International Journal of Chronic Obstructive Pulmonary Disease最新文献

{"title":"Mucolytic Therapy in COPD: Patient Usage and Preferences in Real-World Italian Settings.","authors":"Salvatore D'Antonio, Alfio Pennisi, Mario Cazzola","doi":"10.2147/COPD.S504577","DOIUrl":"10.2147/COPD.S504577","url":null,"abstract":"<p><strong>Introduction: </strong>The Italian COPD Patient Association (Associazione Pazienti BPCO) conducted an online survey among its 2814 members with COPD to investigate the reasons for the widespread use of mucolytic therapies by patients, often including self-prescription using over the counter (OTC) alternatives.</p><p><strong>Methods: </strong>After consulting with several respiratory specialists, the Association's steering committee developed a list of nine questions with possible answers that was posted on the website of the Association. The survey was open to all members of the Association, with responses to be e-mailed to the Association.</p><p><strong>Results: </strong>Approximately 78% the 502 participants surveyed reported having used mucolytics in the previous six months, with 54.5% using prescribed medications and 23.5% opting for OTC medications. Usage patterns revealed that 43.4% utilized mucolytics during episodes of excessive mucus, while 35.5% used them regardless of the presence of mucus. In terms of formulation preferences, water-soluble granulated sachets (34.9%) and effervescent/dispersible tablets (22.8%) were the most preferred, followed by capsules (14.1%) and aerosol ampoules (11.2%). The factors influencing these preferences were the hydration benefits of sachets and tablets, the portability and taste advantages of capsules, and the swallowing difficulties of aerosol formulations. The data showed that 26.5% of survey participants consumed the entire contents of the prescribed or OTC package, while 19.9% utilised it for a minimum of 10 days, 31.5% for a period between 5 and 10 days, and 10.2% for less than 5 days. Cost was cited as a reason for discontinuation by 8.3% of participants. Notably, 29.5% of respondents believed that mucolytic efficacy was dependent on the amount of mucus. Most patients (66.3%) used mucolytics at home, and 57.4% took the medication once daily and 24.3% twice daily. Additionally, 41.8% were aware of the dual antioxidant and mucolytic properties of the medication.</p><p><strong>Conclusion: </strong>These findings emphisise the need for a patient-centred approach, encouraging healthcare providers to consider individual preferences and offer personalised advice that has the potential to improve adherence and overall outcomes for COPD patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"479-486"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Nutritional Management on the Nutritional Status and Quality of Life of Patients with Chronic Obstructive Pulmonary Disease.","authors":"Jian-Hui Zhang","doi":"10.2147/COPD.S494323","DOIUrl":"10.2147/COPD.S494323","url":null,"abstract":"<p><strong>Aim: </strong>Chronic obstructive pulmonary disease (COPD) is a progressive respiratory condition characterized by airflow limitation, which often leads to malnutrition and reduced quality of life. This study aims to evaluate the effect of individualized nutritional management on the nutritional status, pulmonary function, and overall quality of life of patients with COPD.</p><p><strong>Methods: </strong>This research is a retrospective analysis, and the patients were grouped according to the treatment methods. This study involved 100 patients with chronic obstructive pulmonary disease and were hospitalized at our hospital from March 2022 to March 2024. Among them, 43 patients with individualized nutritional management were classified as the observation group, 57 patients with regular dietary therapy management were classified as the control group. We collect clinical data on lung function, nutritional status, scores of quality of life, psychological state evaluation index, clinical efficacy, and diet satisfaction.</p><p><strong>Results: </strong>The total effective rate of the observation group was 88.37%, which was higher than that of the control group (85.96%), and the differences were statistically significant (P < 0.05). The FEV1, FVC and FVE1% of the observation group were significantly higher than those of the control group after intervention (all P < 0.05). Moreover, after the intervention, the 6-Minute Walk Test (6MWT) distance increased, and COPD Assessment Test (CAT) scores decreased significantly in both groups, with the observation group showing greater improvements (P < 0.05).</p><p><strong>Conclusion: </strong>Nutrition management has a remarkable clinical curative effect in treating COPD patients, which can improve their nutritional status and quality of life.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"487-496"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-Based Pulmonary Rehabilitation in an Economically Deprived Area of Jodhpur, India: A Mixed-Methods Feasibility Trial.","authors":"Mahendra Thakor, Vishal Singh, James Manifield, Mark W Orme, Pankaj Bhardwaj, Nishant Kumar Chauhan, Amy C Barradell, Zahira Ahmed, Yashika Bhati, Jesse Matheson, Andy Barton, Arun Kumar Sharma, Sally J Singh","doi":"10.2147/COPD.S488766","DOIUrl":"10.2147/COPD.S488766","url":null,"abstract":"","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"473-478"},"PeriodicalIF":2.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Delphi Consensus Project to Capture Greek Experts' Opinion on the Position of Triple Therapies in COPD: Why, When and to Whom.","authors":"Andriana I Papaioannou, Stelios Loukides, Theodoros Vassilakopoulos, Nikolaos Tzanakis, Konstantinos Kostikas, Georgios Hillas","doi":"10.2147/COPD.S481337","DOIUrl":"10.2147/COPD.S481337","url":null,"abstract":"<p><strong>Background: </strong>In recent years, COPD treatment has become more personalized considering specific patient's characteristics.</p><p><strong>Aim and methods: </strong>We have performed a DELPHI consensus project to assess the level of consensus among Greek experts on the use of triple therapy in COPD as an initial and follow-up treatment. A three-round Delphi online survey was developed. The questionnaire was developed by a 6-member steering committee, included 54 statements, and divided into 3 domains: (A) triple therapy as initial treatment (divided into subdomains examining the impact of exacerbations based on lung function, bronchodilation reversibility and/or blood eosinophil count, smoking, symptoms, and comorbidities), (B) escalation to triple therapy from dual bronchodilation and (C) de-escalation from triple therapy to dual bronchodilation. The survey was funded by AstraZeneca and was hosted and analysed by an independent external company.</p><p><strong>Results: </strong>Consensus was reached in 84.8%, 63% and 80% of statements for domains A, B and C, respectively. Experts agreed that initial treatment with triple therapy is a reasonable option for specific patients, while escalation from dual bronchodilation to triple therapy could be considered, besides frequent exacerbators, also in patients with a history of one moderate exacerbation, mainly in the presence of marked bronchodilator reversibility or high blood eosinophil count. Finally, there was a consensus that de-escalation from triple therapy to dual bronchodilation was inappropriate in patients who had experienced one moderate exacerbation in the previous year.</p><p><strong>Conclusion: </strong>Although consensus was generated in several statements, panelists failed to reach consensus in many aspects of the use of triple therapy, identifying areas for further research.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"457-471"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Pulmonary Bulla Volume Reduction by Transbronchial Puncture Under Electromagnetic Navigation Platform Combined With O-Arm CT Guidance.","authors":"Jing Zhu, Xiaoxiao Xu, Rujuan Wang, Zhenhua Li, Ying Wang, Yi Hu","doi":"10.2147/COPD.S493818","DOIUrl":"10.2147/COPD.S493818","url":null,"abstract":"<p><p>Pulmonary bullae are a common complication of chronic obstructive pulmonary disease (COPD), but treatment options are limited for patients with poor lung function and giant emphysematous bullae (GEB). We reported a case of a 61-year-old female with severe COPD complicated by a newly developed GEB. Using electromagnetic navigation technology, we precisely located and targeted the bronchi adjacent to the bullae within the lung. Guided by O-arm CT imaging, we punctured the bullae with a biopsy needle, evacuated the air, and administered autologous blood and thrombin. A follow-up pulmonary CT scan three days post-procedure revealed a significant reduction in the size of the giant bulla. Additionally, the patient's wheezing symptoms improved, and her performance on the 6-minute walk test showed some enhancement.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"451-455"},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Serum Legumain with Severity and Prognosis Among Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients.","authors":"Qing-Qing Zhang, Meng-Meng Ma, Zi-Yong Chen, Yong-Xia Guo, Kui Liu, Mei-Ling Xie, Ying-Li Wang, Shu-Shu Li, Hui Qian, Xiao-Fei Zhang, Lin Fu, Ya-Lin Jiang","doi":"10.2147/COPD.S507018","DOIUrl":"10.2147/COPD.S507018","url":null,"abstract":"<p><strong>Background: </strong>A number of studies have demonstrated that legumain is engaged in the pulmonary diseases. Nevertheless, the role of legumain is indistinct in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The aim is to identify the correlation of serum legumain with AECOPD patients through a prospective cohort study.</p><p><strong>Methods: </strong>All 202 patients with AECOPD were enrolled. Fasting venous blood was collected. Serum legumain was detected by ELISA.</p><p><strong>Results: </strong>On admission, serum legumain concentration was gradually elevated in line with AECOPD severity scores. Additionally, serum legumain was closely associated with clinical characteristics. Linear regression analysis confirmed the positive relationships of serum legumain with COPD severity scores. Moreover, the poor prognoses were tracked in patients of AECOPD. Serum higher legumain at admission increased the risks of death and acute exacerbation during hospitalization.</p><p><strong>Conclusion: </strong>Serum legumain at admission was positively correlated with the severity and adverse prognosis in AECOPD patients, indicating that legumain plays a vital role in the initiation and development of AECOPD. As a result, serum legumain can become a biomarker in the disease assessment and prognosis prediction for AECOPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"437-447"},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restriction of Parameters and the Common Issue of Multicollinearity in Multivariate Analysis [Letter].","authors":"Ayşegül Erinç, Alİ Kirac, Celal Satici","doi":"10.2147/COPD.S519684","DOIUrl":"https://doi.org/10.2147/COPD.S519684","url":null,"abstract":"","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"449-450"},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of Exacerbations of Chronic Obstructive Pulmonary Disease Associated with the Long-Term Exposure to Air Pollution in the AIREPOC Cohort.","authors":"Astrid Berena Herrera Lopez, Carlos A Torres-Duque, Alejandro Casas Herrera, María Patricia Arbeláez, Horacio Riojas-Rodríguez, José Luis Texcalac-Sangrador, Néstor Y Rojas, Laura Andrea Rodriguez-Villamizar","doi":"10.2147/COPD.S498437","DOIUrl":"10.2147/COPD.S498437","url":null,"abstract":"<p><strong>Background: </strong>Exacerbations of chronic obstructive pulmonary disease (COPD-E) have been associated with levels of air pollution. The occurrence of COPD-E is associated with increased mortality in this population.</p><p><strong>Purpose: </strong>To determine the association between long-term exposure to PM_2.5 and NO₂, and the frequency of COPD-E in patients belonging to AIREPOC, an institutional integrated care program for COPD in Bogota, Colombia.</p><p><strong>Patients and methods: </strong>Retrospective cohort study included patients with COPD living in Bogotá, between 2018 and 2021, who received health care in the AIREPOC program. Each patient´s home address was geolocated. Information from local air quality network stations was used to estimate daily and annual mean PM_2.5 and NO₂ exposure level for each patient using the inverse distance squared weighted regression (IDWR) method. The effect of PM_2.5 and NO₂ concentrations categorized at 15 µg/m³ and 25 µg/m³ respectively on the frequency of COPD-E was estimated using a zero-truncated negative binomial model adjusted for potential confounders. Goodness-of-fit was assessed by residuals.</p><p><strong>Results: </strong>During the observation period, 580 COPD-E occurred in 722 patients. Significant associations were found between COPD-E and NO₂ concentrations ≥25 µg/m³ (incidence density ratio, RDI: 1.29, 95% CI: 1.02-1.67) after adjustment for sun exposure, COPD severity, depression, and ambient humidity. No association was found between the frequency of COPD-E and PM_2.5 concentrations ≥15µg/m³.</p><p><strong>Conclusion: </strong>Prolonged exposure to high levels of NO₂ increases the frequency of COPD exacerbations in patients residing in Bogotá. These results highlight the importance of strengthening air quality control measures and educating people with COPD to know and interpret the local air quality indices and to follow the recommendations derived from its alterations.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"425-435"},"PeriodicalIF":2.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to Inhalation Therapy Among COPD Patients: A Cross-Sectional Study in a Tertiary Hospital in Quito, Ecuador.","authors":"Juan S Izquierdo-Condoy, Fernando Gualpa Álvarez, Estefania Morales-Lapo, Washington David Arias Calvache, Jessica Bermúdez Moreira, Katherine M Quinga-Chiguano, Esteban Ortiz-Prado","doi":"10.2147/COPD.S493992","DOIUrl":"10.2147/COPD.S493992","url":null,"abstract":"<p><strong>Background: </strong>Chronic Obstructive Pulmonary Disease (COPD), the third leading cause of death globally, poses a significant public health burden. Despite its high prevalence, underdiagnosis and poor treatment adherence remain major challenges, contributing to increased hospitalization and mortality.</p><p><strong>Purpose: </strong>This study aimed to assess adherence to inhalation therapy among COPD patients treated at a specialty hospital in Quito, Ecuador.</p><p><strong>Patients and methods: </strong>A cross-sectional study was conducted on 85 patients diagnosed with COPD at a tertiary hospital in Quito. Data was collected through face-to-face surveys, utilizing the TAI-10 questionnaire to assess treatment adherence, along with demographic and clinical characteristics of the patients.</p><p><strong>Results: </strong>Among the participants, 34.1% demonstrated good adherence to inhalation therapy, while 32.9% exhibited intermediate adherence, and 32.9% were non-adherent. The majority were older adults aged ≥76 years (67.1%) with a high prevalence of comorbidities (91.8%), particularly hypertension (58.8%). Non-adherence was primarily associated with forgetfulness and financial constraints. Higher BMI was significantly linked to better adherence, with obese patients showing higher odds of intermediate (OR=7.228, 95% CI 1.866-27.996) and good adherence (OR=9.966, 95% CI 2.538-39.139).</p><p><strong>Conclusion: </strong>Approximately one-third of COPD patients in Ecuador demonstrate good adherence to inhalation therapy, while similar proportions show intermediate or poor adherence. Predominantly older adults and retirees with comorbidities, the population identified forgetfulness and financial constraints as key barriers. These findings emphasize the need for enhanced patient education, regular follow-ups, and tailored support for vulnerable groups.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"399-410"},"PeriodicalIF":2.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143505247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal Muscle Function in Relation to COPD Severity and Its Predictive Significance for Disease Progression.","authors":"Zemin He, Boxiong Cao, Keting Liu, Qiang Wei","doi":"10.2147/COPD.S510425","DOIUrl":"10.2147/COPD.S510425","url":null,"abstract":"<p><strong>Purpose: </strong>To compare skeletal muscle function levels in different COPD severities and explore their relationship with COPD severity and progression.</p><p><strong>Patients and methods: </strong>The study included COPD patients from the First People's Hospital of Shuangliu District, Chengdu between May 2021 and May 2022, categorized into mild, moderate, severe and very severe groups based on FEV1%. Skeletal muscle function (quadriceps strength, respiratory muscle strength, 6MWD) was compared among these groups. Patients were followed up to assess disease progression, and logistic regression was used to analyze the predictive value of skeletal muscle function for COPD progression.</p><p><strong>Results: </strong>Among the 400 subjects, respiratory muscle strength, quadriceps strength, and 6MWD were all higher in the nonsmoking group than in the smoking group, with the mild group better than the moderate group, the moderate group better than the severe group, males stronger than females, the MMRC score ≤ 2 group better than the >2 group, and strength greater in the age ≤ 70 group than in the age >70 group. The mild group had a higher 6MWD than the moderate group, the moderate group was better than the severe group, non-smokers had a higher 6MWD than smokers, and the difference between males and females was greater with statistical significance. There are differences in quadriceps strength, respiratory strength, and 6MWD within the progression group. Logistic regression analysis showed that respiratory muscle strength, quadriceps strength, 6MWD, and COPD severity were risk factors for COPD progression (P < 0.05).</p><p><strong>Conclusion: </strong>COPD patients show skeletal muscle dysfunction that worsens with disease severity. Respiratory muscle strength, quadriceps strength, 6MWD, and COPD severity predict COPD prognosis.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"389-397"},"PeriodicalIF":2.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143505249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}