconds between baseline and 3-months, effect size of -3.30; 95% CI [-5.94 to -0.66] and improved by 4 seconds between baseline and 6-months, effect size of -4.01; 95% CI [-7.42 to -0.61]. There was no significant difference in fear of falling between between baseline, 3 months or 6 months. The program had a high level of acceptability, with all participants intending to continue to do the exercises and 10/12 (83%) participants stating that they would recommend the program to other people with COPD. The program was feasible to implement, with 12/13 participants remaining in the program and attending exercise sessions.</p><p><strong>Conclusion: </strong>On average, participants completed the exercises twice per week rather than the recommended 3 times per week. Despite this, the home-based exercise program improved strength and balance, as measured by the SPPB. The program was acceptable to participants and feasible to implement and has the potential to reduce the risk of falls in older people with COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"3175-3186"},"PeriodicalIF":3.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitatively Assessed Emphysema Severity on HRCT Independently Predicts Coronary Artery Disease in COPD: A Retrospective Cohort Study.","authors":"Luoman Su, Chen Qian, Chunchun Yu, Zhe Weng, Hongjun Zhao, Chengshui Chen","doi":"10.2147/COPD.S540503","DOIUrl":"10.2147/COPD.S540503","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of coronary artery disease (CAD). However, the role of emphysema, which represents an important structural subtype of COPD, in the development of CAD remains insufficiently clarified. This study aimed to evaluate whether quantitatively assessed emphysema on high-resolution computed tomography (HRCT) independently predicts CAD in COPD patients.</p><p><strong>Methods: </strong>This retrospective cohort study included 392 COPD patients with no prior history of CAD between 2015 and 2020. All participants underwent HRCT for automated emphysema quantification using 3D Slicer software. Emphysema extent was quantified as the percentage of low attenuation areas (LAA%) below -950 Hounsfield units, with severe emphysema defined as LAA% >16.95%. Logistic regression and restricted cubic spline (RCS) analysis were employed to assess the relationship between emphysema index and CAD, including subgroup and interaction analyses. The ability of the emphysema index to predict CAD was evaluated using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>Severe emphysema was independently associated with a higher risk of CAD in COPD patients (OR = 2.08, 95% CI: 1.30-3.34; <i>p</i> = 0.002). This association remained robust even after adjusting for confounders (adjusted OR= 2.28, <i>p</i> = 0.005). RCS analysis indicates that the risk of CAD increases with the rise of the emphysema (<i>p</i> for nonlinearity =0.031). The area under the ROC curve for the predictive model was 0.81 (95% CI 0.77, 0.86). Additionally, patients with severe emphysema exhibited significantly more complex coronary lesions, reflected by higher SYNTAX scores (median 10.00 vs 16.29; <i>p</i> = 0.013).</p><p><strong>Conclusion: </strong>Quantitative HRCT-based emphysema independently predicts CAD in COPD and demonstrates additive risk with traditional cardiovascular factors. Integrating emphysema quantification with clinical risk assessment improves CAD risk stratification in COPD patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"3147-3161"},"PeriodicalIF":3.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Criteria Decision Analysis of Biologics in Chronic Obstructive Pulmonary Disease.","authors":"Maria Gabriella Matera, Luigino Calzetta, Paola Rogliani, Mario Cazzola","doi":"10.2147/COPD.S550144","DOIUrl":"10.2147/COPD.S550144","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with limited response to standard anti-inflammatory therapies. Biologics targeting specific inflammatory pathways have emerged as potential treatments, but their efficacy remains variable across distinct COPD endotypes.</p><p><strong>Objective: </strong>To systematically evaluate the efficacy and trial quality of biologics tested in COPD patients using a multicriteria decision analysis (MCDA) approach, with attention to type 2 (T2) and non-T2 inflammatory targets.</p><p><strong>Methods: </strong>We assessed 20 trials encompassing 12 biologics and 9294 patients with COPD. Each trial was scored (0-3 per domain, total 12 points) across four domains: exacerbation reduction, lung function improvement, biomarker stratification, and trial design quality.</p><p><strong>Results: </strong>Dupilumab (anti-IL-4Rα) demonstrated the most robust efficacy in eosinophilic COPD, with consistent reductions in exacerbation rates and improvements in FEV₁, supported by high trial quality. Mepolizumab and benralizumab (anti-IL-5/IL-5R) showed moderate efficacy in biomarker-enriched populations. Anti-alarmins, specifically tozorakimab (anti-IL-33), itepekimab (anti-IL-33/IL-1RL1), astegolimab (anti-ST2), and tezepelumab (anti-TSLP), showed mixed results, with modest lung function gains but largely non-significant effects on exacerbation rates. Agents targeting non-T2 pathways, including infliximab (anti-TNF-α), canakinumab (anti-IL-1β), MEDI8968 (anti-IL-1R1), CNTO6785 (anti-IL-17A), and ABX-IL8 (anti-IL-8), consistently failed to demonstrate clinical efficacy, often due to small sample sizes, early-phase design, and lack of biomarker stratification.</p><p><strong>Conclusion: </strong>Biologics targeting T2 inflammation offer therapeutic promise in eosinophilic COPD when guided by biomarkers. Conversely, current biologics directed at non-T2 and alarmin pathways yield limited or inconsistent benefits, emphasizing the need for improved phenotyping and targeted intervention strategies in non-eosinophilic COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"3163-3173"},"PeriodicalIF":3.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Biomarkers in Chronic Obstructive Pulmonary Disease: A Comprehensive Review.","authors":"Yunpeng Xu, Lei Zhang, Lei Zhu, Zi Yang, Xue Bai, Fanqi Wu, Cuifang He, Dan Zhang, Qingjuan Ai, Hong Guo, Jian Liu","doi":"10.2147/COPD.S531935","DOIUrl":"10.2147/COPD.S531935","url":null,"abstract":"<p><p>Chronic Obstructive Pulmonary Disease (COPD) is a prevalent chronic respiratory disorder characterized by airway inflammation and irreversible airflow limitation. Its marked heterogeneity and complexity pose significant challenges to traditional clinical assessments in terms of prognostic prediction and personalized management. In recent years, the exploration of biomarkers has opened new avenues for the precise evaluation of COPD, particularly through multi-biomarker prediction models and integrative multimodal data strategies, which have substantially improved the accuracy and reliability of prognostic assessments. This review summarizes the key biomarkers associated with COPD prognosis, systematically discusses the practical applications and future potential of combined predictive models and multimodal data integration, and evaluates their translational value in clinical practice. As a narrative review, this study aims to provide a scientific foundation for the precision management of patients with COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"3123-3134"},"PeriodicalIF":3.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COPD Severity as an Independent Predictor of Long-Term Survival in Operable Lung Cancer: A Retrospective Analysis from a High-Volume Thoracic Surgery Center.","authors":"Julia Zimmermann, Johannes Schön, Valentina Pfeiffer, Tim-Mathis Beutel, Annalena Felker, Elvira Stacher-Priehse, Fuad Damirov, Niels Reinmuth, Rudolf A Hatz, Christian P Schneider, Mircea Gabriel Stoleriu","doi":"10.2147/COPD.S518084","DOIUrl":"10.2147/COPD.S518084","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to identify predictors of long-term survival in patients with chronic obstructive pulmonary disease (COPD) undergoing anatomical resections for non-small cell lung cancer (NSCLC), with focus on COPD severity, to improve perioperative risk stratification and patient care.</p><p><strong>Patients and methods: </strong>This retrospective study included all patients with NSCLC and COPD undergoing anatomical resections at the Lung Tumor Center Munich between 2011 and 2020. COPD severity was classified by Global Initiative for Obstructive Lung Disease criteria: Group 1 (mild/moderate obstruction, COPD I-II) and Group 2 (severe obstruction, COPD III-IV). The relationship between COPD severity and perioperative parameters was analyzed using Kaplan-Meier and Cox proportional hazard model.</p><p><strong>Results: </strong>Of 1663 NSCLC patients undergoing anatomical resections, 476 (28.6%) patients with COPD I-IV (40.5% female, median age 67.28 [60.57; 73.27] years) were included. No significant differences were observed between groups in demographics, topography, TNM classification, histology of the primary tumor, and surgical approach. Group 2 experienced more frequently prolonged mechanical ventilation >2 days (p=0.016), air leaks >5 days (p = 0.020), and arrhythmias (p=0.012). Median overall survival (OS) was reduced in Group 2 (43.73 [30.14; 57.33] vs 85.30 [67.46; 103.14] months, p=0.001). Independent predictors of reduced OS included COPD III-IV (p<0.0001), pT_3-4 (p=0.007), pN_1-2 (p<0.0001), preoperative CRP >0.6 mg/dL (p=0.014) and VO₂max <17 mL/min/kg (p=0.040). These predictors increased the risk of death by 1.6 [1.27-1.90], 1.3 [1.06-1.48], 2.1 [1.49-3.03], 1.6 [1.09-2.20] and 1. [1.02-2.00] fold, respectively.</p><p><strong>Conclusion: </strong>COPD severity independently predicts perioperative morbidity and long-term survival in operable NSCLC patients. Comprehensive assessment of COPD severity can help in identifying high-risk patients and optimizing perioperative care.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"3073-3091"},"PeriodicalIF":3.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}