PATHOLOGICA最新文献_第10页

COVID-19: detection methods in post-mortem samples. COVID-19：尸体样本中的检测方法。

IF 3.5

PATHOLOGICA Pub Date : 2023-10-01 DOI: 10.32074/1591-951X-933

Ilaria Tedesco, Federica Zito Marino, Andrea Ronchi, Amaro Nunes Duarte Neto, Marisa Dolhnikoff, Maurizio Municinò, Carlo Pietro Campobasso, Giuseppe Pannone, Renato Franco

引用次数: 0

Exploring the pathologist's role in understanding COVID-19: from pneumonia to long-COVID lung sequelae. 探索病理学家在理解 COVID-19 方面的作用：从肺炎到长期 COVID 肺部后遗症。

IF 3.5

PATHOLOGICA Pub Date : 2023-10-01 DOI: 10.32074/1591-951X-906

Gheorghe-Emilian Olteanu, Federica Pezzuto, Francesca Lunardi, Francesco Fortarezza, Alessandra Dubini, Fiorella Calabrese

{"title":"Exploring the pathologist's role in understanding COVID-19: from pneumonia to long-COVID lung sequelae.","authors":"Gheorghe-Emilian Olteanu, Federica Pezzuto, Francesca Lunardi, Francesco Fortarezza, Alessandra Dubini, Fiorella Calabrese","doi":"10.32074/1591-951X-906","DOIUrl":"10.32074/1591-951X-906","url":null,"abstract":"The crucial role of pathologists in enhancing our understanding of SARS-CoV-2-related disease, from initial pneumonia manifestations to persistent long COVID lung symptoms, is the focus of this review. Pathological explorations have offered unprecedented insights into the early stages of severe COVID-19, shedding light on the interplay between the virus and subsequent complications, thereby shaping clinical approaches. Growing interest is directed to residual lung abnormalities of COVID-19 survivors. Although various radiological studies reported long-lasting pulmonary changes (e.g., ground glass opacities, reticulations, and bronchiectasis), the true incidence of pulmonary fibrosis and corresponding pathological findings in these patients remains largely unknown. There are a few high-impact and knowledgeable works on late complications in COVID-19 survivors, several coming from explant or autopsy cases, and rare cases from in vivo sampling. The study of biopsy samples has further deepened our knowledge of the aftermath of COVID-19 on lung tissue, uncovering alterations at the cellular level and shifts in vascular and epithelial dynamics. Despite the substantial progress made, future research is needed to devise a uniform strategy for interpreting lung biopsies, with a focus on leveraging advanced tools such as molecular and digital pathology techniques, along with artificial intelligence.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"115 5","pages":"275-283"},"PeriodicalIF":3.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10699331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of post-mortem examination in SARS-CoV-19 infections. 对 SARS-CoV-19 感染进行尸检的管理。

IF 3.5

PATHOLOGICA Pub Date : 2023-10-01 DOI: 10.32074/1591-951X-921

Mattia Riefolo, Francesca Ambrosi, Alessandra De Palma, Carmine Gallo, Stefania Damiani

引用次数: 0

Gastric (gastrointestinal)-type endometrial adenocarcinoma presenting as a solitary endometrial polyp: a case report and literature review on a novel and potentially aggressive endometrial cancer histotype. 胃(胃肠)型子宫内膜腺癌表现为孤立的子宫内膜息肉:一种新型且具有潜在侵袭性的子宫内膜癌组织型的病例报告和文献综述。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 DOI: 10.32074/1591-951X-870

Emma Bragantini, Giuseppe Angelico, Maria Giulia Disanto, Elena Magri, Livia Maccio, Mattia Barbareschi

引用次数: 0

Molecular testing in indeterminate thyroid nodules: an additional tool for clinical decision-making. 不确定甲状腺结节的分子检测:临床决策的附加工具。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 DOI: 10.32074/1591-951X-887

Caterina Fumagalli, Giovanni Serio

{"title":"Molecular testing in indeterminate thyroid nodules: an additional tool for clinical decision-making.","authors":"Caterina Fumagalli, Giovanni Serio","doi":"10.32074/1591-951X-887","DOIUrl":"10.32074/1591-951X-887","url":null,"abstract":"Thyroid nodules are commonly encountered in clinical practice, affecting up to 50% of the population. The large majority of thyroid lumps are benign incidental findings detected by imaging, while approximately 5-15% harbor malignancy. For a target patient's care, it is of paramount importance to identify and treat thyroid malignancy, while preventing unnecessary invasive surgery in patients with benign lesions. Although fine needle aspiration (FNA) associated with cytological examination provides malignant risk information, 20-30% of diagnoses fall into the \"indeterminate thyroid nodule\" (ITN) category. ITN clinical management remains a challenging issue for physicians since the ITN risk of malignancy varies from 5% to 40% and most thyroid nodules undergo overtreatment with surgery procedures. ITN molecular testing may better define malignant risk in the single nodule and is able to discriminate with accuracy benign from malignant nodules. Nowadays there are different technologies and different molecular panels, each with its own specificity, sensitivity and predictive values. In view of widespread introduction of molecular testing , some outstanding questions remain and are addressed in the present review such as the presence of molecular panels acting as \"rule in\" or \"rule out\" tools, the effective impact of testing results in the clinical decision-making process, and the prohibitive cost of commercial assays associated with the lack of test reimbursement in national health systems.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"115 4","pages":"205-216"},"PeriodicalIF":3.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10284865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Answers by phone to 15 common questions concerning perinatal foetal autopsy in the Italian legislative framework. 通过电话回答了意大利立法框架中关于围产期胎儿尸检的15个常见问题。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 DOI: 10.32074/1591-951X-869

Alessandro Bonsignore, Francesca Buffelli, Francesca Monari, Ezio Fulcheri

引用次数: 0

Professional liability subsequent to the Cartabia Reform: implications for pathologists. Cartabia改革后的职业责任:对病理学家的启示。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 DOI: 10.32074/1591-951X-878

Edoardo Orlandi, Eleonora Nardi, Chiara Siodambro, Daniela Massi, Vilma Pinchi

引用次数: 0

Diagnostic concordance between traditional and digital workflows. A study on 1427 prostate biopsies. 传统和数字工作流程之间的诊断一致性。1427例前列腺活检的研究。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 DOI: 10.32074/1591-951X-896

Evelin Torresani, Maria Adalgisa Gentilini, Stefano Grassi, Luca Cima, Irene Pedrolli, Tommaso Cai, Marco Puglisi, Valentino Vattovani, Bianca Guadin, Matteo Brunelli, Claudio Doglioni, Mattia Barbareschi

{"title":"Diagnostic concordance between traditional and digital workflows. A study on 1427 prostate biopsies.","authors":"Evelin Torresani, Maria Adalgisa Gentilini, Stefano Grassi, Luca Cima, Irene Pedrolli, Tommaso Cai, Marco Puglisi, Valentino Vattovani, Bianca Guadin, Matteo Brunelli, Claudio Doglioni, Mattia Barbareschi","doi":"10.32074/1591-951X-896","DOIUrl":"10.32074/1591-951X-896","url":null,"abstract":"Objective: To evaluate intra-observer diagnostic reproducibility using traditional slides (TS) versus whole slide images (WSI).Methods: TS and WSI of 1427 prostatic biopsies (107 consecutive patients) were evaluated by a single pathologist. Agreement between readings was evaluated with Gwet's Agreement coefficient (AC) and Landis and Koch benchmark scale.Results: The positive/negative agreement between the readings was almost perfect (AC1= 0.962; 95% CI[0.949,0.974]), with method independent distribution of discrepancies. Among positive biopsies, 212 had identical Gleason score (GS) on TS and WSI and discordant GS in 69 cases (AC2 = 0.932; 95% CI[0.907, 0.956]). Concordant negative and positive patient classification was observed in 39 and 64 cases, respectively; two cases were assigned to the positive group on TS and 2 on WSI configuring an almost perfect agreement (AC1=0.929; 95% C1[0.860, 0.998]). ISUP Grade group (ISUP GG) agreement was evaluated in the 60 concordantly positive cases: in 45 cases it was identical on TS and WSI; in 10 biopsies the discrepancy implied a modification of the assigned ISUP GG of ≤ 1 class and in 5 the discrepancy implied a modification of 2 classes. Gwet's agreement coefficient was (95% CI [0.834, 0.962]), i.e.: almost perfect agreement.Conclusions: Our data show almost perfect agreement between digital and traditional diagnostic activity in a routine setting, confirming that digital pathology can be safely introduced into routine workflows.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"115 4","pages":"221-226"},"PeriodicalIF":3.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histology for nephrology, from pre-implantation to post-transplant kidney biopsy. Lesson learned from ReBIrth (Renal BIopsy for Kidney Transplantation Therapy). 肾学组织学，从植入前到移植后肾活检。重生(肾移植治疗的肾活检)的经验教训。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 Epub Date: 2023-06-13 DOI: 10.32074/1591-951X-858

Anna Caliò, Antonella Barreca, Stefano Marletta, Maria Italia Sara Achenza, Marianna Alessi, Roberta Angelico, Luca Apicella, Davide Argiolas, Nicola Bossini, Rosa Carrano, Concetta Carriero, Giuseppe Castellano, Giorgia Comai, Caterina Di Bella, Francesco D'Ignoto, Agnese Gallico, Fiorella Gastaldon, Guido Merlotti, Vera Paloschi, Alessandra Panarese, Angelica Parodi, Francesco Perna, Daniela Picciotto, Anna Regalia, Michele Rossini, Enrico Russo, Maria Paola Salerno, Luca Toti, Patrizia Tulissi, Gisella Vischini, Gianluigi Zaza, Albino Eccher

{"title":"Histology for nephrology, from pre-implantation to post-transplant kidney biopsy. Lesson learned from ReBIrth (Renal BIopsy for Kidney Transplantation Therapy).","authors":"Anna Caliò, Antonella Barreca, Stefano Marletta, Maria Italia Sara Achenza, Marianna Alessi, Roberta Angelico, Luca Apicella, Davide Argiolas, Nicola Bossini, Rosa Carrano, Concetta Carriero, Giuseppe Castellano, Giorgia Comai, Caterina Di Bella, Francesco D'Ignoto, Agnese Gallico, Fiorella Gastaldon, Guido Merlotti, Vera Paloschi, Alessandra Panarese, Angelica Parodi, Francesco Perna, Daniela Picciotto, Anna Regalia, Michele Rossini, Enrico Russo, Maria Paola Salerno, Luca Toti, Patrizia Tulissi, Gisella Vischini, Gianluigi Zaza, Albino Eccher","doi":"10.32074/1591-951X-858","DOIUrl":"10.32074/1591-951X-858","url":null,"abstract":"A meeting entitled Renal BIopsy for Kidney Transplantation Therapy (ReBIrth) took place on May 31st, 2022 in Bologna, Italy. The meeting drew together nephrologists, surgeons, and pathologists and recognized as experts in the field of kidney transplantation in Italy. In this paper, we present our experience working with kidney transplants in the current era of immunosuppression therapy. The primary aim is to report the histopathological characteristics of failed kidney allografts after a consensus of experts reviewed the cases on a wholeslide imaging digital platform. Regardless of the cases discussed, digital pathology was reliable in identifying all the morphological and immunohistochemical features required to improve the correct use of immunosuppressive therapy to prevent graft failure and optimize patient management.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"115 4","pages":"199-204"},"PeriodicalIF":3.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10238295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian schistosomiasis: challenges of a neglected ectopic involvement of blood flukes. Case report and review of literature. 卵巢血吸虫病:被忽视的异位参与血吸虫的挑战。病例报告及文献复习。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 DOI: 10.32074/1591-951X-891

Edrick Elias, Valeria Silvestri, Vivian Mushi, Martina Mandarano

{"title":"Ovarian schistosomiasis: challenges of a neglected ectopic involvement of blood flukes. Case report and review of literature.","authors":"Edrick Elias, Valeria Silvestri, Vivian Mushi, Martina Mandarano","doi":"10.32074/1591-951X-891","DOIUrl":"10.32074/1591-951X-891","url":null,"abstract":"Summary Introduction Female genital schistosomiasis (FGS), infection of Schistosoma spp. trematode in the gynaecological apparatus, is the most neglected sexual and reproductive health condition in sub-Saharan Africa with an estimated of 20-120 million cases. The ectopic entrapment of Schistosome eggs after oviposition can occur in 0.5% of cases in fallopian tubes and ovaries. The case We report a case of 38-years-old woman assessed for a 10 year history of infertility. On ultrasound, multiple cystic formations were observed in the ovary. Histology after oophorectomy to exclude malignancy showed granulomatous formations surrounding Schistosoma spp. eggs in proximity of corpus luteus and haemorragicum. Discussion Ectopic Schistosome oviposition, seen in the ovary and fallopian tubes as in our case, can be a potential cause of reproductive organ damage and complications such as infertility, ectopic pregnancy, miscarriage, premature birth, low birth weight, and even maternal death. Conclusions More studies are needed on ovarian FGS and its impact on women fertility to guide specific interventions targeting vulnerable population of childbearing age, contributing to the NTD WHO 2030 aim of eliminating schistosomiasis as a matter of public health.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"115 4","pages":"237-245"},"PeriodicalIF":3.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0