Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) Patients.

IF 2.7 3区 医学 Q2 RESPIRATORY SYSTEM
Jose Miguel Escamilla-Gil, Carlos A Torres-Duque, Kevin Llinás-Caballero, Nadia Juliana Proaños-Jurado, María M De Vivero, Jonathan Camilo Ramirez, Ronald Regino, Lucila Teresa Florez de Arco, Rodolfo Dennis, Mauricio González-García, Luis Caraballo, Nathalie Acevedo
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引用次数: 0

Abstract

Purpose: Asthma and chronic obstructive pulmonary disease overlap patients (ACO) have more exacerbations and a worse prognosis than pure asthma or COPD, and it is of great interest to identify differential biomarkers of ACO. We compared blood eosinophil counts, plasma IgE and protein levels among patients with asthma, ACO, COPD, and healthy subjects to identify those associated with ACO.

Patients and methods: 397 adults (age 40-90 years) were recruited from two Colombian cities: asthma (n=123), COPD (n=100), ACO (n=74) and healthy control (HC, n=100). Plasma protein levels were measured using the Proximity Extension Assay (Olink Proteomics).

Results: There were no differences in blood eosinophil counts between the patient groups. Total and specified IgE levels were higher in patients with ACO than in those with COPD. Ten plasma proteins showed significant differences between the patients with ACO and HC. In patients above 60 years old, CXCL9 discriminates ACO from asthma patients with AUC 0.73 (0.63-0.82, DeLong test p=0.007), and in patients below 60 years old, MCP-3 discriminates ACO from COPD patients with AUC 0.84 (0.62-1.0, DeLong test p=0.006). CUB domain-containing protein 1 (CDCP1) levels (OR, 0.47; p=0.008) and age > 60 years (OR, 0.25; p=0.001) were negatively associated with ACO.

Conclusion: CXCL9 levels could be used to discriminate ACO from asthma patients and MCP-3 to discriminate ACO from COPD. Protein inflammatory signatures in plasma of ACO patients were similar to the COPD group. This study revealed novel biomarkers that may help characterize patients with ACO.

哮喘-慢性阻塞性肺病重叠(ACO)患者血浆CXCL9和MCP-3水平升高
目的:哮喘和慢性阻塞性肺疾病重叠患者(ACO)比单纯哮喘或COPD有更多的加重和更差的预后,鉴别ACO的差异生物标志物具有重要意义。我们比较了哮喘、ACO、COPD患者和健康受试者的血嗜酸性粒细胞计数、血浆IgE和蛋白水平,以确定与ACO相关的因素。患者和方法:从哥伦比亚两个城市招募397名成年人(40-90岁):哮喘(n=123), COPD (n=100), ACO (n=74)和健康对照(HC, n=100)。血浆蛋白水平采用邻近扩展法(Olink蛋白质组学)测定。结果:两组患者血嗜酸性粒细胞计数无明显差异。ACO患者的总IgE和特异性IgE水平高于COPD患者。10种血浆蛋白在ACO和HC患者之间有显著差异。在60岁以上患者中,CXCL9区分ACO与AUC为0.73的哮喘患者(0.63-0.82,DeLong检验p=0.007),在60岁以下患者中,MCP-3区分ACO与AUC为0.84的COPD患者(0.62-1.0,DeLong检验p=0.006)。CUB结构域含蛋白1 (CDCP1)水平(OR, 0.47;p=0.008),年龄在60岁以下(OR, 0.25;p=0.001)与ACO呈负相关。结论:CXCL9水平可用于区分ACO与哮喘患者,MCP-3水平可用于区分ACO与COPD患者。ACO患者血浆蛋白炎症特征与COPD组相似。这项研究揭示了新的生物标志物,可能有助于表征ACO患者。
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来源期刊
CiteScore
4.80
自引率
10.70%
发文量
372
审稿时长
16 weeks
期刊介绍: An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals
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