{"title":"Life's Crucial 9 Score as a Novel Role for Chronic Obstructive Pulmonary Disease Screening.","authors":"Wenqiang Li, Youli Wen, Yuting Fan, Zefu Hu, Zhiping Deng, Qian Huang","doi":"10.2147/COPD.S515649","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the association between the Life's Crucial 9 (LC9) score and chronic obstructive pulmonary disease (COPD) in middle-aged and older adults.</p><p><strong>Patients and methods: </strong>We screened the NHANES database for data from 2007-2018. Logistic regression analysis and subgroup analysis were used to explore the association between LC9 score and COPD in middle-aged and older adults. Additionally, restricted cubic spline (RCS) was plotted to visually depict the dose-response relationship between the two.</p><p><strong>Results: </strong>A total of 12,030 participants were included, of whom 815 had COPD. After multivariate adjustment, the LC9 score was found to be inversely associated with COPD diagnosis. The RCS visually demonstrated a linear decreasing relationship between the two. Furthermore, subgroup analysis revealed no significant interaction across different subgroups, except for education level.</p><p><strong>Conclusion: </strong>The LC9 score is linearly and inversely associated with COPD diagnosis. Higher LC9 scores are associated with a lower COPD diagnosis in individuals aged 40 and above.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2161-2171"},"PeriodicalIF":3.1000,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229238/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Chronic Obstructive Pulmonary Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/COPD.S515649","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: This study aims to investigate the association between the Life's Crucial 9 (LC9) score and chronic obstructive pulmonary disease (COPD) in middle-aged and older adults.
Patients and methods: We screened the NHANES database for data from 2007-2018. Logistic regression analysis and subgroup analysis were used to explore the association between LC9 score and COPD in middle-aged and older adults. Additionally, restricted cubic spline (RCS) was plotted to visually depict the dose-response relationship between the two.
Results: A total of 12,030 participants were included, of whom 815 had COPD. After multivariate adjustment, the LC9 score was found to be inversely associated with COPD diagnosis. The RCS visually demonstrated a linear decreasing relationship between the two. Furthermore, subgroup analysis revealed no significant interaction across different subgroups, except for education level.
Conclusion: The LC9 score is linearly and inversely associated with COPD diagnosis. Higher LC9 scores are associated with a lower COPD diagnosis in individuals aged 40 and above.
期刊介绍：
An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals
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