International Journal of Chronic Obstructive Pulmonary Disease最新文献

{"title":"Evolution of Peak Inspiratory Flow During Hospitalization of Patients with COPD - A Prospective Monocentric Observational Study.","authors":"Philipp Suter, Thomas Grobéty, Julien Vaucher, Gaël Grandmaison","doi":"10.2147/COPD.S512880","DOIUrl":"https://doi.org/10.2147/COPD.S512880","url":null,"abstract":"<p><strong>Purpose: </strong>Effective treatment of chronic obstructive pulmonary disease (COPD) primarily relies on treatment delivered through inhaler devices. The effectiveness of dry powder inhalers is compromised by insufficient peak inspiratory flow (PIF). Understanding the evolution of PIF during hospitalization is crucial for optimizing inhaler selection and improving patient outcomes.</p><p><strong>Patients and methods: </strong>A prospective monocentric observational study was conducted at Fribourg Hospital, Switzerland, from August 2022 to December 2022. PIF was assessed at hospital admission and discharge in all patients with COPD admitted to the internal medicine division. The primary outcome was the evolution of maximum PIF at a fixed medium-low resistance (R2) during hospitalization. Secondary outcomes included the variation of PIF in the intra-assessment evaluation and transitioning between sufficient and insufficient PIF.</p><p><strong>Results: </strong>Forty-nine patients were enrolled, 61% were men and 65% experienced an acute COPD exacerbation (AECOPD). The maximum PIF for R2 increased from 64.8 ± 17.2 L/min at admission to 70.7 ± 17.9 L/min at discharge, showing a 5.9 L/min improvement (95% CI: 2.4-9.5, p < 0.01). A hospitalization >5 days in patients hospitalized for an AECOPD is associated with a higher increase in PIF (p < 0.05). In the intra-assessment measurement, we observed an increase in PIF in the successive measurements (p < 0.01).</p><p><strong>Conclusion: </strong>Hospitalized patients with COPD experienced a significant increase in PIF during their stay. These results appear to be independent of the reason for hospitalization but need to be confirmed with a larger sample. Nevertheless, these findings underscore the importance of regular PIF assessment and influence inhaler selection.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"957-969"},"PeriodicalIF":2.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11977561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Efficacy of Jiangqi Dingchuan Pill Based on Network Pharmacology Analysis and Cigarette Smoke and Lipopolysaccharide Induced Chronic Obstructive Pulmonary Disease Rat Model.","authors":"Jiewen Zhou, Jinbin Song, Danting Peng, Yanqiu Zheng, Na Ning, Guirong Chen, Qiuling Huang, Yanwu Li","doi":"10.2147/COPD.S489696","DOIUrl":"10.2147/COPD.S489696","url":null,"abstract":"<p><strong>Background: </strong>Jiangqi Dingchuan Pill (JDP) is a patent Chinese medicine in the treatment of asthma. JDP consists of six herbal drugs, namely, Ephedrae Herba, Mori Cortex, Citri Reticulatae Pericarpium, Perillae Fructus, Descurainiae Semen, Sinapis Semen.</p><p><strong>Objective: </strong>To employ the tools of network pharmacology and in vivo experiments, exploring the possible mechanism of JDP in treating chronic obstructive pulmonary disease (COPD).</p><p><strong>Materials and methods: </strong>Chemical constituents of JDP, collection of targets of COPD, target prediction were conducted, and then network pharmacological analysis was performed based on protein-protein interaction (PPI). The cigarette smoke and lipopolysaccharide-induced COPD model was applied to assess the effects of JDP. Rats were randomly divided into five groups (n = 8), ie, a sham group, a COPD-control group, two COPD groups treated with different doses of JDP (1.26 and 2.52 g/kg/d, respectively), and one COPD group treated with aminophylline (54 mg/kg/d). Pulmonary functions were assessed. The inflammatory cytokines in bronchial alveolar lavage fluid (BALF) were quantified using enzyme-linked immunosorbent assay (ELISA). The expression of matrix metalloprotein-9 (MMP-9) was quantified using Western blot.</p><p><strong>Results: </strong>A total of 108 genes were found to be the main target genes regulated by JDP in the treatment of COPD, according to PPI analysis. Compared with the COPD-control group, rats in the JDP group exhibited amelioration in lung function, including 20 ms forced expiratory volume/forced vital capacity, maximal mid-expiratory flow curve, and airway resistance (all <i>p</i> < 0.05). A reduction of IL-1β and TNF-α expressions in BALF was also observed (both <i>p</i> < 0.05). Compared with the COPD-control group, the expression of MMP-9 in lung tissue was down-regulated in the JDP group (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>This study explored the effects and its mechanisms of JDP in COPD treatment. JDP exhibited therapeutic potential as a COPD intervention drug.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"929-941"},"PeriodicalIF":2.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Visceral Adipose Tissue and Chronic Respiratory Diseases: A Two-Sample Multivariable Mendelian Randomization Study in European Population.","authors":"Jin-Xian Huang, Bing-Jie Xiao, Yu-Xin Yan, Wei Xie, Le-Yi Feng, Xue-Mei Liu","doi":"10.2147/COPD.S510828","DOIUrl":"10.2147/COPD.S510828","url":null,"abstract":"<p><strong>Background: </strong>The relationship between obesity and some respiratory diseases has been well documented. However there have been few studies on the association between visceral adipose tissue (VAT) and chronic respiratory diseases (CRDs), it remains unclear whether VAT is causally associated with CRDs.</p><p><strong>Methods: </strong>We used two-sample Mendelian randomization (MR) to illuminate the effects of VAT on four CRDs: chronic obstructive pulmonary disease (COPD), allergic asthma, interstitial lung disease (ILD), and sarcoidosis. Inverse variance weighted (IVW) served as the primary assessment method. MR Egger, weighted median, Simple mode and Weighted mode were the supplementary methods for MR analysis. We used multivariate MR analysis to adjust for the effect of body mass index (BMI) on outcomes, Egger intercept, MR-pleiotropy residual sum and outlier, and leave-one-out analysis to confirm the MR results' consistency.</p><p><strong>Results: </strong>Genetically-predicted VAT was associated with an increased risk of COPD (OR = 1.56; 95% CI: 1.34-1.82; <i>P</i> = 1.16×10^-8), allergic asthma (OR = 1.44; 95% CI: 1.20-1.73; <i>P</i> = 8.63×10^-5), and ILD (OR = 1.15; 95% CI: 1.04-1.26; <i>P</i> = 4.62×10^-3). However, there was limited evidence to support an association between VAT and sarcoidosis. In multivariate MR analysis, VAT's associations with COPD, allergic asthma, and ILD persisted after adjusting for BMI.</p><p><strong>Conclusion: </strong>This study provides evidence for a potential causal relationship between VAT and COPD, allergic asthma, and ILD; these relationships were independent of the effect of BMI.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"919-928"},"PeriodicalIF":2.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sputum SLC40A1 as a Novel Biomarker is Increased in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.","authors":"Xu Ju, Zhihong Chen, Lei Gao, Mengjie Chen, Qian Wang, Zhilong Jiang","doi":"10.2147/COPD.S499176","DOIUrl":"10.2147/COPD.S499176","url":null,"abstract":"<p><strong>Background: </strong>Solute carrier family 40 member 1 (SLC40A1 or Ferroportin) is a cell surface glycoprotein that participates in the efflux of cellular iron and disease pathogenesis. Induced sputum is a non-invasive method for lung sample collection. However, it remains unknown whether SLC40A1 is a potential diagnostic biomarker in induced sputum cells of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We in this study aimed to investigate the expression and the anti-inflammatory role of SLC40A1 in the induced-sputum cells of AECOPD patients.</p><p><strong>Methods: </strong>A total of 35 induced sputum samples were collected from patients with AECOPD. Flow cytometry analysis was used to determine inflammatory cell phenotypes and SLC40A1 expression. Murine RAW 264.7 cell lines were treated with cigarette smoke extract (CSE) and SLC40A1-shRNA for SLC40A1 expression in vitro. ELISA was used for measurement of pro-inflammatory cytokine expression in vitro.</p><p><strong>Results: </strong>Flow cytometry analysis showed that sputum neutrophils were increased in AECOPD patients with 3-5 exacerbations per year compared to 1 exacerbation per year, accompanied by elevated expression of CD40 and SLC40A1 in macrophages. The lung function (FEV1%pred) was reduced with a higher COPD exacerbation rate. There was a negative correlation between the FEV1% predicted and sputum neutrophil count. Patients expressing high levels of SLC40A1 exhibited higher exacerbation rates. SLC40A1 expression levels positively correlated with sputum neutrophils and negatively correlated with predicted FEV1%. In addition, mechanical ventilation reduces sputum neutrophils and SLC40A1 expression, particularly in patients with a high exacerbation rate. Further analysis in RAW 264.7 macrophage cell lines showed that cigarette smoke extract (CSE) increased the expression of SLC40A1, TNF-α, IL-6 and IL-10 at a concentration-dependent manner. SLC40A1 knockdown increased the expression of TNF-α and IL-6 and reduced the expression of IL-10 in CSE-treated macrophages.</p><p><strong>Conclusion: </strong>SLC40A1 in sputum macrophages is increased and closely related to AECOPD severity, it would be a potential anti-inflammatory biomarker of patients with AECOPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"943-955"},"PeriodicalIF":2.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of the Advanced Lung Cancer Inflammation Index as a Risk Marker for Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome and COPD: Evidence from NHANES 2007-2018.","authors":"Nanxin Chen, Yuxia Liu, Qi Wang, Min Wang, Jun Wang, Wenjing Chen","doi":"10.2147/COPD.S518600","DOIUrl":"10.2147/COPD.S518600","url":null,"abstract":"<p><strong>Background: </strong>The Advanced Lung Cancer Inflammation Index (ALI) is widely recognized as an emerging metric for assessing both inflammation and nutritional levels. However, it is unclear whether there is a correlation between ALI and Asthma-Chronic Obstructive Pulmonary Disease Overlap (ACO), Chronic Obstructive Pulmonary Disease (COPD), and asthma.</p><p><strong>Materials and methods: </strong>ALI was considered as a continuous and categorical variable (Q1, Q2, Q3, Q4), respectively, and the categories of its categorical variables were based on the quartiles of ALI. Logistic regression models were then developed to analyze the correlation between ALI and ACO, COPD, and asthma. Finally, correlations were further analyzed by propensity score matching (PSM) methods. In addition, we calculated the area under the curve (AUC) of the ROC curve to assess the predictive performance of the ALI.</p><p><strong>Results: </strong>Results with ALI as a continuous variable: ALI was negatively associated with both ACO and COPD (ACO: OR=0.70; 95% CI: 0.58-0.86; <i>P</i><0.001; COPD: OR=0.72; 95% CI: 0.65-0.79; <i>P</i><0.001), whereas there was no association between ALI and asthma (OR=1.08; 95% CI: 0.97-1.20; <i>P</i>=0.140). Results of ALI as a categorical variable: the negative ALI-ACO association persisted in Q4 groups (Q4: OR=0.66; 95% CI: 0.49-0.88; <i>P</i>=0.006); the negative ALI-COPD association was maintained in all groups. After PSM, ALI remained negatively associated with ACO and COPD (ACO: OR=0.61; 95% CI: 0.45-0.83; <i>P</i>=0.002; COPD: OR=0.56; 95% CI: 0.48-0.64; <i>P</i><0.001). The AUC was 0.69 for ALI-ACO and 0.73 for ALI-COPD.</p><p><strong>Conclusion: </strong>High levels of ALI may be associated with a reduced risk of ACO and COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"905-917"},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Urinary Glyphosate Concentrations and Chronic Obstructive Pulmonary Disease in USA Participants: Evidence from NHANES 2013-2018.","authors":"Yushan Shi, Shuangshuang Pu, Ning Huang, Yan Wang","doi":"10.2147/COPD.S500429","DOIUrl":"10.2147/COPD.S500429","url":null,"abstract":"<p><strong>Background: </strong>Glyphosate has raised health concerns due to its widespread detection in environment and human tissues. Limited evidence exists found in the association between urinary glyphosate concentrations and chronic obstructive pulmonary disease.</p><p><strong>Methods: </strong>Analyzing data from 2588 participants, we applied survey-weighted logistic regression models and cubic spline techniques to quantify link between urinary glyphosate concentrations and prevalence of COPD. Further subgroup and sensitivity analyses were also conducted.</p><p><strong>Results: </strong>Study revealed a significant association between higher urinary glyphosate concentrations that increased risk of COPD. In fully adjusted models, a one-unit increase in natural logarithm of urinary glyphosate was associated with a 35% increased risk of COPD (OR, 1.35, 95% CI, 1.01-1.82, P=0.043). Subgroup analyses showed consistent associations across different demographic groups with a pronounced association in current smokers and females. Sensitivity analyses and exclusion of participants with chronic kidney disease reinforced the robustness of the findings.</p><p><strong>Conclusion: </strong>Findings provide evidence of a positive association between urinary glyphosate concentrations and prevalence of COPD in a representative sample of the adult population at the United States of America. Further studies are needed to investigate the influence of factors and other environmental pollutants on COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"883-894"},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Compliance with Pulmonary Rehabilitation in Patients with Stable COPD: a Cross Sectional Study.","authors":"Xiao Xia, Kun Xia, Xiaoyan Yao, Jianjun Song, Yanyi Liu, Xiaohong Liu, Haoxiang Zhang, Guangxi Li","doi":"10.2147/COPD.S506248","DOIUrl":"10.2147/COPD.S506248","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary rehabilitation (PR) is recognized as a cost-effective non-pharmacological treatment modality to promote quality of life and delay disease progression in patients with chronic obstructive pulmonary disease (COPD). Although PR has been shown to be effective, it is underutilized in clinical practice. This study aimed to investigate the factors associated with affecting compliance with PR in stable COPD patients.</p><p><strong>Methods: </strong>This study is a cross-sectional survey. Patients with stable COPD were included using convenience sampling method. Data were collected using questionnaires including the demographic questionnaire, PR Compliance Questionnaire, mMRC dyspnea Scale, Family Support Scale, and Chronic Disease Self-Efficacy Scale (SES6G). Univariate analysis and multiple linear regression analysis were used to analyze the data.</p><p><strong>Results: </strong>The 100 patients with stable COPD were moderately compliant with PR (3.51 ± 0.65), with the highest compliance with medication (4.10 ± 0.86) and the lowest with exercise (3.03 ± 1.16). Univariate analysis showed statistically significant influences on PR compliance were gender (P = 0.029), educational level (P = 0.021), exercise habits (P < 0.01), willingness to PR (P < 0.01), difficulty of PR (P = 0.030), mMRC (P = 0.002), and SES6G (P = 0.002). The following equation represents the multiple linear regression model: PR compliance = 0.235 × exercise habits + 0.609 × willingness to PR + 0.325 × difficulty of PR (P < 0.0001), adjusted R² = 0.330, F=7.974, and Durbin-Watson ratio = 2.049. Patients' good exercise habits in regular life, stronger willingness to PR, and easier PR programs may contribute to improved PR compliance.</p><p><strong>Conclusion: </strong>This study suggested that stable COPD patients were not sufficiently compliant with PR and revealed related important factors affecting the compliance. Exercise habits, willingness to PR, and PR difficulty were found to be significant influencing factors. The results of this study can provide evidence for developing a more appropriate PR program and promoting PR compliance in the future.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"895-904"},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating the Relationship Between Body Fat Index and Pulmonary Health: Insights from Cross-Sectional Analysis and Mendelian Randomization.","authors":"Qing Zhang, Zihui Wang, Weijuan Liu, Guannan Cai, Yuan Gao, Yilin Chen, Yuan Han, Anliu Nie, Ruan Liang, Fei Cui, Ying Chen","doi":"10.2147/COPD.S488523","DOIUrl":"10.2147/COPD.S488523","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between body fat index and pulmonary health.</p><p><strong>Methods: </strong>In the multiethnic population-based cross-sectional study, a multivariable linear regression model was adapted to assess the association of fat mass/percentage with forced expiratory volume in 1 second (FEV₁)/forced vital capacity (FVC). The Mendelian Randomization (MR) method was used to assess the causal associations of fat mass/percentage in specific body parts with FEV₁ and COPD risk. Sensitivity analysis of MR was performed to assess the robustness of estimates.</p><p><strong>Results: </strong>In the cross-sectional analysis, a non-linear relationship was observed between fat mass and FEV₁ without adjustment. After multivariate adjustment, the negative associations of fat mass/percentage with FEV₁/FVC were found. In the MR study, genetically determined fat presented a negative causal effect on FEV₁ (e.g., estimate = -0.170, P < 0.001 for left leg fat mass). The causal associations of genetically determined body fat with clinical diagnosis COPD were also determined (e.g., OR = 1.936, P < 0.001 per 1.9 kilograms increase in left leg fat mass).</p><p><strong>Conclusion: </strong>We present strong evidence on the causal relationship between body fat mass/percentage and both the deterioration of lung function and the increased risk of COPD. Additional efforts are required to mitigate the negative effects of body fat.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"869-882"},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between the Non-High-Density Lipoprotein Cholesterol-to-High-Density Lipoprotein Cholesterol Ratio (NHHR) and Mortality in Patients with COPD: Evidence From the NHANES 1999-2018.","authors":"Yuhua Zhong, Kesi Zhou, Sheng Li, Renzi Zhang, Daoxin Wang","doi":"10.2147/COPD.S508481","DOIUrl":"10.2147/COPD.S508481","url":null,"abstract":"<p><strong>Purpose: </strong>The non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) is a new composite blood lipid index. We aimed to investigate the relationships of the NHHR with mortality from all-causes, cardiovascular disease (CVD), and chronic lower respiratory disease (CLRD) in US patients with COPD.</p><p><strong>Methods: </strong>We assessed the association between the NHHR and mortality via weighted multivariate Cox proportional hazards regression models with restricted cubic splines (RCSs). Between-group survival rates at specific time points were compared via Kaplan‒Meier (KM) curves and Log rank tests. Receiver operating characteristic (ROC) curves were constructed to evaluate the efficiency of the NHHR for predicting mortality risk in COPD patients.</p><p><strong>Results: </strong>After adjusting for confounding factors, weighted multivariate Cox proportional hazards regression model showed that higher NHHR was not significantly associated with all-cause mortality (HRs = 1.74), CVD mortality (HRs = 1.19), and CLRD-related mortality (HRs = 0.65), but HRs tended to increase as NHHR increased. RCS revealed U-shaped associations between the NHHR and all-cause mortality. KM survival analysis revealed a significantly lower survival rate for patients in the high-NHHR group (Log rank test P<0.001). In addition, the NHHR had superior performance in predicting mortality, with AUC values of 0.85 and 0.883 for all-cause mortality, 0.769 and 0.815 for CVD mortality, and 0.765 and 0.815 for CLRD-related mortality at 5 and 10 years, respectively.</p><p><strong>Conclusion: </strong>The higher the NHHR is, the greater the risk of all-cause mortality in COPD patients. The NHHR was significantly superior to other haematological biomarkers in predicting mortality.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"857-868"},"PeriodicalIF":2.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Age and Disease Entity on Small Airway Dysfunction in Obstructive Airway Diseases.","authors":"Yang Li, Kang-Cheng Su, Yi-Han Hsiao, Kun-Ta Chou, Yen-Jung Li, Tien-Hsin Jeng, Hsin-Kuo Ko, Diahn-Warng Perng","doi":"10.2147/COPD.S505855","DOIUrl":"10.2147/COPD.S505855","url":null,"abstract":"<p><strong>Purpose: </strong>Small airway dysfunction (SAD) is prevalent in asthma and chronic obstructive pulmonary disease (COPD). Aging is acknowledged to be associated with the loss of small airway structures. However, the impact of aging and pathophysiological changes on SAD in asthma and COPD remains unclear. We aimed to investigate the impact of aging and disease entity on pathophysiological change-related SAD in asthma and COPD assessed by spirometry and impulse oscillometry (IOS).</p><p><strong>Patients and methods: </strong>We retrospectively reviewed adult patients diagnosed with asthma or COPD between May 2017 and August 2021 in Taipei Veterans General Hospital. Treatment-naïve COPD patients aged ≥60 years were enrolled, along with age- and gender-matched elderly asthmatics (EA), and younger asthmatics aged <60 years (YA) for comparison. All participants underwent spirometry and IOS with a bronchodilator test. Blood eosinophil counts (BECs) and immunoglobulin E(IgE) levels were documented if blood tests were conducted at the time of diagnosis.</p><p><strong>Results: </strong>The mean age of YA, EA, and COPD were 44, 73, and 73 years, respectively. The FEV₁, FEV₁/FVC and FEF_25-75% were higher in the YA followed by EA and COPD groups. The spirometric values were significantly correlated with IOS parameters in both asthmatic and COPD groups. No significant differences were observed in baseline IOS parameters among the three groups for participants with FEV₁ ≥80% predicted. However, in patients with FEV₁< 80% predicted, COPD patients exhibited significantly worse spirometric values and most IOS parameters (except R₅-R₂₀) compared to asthmatics. Additionally, asthmatics with AX reduction ≥35% exhibited significantly higher levels of blood eosinophil counts and IgE.</p><p><strong>Conclusion: </strong>Aging process contributes to more impact on small airway reactance in asthma, while disease entity in COPD exhibits worse spirometric and IOS parameters compared to the age- and gender-matched EA.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"821-830"},"PeriodicalIF":2.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}