The Effects of Smoking and Airway Restriction on Subclinical Atherosclerosis.

IF 2.7 3区 医学 Q2 RESPIRATORY SYSTEM
Mihrican Yeşildağ, Zeynep Keskin, Durdu Mehmet Yavşan, Taha Tahir Bekci, Usame Omer Osmanoglu
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Abstract

Purpose: Chronic obstructive pulmonary disease (COPD) is a chronic disease associated with systemic inflammation that may accelerate the atherosclerotic process. Smoking is a common risk factor for COPD and atherosclerosis. The goal of this study was to investigate the effects of COPD and smoking on carotid intima-media thickness (CIMT), in order to emphasise their importance in terms of subclinical atherosclerosis.

Materials and methods: The study involved 208 male patients aged 45-65 years and was designed as a prospective, observational case-control study. Patients were separated into three groups, as follows: Group 1-non-smokers without airway obstruction (control) (n= 70); Group 2-smokers without airway obstruction (n= 70); and Group 3-smokers with airway obstruction(COPD) (n= 68). They were also classified into thickened CIMT (≥0.8mm) and normal CIMT (<0.8mm) groups. Pulmonary function tests (PFT), carotid Doppler ultrasound, and biochemical and haematological tests were applied to all the participants.

Results: CIMT values were markedly increased in the COPD group (1.00 [0.90-1.30] mm), compared to the smoker group without airway obstruction (0.70 [0.58-0.90] mm) and the non-smoker control group (0.60 [0.50-0.70] mm). The factors associated with CIMT were FEV₁/FVC ratio (Exp B 0.0952, p=0.003), age (Exp B 1.082, p<0.001), and cigarette pack-years (Exp B 1.030, p=0.020). In feature importance analysis, the most influential factor on CIMT was the FEV₁/FVC ratio (0.54) indicating COPD, followed by age (0.33) and cigarette pack-years (0.13).

Conclusion: Among the factors influencing CIMT, the impact of a decreased FEV₁/FVC ratio was found to be the highest. Therefore, screening with carotid US should be considered for the early detection of subclinical atherosclerosis in patients with COPD.

吸烟和气道限制对亚临床动脉粥样硬化的影响。
目的:慢性阻塞性肺疾病(COPD)是一种与全身炎症相关的慢性疾病,可加速动脉粥样硬化过程。吸烟是慢性阻塞性肺病和动脉粥样硬化的常见危险因素。本研究的目的是研究慢性阻塞性肺病和吸烟对颈动脉内膜-中膜厚度(CIMT)的影响,以强调它们在亚临床动脉粥样硬化方面的重要性。材料与方法:本研究纳入208例45-65岁男性患者,设计为前瞻性、观察性病例对照研究。患者分为三组:第一组,不吸烟,无气道阻塞(对照组)(n= 70);2组:无气道阻塞的吸烟者(n= 70);组3伴有气道阻塞(COPD)的吸烟者(n= 68)。结果:慢性阻塞性肺病组的CIMT值(1.00 [0.90-1.30]mm)明显高于无气道阻塞的吸烟组(0.70 [0.58-0.90]mm)和非吸烟对照组(0.60 [0.50-0.70]mm)。与CIMT相关的因素有FEV₁/FVC比(Exp B 0.0952, p=0.003)、年龄(Exp B 1.082, p)。结论:在影响CIMT的因素中,FEV₁/FVC比降低的影响最大。因此,在早期发现COPD患者亚临床动脉粥样硬化时,应考虑颈动脉US筛查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.80
自引率
10.70%
发文量
372
审稿时长
16 weeks
期刊介绍: An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals
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