International Journal of Chronic Obstructive Pulmonary Disease最新文献

{"title":"Long-Term Effects of COVID-19 on Chronic Obstructive Pulmonary Disease.","authors":"Chi-Tai Lee, Ping-Huai Wang, Shih-Lung Cheng","doi":"10.2147/COPD.S523149","DOIUrl":"https://doi.org/10.2147/COPD.S523149","url":null,"abstract":"<p><strong>Background: </strong>Research has demonstrated that chronic obstructive pulmonary disease (COPD) is a negative prognostic factor for patients with the coronavirus disease 2019 (COVID-19). The long-term complications of COVID-19 among patients with COPD remain poorly understood due to limited studies.</p><p><strong>Methods: </strong>This retrospective study included patients with COPD who underwent regular follow-ups in a medical center between January 1, 2020, and December 31, 2022. The patients were categorized into COVID-19 and non-COVID-19 groups. Comparative analyses were conducted to assess clinical demographics, characteristics, acute exacerbations of COPD (AECOPD), and survival rates between the two groups. Subgroup analysis was performed based on inpatient and outpatient status within the COVID-19 group.</p><p><strong>Results: </strong>Of the 696 patients with COPD, 86 (12.4%) were included in the COVID-19 group, while 610 (87.6%) were included in the non-COVID-19 group. Patients in the COVID-19 group were significantly older (age: 75.0 ± 8.8 years versus 72.0 ± 9.0 years, <i>p</i> = 0.004), exhibited higher mortality rates (4.6% versus 0%, <i>p</i> < 0.001), and increased annual times of AECOPD (0.17 versus 0.08, <i>p</i> = 0.018) than those in the non-COVID-19 group after COVID-19. Multivariate analysis revealed that COVID-19 infection is an independent risk factor for increased AECOPD incidence (adjusted odds ratio: 1.74; 95% confidence interval [CI]: 1.07-2.83, <i>p</i> = 0.024). Within the COVID-19 group, the inpatient subgroup exhibited a higher prevalence of heart failure comorbidity (20% versus 2.8%, <i>p</i> = 0.035) and lower forced vital capacity than the outpatient subgroup (2.03 ± 0.60 L versus 2.56 ± 0.72 L, <i>p</i> = 0.016).</p><p><strong>Conclusion: </strong>Age is a significant risk factor for COVID-19 infection among patients with COPD. After COVID-19, these patients exhibit an increased frequency of severe exacerbations and a high risk of mortality. Notably, the susceptibility to severe exacerbations persists regardless of whether the patients receive inpatient or outpatient care.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2539-2548"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulation of ARHGAP18 by miR-613 Inhibits Cigarette Smoke Extract-Induced Apoptosis and Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells.","authors":"Haifan Fu, Kai Liu, Yamei Zheng, Jie Zhao, Tian Xie, Yipeng Ding","doi":"10.2147/COPD.S524723","DOIUrl":"https://doi.org/10.2147/COPD.S524723","url":null,"abstract":"<p><strong>Objective: </strong>Chronic Obstructive Pulmonary Disease (COPD) is a major chronic respiratory disease affecting human health worldwide. However, there is still a lack of effective drugs for treating COPD. This study is intended to explore the function and molecular mechanism of <i>ARHGAP18</i> and miR-613 in COPD pathogenesis.</p><p><strong>Methods: </strong>We initially identified the marker gene closely related to epithelial dysfunction in COPD by integrating bioinformatic analyses. <i>ARHGAP18</i> expression in CSE-induced bronchial epithelial cells (BEAS-2B) was detected by qRT-PCR. Besides, <i>ARHGAP18</i> levels were modulated by lentivirus-mediated overexpression. Thereafter, cell variability, apoptosis, and migration were detected by CCK8, flow cytometry, and wound healing assay. IL-1β and TNF-α levels were examined by qRT-PCR. Epithelial-mesenchymal transition (EMT)-associated proteins were determined by Western blotting. The function of miR-613 in COPD was further detected. Functional rescue experiments were performed to determine the mechanism of <i>ARHGAP18</i> in COPD.</p><p><strong>Results: </strong>Our study identified <i>ARHGAP18</i> as the key gene associated with epithelial dysfunction in COPD. <i>ARHGAP18</i> was downregulated in CSE-induced BEAS-2B cells. Overexpression of <i>ARHGAP18</i> inhibited cell apoptosis of BEAS-2B cells and enhanced their proliferation and migration. Besides, <i>ARHGAP18</i> overexpression reduced IL-1 β and TNF-α levels, enhanced E-cadherin expression, and suppressed Vimentin and N-cadherin expression. In contrast, miR-613 mimics exerted opposite effects. Furthermore, downregulation of <i>ARHGAP1</i>, mediated by miR-613 inhibitor promoted cell apoptosis and EMT of CSE-induced BEAS-2B cells, suggesting a regulatory role of miR-613 in COPD pathogenesis.</p><p><strong>Conclusion: </strong>These findings highlight miR-613/<i>ARHGAP18</i> axis as a critical regulator of epithelial dysfunction in COPD, offering a potential therapeutic target to counteract apoptosis, inflammation, and airway remodeling.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2525-2537"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Advanced Lung Cancer Inflammation Index and Mortality in US Adults with Chronic Obstructive Pulmonary Disease.","authors":"Xiaozhou Su, Huiqing Rao, Chunli Zhao, Xianwei Zhang, Donghua Li","doi":"10.2147/COPD.S516286","DOIUrl":"https://doi.org/10.2147/COPD.S516286","url":null,"abstract":"<p><strong>Purpose: </strong>Identifying reliable prognostic markers is critical for improving chronic obstructive pulmonary disease (COPD) management. The advanced lung cancer inflammation index (ALI) is a novel marker reflecting inflammation and nutritional status. This study evaluated the association between ALI and all-cause and cause-specific mortality in COPD patients.</p><p><strong>Patients and methods: </strong>Data from 4616 adults with COPD in the National Health and Nutrition Examination Survey (1999-2018) were analyzed. Mortality outcomes were obtained from the National Death Index. Multivariable Cox proportional hazards models and restricted cubic splines assessed the association between the natural logarithm of ALI (lnALI) and mortality. Time-dependent receiver operating characteristic (ROC) curves evaluated the predictive performance of lnALI at 3, 5, and 10 years. Mediation analysis examined whether estimated glomerular filtration rate (eGFR) mediated these associations.</p><p><strong>Results: </strong>During a median 80-month follow-up, 1202 participants died: 349 from cardiovascular disease, 263 from cancer, and 194 from chronic lower respiratory diseases (CLRD). Higher lnALI was significantly associated with lower risks of all-cause, cardiovascular, and CLRD mortality. L-shaped associations were observed for all-cause and cardiovascular mortality, with inflection points at 4.04 and 3.64, respectively. The AUCs for predicting all-cause mortality were 0.670, 0.646, and 0.634; for cardiovascular mortality, 0.659, 0.653, and 0.629; and for CLRD mortality, 0.770, 0.751, and 0.739 at 3, 5, and 10 years. eGFR partially mediated the associations between lnALI and both all-cause and cardiovascular mortality.</p><p><strong>Conclusion: </strong>Higher lnALI values were significantly associated with lower risks of all-cause, cardiovascular, and CLRD mortality in COPD patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2481-2492"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Support and Its Effect for Persons Affected by COPD and Their Next of Kin - an Systematic Integrative Review.","authors":"Helena Johansson, Lise-Lotte Jonasson, Carina Berterö","doi":"10.2147/COPD.S507905","DOIUrl":"https://doi.org/10.2147/COPD.S507905","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic Obstructive Pulmonary Disease (COPD) is an irreversible lung disease. People with COPD and their next of kin are affected in daily life and need support from each other, health care, and the surrounding society.</p><p><strong>Objective: </strong>This systematic integrative review aims to identify which support is given to persons affected by COPD and/or their next of kin from the health care and surrounding society. A second aim was to evaluate the support.</p><p><strong>Methods: </strong>A systematic integrative review was conducted to aggregate the knowledge by searching PubMed, CINAHL, PsycINFO, Scopus, and Web of Science databases. Search terms were chronic obstructive pulmonary disease (COPD) and support. The time limit was 2014-2023. The review protocol was registered on PROSPERO (CRD42023462784). The inclusion was selected from the aim, and quality review instruments checked quality. The result was analyzed with a constant comparison method.</p><p><strong>Results: </strong>Persons with COPD receive support from their next of kin, practically and emotionally. Health care also supplies support through information, knowledge, and different training programs. Health care can be in all types of health care, from hospital and primary care to care in the home, all with varying types of support. The next of kin supplies support to their sick relative, becomes support from health care on a small scale, and wishes for more information, knowledge, and understanding about the disease, symptoms, and treatment. The sick person and their carer want to be acknowledged and supported more on their terms.</p><p><strong>Conclusion: </strong>Support for next of kin is virtually non-existent. Next of kin needs more support from health care and the surrounding society. Healthcare interventions in the future need to involve the person with COPD and the next of kin in a person-centered approach out of every person´s needs and support more on their terms.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2459-2480"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Literature Review of the Humanistic, Economic, Sociodemographic, and Environmental Burden Associated with Severe COPD.","authors":"Ioanna Vlachaki, Simon Donhauser, Robert A Wise, Yahong Chen, Alessandra Madoni, Ulrica Scaffidi Argentina, Jahangir Nabi Mir, Jennifer K Quint","doi":"10.2147/COPD.S510623","DOIUrl":"https://doi.org/10.2147/COPD.S510623","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is a highly prevalent and progressive disease, hence greater understanding of its humanistic, economic, and environmental impact is essential for guiding effective management strategies. A systematic literature review (SLR; 2021-2023), complemented with a targeted literature review (TLR; 2013-2023) identified 2039 publications on the economic and humanistic burden of severe COPD. Additionally, an SLR and complementary TLR to evaluate the impact of environmental and sociodemographic factors on COPD (2013-2023), identified 1018 records. All searches were conducted on November 17, 2023. After applying prespecified selection criteria, 50 studies reporting on the humanistic and economic impact of COPD, and six studies on the environmental and sociodemographic impact, were selected. Severe COPD significantly impairs health-related quality of life, exerting effects on physical and psychological well-being, with a progressive decline as COPD worsens from mild to very severe. Evidence indicates that there is a significant burden of disease due to exacerbations of COPD, with their frequency and severity increasing with disease progression, and an increased mortality risk associated with very severe versus severe COPD. The studies reported a high frequency of healthcare resource utilization, including primary care visits, emergency department visits, and hospitalizations among patients with severe COPD, all of which contribute to a significant economic burden, particularly in patients with advanced disease. Environmental factors demonstrated diverse impacts on outcomes for individuals with severe COPD, varying by type of pollutant, disease severity, and patient characteristics. Studies examining the sociodemographic impact of underserved populations on the burden of severe COPD were not identified. Severe COPD is a multifaceted disease that imposes considerable humanistic and economic impact on both patients and healthcare systems. Further work is needed to understand the impact of environmental and sociodemographic factors on the burden of COPD, with such insights ultimately optimizing patient care.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2493-2523"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Lactic Dehydrogenase-to-Albumin Ratio and Short-Time Mortality in Patients with Chronic Obstructive Pulmonary Disease.","authors":"Xiqing Yao, Haoyue Xue, Jiye Luo","doi":"10.2147/COPD.S521192","DOIUrl":"10.2147/COPD.S521192","url":null,"abstract":"<p><strong>Purpose: </strong>The lactate dehydrogenase-to-albumin ratio (LAR) has emerged as a prognostic marker for critically ill patients, yet its relationship with mortality in chronic obstructive pulmonary disease (COPD) remains poorly understood. Our purpose is to assess the predictive value of LAR in COPD patients.</p><p><strong>Patients and methods: </strong>In this retrospective cohort study, data were extracted from the MIMIC IV database. COPD patients were divided into two groups based on 28-day all-cause mortality. To investigate the relationship between LAR and short-term mortality, multivariate Cox regression, receiver operating characteristic (ROC) analysis, and Kaplan-Meier survival analysis were performed.</p><p><strong>Results: </strong>The study included 1048 COPD patients, with 37% experiencing 28-day mortality. LAR was identified as an independent predictor of 28-day mortality (hazard ratio [HR] 1.01, 95% confidence interval [CI]: 1.01-1.01, P < 0.001). ROC analysis showed that LAR had an area under the curve (AUC) of 69.48% (95% CI: 65.67-73.29%), demonstrating superior discriminatory power compared to lactate dehydrogenase (AUC = 66.69%) or albumin (AUC = 36.88%) alone. Additionally, LAR's predictive performance was comparable to that of the Simplified Acute Physiology Score II (SAPSII), which yielded an AUC of 76.8% (95% CI: 73.54-80.06%). COPD patients with high LAR values (>120) had significantly higher 28-day mortality rates (P < 0.001).</p><p><strong>Conclusion: </strong>Elevated LAR is an independent predictor of 28-day mortality in ICU patients with COPD. LAR proves to be a valuable prognostic tool that may assist in the early identification of high-risk patients with CPPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2435-2444"},"PeriodicalIF":2.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12275921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty in COPD: Clinical Impact, Diagnosis, Biomarkers, and Management Strategies.","authors":"Rakhima Azhimamatova, Rana Sherbaevna Salieva, Tazagul Bayishbecovna Zalova, Kunduzkhan Karimova, Dilshat S Karimova, Shekerbubu Anarbekovna Dyikanova, Roman Kalmatov, Urmatbek M Tynaliev","doi":"10.2147/COPD.S522862","DOIUrl":"10.2147/COPD.S522862","url":null,"abstract":"<p><p>Frailty is a complex clinical syndrome characterized by reduced physiological resilience and heightened susceptibility to external stressors, culminating in increased risks of functional decline, hospitalization, and mortality. In individuals with chronic obstructive pulmonary disease (COPD), frailty exacerbates disease burden and is closely linked to adverse outcomes, including increased exacerbation frequency, diminished quality of life, and poor prognosis. This review synthesizes current evidence on the interplay between frailty and COPD, emphasizing clinical implications, diagnostic frameworks, emerging biomarkers, and tailored management strategies. A systematic literature search was conducted across PubMed, Scopus, and Embase databases, employing key terms such as \"frailty\", \"chronic obstructive pulmonary disease\", \"COPD\", \"frailty assessment\", \"biomarkers\", and \"frailty management in COPD\". Inclusion criteria targeted English-language studies reporting original data with a direct focus on frailty in the context of COPD. By synthesizing multidimensional assessment strategies and potential therapeutic modalities, this review supports the development of precision-based interventions to reduce frailty and improve outcomes in patients with COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2445-2458"},"PeriodicalIF":2.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12275923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Density Lipoprotein Cholesterol as a Protective Factor in COPD and Implications for Statin Therapy: A Multi-Omics Genetic Epidemiology Study.","authors":"Tiantao Du, Jianye Cao, Ziyao Dai, Xianting Xie, Guoshu Zhang, Yulin Li, Baiyu Chen, Tao Xu, Jia Feng","doi":"10.2147/COPD.S516906","DOIUrl":"10.2147/COPD.S516906","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a complex lung condition primarily affecting the airways and alveoli, characterized by persistent progressive airflow limitation. COPD ranks as the third leading cause of death worldwide, with its incidence and mortality rates escalating annually due to an aging population. This study aimed to explore the association between low-density lipoprotein cholesterol (LDL-C) and COPD, as well as the impact of statin drugs on the progression of COPD.</p><p><strong>Methods: </strong>Employing an integrated approach that encompasses observational studies, genetic epidemiology, and molecular biology, this research investigated the link between LDL-C and COPD using clinical survey data, genome-wide association study (GWAS) data, and transcriptomic data. Additionally, it assessed the potential role of statin drugs in the treatment of COPD.</p><p><strong>Results: </strong>The study discovered that LDL-C serves as a protective factor for COPD, and statin drugs may promote the progression of COPD by reducing LDL-C levels. This finding provides a new perspective on the metabolic disruptions in COPD and offers significant guidance for future therapeutic strategies.</p><p><strong>Conclusion: </strong>This research confirms the inverse correlation between LDL-C and COPD and reveals that statin drugs might influence the progression of COPD by affecting LDL-C levels. These findings underscore the importance of considering metabolic factors in COPD management and suggest new directions for therapeutic strategies.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2409-2422"},"PeriodicalIF":2.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dietary Inflammatory Index (DII) and COPD: A Cross-Sectional Study from the NHANES.","authors":"Zhi Jian Luo, Haiying Yang, Yuan Wang","doi":"10.2147/COPD.S523653","DOIUrl":"10.2147/COPD.S523653","url":null,"abstract":"<p><strong>Background: </strong>While diet may impact the risk of chronic obstructive pulmonary disease (COPD), the relationship between COPD and dietary inflammatory potential remains largely unexplored. This study aimed to evaluate the association between COPD status and the dietary inflammatory index (DII).</p><p><strong>Methods: </strong>Utilizing NHANES data from 2013 to 2018, the study investigated the relationship between Dietary Inflammatory Index (DII) scores, derived from 24-hour dietary recall interviews, and COPD status. Weighted logistic regression and restricted cubic spline (RCS) analyses were employed to assess this association. Additionally, stratified and interaction analyses were conducted to evaluate the consistency of the relationship and identify potential modifiers.</p><p><strong>Results: </strong>Individuals diagnosed with COPD demonstrated significantly elevated DII scores in comparison to those without COPD. An increment of one unit in the DII was correlated with an increased risk of developing COPD, as indicated by an odds ratio (OR) of 1.05 (95% CI:1.09, 1.21; <i>P</i>=0.007). Following comprehensive multivariate adjustments, the odds ratio for COPD, when comparing individuals in the highest quartile of DII scores to those in the lowest quartile, was 1.34 (95% CI:1.01, 1.77; <i>P</i><0.001). A positive linear association was observed between DII and COPD, although the relationship was nonlinear (<i>P</i>=0.618). Moreover, the association between DII and COPD was consistent across various stratified analyses.</p><p><strong>Conclusion: </strong>The study results imply that consuming a pro-inflammatory diet is connected to a greater chance of developing COPD among US residents. Dietary strategies aimed at reducing inflammation might help in preventing COPD and associated illnesses.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2423-2434"},"PeriodicalIF":2.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and Quality of Life of Patients with COPD with Different Degrees of Exercise-Induced Desaturation on Six-minute Walk Test.","authors":"Beiyao Gao, Siyuan Wang, Li Zhao, Hongbin Liao, Shiwei Qumu, Peijian Wang, Ting Yang, Shan Jiang","doi":"10.2147/COPD.S513089","DOIUrl":"10.2147/COPD.S513089","url":null,"abstract":"<p><strong>Objective: </strong>To identify predictive factors for different exercise-induced desaturation (EID) severities and evaluate health-related quality of life six months later in chronic obstructive pulmonary disease (COPD) patients.</p><p><strong>Methods: </strong>This retrospective study consecutively analyzed 116 COPD outpatients (male: 82.8% [96/116]; age: 63.48 ± 7.48 years; disease severity distribution: GOLD 1/2/3/4 = 55.8%/34.6%/7.7%/1.9%). Patients were categorized into three groups based on oxygen desaturation (SpO₂) during the six-minute walk test (6MWT): non-EID (n = 52), mild-EID (n = 42), and severe-EID (n = 22). EID was classified as follows: Mild EID: SpO₂ decrease ≥4% with nadir SpO₂ ≥90%. Severe EID: SpO₂ decrease ≥4% with nadir SpO₂ ≤90%. Non EID: SpO₂ decrease <4% with nadir SpO₂ ≥90%. A six-month follow-up was conducted via telephone to record adverse events and assess quality of life using the Chinese version of the EQ-5D questionnaire, which includes five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, along with the EQ-VAS scale.</p><p><strong>Results: </strong>Significant differences were observed across the three groups in peripheral blood oxygen saturation (SpO₂, %), peak expiratory flow (PEF, L/s), PEF (%), forced expiratory volume in the first second (FEV1, L), FEV1 (%), 6MWT distance (6MWD, m), Borg dyspnea, and Borg fatigue scores. The optimal cutoff values for predicting EID severity was 54.45% for FEV1% (AUC=0.716), 450.5 m for 6MWD (AUC = 0.761), and 94.5% for resting SpO₂ (AUC = 0.737). Multivariate logistic regression analysis identified low FEV1%, reduced 6MWD, and low resting SpO₂ as risk factors for severe EID (FEV1%: p = 0.002; 6MWD: p = 0.008; SpO₂: p = 0.018. Severe EID patients had significantly lower EQ-5D index and EQ-VAS scores (EQ-5D index: p = 0.002; EQ-VAS: P = 0.005), particularly in mobility and usual activities dimensions (mobility: p = 0.001; usual activities: p = 0.038).</p><p><strong>Conclusion: </strong>Low FEV1%, reduced 6MWD, and low resting SpO₂ are key risk factors for severe EID, provide practical thresholds for clinical management of EID in COPD patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2381-2391"},"PeriodicalIF":2.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}