IF 2.9

PATHOLOGICA Pub Date : 2026-02-01 DOI: 10.32074/1591-951X-1943

Alessia Di Lorito, Federica Giuliani, Edvige Morea, Alessandra Capo, Paolo Amerio

引用次数: 0

A consideration of the trends in thyroid fine-needle aspiration cytology - Results from the Italian Cytopathology Committee National Practice Survey in Thyroidology. 甲状腺细针穿刺细胞学趋势的考虑——来自意大利细胞病理学委员会甲状腺学全国实践调查的结果。

IF 2.9

PATHOLOGICA Pub Date : 2026-02-01 DOI: 10.32074/1591-951X-1852

Ilker Sengul, Demet Sengul

引用次数: 0

"Adnexotropic" lichen striatus: a potential histological mimicker of mycosis fungoides. “附着性”纹状地衣：一种潜在的蕈样真菌病的组织学模拟物。

IF 2.9

PATHOLOGICA Pub Date : 2026-02-01 DOI: 10.32074/1591-951X-1996

Francesco Fortarezza, Francesca Caroppo, Alessandra Meneghel, Francesca Tirelli, Cesare Tiengo, Anna Belloni Fortina, Francesco Zulian, Angelo Paolo Dei Tos

引用次数: 0

A case of chorea, epilepsy and cerebral atrophy in the work of Ettore Ravenna (1920s). 一个舞蹈病，癫痫和脑萎缩的情况下，埃托拉文纳的工作（1920年）。

IF 2.9

PATHOLOGICA Pub Date : 2026-02-01 DOI: 10.32074/1591-951X-1848

Giovanni Magno, Irene Kollhof, Alberto Zanatta

{"title":"A case of chorea, epilepsy and cerebral atrophy in the work of Ettore Ravenna (1920s).","authors":"Giovanni Magno, Irene Kollhof, Alberto Zanatta","doi":"10.32074/1591-951X-1848","DOIUrl":"10.32074/1591-951X-1848","url":null,"abstract":"This study re-examines a rare neuropathological case documented by Ettore Ravenna in 1900, involving a young patient with chorea, epilepsy, and marked frontal lobe atrophy. Using Ravenna's original autopsy notes and the preserved anatomical preparation at the Morgagni Museum of Human Anatomy (Padua), the case is reassessed in light of modern neurological knowledge. Macroscopic examination confirmed severe anterior frontal atrophy with relative preservation of peri-Sylvian regions, consistent with the patient's ability to sing despite profound language impairment. Ravenna described gliosis, fibrotic tissue replacement, and neuronal hyaline degeneration, interpreted as ulegyria of inflammatory origin. Although he considered epilepsy and chorea expressions of a single pathology, current research differentiates their mechanisms. However, juvenile neurodegenerative disorders such as Huntington disease show overlapping seizures, chorea, and cortical atrophy, partially supporting his observations. Re-evaluating this case highlights its historical relevance and the value of anatomical collections in reassessing early diagnoses.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"118 1","pages":"45-48"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of histological parameters of aggressiveness in resected lung squamous cell carcinoma. 肺鳞癌切除后侵袭性组织学参数分析。

IF 2.9

PATHOLOGICA Pub Date : 2026-02-01 DOI: 10.32074/1591-951X-1726

Giorgia Andrea Impalà, Alessandra Pittaro, Francesco Guerrera, Simona Sobrero, Giuseppe Bogina, Giulia Orlando, Vanessa Zambelli, Francesca Napoli, Francesco Leo, Enrico Ruffini, Marco Volante, Mauro Papotti, Luisella Righi

{"title":"Analysis of histological parameters of aggressiveness in resected lung squamous cell carcinoma.","authors":"Giorgia Andrea Impalà, Alessandra Pittaro, Francesco Guerrera, Simona Sobrero, Giuseppe Bogina, Giulia Orlando, Vanessa Zambelli, Francesca Napoli, Francesco Leo, Enrico Ruffini, Marco Volante, Mauro Papotti, Luisella Righi","doi":"10.32074/1591-951X-1726","DOIUrl":"10.32074/1591-951X-1726","url":null,"abstract":"Introduction: Lung squamous cell carcinoma (LUSCC) lacks consistent morphological criteria for tumour grading. Tumour budding (TB), defined as isolated cells or clusters of fewer than 4 cells at the invasive front, is prognostic in several carcinomas but remains insufficiently validated in LUSCC.Objective: To assess histopathological features of aggressiveness (including TB) in resected LUSCC as prognostic parameters and grading factors.Methods: We retrospectively analysed 296 LUSCC cases (2010-2021, University of Turin). Clinical data were collected and slides were reviewed for subtype, nuclear features, mitotic count, infiltration pattern, TB, spread through air spaces (STAS), desmoplasia, pleural/vascular/perineural invasion, and tumour-infiltrating lymphocytes. Associations with recurrence-free and overall survival were tested.Results: High TB (≥ 5 buds) correlated with pleural invasion and advanced T stage and was significantly associated with shorter recurrence-free (HR 1.84, p = 0.008) and overall survival (HR 1.73, p = 0.003), independently of stage. Nuclear enlargement and necrosis also predicted worse outcomes, while surgery had an overall protective impact.Conclusion: TB, necrosis, and nuclear size are independent predictors of outcome in LUSCC. Their inclusion in pathology reports may improve grading, refine prognosis, and guide management.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"118 1","pages":"20-29"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MesoRet: a reticulin stain-based deep learning algorithm to assist diffuse mesothelioma subtyping. MesoRet：一种基于网状蛋白染色的深度学习算法，帮助弥漫性间皮瘤分型。

IF 2.9

PATHOLOGICA Pub Date : 2026-02-01 DOI: 10.32074/1591-951X-1583

Giulia Orlando, Anna Paola Ferrero, Giorgia Andrea Impalà, Alessandra Pittaro, Luisa Delsedime, Rute Pedrosa, Darshan Kumar, Luisella Righi, Giuseppe Pelosi, Mauro Giulio Papotti, Eleonora Duregon

{"title":"MesoRet: a reticulin stain-based deep learning algorithm to assist diffuse mesothelioma subtyping.","authors":"Giulia Orlando, Anna Paola Ferrero, Giorgia Andrea Impalà, Alessandra Pittaro, Luisa Delsedime, Rute Pedrosa, Darshan Kumar, Luisella Righi, Giuseppe Pelosi, Mauro Giulio Papotti, Eleonora Duregon","doi":"10.32074/1591-951X-1583","DOIUrl":"10.32074/1591-951X-1583","url":null,"abstract":"Objective: To develop and validate a deep learning model trained on reticulin-stained whole slide images (MesoRet) to accurately identify transitional features and assist in the histologic subtyping of diffuse mesothelioma.Methods: A total of 115 cases of diffuse mesothelioma were collected from two institutions and reviewed by expert thoracic pathologists. Reticulin-stained whole-slide images were used to train a supervised deep learning model on the Aiforia Create platform to distinguish epithelioid, sarcomatoid, and transitional patterns. Model performance was validated on independent slides and compared with expert pathologists' assessments.Results: MesoRet accurately identified reticulin patterns across mesothelioma histotypes achieving 96.32% precision and 99.06% sensitivity, excluding artifacts and non-tumour tissue. It outperformed pathologists in identifying transitional patterns, reducing diagnostic time and minimising errors.Conclusions: MesoRet provides an accurate and objective approach for detecting reticulin patterns in mesothelioma, supporting histological subtyping and contributing to more consistent diagnoses. Although further validation is required, it represents a promising model to improve diagnostic precision and guide therapeutic decision-making.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"118 1","pages":"12-19"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standardisation of histologic reporting in eosinophilic oesophagitis: Expert recommendations. 嗜酸性粒细胞性食管炎组织学报告的标准化：专家建议。

IF 2.9

PATHOLOGICA Pub Date : 2026-02-01 DOI: 10.32074/1591-951X-1842

Carla Giordano, Valentina Angerilli, Marco Masci, Maria D'Armiento, Paola Parente, Emanuela Pilozzi, Alessandro Vanoli, Salvatore Oliva, Edoardo Vincenzo Savarino, Matteo Fassan, Luca Mastracci

{"title":"Standardisation of histologic reporting in eosinophilic oesophagitis: Expert recommendations.","authors":"Carla Giordano, Valentina Angerilli, Marco Masci, Maria D'Armiento, Paola Parente, Emanuela Pilozzi, Alessandro Vanoli, Salvatore Oliva, Edoardo Vincenzo Savarino, Matteo Fassan, Luca Mastracci","doi":"10.32074/1591-951X-1842","DOIUrl":"10.32074/1591-951X-1842","url":null,"abstract":"Over the past decade, significant progress has been made in understanding eosinophilic oesophagitis (EoE), leading to the refinement of diagnostic criteria and the development of evidence-based management guidelines. Nevertheless, despite the central role of histology in both diagnosis and disease monitoring, significant variability remains in histopathological reporting across institutions and among pathologists.This study seeks to provide recommendations for standardised histological reporting in EoE. To this end, a multidisciplinary panel of gastroenterologists and pathologists convened to review current practices and address persistent challenges in histologic assessment. Through an extensive literature review and critical appraisal of existing scoring systems, the panel reached consensus on both essential and desirable histological features for routine reporting, including eosinophil counts, additional inflammatory parameters, and fibrostenotic changes.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"118 1","pages":"4-14"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palisading adenocarcinoma. State of the art and first case report in the parotid gland of a 44-year-old woman. 栅栏样的腺癌。一名44岁女性腮腺的最新技术和首例病例报告。

IF 2.9

PATHOLOGICA Pub Date : 2026-02-01 DOI: 10.32074/1591-951X-1756

Emilia Corina, Luigi Corina, Lea Calo', Giorgia Rossi, Antonino Mulè, Esther Diana Rossi, Jacopo Galli

{"title":"Palisading adenocarcinoma. State of the art and first case report in the parotid gland of a 44-year-old woman.","authors":"Emilia Corina, Luigi Corina, Lea Calo', Giorgia Rossi, Antonino Mulè, Esther Diana Rossi, Jacopo Galli","doi":"10.32074/1591-951X-1756","DOIUrl":"10.32074/1591-951X-1756","url":null,"abstract":"Palisading adenocarcinoma is a newly described salivary gland tumor known for its predilection for sublingual and submandibular glands. The mass tends to have a non-invasive growth, although signs of infiltrative growth can occur resulting in a neoformation more adherent to deep neck structures. The main histological feature is a biphasic cellular pattern composed of polygonal epithelioid cells with small nuclei arranged in trabeculae and pseudo-rosette like structures and a second population of scattered well-formed ductal structures with occasional mucocytes. The mass, located in the parotid gland, resembled a neuroendocrine neoplasia regarding its histological architecture and positivity for CD56, whereas the cytological examination resembled that of a pleomorphic adenoma. An accurate histological and immunohistochemical study was crucial to guide the differential diagnosis. Here we present the first case of palisading adenocarcinoma affecting the parotid gland to further enrich the literature and to shed additional light on this peculiar and recently investigated neoplastic entity.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"118 1","pages":"38-44"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated paraffin embedding of tissue samples significantly reduces overall workflow time in routine pathology practice. 组织样品的自动石蜡包埋显着减少了常规病理实践的整体工作流程时间。

IF 2.9

PATHOLOGICA Pub Date : 2026-02-01 DOI: 10.32074/1591-951X-1773

Alessandro Gambella, Laura Zito, Cristina Bottaro, Michele Paudice, Giulia Tacchino, Viviana Accorrà, Claudio Piccione, Martina Terrile, Anna Silvana Bevere, Barbara Massa, Silvia Bozzano, Federica Grillo, Luca Mastracci

{"title":"Automated paraffin embedding of tissue samples significantly reduces overall workflow time in routine pathology practice.","authors":"Alessandro Gambella, Laura Zito, Cristina Bottaro, Michele Paudice, Giulia Tacchino, Viviana Accorrà, Claudio Piccione, Martina Terrile, Anna Silvana Bevere, Barbara Massa, Silvia Bozzano, Federica Grillo, Luca Mastracci","doi":"10.32074/1591-951X-1773","DOIUrl":"10.32074/1591-951X-1773","url":null,"abstract":"Objective: Automated paraffin embedding (AE) offers a solution to the operator-dependent variability and time demands manual embedding (ME), but comparative data are limited.Methods: We quantitatively assessed AE versus ME using 186 endoscopic biopsies, 106 needle biopsies, and 62 transurethral resections, recording the time (seconds, s) required for preparation, embedding, trimming, and sectioning.Results: AE substantially reduced embedding time (5 s for all sample types) compared with ME (43 s for endoscopic biopsies, 66.5 s for needle biopsies, and 105 s for transurethral samples), and it allowed laboratory technicians to perform other tasks concurrently. AE also shortened total time: 150.2 s (AE) vs. 250.4 s (ME) for endoscopic biopsies, 176.9 s (AE) vs. 324.2 s (ME) for needle biopsies, and 149.5 s (AE) vs. 335 s (ME) for transurethral resections.Conclusions: These real-world data provide quantitative evidence of AE-related time savings in daily routine activity, supporting its role in workflow automation and standardization in pathology units.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"118 1","pages":"30-37"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding the spectrum of AFF2 undifferentiated sarcoma associated to endometriosis: a novel ZDHHC9::AFF2 fusion sarcoma with high-grade features and poor prognosis. 扩大与子宫内膜异位症相关的AFF2未分化肉瘤的范围：一种具有高级别特征和预后不良的新型ZDHHC9::AFF2融合肉瘤。

IF 2.9

PATHOLOGICA Pub Date : 2025-12-01 DOI: 10.32074/1591-951X-1221

Damiano Arciuolo, Rita Alaggio, Antonio Travaglino, Giulia Scaglione, Angela Santoro, Isabella Giovannoni, Sabina Barresi, Sara Patrizi, Evelina Miele, Luigi Pedone Anchora, Frediano Inzani, Gian Franco Zannoni

{"title":"Expanding the spectrum of AFF2 undifferentiated sarcoma associated to endometriosis: a novel ZDHHC9::AFF2 fusion sarcoma with high-grade features and poor prognosis.","authors":"Damiano Arciuolo, Rita Alaggio, Antonio Travaglino, Giulia Scaglione, Angela Santoro, Isabella Giovannoni, Sabina Barresi, Sara Patrizi, Evelina Miele, Luigi Pedone Anchora, Frediano Inzani, Gian Franco Zannoni","doi":"10.32074/1591-951X-1221","DOIUrl":"10.32074/1591-951X-1221","url":null,"abstract":"The AFF2 gene encodes a protein involved in transcriptional regulation and chromatin remodeling. While primarily associated with Fragile X syndrome, AFF2 fusions have recently been identified in certain malignancies, mostly sinonasal squamous cell carcinoma. Recently it has been implicated in an intra-abdominal sarcoma linked to endometriosis. We present the case of a 71-year-old woman with a 19 cm ovarian mass arising in cystic endometriosis. Histological examination revealed high-grade undifferentiated sarcoma with spindle to epithelioid morphology, high nuclear atypia, a high mitotic index, and extensive necrosis. Immunohistochemistry demonstrated positivity for Vimentin, ER, PR, CD10, focal WT1, Desmin, and NTRK, with aberrant p53 expression in 75% of tumor cells. RNA sequencing identified a novel ZDHHC9::AFF2 fusion. The patient underwent chemotherapy with epirubicin and ifosfamide but experienced recurrence with lymph node and peritoneal involvement and succumbed to the disease after 9 months.In conclusion, this case expands the morphological spectrum of AFF2-related sarcomas, providing further evidence of their pathological heterogeneity. Moreover, it identifies a novel fusion, which may have implications for tumor classification and diagnostic refinement. The morphological findings also suggest a possible association with poor clinical outcomes.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"117 5","pages":"513-518"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PATHOLOGICA最新文献