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Melanoma of the external auditory canal: case report and systematic literature review. 外耳道黑色素瘤：病例报告和系统文献综述。
IF 4.4
PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-980
Marco Demattè, Carlotta Liberale, Anna Bonsembiante, Marco Bottazzoli, Alessandro Ioppi, Alessandro La Boria, Alessandra Marcantoni, Pietro Perotti, Raffaele Rosaia, Vittorio Torta, Maria Grazia Zorzi, Ottavio Piccin
{"title":"Melanoma of the external auditory canal: case report and systematic literature review.","authors":"Marco Demattè, Carlotta Liberale, Anna Bonsembiante, Marco Bottazzoli, Alessandro Ioppi, Alessandro La Boria, Alessandra Marcantoni, Pietro Perotti, Raffaele Rosaia, Vittorio Torta, Maria Grazia Zorzi, Ottavio Piccin","doi":"10.32074/1591-951X-980","DOIUrl":"10.32074/1591-951X-980","url":null,"abstract":"<p><p>Melanoma of the external auditory canal (EAC) is particularly rare and poorly understood, with limited available data on management and survival. This systematic review aims to analyze existing data and provide insights into the management and prognosis the beginning of EAC melanoma. It is conducted using Pubmed and Scopus databases from the beginning to July 2023 and it follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines. Searches are performed using the search string \"(melanoma) AND (external auditory canal)\".</p><p><p>The review includes a total of 30 patients diagnosed with EAC melanoma, supplemented by an additional case from the authors' clinical experience. The role of Breslow thickness as a determining factor for the choice of surgery remains inconclusive due to limited available data. Sentinel lymph node biopsy and adjuvant therapy are sparingly employed, indicating the need for standardized guidelines. Patients in the study demonstrate a 50% overall survival rate at 5 years.</p><p><p>EAC Melanoma is a rare and aggressive malignancy with limited therapeutic guidelines. Surgical interventions, including wide local excision and lateral temporal bone resection, are the primary treatment options for patients without distant metastases.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 3","pages":"144-152"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-C19MC-altered embryonal tumor with multilayered rosettes in a young woman with DICER1 syndrome: case report and review of the literature. 一名患有 DICER1 综合征的年轻女性的非 C19MC 变异胚胎瘤伴多层玫瑰花簇：病例报告和文献综述。
IF 4.4
PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-970
María Concepción Campos Mármol, María Aguado, Teresa Ramón Y Cajal, Alberto Gallardo, Luis Catasús, Allan Gonzalez, Jorge Eliecer Méndez, Adriana Lasa, Montse Arumi, Oscar Gallego Rubio, Josep Balart Serra, Fernando Muñoz Hernandez, Andreas von Deimling, Felix K F Kommoss, Iñigo Espinosa
{"title":"Non-C19MC-altered embryonal tumor with multilayered rosettes in a young woman with DICER1 syndrome: case report and review of the literature.","authors":"María Concepción Campos Mármol, María Aguado, Teresa Ramón Y Cajal, Alberto Gallardo, Luis Catasús, Allan Gonzalez, Jorge Eliecer Méndez, Adriana Lasa, Montse Arumi, Oscar Gallego Rubio, Josep Balart Serra, Fernando Muñoz Hernandez, Andreas von Deimling, Felix K F Kommoss, Iñigo Espinosa","doi":"10.32074/1591-951X-970","DOIUrl":"10.32074/1591-951X-970","url":null,"abstract":"<p><p>Embryonal tumors with multilayered rosettes (ETMR) are highly aggressive and therapy-resistant pediatric central nervous system (CNS) tumors that have three histological patters: embryonal tumor with abundant neuropil and true rosettes, ependymoblastoma, and medulloepithelioma. We present a case of ETMR in an 18-year-old woman with DICER1 syndrome. This report confirms the important role of DNA-methylation analysis in the classification of CNS embryonal tumors and the importance of investigating somatic and germline DICER1 mutations in all CNS embryonal tumors.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 3","pages":"170-175"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rudolph Virchow's Upper Silesia report: the starting point for his simultaneous engagement with public health and antisemitism. 鲁道夫-维尔肖的上西里西亚报告：他同时参与公共卫生和反犹太主义的起点。
IF 4.4
PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-982
Consolato Maria Sergi
{"title":"Rudolph Virchow's Upper Silesia report: the starting point for his simultaneous engagement with public health and antisemitism.","authors":"Consolato Maria Sergi","doi":"10.32074/1591-951X-982","DOIUrl":"10.32074/1591-951X-982","url":null,"abstract":"<p><p>In 2023 an important anniversary took place. It regards Virchow's report on the Upper Silesia epidemic typhus, which was associated with the death of numerous Polish peasants. It is also the starting point of Virchow's political career and fight against antisemitism, which has reached fearful levels in academia. Antisemitism is not new, but the recrudescence following the October 7<sup>th</sup> massacre of Jewish and not-Jewish people is appalling and recalls Virchow's vehemence of the past a few decades before the Nazi extermination of the Shoah during the World War II.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 3","pages":"186-188"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antonio Grossich, the doctor and the irredentist. 安东尼奥-格罗西奇，医生和不可分割主义者。
IF 4.4
PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-956
Carlo Patriarca, Carlo Alfredo Clerici, Maura Massimino
{"title":"Antonio Grossich, the doctor and the irredentist.","authors":"Carlo Patriarca, Carlo Alfredo Clerici, Maura Massimino","doi":"10.32074/1591-951X-956","DOIUrl":"10.32074/1591-951X-956","url":null,"abstract":"<p><p>The routine use of iodine tincture in medicine represents a turning point in the history of surgical procedures. It was the Istrian doctor Antonio Grossich (1849-1926) who first defined and applied the best formula and demonstrated to the world its superiority over other antiseptics. Although his was a life guided by medicine and the steadfast translation of his political ideals into practice, Grossich's achievements were somewhat obscured by his active involvement in the Istrian irredentism of the first decades of the wentieth century.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 3","pages":"180-185"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A diagnosis you wouldn't expect in a supraclavicular mass. 锁骨上肿块的诊断结果出乎你的意料。
IF 4.4
PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-962
Simone Mauramati, Fabio Pedretti, Irene Herman, Giuseppe Trisolini, Alberto Luchena, Rebecca Gelli, Emanuele Robiolio, Marta Minuti, Maria Vittoria Veneroni, Giulia Bertino, Monica Feltri, Gioacchino D'Ambrosio, Marco Benazzo, Patrizia Morbini
{"title":"A diagnosis you wouldn't expect in a supraclavicular mass.","authors":"Simone Mauramati, Fabio Pedretti, Irene Herman, Giuseppe Trisolini, Alberto Luchena, Rebecca Gelli, Emanuele Robiolio, Marta Minuti, Maria Vittoria Veneroni, Giulia Bertino, Monica Feltri, Gioacchino D'Ambrosio, Marco Benazzo, Patrizia Morbini","doi":"10.32074/1591-951X-962","DOIUrl":"10.32074/1591-951X-962","url":null,"abstract":"","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 3","pages":"189-191"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrent presence of primary hemangioma and breast cancer metastasis within a lymph node: a case report inspired by the legacy of Professor Juan Rosai. 淋巴结内同时存在原发性血管瘤和乳腺癌转移：受胡安-罗赛教授遗产启发的病例报告。
IF 4.4
PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-911
Mariia Ivanova, Marianna D'Ercole, Francesca Maria Porta, Benedetta Di Venosa, Chiara Frascarelli, Camillo Di Bella, Fabio Pagni, Elena Guerini-Rocco, Nicola Fusco
{"title":"Concurrent presence of primary hemangioma and breast cancer metastasis within a lymph node: a case report inspired by the legacy of Professor Juan Rosai.","authors":"Mariia Ivanova, Marianna D'Ercole, Francesca Maria Porta, Benedetta Di Venosa, Chiara Frascarelli, Camillo Di Bella, Fabio Pagni, Elena Guerini-Rocco, Nicola Fusco","doi":"10.32074/1591-951X-911","DOIUrl":"10.32074/1591-951X-911","url":null,"abstract":"<p><p>Secondary neoplastic lesions in lymph nodes are predominantly metastases from solid tumors, whereas primary lymph node hemangiomas are exceptionally uncommon, with only 24 well-documented cases in the literature. Histologically, they are characterized by endothelial cells that may appear flattened or enlarged, with variable vascular density, and the presence of stromal elements. Notably, the concurrent presence of a primary hemangioma and a metastasis from breast cancer - the latter being the most prevalent secondary lesion in axillary lymph nodes - represents an unprecedented observation. The unique case presented herein underscores the exceptional rarity of primary lymph node hemangiomas and demonstrates for the first time their possible coexistence with breast cancer metastasis within the same axillary lymph node. In sharing and discussing this case study, we pay homage to Professor Juan Rosai, whose work in redefining rare and complex diagnoses continues to enlighten our understanding of lymph node vascular lesions.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 3","pages":"153-157"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometrial serous carcinoma with a corded and hyalinized pattern: a clinicopathological and molecular analysis. 子宫内膜浆液性癌：临床病理和分子分析。
IF 4.4
PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-974
Antonio Travaglino, Angela Santoro, Damiano Arciuolo, Giulia Scaglione, Antonio Raffone, Alessia Piermattei, Maria Elisabetta Onori, Angelo Minucci, Luigi Pedone Anchora, Francesco Fanfani, Gian Franco Zannoni
{"title":"Endometrial serous carcinoma with a corded and hyalinized pattern: a clinicopathological and molecular analysis.","authors":"Antonio Travaglino, Angela Santoro, Damiano Arciuolo, Giulia Scaglione, Antonio Raffone, Alessia Piermattei, Maria Elisabetta Onori, Angelo Minucci, Luigi Pedone Anchora, Francesco Fanfani, Gian Franco Zannoni","doi":"10.32074/1591-951X-974","DOIUrl":"10.32074/1591-951X-974","url":null,"abstract":"<p><p>A corded and hyalinized pattern has been described in endometrial endometrioid carcinoma. Herein, we describe a clinicopathological and molecular analysis of the first reported case of endometrial serous carcinoma with a corded and hyalinized pattern.</p><p><p>A 64-year-old woman underwent hysterectomy and bilateral salpingo-oophorectomy due to a 5.5 cm endometrial lesion. Histologically, the tumor was composed of a minor (20%) serous carcinoma component and a predominant corded component embedded in a hyaline-to-myxoid matrix. This component showed diffuse and strong p53 and p16 expression, heterogeneous positivity for epithelial markers and WT1, focal positivity for estrogen and progesterone receptors, retained MMR, SMARCA4/BRG1, and SMARCB1/INI1 expression, and negativity for smooth muscle, germ cell, sex cord, neuroendocrine, endothelial, and melanocytic markers and GATA3. Next-generation sequencing showed a mutation of uncertain significance in APC and no mutations in MLH1, MSH2, MSH6, PMS2, MUTYH, POLE, POLD1, EPCAM, or CTNNB1. The patient had a recurrence on the vaginal stump after 15 months.</p><p><p>In conclusion, endometrial serous carcinoma can show a corded and hyalinized pattern, which may represent a diagnostic challenge.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 3","pages":"176-179"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pink-on-pink: hepatocellular carcinoma metastatic to oncocytic carcinoma of the thyroid. 粉红色对粉红色：肝细胞癌转移到甲状腺肿瘤细胞癌。
IF 4.4
PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-922
Marcello Maestri, Ottavia Cicerone, Alessia Messina, Anna Gallotti, Salvatore Corallo, Simone Mauramati, Pietro Canzi, Giacomo Fiandrino, Marco Paulli, Alessandro Vanoli
{"title":"Pink-on-pink: hepatocellular carcinoma metastatic to oncocytic carcinoma of the thyroid.","authors":"Marcello Maestri, Ottavia Cicerone, Alessia Messina, Anna Gallotti, Salvatore Corallo, Simone Mauramati, Pietro Canzi, Giacomo Fiandrino, Marco Paulli, Alessandro Vanoli","doi":"10.32074/1591-951X-922","DOIUrl":"10.32074/1591-951X-922","url":null,"abstract":"<p><p>Hepatocellular carcinoma typically metastasizes within the liver and may involve extrahepatic sites such as the lungs, adrenal glands, and bones at advanced stages. However, hepatocellular carcinoma metastasis to the thyroid is very uncommon and tumor-to-tumor metastasis from a hepatocellular cancer to a thyroid neoplasm is extremely rare. In this report, we present a case of a 70-year-old man with a hepatocellular carcinoma metastasizing to oncocytic thyroid carcinoma, emphasizing the importance of clinical history and of a multidisciplinary approach, as well as the usefulness of site-specific immunohistochemical markers, in diagnosing and managing cases of Rosai's metastasis, especially when donor and recipient neoplasms share similar histologic features.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 3","pages":"158-162"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SMARCB1/INI1-deficient undifferentiated tumour of the thorax: a case report and review of the literature. SMARCB1/INI1缺陷型胸部未分化肿瘤：病例报告和文献综述。
IF 4.4
PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-955
Moreno Zagni, Alessandro Marando, Mariachiara Negrelli, Calogero Lauricella, Valentina Motta, Giulia Paglino, Silvio Veronese, Emanuele Valtorta, Emanuela Bonoldi, Giuseppe Pelosi
{"title":"SMARCB1/INI1-deficient undifferentiated tumour of the thorax: a case report and review of the literature.","authors":"Moreno Zagni, Alessandro Marando, Mariachiara Negrelli, Calogero Lauricella, Valentina Motta, Giulia Paglino, Silvio Veronese, Emanuele Valtorta, Emanuela Bonoldi, Giuseppe Pelosi","doi":"10.32074/1591-951X-955","DOIUrl":"10.32074/1591-951X-955","url":null,"abstract":"<p><p>The 5th WHO classification of thoracic tumours includes thoracic SMARCA4-deficient undifferentiated tumour (SMARCA4-UT) among the \"other epithelial tumours of the lung\" chapter. Herein, we present a case of undifferentiated thoracic neoplasm with retention of SMARCA4 expression, lack of NUT fusion protein and loss of SMARCB1/INI1 expression. After presenting the clinical and pathological features of the tumour, we carried out a review of the literature on the same topic. Albeit very rare, we believe this entity should be included in the heterogeneous group of undifferentiated neoplasms of the thorax.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 3","pages":"163-169"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular pathology in vasculitis. 脉管炎的心血管病变。
IF 3.5
PATHOLOGICA Pub Date : 2024-04-01 DOI: 10.32074/1591-951X-993
Monica De Gaspari, Andrea Ascione, Chiara Baldovini, Andrea Marzullo, Angela Pucci, Stefania Rizzo, Cecilia Salzillo, Annalisa Angelini, Cristina Basso, Giulia d'Amati, Cira Rosaria Tiziana di Gioia, Allard C van der Wal, Carla Giordano
{"title":"Cardiovascular pathology in vasculitis.","authors":"Monica De Gaspari, Andrea Ascione, Chiara Baldovini, Andrea Marzullo, Angela Pucci, Stefania Rizzo, Cecilia Salzillo, Annalisa Angelini, Cristina Basso, Giulia d'Amati, Cira Rosaria Tiziana di Gioia, Allard C van der Wal, Carla Giordano","doi":"10.32074/1591-951X-993","DOIUrl":"10.32074/1591-951X-993","url":null,"abstract":"<p><p>Vasculitides are diseases that can affect any vessel. When cardiac or aortic involvement is present, the prognosis can worsen significantly. Pathological assessment often plays a key role in reaching a definite diagnosis of cardiac or aortic vasculitis, particularly when the clinical evidence of a systemic inflammatory disease is missing. The following review will focus on the main histopathological findings of cardiac and aortic vasculitides.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 2","pages":"78-92"},"PeriodicalIF":3.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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