Breath and Bottle: Evaluating Pharmacotherapy for Alcohol Use Disorder on COPD Exacerbation Outcomes.

IF 3.1 3区医学 Q2 RESPIRATORY SYSTEM

International Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2025-08-04 eCollection Date: 2025-01-01 DOI:10.2147/COPD.S524905

Teng Zhang, Qin Ding, Mengmeng Liu, Yanning Song, Lvfeng Zhang, Na Liang, Xia Zhao, Qian Wang, Xueli Guo, Guangmei Yang, Hongwei Zhang, Wei Chen

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引用次数: 0

Abstract

Background: The role of pharmacotherapy for alcohol use disorder (AUD) in mitigating COPD exacerbations remains underexplored. This study aims to evaluate the impact of AUD pharmacotherapy on COPD-related clinical outcomes.

Methods: A retrospective cohort study was conducted on 635 COPD patients with comorbid AUD. Patients were categorized into two groups based on whether they received medication for AUD (MAUD group) or not (no-MAUD group). Data on demographics, COPD severity, exacerbation rates, and AUD treatment were extracted from electronic medical records.

Results: Individuals in the MAUD group (n=229) exhibited a substantially reduced frequency of COPD exacerbations when compared to those in the non-MAUD group (n=406), with a significant difference observed (P<0.001). Additionally, the MAUD group experienced a longer duration before the first exacerbation event (P<0.001).

Conclusion: Pharmacotherapy for AUD appears to have a protective effect against the occurrence of COPD exacerbations and improved clinical outcomes in patients with comorbid AUD. These findings suggest that AUD treatment should be considered as part of a comprehensive management strategy for COPD patients with AUD.

Abstract Image

查看原文本刊更多论文

呼吸和瓶子：评估酒精使用障碍的药物治疗对COPD加重结果的影响。

背景：药物治疗酒精使用障碍（AUD）在缓解COPD加重中的作用仍未得到充分探讨。本研究旨在评估AUD药物治疗对copd相关临床结局的影响。方法：对635例COPD合并AUD患者进行回顾性队列研究。根据是否接受AUD治疗（MAUD组）和是否接受AUD治疗（no-MAUD组），将患者分为两组。从电子病历中提取人口统计数据、COPD严重程度、加重率和AUD治疗。结果：与非MAUD组（n=406）相比，MAUD组（n=229）的个体COPD恶化频率显著降低，且观察到显著差异(pp结论：AUD的药物治疗似乎对COPD恶化的发生具有保护作用，并改善合并症AUD患者的临床结局。这些发现表明，AUD治疗应被视为COPD AUD患者综合管理策略的一部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Chronic Obstructive Pulmonary Disease RESPIRATORY SYSTEM-

CiteScore

4.80

自引率

10.70%

发文量

372

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals