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The pitfalls of an invasive non-neuroendocrine GATA3- and TTF1+ urothelial carcinoma. 侵袭性非神经内分泌性GATA3-和TTF1+尿路上皮癌的陷阱。
IF 4.4
PATHOLOGICA Pub Date : 2024-10-01 DOI: 10.32074/1591-951X-1102
Giacomo Maria Pini, Monica Giordano, Maurizio Colecchia, Carlo Patriarca
{"title":"The pitfalls of an invasive non-neuroendocrine GATA3- and TTF1+ urothelial carcinoma.","authors":"Giacomo Maria Pini, Monica Giordano, Maurizio Colecchia, Carlo Patriarca","doi":"10.32074/1591-951X-1102","DOIUrl":"https://doi.org/10.32074/1591-951X-1102","url":null,"abstract":"","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 5","pages":"335-337"},"PeriodicalIF":4.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathologist assistants in a Pathology Department: perceptions of their changing role. 病理科病理学助理：对其角色转变的认识。
IF 4.4
PATHOLOGICA Pub Date : 2024-10-01 DOI: 10.32074/1591-951X-1050
Luca Ghirotto, Ilaria Arpaia, Mara Bortesi, Fabiola Caggiano, Marilena Ganassi, Marialisa Marchetti, Letizia Marchi, Cristina Pedroni, Mirco Ghirelli, Massimo Costantini, Simonetta Piana
{"title":"Pathologist assistants in a Pathology Department: perceptions of their changing role.","authors":"Luca Ghirotto, Ilaria Arpaia, Mara Bortesi, Fabiola Caggiano, Marilena Ganassi, Marialisa Marchetti, Letizia Marchi, Cristina Pedroni, Mirco Ghirelli, Massimo Costantini, Simonetta Piana","doi":"10.32074/1591-951X-1050","DOIUrl":"https://doi.org/10.32074/1591-951X-1050","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to understand the dynamics of including Pathologists' Assistants in a surgical pathology department.</p><p><strong>Methods: </strong>A qualitative ethnographic study employed covert participant observation and semi-structured interviews. Field notes and interview transcripts were descriptively analysed to identify categories.</p><p><strong>Results: </strong>We developed three cross-cutting categories: (i) a testing welcome, (ii) recognising the added value, and (iii) open issues. Initially, disagreements existed regarding the integration of Pathologists' Assistants, but over time, clearer role definitions promoted collaboration. The study revealed the recognised value of Pathologists' Assistants, particularly in time-saving and professional growth opportunities.</p><p><strong>Conclusions: </strong>Despite initial challenges, recognising the value of Pathologists' Assistants is crucial for effective collaboration and optimal utilisation of their skills. Addressing unresolved issues, such as institutionalising their role and improving academic training, is essential. Creating a community of practice and fostering effective communication and professional development are key to successful integration. Further research and stakeholder collaboration are needed to integrate Pathologists' Assistants into the healthcare system fully.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 5","pages":"295-302"},"PeriodicalIF":4.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary pulmonary meningioma mimicking a carcinoid tumor in a middle-aged female. 中年女性原发性肺脑膜瘤似类癌。
IF 4.4
PATHOLOGICA Pub Date : 2024-10-01 DOI: 10.32074/1591-951X-1059
Federica Pezzuto, Chiara Giraudo, Matteo Baldi, Andrea dell'Amore, Fiorella Calabrese
{"title":"Primary pulmonary meningioma mimicking a carcinoid tumor in a middle-aged female.","authors":"Federica Pezzuto, Chiara Giraudo, Matteo Baldi, Andrea dell'Amore, Fiorella Calabrese","doi":"10.32074/1591-951X-1059","DOIUrl":"10.32074/1591-951X-1059","url":null,"abstract":"<p><p>A 46-year-old female complained of cough and dyspnea. A chest X-ray and CT scan showed a solitary subpleural pulmonary nodule in the left upper lobe. Surgical resection was performed. The frozen examination was presumptive of a benign/low grade lesion, likely a carcinoid. Definitive histology revealed uniformly sized eosinophilic cells arranged in solid nests, immunoreactive for epithelial membrane antigen and progesterone receptors. The diagnosis of grade 1 meningothelial meningioma was finally achieved. This case of a meningioma mimicking a carcinoid tumor highlights its rarity and warns diagnostic specialists of the potential for misdiagnosis and overtreatment.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 5","pages":"324-327"},"PeriodicalIF":4.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive lobular carcinoma of the breast: we diagnose it, but do we know what it is? 乳腺浸润性小叶癌：我们诊断了它，但我们知道它是什么吗？
IF 4.4
PATHOLOGICA Pub Date : 2024-10-01 DOI: 10.32074/1591-951X-1043
Gábor Cserni
{"title":"Invasive lobular carcinoma of the breast: we diagnose it, but do we know what it is?","authors":"Gábor Cserni","doi":"10.32074/1591-951X-1043","DOIUrl":"10.32074/1591-951X-1043","url":null,"abstract":"<p><p>Invasive lobular carcinoma of the breast is the most common special type breast cancer. It has been defined using morphological features, has a characteristic immunophenotype associated with the loss of E-cadherin mediated intercellular adhesion, and the background of this immunohistochemistry and morphology is generally a biallelic genetic alteration of the CDH-1 gene coding E-cadherin. However, the morphology may often deviate from the classical, and immunohistochemistry may also deviate from the typical, and then the diagnosis of invasive lobular carcinoma becomes less straight forward. Eventually, the definitions of this histological type, although similar, are not identical and this may also give ground to occasional different interpretations. This review summarizes different approaches to invasive lobular carcinomas and the deviations from what is considered normal.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 5","pages":"273-284"},"PeriodicalIF":4.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BRCA testing in metastatic castration-resistant prostate cancer: successes and troubles in a real world setting. An Italian Multicentric study. BRCA在转移性去势抵抗性前列腺癌中的检测：在现实世界中的成功与麻烦。意大利多中心研究。
IF 4.4
PATHOLOGICA Pub Date : 2024-10-01 DOI: 10.32074/1591-951X-1010
Stefania Tommasi, Claudio Antonio Coppola, Alessandro Caniglia, Brunella Pilato, Francesco Alfredo Zito, Mariantonia Carosi, Elisa Melucci, Beatrice Casini, Andrea Russo, Viviana Gismondi, Gabriella Cirmena, Michele Paudice, Umberto Malapelle, Francesco Pepe, Giancarlo Troncone, Gabriella Fontanini, Rossella Bruno, Pinuccia Faviana, Davide Vacirca, Sergio Vincenzo Taormina, Simona Francesconi, Cecilia Caprera, Matteo Corsi, Sergio Bracarda, Massimo Barberis
{"title":"BRCA testing in metastatic castration-resistant prostate cancer: successes and troubles in a real world setting. An Italian Multicentric study.","authors":"Stefania Tommasi, Claudio Antonio Coppola, Alessandro Caniglia, Brunella Pilato, Francesco Alfredo Zito, Mariantonia Carosi, Elisa Melucci, Beatrice Casini, Andrea Russo, Viviana Gismondi, Gabriella Cirmena, Michele Paudice, Umberto Malapelle, Francesco Pepe, Giancarlo Troncone, Gabriella Fontanini, Rossella Bruno, Pinuccia Faviana, Davide Vacirca, Sergio Vincenzo Taormina, Simona Francesconi, Cecilia Caprera, Matteo Corsi, Sergio Bracarda, Massimo Barberis","doi":"10.32074/1591-951X-1010","DOIUrl":"https://doi.org/10.32074/1591-951X-1010","url":null,"abstract":"<p><strong>Objective: </strong>Prostate cancer (PCa) is the most common cause of cancer-related deaths in men worldwide. BRCA1/2 genes are reported altered in approximately 1% and 8% of PCa cases, respectively. To date, formalin-fixed paraffin-embedded (FFPE) tissues have a consolidate use in the clinical practice, but with a significant drawback related to DNA/RNA degradation during the pre-analytical process. The purpose of this study is to evaluate the feasibility of detecting BRCA1/2 alterations in DNA extracted from FFPE tissues collected from PCa patients after various years of storage in seven Italian hospitals.</p><p><strong>Methods: </strong>A total of 241 DNA samples were extracted from FFPE tissue with different storage times (1-12 y) and sequenced with NGS technology. BRCA1/2 evaluability was assessed performing data analysis with a chi-square test to study the impact of the storage time on the DNA degradation.</p><p><strong>Results: </strong>The data collected showed a strict relation not only between the storage time and the BRCA1/2 evaluability, but even between the storage time and DNA degradation (DIN). Taken together, all the parameters considered decrease with an increase in the storage time.</p><p><strong>Conclusions: </strong>Excessive FFPE tissues storage time (more than 3 years) can harshly affect DNA analysis and evaluability, hindering the achievement of a result useful in the clinical practice. Hence, it should be considered to perform the analysis as soon as possible to increase the evaluability of the test.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 5","pages":"303-309"},"PeriodicalIF":4.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-grade endometrial endometrioid carcinoma of the p53-abnormal group: case presentation and diagnostic issues. p53异常组的低级别子宫内膜样癌：病例表现和诊断问题。
IF 4.4
PATHOLOGICA Pub Date : 2024-10-01 DOI: 10.32074/1591-951X-1044
Susanna Ronchi, Eleonora Di Lauro, Carla Facco, Antonio Raffone, Caterina Fulgione, Jvan Casarin, Angela Santoro, Damiano Arciuolo, Giuseppe Angelico, Gian Franco Zannoni, Stefano La Rosa, Antonio Travaglino
{"title":"Low-grade endometrial endometrioid carcinoma of the p53-abnormal group: case presentation and diagnostic issues.","authors":"Susanna Ronchi, Eleonora Di Lauro, Carla Facco, Antonio Raffone, Caterina Fulgione, Jvan Casarin, Angela Santoro, Damiano Arciuolo, Giuseppe Angelico, Gian Franco Zannoni, Stefano La Rosa, Antonio Travaglino","doi":"10.32074/1591-951X-1044","DOIUrl":"https://doi.org/10.32074/1591-951X-1044","url":null,"abstract":"<p><p>P53-abnormal endometrial carcinomas are high-grade and aggressive tumors which should be treated with chemo-/radiotherapy. In low-grade endometrioid carcinoma (LGEC), abnormal expression of p53 is an exceptional finding and is typically accompanied by patchy p16 positivity and diffuse hormone receptor expression.</p><p><p>Herein, we report a case of LGEC exhibiting both p53 and p16 overexpression, highlighting the diagnostic pitfalls related to such phenotype.</p><p><p>A 60-year-old woman underwent hysterectomy and bilateral salpingo-oophorectomy with pelvic lymphadenectomy due to a deeply myoinvasive endometrial mass. The tumor showed glandular architecture, low-grade nuclei and glandular differentiation. Focal lymphovascular space invasion and no lymph node metastases were observed. Immunohistochemically, the tumor showed p53 overexpression, p16 block-type positivity, diffuse hormone receptors positivity and retained mismatch repair proteins expression. No POLE mutations were identified. A diagnosis of p53-abnormal LGEC was eventually made.</p><p><p>A glandular neoplasm with p53 and/or p16-overexpression on endometrial biopsy specimens may raise the concern of other entities such as serous carcinoma, HPV-related endocervical adenocarcinoma, and gastric-type adenocarcinoma. An immunohistochemical panel including hormone receptors, p53, p16 and mismatch repair proteins appears necessary for an accurate diagnosis of uterine adenocarcinomas.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 5","pages":"320-323"},"PeriodicalIF":4.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mutational profiling of SMARCA4 and SMARCB1 in ampullary adenocarcinoma: a preliminary study. 壶腹腺癌中SMARCA4和SMARCB1突变谱的初步研究
IF 4.4
PATHOLOGICA Pub Date : 2024-10-01 DOI: 10.32074/1591-951X-1028
Paola Parente, Francesco Pepe, Claudia Covelli, Gianluca Russo, Federica Russo, Giancarlo Troncone, Paolo Graziano, Umberto Malapelle
{"title":"Mutational profiling of SMARCA4 and SMARCB1 in ampullary adenocarcinoma: a preliminary study.","authors":"Paola Parente, Francesco Pepe, Claudia Covelli, Gianluca Russo, Federica Russo, Giancarlo Troncone, Paolo Graziano, Umberto Malapelle","doi":"10.32074/1591-951X-1028","DOIUrl":"https://doi.org/10.32074/1591-951X-1028","url":null,"abstract":"","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 5","pages":"331-334"},"PeriodicalIF":4.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The uropathologist of the future: getting ready with intelligence for the prostate cancer tsunami. 未来的泌尿病理学家：为前列腺癌海啸做好准备。
IF 4.4
PATHOLOGICA Pub Date : 2024-10-01 DOI: 10.32074/1591-951X-1047
Alessia Cimadamore, Rodolfo Montironi, Liang Cheng, Antonio Lopez-Beltran, Eamonn T Rogers, Carmine Franzese, Alessandro Crestani, Gianluca Giannarini
{"title":"The uropathologist of the future: getting ready with intelligence for the prostate cancer tsunami.","authors":"Alessia Cimadamore, Rodolfo Montironi, Liang Cheng, Antonio Lopez-Beltran, Eamonn T Rogers, Carmine Franzese, Alessandro Crestani, Gianluca Giannarini","doi":"10.32074/1591-951X-1047","DOIUrl":"10.32074/1591-951X-1047","url":null,"abstract":"<p><p>According to the recently published paper by the Lancet Commission on prostate cancer (PCa) <sup>1</sup>, the projections of new cases of PCa will rise from 1.4 million in 2020 to 2.9 million by 2040. Such a rise cannot be prevented by public health interventions and lifestyle changes. Late diagnosis of PCa is \"widespread worldwide but especially in low-income and middle-income countries\" <sup>1</sup>. The best way to cope with the harm due to the increase in case numbers is to develop systems for earlier diagnosis. Early diagnosis systems will have to integrate the growing power of artificial intelligence (AI), including digital pathology (DP) diagnostics, to aid the interpretation of prostate tissue specimens <sup>1</sup>. This contribution aims to point out how DP and AI can help pathologists for the prostate cancer \"tsunami\" about to come.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 5","pages":"267-272"},"PeriodicalIF":4.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Not all pancreatic cystic lesions are the same: lesson from a case with three different coexisting neoplasms. 并非所有胰腺囊性病变都是相同的：来自三种不同肿瘤共存病例的教训。
IF 4.4
PATHOLOGICA Pub Date : 2024-10-01 DOI: 10.32074/1591-951X-960
Anna Caterina Milanetto, Alice Sabrina Tonello, Valentina Angerilli, Matteo Fassan, Claudio Pasquali
{"title":"Not all pancreatic cystic lesions are the same: lesson from a case with three different coexisting neoplasms.","authors":"Anna Caterina Milanetto, Alice Sabrina Tonello, Valentina Angerilli, Matteo Fassan, Claudio Pasquali","doi":"10.32074/1591-951X-960","DOIUrl":"https://doi.org/10.32074/1591-951X-960","url":null,"abstract":"<p><p>An asymptomatic 79-year old woman presented with a 40 mm pancreatic cystic lesion, located in the pancreatic body-tail and consistent with branch-duct intraductal papillary mucinous neoplasm (BD-IPMN) without \"high risk stigmata\". During a 4-year follow-up period, imaging showed no mural nodules or main pancreatic duct dilation, and serum CEA and CA19.9 were within normal range. Later, computed tomography showed a rapid increase in cyst size up to 59 mm, which led to a clinical suspicion of malignant transformation. The patient underwent distal pancreatectomy, and final histology revealed the presence of three distinct pancreatic neoplasms: serous cystadenoma (SCA), BD-IPMN, and well-differentiated G1 neuroendocrine tumour (PanNET-G1). The co-occurrence of pancreatic neuroendocrine and exocrine tumours is exceedingly rare. To the best of our knowledge, this is the first reported case of the concomitant presence of three different pancreatic tumors in the same pancreatic specimen arose adjacent one to each other within the same macroscopic lesion.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 5","pages":"328-330"},"PeriodicalIF":4.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA-Based Next-Generation Sequencing in Non-Small Cell Lung Cancer patients: data from Campania, Italy. 非小细胞肺癌患者基于rna的新一代测序：来自意大利坎帕尼亚的数据
IF 4.4
PATHOLOGICA Pub Date : 2024-10-01 DOI: 10.32074/1591-951X-1015
Pasquale Pisapia, Antonino Iaccarino, Caterina De Luca, Francesco Pepe, Gianluca Russo, Mariantonia Nacchio, Francesca Ambrosio, Roberto Bianco, Severo Campione, Alessandro Caputo, Pietro Carotenuto, Antonio D'Antonio, Maria D'Armiento, Vincenzo Damiano, Bruno Daniele, Giovanni De Chiara, Marco De Felice, Luigi Della Gravara, Teresa Fabozzi, Salvatore Feliciano, Cesare Gridelli, Elia Guadagno, Gennaro Ilardi, Davide Leopardo, Annamaria Libroia, Paolo Maione, Floriana Morgillo, Jessica Orefice, Luigi Panico, Danilo Rocco, Alberto Servetto, Silvia Varricchio, Pio Zeppa, Elena Vigliar, Claudio Bellevicine, Giancarlo Troncone, Umberto Malapelle
{"title":"RNA-Based Next-Generation Sequencing in Non-Small Cell Lung Cancer patients: data from Campania, Italy.","authors":"Pasquale Pisapia, Antonino Iaccarino, Caterina De Luca, Francesco Pepe, Gianluca Russo, Mariantonia Nacchio, Francesca Ambrosio, Roberto Bianco, Severo Campione, Alessandro Caputo, Pietro Carotenuto, Antonio D'Antonio, Maria D'Armiento, Vincenzo Damiano, Bruno Daniele, Giovanni De Chiara, Marco De Felice, Luigi Della Gravara, Teresa Fabozzi, Salvatore Feliciano, Cesare Gridelli, Elia Guadagno, Gennaro Ilardi, Davide Leopardo, Annamaria Libroia, Paolo Maione, Floriana Morgillo, Jessica Orefice, Luigi Panico, Danilo Rocco, Alberto Servetto, Silvia Varricchio, Pio Zeppa, Elena Vigliar, Claudio Bellevicine, Giancarlo Troncone, Umberto Malapelle","doi":"10.32074/1591-951X-1015","DOIUrl":"https://doi.org/10.32074/1591-951X-1015","url":null,"abstract":"<p><strong>Objective: </strong>ALK, ROS1, NTRK, and RET gene fusions and MET exon 14 skipping alterations represent fundamental predictive biomarkers for advanced non-small cell lung cancer (NSCLC) patients to ensure the best treatment choice. In this scenario, RNA-based NGS approach has emerged as an extremely useful tool for detecting these alterations. In this study, we report our NGS molecular records on ALK, ROS1, NTRK, and RET gene fusions and MET exon 14 skipping alterations detected by using a narrow RNA-based NGS panel, namely SiRe fusion.</p><p><strong>Methods: </strong>We retrospectively reviewed data on 201 advanced stage NSCLC patients who were referred to our laboratory for RNA-based molecular evaluation of ALK, ROS1, RET, NTRK gene rearrangements as well as MET exon 14 skipping.</p><p><strong>Results: </strong>Overall, 23 (11.4%) positive cases were retrieved. Regarding molecular assessment, 11 (5.5%), 2 (1.0%), 9 (4.5%), and 1 (0.5%) out of 201 harbored an ALK, ROS1, RET gene rearrangement, or MET exon 14 skipping, respectively.</p><p><strong>Conclusions: </strong>In this study, we provide real-world experience on RNA-based NGS analysis in patients with advanced stage NSCLC.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 5","pages":"310-319"},"PeriodicalIF":4.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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