Frailty in COPD: Clinical Impact, Diagnosis, Biomarkers, and Management Strategies.

IF 2.7 3区医学 Q2 RESPIRATORY SYSTEM

International Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2025-07-15 eCollection Date: 2025-01-01 DOI:10.2147/COPD.S522862

Rakhima Azhimamatova, Rana Sherbaevna Salieva, Tazagul Bayishbecovna Zalova, Kunduzkhan Karimova, Dilshat S Karimova, Shekerbubu Anarbekovna Dyikanova, Roman Kalmatov, Urmatbek M Tynaliev

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引用次数: 0

Abstract

Frailty is a complex clinical syndrome characterized by reduced physiological resilience and heightened susceptibility to external stressors, culminating in increased risks of functional decline, hospitalization, and mortality. In individuals with chronic obstructive pulmonary disease (COPD), frailty exacerbates disease burden and is closely linked to adverse outcomes, including increased exacerbation frequency, diminished quality of life, and poor prognosis. This review synthesizes current evidence on the interplay between frailty and COPD, emphasizing clinical implications, diagnostic frameworks, emerging biomarkers, and tailored management strategies. A systematic literature search was conducted across PubMed, Scopus, and Embase databases, employing key terms such as "frailty", "chronic obstructive pulmonary disease", "COPD", "frailty assessment", "biomarkers", and "frailty management in COPD". Inclusion criteria targeted English-language studies reporting original data with a direct focus on frailty in the context of COPD. By synthesizing multidimensional assessment strategies and potential therapeutic modalities, this review supports the development of precision-based interventions to reduce frailty and improve outcomes in patients with COPD.

查看原文本刊更多论文

慢性阻塞性肺病的衰弱：临床影响、诊断、生物标志物和管理策略。

虚弱是一种复杂的临床综合征，其特征是生理弹性降低，对外部压力源的易感性增加，最终导致功能下降、住院和死亡的风险增加。在慢性阻塞性肺疾病（COPD）患者中，虚弱加剧了疾病负担，并与不良后果密切相关，包括加重频率增加、生活质量下降和预后不良。本综述综合了虚弱和COPD之间相互作用的现有证据，强调了临床意义、诊断框架、新兴生物标志物和量身定制的管理策略。在PubMed、Scopus和Embase数据库中进行了系统的文献检索，检索关键词包括“衰弱”、“慢性阻塞性肺疾病”、“COPD”、“衰弱评估”、“生物标志物”和“COPD中的衰弱管理”。纳入标准针对报告原始数据的英语研究，直接关注COPD背景下的虚弱。通过综合多维评估策略和潜在的治疗模式，本综述支持基于精确的干预措施的发展，以减少COPD患者的虚弱和改善预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Chronic Obstructive Pulmonary Disease RESPIRATORY SYSTEM-

CiteScore

4.80

自引率

10.70%

发文量

372

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals