International Journal of Chronic Obstructive Pulmonary Disease最新文献

{"title":"The Association Between COPD, Acute Exacerbations of COPD, and Survival in COPD, with Fat-Free Body Mass Index: A Systematic Review and Meta-Analysis.","authors":"Chenyu Hu, Benyan Song, Xiangfeng Liu, Lan Sun, Mingfeng Li, Xing He","doi":"10.2147/COPD.S526194","DOIUrl":"10.2147/COPD.S526194","url":null,"abstract":"<p><strong>Objective: </strong>Nutritional status critically influences disease progression and prognosis in chronic obstructive pulmonary disease (COPD). This meta-analysis evaluates the clinical significance of fat-free mass index (FFMI) in COPD prognosis.</p><p><strong>Methods: </strong>A systematic search of PubMed, Embase, Web of Science, Scopus, Ovid, and Cochrane Library (up to December 7, 2024) identified studies comparing FFMI among non-smokers, smokers, COPD patients, and those with acute exacerbations (AE) or mortality. Pooled weighted mean differences (WMD), odds ratios (OR), and hazard ratios (HR) were calculated. Subgroup analyses assessed smoking status and AE sources, with Sensitivity analyses, Egger's test and trim-and-fill method evaluating robustness and publication bias.</p><p><strong>Results: </strong>A pooled analysis including 17 studies involving 4239 patients with COPD revealed that FFMI levels in COPD group were significantly lower than those in control group (WMD = -0.84; 95% CI: -1.63, -0.05). Among COPD patients, no significant difference in FFMI levels was found between AE and non-AE groups (WMD = -1.32; 95% CI: -2.76, 0.11); furthermore, FFMI levels in death group were significantly lower compared to those in survival group (WMD = -1.23; 95% CI: -1.73, -0.74). Notably, FFMI emerged as a critical factor associated with AE occurrence (OR = 0.82; 95% CI: 0.72, 0.95) and survival outcomes (HR = 0.89; 95% CI: 0.86, 0.93) among patients with COPD.</p><p><strong>Conclusion: </strong>Low FFMI is strongly associated with adverse disease progression and poor prognosis in COPD. Tailored interventions targeting nutritional status and body composition may optimize disease management and survival outcomes.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2589-2600"},"PeriodicalIF":3.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum IL-33/ST2 Axis Expression in Acute Exacerbations of COPD: Correlation with Pulmonary Function.","authors":"Yan Wei, Liu Ling, Hongping Zhu, Qinrong Huang","doi":"10.2147/COPD.S514152","DOIUrl":"10.2147/COPD.S514152","url":null,"abstract":"<p><strong>Background: </strong> Chronic obstructive pulmonary disease (COPD) exacerbations significantly contribute to morbidity and mortality. Identifying biomarkers linked to disease severity can enhance COPD management. This study investigates the relationship between serum IL-33 and ST2 levels and reduced pulmonary function during acute exacerbations of COPD (AECOPD).</p><p><strong>Methods: </strong> We conducted a cross-sectional analysis of 194 AECOPD patients assessing IL-33 and ST2 serum levels and their associations with pulmonary function parameters. Patients were stratified into subgroups by age, gender, and the presence of pulmonary hypertension (PH) to explore differential biomarker impacts.</p><p><strong>Results: </strong> IL-33 and ST2 levels demonstrated significant inverse correlations with FEV1% predicted (IL-33: r = -0.561, ST2: r = -0.545, p < 0.001) and the FEV1/FVC ratio. Logistic regression confirmed IL-33 (OR = 1.32, p < 0.001) and ST2 (OR = 1.29, p < 0.001) was associated with reduced pulmonary function. Subgroup analysis revealed more pronounced associations in older patients (≥ 67 years), males, and those with PH.</p><p><strong>Conclusion: </strong> IL-33 and ST2 are promising biomarkers for identifying individuals at higher risk of reduced pulmonary function during AECOPD. Their utility is particularly significant in specific demographics, emphasizing the need for integrated biomarker-guided COPD management strategies.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2581-2587"},"PeriodicalIF":3.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying the Core Symptoms in Chinese Patients of Chronic Obstructive Pulmonary Disease: A Contemporaneous Symptom Network Analysis.","authors":"Zhenjiao Yang, Miaoling Cui, Jianquan Zhang, Zixiu Wang, Guirui Yao, Xia Fu","doi":"10.2147/COPD.S511879","DOIUrl":"10.2147/COPD.S511879","url":null,"abstract":"<p><strong>Context: </strong>Patients with chronic obstructive pulmonary disease (COPD) exhibit various patterns of co-occurring complex symptoms. However, identifying core symptoms based on these distinct symptom patterns remains limited.</p><p><strong>Objective: </strong>The aims of this current study were to explore symptom subgroups among patients with COPD based on their unique symptom experiences and to identify the core symptoms within these subgroups, along with the correlation of these core symptoms with laboratory indicators.</p><p><strong>Methods: </strong>From May 2018 to December 2023, we recruited 252 participants with COPD through a convenience sample in China. Participants were investigated using the Revised Memorial Symptom Assessment Scale (RMSAS). Latent profile analysis (LPA) was conducted to identify symptom subgroups, while network analysis was used to reveal core symptoms among subgroups identified by LPA.</p><p><strong>Results: </strong>Based on symptom experiences, two subgroups of patients were identified: the \"low\" symptom burden subgroup and the \"high\" symptom burden subgroup. In both the total sample and the low symptom burden subgroup, \"feeling sad\" was identified as the core symptom, whereas \"feeling drowsy\" was the core symptom in the high symptom burden subgroup. The neutrophil-to-lymphocyte ratio was associated with the severity of drowsiness.</p><p><strong>Conclusion: </strong>This study highlights the heterogeneity among COPD patients with multiple symptoms, resulting in the identification of two distinct symptom subgroups. Addressing symptoms of sadness and drowsiness may serve as a crucial target for alleviating the overall symptom burden in individuals with COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2569-2579"},"PeriodicalIF":3.1,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung Health of Early COPD (LHEC): A Multi-Center Cohort Study-Rational and Design.","authors":"Wei Li, Jieping Lei, Baicun Li, Xingyao Tang, Yaodie Peng, Ke Huang, Ting Yang","doi":"10.2147/COPD.S517185","DOIUrl":"10.2147/COPD.S517185","url":null,"abstract":"<p><strong>Introduction: </strong>Little is known about the early stage of chronic obstructive pulmonary disease (COPD), especially in nonsmokers. More efforts should be made to investigate the characteristics of this stage, as well as to identify biomarkers for early diagnosis. This study aimed to build a national cohort of patients with early COPD in China to address the current research gaps in this area.</p><p><strong>Methods and analysis: </strong>We intend to enroll 1500 participants aged 35 to 75 years with post-bronchodilator spirometry showing a forced expiratory volume in one second (FEV1)/forced vital capacity ratio below 0.8 and an FEV1% predicted of at least 80%, classified as early COPD subjects. Recruitment will take place across 24 centers located in various provinces throughout China. Participants will be categorized into four groups based on their smoking status and spirometry results: pre-COPD smokers, mild COPD smokers, pre-COPD nonsmokers, and mild COPD nonsmokers. Each participant will undergo three visits over a 2-year period, including one baseline visit and two follow-up visits. Comprehensive and follow-up questionnaires will be administered, and the participants will undergo physical examination, pulmonary function testing, high-resolution computed tomography (CT), routine blood tests, and biological sample collection. We will analyze the changes in lung function, CT images, symptoms, biomarkers, and other relevant parameters across the different groups.</p><p><strong>Discussion: </strong>There is an urgent need for a more precise definition of early COPD for intervention at an earlier stage. By setting a narrower range of lung function thresholds to define pre- and mild-COPD, this study will effectively observe the early disease progression of COPD patients in a shorter period of time. By including a considerable proportion of nonsmokers, this study is more likely to identify new factors influencing early COPD.</p><p><strong>Ethics and dissemination: </strong>Ethical approval was obtained China-Japan Friendship Hospital (Beijing, PR China; approval number 2022-KY-141). Participants will provide written informed consent. Study findings will be disseminated through conferences and peer-reviewed scientific and professional journals.</p><p><strong>Trail registration number: </strong>NCT05466396.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2561-2568"},"PeriodicalIF":2.7,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major Adverse Cardiovascular Events and Cause-Specific Mortality After Hospitalisation in COPD.","authors":"Anne E Ioannides, Hannah R Whittaker, Jennifer K Quint","doi":"10.2147/COPD.S529171","DOIUrl":"10.2147/COPD.S529171","url":null,"abstract":"<p><strong>Purpose: </strong>People with chronic obstructive pulmonary disease (COPD) are at elevated risk of cardiovascular events and mortality. We aimed to determine, in a COPD population, the relationship between hospitalization and post-discharge one-year rates of (i) major adverse cardiovascular events (MACE) and (ii) cause-specific mortality.</p><p><strong>Patients and methods: </strong>We conducted a prospective cohort study on a COPD population, between 01/01/2010 and 31/12/2019, using nationally-representative, routinely collected electronic healthcare records in England (Clinical Practice Research Datalink Aurum primary care data, linked with secondary care [Hospital Episode Statistics], and mortality [Office of National Statistics] data). The exposure was ≥one hospitalization, and the control group was no hospitalization. Outcomes were one-year rates of (i) non-fatal MACE (acute coronary syndrome, arrhythmia, heart failure, or ischemic stroke) and (ii) cause-specific mortality. Exposures were stratified by hospitalization type (elective and emergency) and cause (all-cause, cardiovascular, respiratory, and non-cardiorespiratory). We implemented adjusted Cox proportional hazard regression models, and sensitivity doubly robust propensity score-adjusted models.</p><p><strong>Results: </strong>Hospitalized COPD patients had significantly higher rates (incidence rate [IR, per 1000 person-years]; adjusted hazard ratio {aHR} [95% confidence interval {95% CI}] of MACE in the year following hospitalization, whether elective (IR=33.3; 7.04 [6.19-8.07]) or emergency (IR=70.0; 8.85 [7.78-10.06]), versus those without hospitalization (IR=3.4). Emergency hospitalization was associated with increased all-cause mortality (IR=146.5; 2.49 [2.37-2.61]), regardless of hospitalization cause, compared to those not hospitalized (IR=30.3). Elective hospitalization was also associated with increased all-cause mortality (IR=54.6; 1.32 [1.25-1.38]), except for cardiovascular elective hospitalization (1.00 [0.89-1.12]). Cause-specific mortality was influenced largely by hospitalization cause.</p><p><strong>Conclusion: </strong>Hospitalized COPD patients experienced increased subsequent one-year MACE and mortality rates, regardless of hospitalization cause or type. Hospitalization for any reason in COPD patients provides an opportunity to provide primary prevention for MACE.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2549-2560"},"PeriodicalIF":2.7,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Effects of COVID-19 on Chronic Obstructive Pulmonary Disease.","authors":"Chi-Tai Lee, Ping-Huai Wang, Shih-Lung Cheng","doi":"10.2147/COPD.S523149","DOIUrl":"10.2147/COPD.S523149","url":null,"abstract":"<p><strong>Background: </strong>Research has demonstrated that chronic obstructive pulmonary disease (COPD) is a negative prognostic factor for patients with the coronavirus disease 2019 (COVID-19). The long-term complications of COVID-19 among patients with COPD remain poorly understood due to limited studies.</p><p><strong>Methods: </strong>This retrospective study included patients with COPD who underwent regular follow-ups in a medical center between January 1, 2020, and December 31, 2022. The patients were categorized into COVID-19 and non-COVID-19 groups. Comparative analyses were conducted to assess clinical demographics, characteristics, acute exacerbations of COPD (AECOPD), and survival rates between the two groups. Subgroup analysis was performed based on inpatient and outpatient status within the COVID-19 group.</p><p><strong>Results: </strong>Of the 696 patients with COPD, 86 (12.4%) were included in the COVID-19 group, while 610 (87.6%) were included in the non-COVID-19 group. Patients in the COVID-19 group were significantly older (age: 75.0 ± 8.8 years versus 72.0 ± 9.0 years, <i>p</i> = 0.004), exhibited higher mortality rates (4.6% versus 0%, <i>p</i> < 0.001), and increased annual times of AECOPD (0.17 versus 0.08, <i>p</i> = 0.018) than those in the non-COVID-19 group after COVID-19. Multivariate analysis revealed that COVID-19 infection is an independent risk factor for increased AECOPD incidence (adjusted odds ratio: 1.74; 95% confidence interval [CI]: 1.07-2.83, <i>p</i> = 0.024). Within the COVID-19 group, the inpatient subgroup exhibited a higher prevalence of heart failure comorbidity (20% versus 2.8%, <i>p</i> = 0.035) and lower forced vital capacity than the outpatient subgroup (2.03 ± 0.60 L versus 2.56 ± 0.72 L, <i>p</i> = 0.016).</p><p><strong>Conclusion: </strong>Age is a significant risk factor for COVID-19 infection among patients with COPD. After COVID-19, these patients exhibit an increased frequency of severe exacerbations and a high risk of mortality. Notably, the susceptibility to severe exacerbations persists regardless of whether the patients receive inpatient or outpatient care.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2539-2548"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulation of ARHGAP18 by miR-613 Inhibits Cigarette Smoke Extract-Induced Apoptosis and Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells.","authors":"Haifan Fu, Kai Liu, Yamei Zheng, Jie Zhao, Tian Xie, Yipeng Ding","doi":"10.2147/COPD.S524723","DOIUrl":"10.2147/COPD.S524723","url":null,"abstract":"<p><strong>Objective: </strong>Chronic Obstructive Pulmonary Disease (COPD) is a major chronic respiratory disease affecting human health worldwide. However, there is still a lack of effective drugs for treating COPD. This study is intended to explore the function and molecular mechanism of <i>ARHGAP18</i> and miR-613 in COPD pathogenesis.</p><p><strong>Methods: </strong>We initially identified the marker gene closely related to epithelial dysfunction in COPD by integrating bioinformatic analyses. <i>ARHGAP18</i> expression in CSE-induced bronchial epithelial cells (BEAS-2B) was detected by qRT-PCR. Besides, <i>ARHGAP18</i> levels were modulated by lentivirus-mediated overexpression. Thereafter, cell variability, apoptosis, and migration were detected by CCK8, flow cytometry, and wound healing assay. IL-1β and TNF-α levels were examined by qRT-PCR. Epithelial-mesenchymal transition (EMT)-associated proteins were determined by Western blotting. The function of miR-613 in COPD was further detected. Functional rescue experiments were performed to determine the mechanism of <i>ARHGAP18</i> in COPD.</p><p><strong>Results: </strong>Our study identified <i>ARHGAP18</i> as the key gene associated with epithelial dysfunction in COPD. <i>ARHGAP18</i> was downregulated in CSE-induced BEAS-2B cells. Overexpression of <i>ARHGAP18</i> inhibited cell apoptosis of BEAS-2B cells and enhanced their proliferation and migration. Besides, <i>ARHGAP18</i> overexpression reduced IL-1 β and TNF-α levels, enhanced E-cadherin expression, and suppressed Vimentin and N-cadherin expression. In contrast, miR-613 mimics exerted opposite effects. Furthermore, downregulation of <i>ARHGAP1</i>, mediated by miR-613 inhibitor promoted cell apoptosis and EMT of CSE-induced BEAS-2B cells, suggesting a regulatory role of miR-613 in COPD pathogenesis.</p><p><strong>Conclusion: </strong>These findings highlight miR-613/<i>ARHGAP18</i> axis as a critical regulator of epithelial dysfunction in COPD, offering a potential therapeutic target to counteract apoptosis, inflammation, and airway remodeling.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2525-2537"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Advanced Lung Cancer Inflammation Index and Mortality in US Adults with Chronic Obstructive Pulmonary Disease.","authors":"Xiaozhou Su, Huiqing Rao, Chunli Zhao, Xianwei Zhang, Donghua Li","doi":"10.2147/COPD.S516286","DOIUrl":"10.2147/COPD.S516286","url":null,"abstract":"<p><strong>Purpose: </strong>Identifying reliable prognostic markers is critical for improving chronic obstructive pulmonary disease (COPD) management. The advanced lung cancer inflammation index (ALI) is a novel marker reflecting inflammation and nutritional status. This study evaluated the association between ALI and all-cause and cause-specific mortality in COPD patients.</p><p><strong>Patients and methods: </strong>Data from 4616 adults with COPD in the National Health and Nutrition Examination Survey (1999-2018) were analyzed. Mortality outcomes were obtained from the National Death Index. Multivariable Cox proportional hazards models and restricted cubic splines assessed the association between the natural logarithm of ALI (lnALI) and mortality. Time-dependent receiver operating characteristic (ROC) curves evaluated the predictive performance of lnALI at 3, 5, and 10 years. Mediation analysis examined whether estimated glomerular filtration rate (eGFR) mediated these associations.</p><p><strong>Results: </strong>During a median 80-month follow-up, 1202 participants died: 349 from cardiovascular disease, 263 from cancer, and 194 from chronic lower respiratory diseases (CLRD). Higher lnALI was significantly associated with lower risks of all-cause, cardiovascular, and CLRD mortality. L-shaped associations were observed for all-cause and cardiovascular mortality, with inflection points at 4.04 and 3.64, respectively. The AUCs for predicting all-cause mortality were 0.670, 0.646, and 0.634; for cardiovascular mortality, 0.659, 0.653, and 0.629; and for CLRD mortality, 0.770, 0.751, and 0.739 at 3, 5, and 10 years. eGFR partially mediated the associations between lnALI and both all-cause and cardiovascular mortality.</p><p><strong>Conclusion: </strong>Higher lnALI values were significantly associated with lower risks of all-cause, cardiovascular, and CLRD mortality in COPD patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2481-2492"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Support and Its Effect for Persons Affected by COPD and Their Next of Kin - an Systematic Integrative Review.","authors":"Helena Johansson, Lise-Lotte Jonasson, Carina Berterö","doi":"10.2147/COPD.S507905","DOIUrl":"10.2147/COPD.S507905","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic Obstructive Pulmonary Disease (COPD) is an irreversible lung disease. People with COPD and their next of kin are affected in daily life and need support from each other, health care, and the surrounding society.</p><p><strong>Objective: </strong>This systematic integrative review aims to identify which support is given to persons affected by COPD and/or their next of kin from the health care and surrounding society. A second aim was to evaluate the support.</p><p><strong>Methods: </strong>A systematic integrative review was conducted to aggregate the knowledge by searching PubMed, CINAHL, PsycINFO, Scopus, and Web of Science databases. Search terms were chronic obstructive pulmonary disease (COPD) and support. The time limit was 2014-2023. The review protocol was registered on PROSPERO (CRD42023462784). The inclusion was selected from the aim, and quality review instruments checked quality. The result was analyzed with a constant comparison method.</p><p><strong>Results: </strong>Persons with COPD receive support from their next of kin, practically and emotionally. Health care also supplies support through information, knowledge, and different training programs. Health care can be in all types of health care, from hospital and primary care to care in the home, all with varying types of support. The next of kin supplies support to their sick relative, becomes support from health care on a small scale, and wishes for more information, knowledge, and understanding about the disease, symptoms, and treatment. The sick person and their carer want to be acknowledged and supported more on their terms.</p><p><strong>Conclusion: </strong>Support for next of kin is virtually non-existent. Next of kin needs more support from health care and the surrounding society. Healthcare interventions in the future need to involve the person with COPD and the next of kin in a person-centered approach out of every person´s needs and support more on their terms.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2459-2480"},"PeriodicalIF":3.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Literature Review of the Humanistic, Economic, Sociodemographic, and Environmental Burden Associated with Severe COPD.","authors":"Ioanna Vlachaki, Simon Donhauser, Robert A Wise, Yahong Chen, Alessandra Madoni, Ulrica Scaffidi Argentina, Jahangir Nabi Mir, Jennifer K Quint","doi":"10.2147/COPD.S510623","DOIUrl":"10.2147/COPD.S510623","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is a highly prevalent and progressive disease, hence greater understanding of its humanistic, economic, and environmental impact is essential for guiding effective management strategies. A systematic literature review (SLR; 2021-2023), complemented with a targeted literature review (TLR; 2013-2023) identified 2039 publications on the economic and humanistic burden of severe COPD. Additionally, an SLR and complementary TLR to evaluate the impact of environmental and sociodemographic factors on COPD (2013-2023), identified 1018 records. All searches were conducted on November 17, 2023. After applying prespecified selection criteria, 50 studies reporting on the humanistic and economic impact of COPD, and six studies on the environmental and sociodemographic impact, were selected. Severe COPD significantly impairs health-related quality of life, exerting effects on physical and psychological well-being, with a progressive decline as COPD worsens from mild to very severe. Evidence indicates that there is a significant burden of disease due to exacerbations of COPD, with their frequency and severity increasing with disease progression, and an increased mortality risk associated with very severe versus severe COPD. The studies reported a high frequency of healthcare resource utilization, including primary care visits, emergency department visits, and hospitalizations among patients with severe COPD, all of which contribute to a significant economic burden, particularly in patients with advanced disease. Environmental factors demonstrated diverse impacts on outcomes for individuals with severe COPD, varying by type of pollutant, disease severity, and patient characteristics. Studies examining the sociodemographic impact of underserved populations on the burden of severe COPD were not identified. Severe COPD is a multifaceted disease that imposes considerable humanistic and economic impact on both patients and healthcare systems. Further work is needed to understand the impact of environmental and sociodemographic factors on the burden of COPD, with such insights ultimately optimizing patient care.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"2493-2523"},"PeriodicalIF":3.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}