一份用于高海拔地区COPD筛查的简短有效问卷。

IF 2.7 3区 医学 Q2 RESPIRATORY SYSTEM
Jia Cui, Yuxia Wang, Yaqi Tong, Yixuan Liao, Yan Liu, Di Chai, Zhenzhen Xing, Huanyu Long, Yanfei Guo
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引用次数: 0

摘要

目的:为高海拔地区初级卫生保健机构编制可靠的慢性阻塞性肺疾病(COPD)筛查问卷。患者和方法:这是一项大型横断面研究。该研究包括居住在海拔2100米以上、年龄在35岁或以上的个体。数据以7:3的比例随机分为开发集和验证集。采用单因素和多因素logistic回归方程识别相关变量,构建评分体系。采用受试者工作特征(ROC)曲线、曲线下面积(AUC)、阳性预测值(PPV)和阴性预测值(NPV)评价问卷的判别能力。结果:共纳入受试者2909人,其中男性1304人,占44.83%,中位年龄47.00(41.00 ~ 55.00)岁。发展集的多变量分析显示,年龄、肺结核史、吸烟状况、家庭空气污染暴露和CPOD评估测试(CAT)评分5个变量与COPD显著相关。在这些发现的基础上构建了一个评分系统。开发集中模型的AUC是0.714,而验证集中的AUC是0.726。ROC分析显示,该评分的最佳诊断临界值为22分,敏感性为85.0%,特异性为48.4%。结果表明,该模型在海拔2100 ~ 3000 m范围内敏感性最高(87.3%),而在海拔> ~ 4000 m范围内特异性最高(80.9%)。用正常下限(LLN)对不同海拔地区的数值进行验证,结论基本一致。结论:COPD筛查问卷能有效筛查高海拔地区初级卫生保健机构的COPD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Brief and Effective Questionnaire for COPD Screening in High-Altitude Areas.

Purpose: To develop a reliable screening questionnaire for chronic obstructive pulmonary disease (COPD) for primary health care institutions in high-altitude areas.

Patients and methods: This was a large cross-sectional study. The study included individuals who resided at an altitude of more than 2100 meters, were aged 35 years or older. The data were randomly divided into a development set and a validation set at a ratio of 7:3. Single-factor and multifactor logistic regression equations were employed to identify pertinent variables and construct a scoring system. The receiver operating characteristic (ROC) curve, area under the curve (AUC), positive predictive value (PPV) and negative predictive value (NPV) were used to evaluate the discriminative ability of the questionnaire.

Results: A total of 2909 individuals were included in this study, including 1304 males (44.83%), with a median age of 47.00 (41.00-55.00) years. A multivariate analysis of the development set revealed that five variables (age, history of pulmonary tuberculosis, smoking status, household air pollution exposure and CPOD Assessment Test (CAT) score) were significantly correlated with COPD. A scoring system was constructed on the basis of these findings. The AUC for the model in the development set was 0.714, whereas that for the validation set was 0.726. ROC analysis indicated that the optimal diagnostic cutoff value for the score was 22 points, with a sensitivity of 85.0% and a specificity of 48.4%. The results indicated that the sensitivity of the model was the highest (87.3%) at altitudes between 2100 and 3000 meters, whereas the specificity was the highest (80.9%) at altitudes >4000 meters. The conclusions were essentially consistent when the lower limit of normal (LLN) was used to verify the values in different altitude areas.

Conclusion: The COPD screening questionnaire effectively screens COPD in high-altitude primary healthcare settings.

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来源期刊
CiteScore
4.80
自引率
10.70%
发文量
372
审稿时长
16 weeks
期刊介绍: An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals
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