Mengyuan Qiao, Hui Yang, Mengzhen Qin, Yingyang Li, Haiyan Wang
{"title":"危重COPD患者应激性高血糖率升高预示不良临床结局:一项回顾性研究","authors":"Mengyuan Qiao, Hui Yang, Mengzhen Qin, Yingyang Li, Haiyan Wang","doi":"10.2147/COPD.S520418","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Stress hyperglycemia ratio (SHR) was introduced as an indicator of relative hyperglycaemia and is widely used for prognostic prediction in critically ill patients. The present study aimed to investigate the relationship between SHR and adverse clinical outcomes in critically ill COPD patients.</p><p><strong>Methods: </strong>A total of 1,580 patients diagnosed with COPD were included in this retrospective cohort study. SHR = ABG (mmol/L) / [1.59 × HbA1c (%) - 2.59]. Primary endpoints included ICU mortality and in-hospital mortality. Secondary endpoints were acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and acute respiratory failure (ARF). Logistic regression, Restricted Cubic Sample (RCS) and Receiver Operating Characteristic (ROC) were used to explore the relationship between SHR and prognosis of COPD patients. In addition, subgroup analyses and interaction tests were performed to investigate potential heterogeneity.</p><p><strong>Results: </strong>Multivariate logistic regression analysis showed that elevated SHR was not associated with ICU mortality and in-hospital mortality. In contrast, SHR quartiles were correlated with ICU mortality and in-hospital mortality. Restricted cubic spline regression models showed a nonlinear correlation between SHR and both ICU mortality and in-hospital mortality (all <i>P</i><0.001). In addition, a linear correlation was found between SHR and AECOPD and ARF, with elevated SHR associated with increased risk of AECOPD and ARF. <i>ROC</i> analyses showed that SHR was a more effective predictor of mortality and prognosis than admission blood glucose (ABG) and hemoglobin A1c (HbA1c) in patients with COPD, with the former being a better predictor of mortality and prognosis. In subgroup analyses, after adjusting for all covariates considered in the present study, the relationship between SHR and prognostic risk in patients with COPD remained stable across gender, age, BMI, smoking, drinking, history of hypertension, coronary heart disease, diabetes, and cerebrovascular disease.</p><p><strong>Conclusion: </strong>SHR is independently associated with an increased risk of adverse clinical outcomes in critically ill COPD patients.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1203-1215"},"PeriodicalIF":2.7000,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036676/pdf/","citationCount":"0","resultStr":"{\"title\":\"Increased Stress Hyperglycemia Ratio Predicts Poor Clinical Outcome in Critically Ill COPD Patients: A Retrospective Study.\",\"authors\":\"Mengyuan Qiao, Hui Yang, Mengzhen Qin, Yingyang Li, Haiyan Wang\",\"doi\":\"10.2147/COPD.S520418\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Stress hyperglycemia ratio (SHR) was introduced as an indicator of relative hyperglycaemia and is widely used for prognostic prediction in critically ill patients. The present study aimed to investigate the relationship between SHR and adverse clinical outcomes in critically ill COPD patients.</p><p><strong>Methods: </strong>A total of 1,580 patients diagnosed with COPD were included in this retrospective cohort study. SHR = ABG (mmol/L) / [1.59 × HbA1c (%) - 2.59]. Primary endpoints included ICU mortality and in-hospital mortality. Secondary endpoints were acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and acute respiratory failure (ARF). Logistic regression, Restricted Cubic Sample (RCS) and Receiver Operating Characteristic (ROC) were used to explore the relationship between SHR and prognosis of COPD patients. In addition, subgroup analyses and interaction tests were performed to investigate potential heterogeneity.</p><p><strong>Results: </strong>Multivariate logistic regression analysis showed that elevated SHR was not associated with ICU mortality and in-hospital mortality. In contrast, SHR quartiles were correlated with ICU mortality and in-hospital mortality. Restricted cubic spline regression models showed a nonlinear correlation between SHR and both ICU mortality and in-hospital mortality (all <i>P</i><0.001). In addition, a linear correlation was found between SHR and AECOPD and ARF, with elevated SHR associated with increased risk of AECOPD and ARF. <i>ROC</i> analyses showed that SHR was a more effective predictor of mortality and prognosis than admission blood glucose (ABG) and hemoglobin A1c (HbA1c) in patients with COPD, with the former being a better predictor of mortality and prognosis. In subgroup analyses, after adjusting for all covariates considered in the present study, the relationship between SHR and prognostic risk in patients with COPD remained stable across gender, age, BMI, smoking, drinking, history of hypertension, coronary heart disease, diabetes, and cerebrovascular disease.</p><p><strong>Conclusion: </strong>SHR is independently associated with an increased risk of adverse clinical outcomes in critically ill COPD patients.</p>\",\"PeriodicalId\":48818,\"journal\":{\"name\":\"International Journal of Chronic Obstructive Pulmonary Disease\",\"volume\":\"20 \",\"pages\":\"1203-1215\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-04-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036676/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Chronic Obstructive Pulmonary Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/COPD.S520418\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Chronic Obstructive Pulmonary Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/COPD.S520418","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Increased Stress Hyperglycemia Ratio Predicts Poor Clinical Outcome in Critically Ill COPD Patients: A Retrospective Study.
Objective: Stress hyperglycemia ratio (SHR) was introduced as an indicator of relative hyperglycaemia and is widely used for prognostic prediction in critically ill patients. The present study aimed to investigate the relationship between SHR and adverse clinical outcomes in critically ill COPD patients.
Methods: A total of 1,580 patients diagnosed with COPD were included in this retrospective cohort study. SHR = ABG (mmol/L) / [1.59 × HbA1c (%) - 2.59]. Primary endpoints included ICU mortality and in-hospital mortality. Secondary endpoints were acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and acute respiratory failure (ARF). Logistic regression, Restricted Cubic Sample (RCS) and Receiver Operating Characteristic (ROC) were used to explore the relationship between SHR and prognosis of COPD patients. In addition, subgroup analyses and interaction tests were performed to investigate potential heterogeneity.
Results: Multivariate logistic regression analysis showed that elevated SHR was not associated with ICU mortality and in-hospital mortality. In contrast, SHR quartiles were correlated with ICU mortality and in-hospital mortality. Restricted cubic spline regression models showed a nonlinear correlation between SHR and both ICU mortality and in-hospital mortality (all P<0.001). In addition, a linear correlation was found between SHR and AECOPD and ARF, with elevated SHR associated with increased risk of AECOPD and ARF. ROC analyses showed that SHR was a more effective predictor of mortality and prognosis than admission blood glucose (ABG) and hemoglobin A1c (HbA1c) in patients with COPD, with the former being a better predictor of mortality and prognosis. In subgroup analyses, after adjusting for all covariates considered in the present study, the relationship between SHR and prognostic risk in patients with COPD remained stable across gender, age, BMI, smoking, drinking, history of hypertension, coronary heart disease, diabetes, and cerebrovascular disease.
Conclusion: SHR is independently associated with an increased risk of adverse clinical outcomes in critically ill COPD patients.
期刊介绍:
An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals