探索病理学家在理解 COVID-19 方面的作用:从肺炎到长期 COVID 肺部后遗症。

IF 4.4 Q1 PATHOLOGY
PATHOLOGICA Pub Date : 2023-10-01 DOI:10.32074/1591-951X-906
Gheorghe-Emilian Olteanu, Federica Pezzuto, Francesca Lunardi, Francesco Fortarezza, Alessandra Dubini, Fiorella Calabrese
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引用次数: 0

摘要

病理学家在加深我们对 SARS-CoV-2 相关疾病(从最初的肺炎表现到持续时间较长的 COVID 肺部症状)的认识方面发挥了至关重要的作用,是本综述的重点。病理学探索为我们了解严重 COVID-19 的早期阶段提供了前所未有的视角,揭示了病毒与后续并发症之间的相互作用,从而影响了临床治疗方法。人们对 COVID-19 存活者的残留肺部异常越来越感兴趣。尽管各种放射学研究报告了长期存在的肺部变化(如磨玻璃不透明、网状结构和支气管扩张),但这些患者肺纤维化和相应病理结果的真实发生率在很大程度上仍不为人所知。关于 COVID-19 幸存者的晚期并发症,有几篇影响较大、知识渊博的文章,其中几篇来自外植体或尸检病例,还有极少数病例来自体内取样。对活检样本的研究进一步加深了我们对 COVID-19 对肺组织后遗症的了解,发现了细胞水平的改变以及血管和上皮动态的变化。尽管取得了重大进展,但未来的研究仍需制定统一的肺活检解读策略,重点是利用分子和数字病理学技术等先进工具以及人工智能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the pathologist's role in understanding COVID-19: from pneumonia to long-COVID lung sequelae.

The crucial role of pathologists in enhancing our understanding of SARS-CoV-2-related disease, from initial pneumonia manifestations to persistent long COVID lung symptoms, is the focus of this review. Pathological explorations have offered unprecedented insights into the early stages of severe COVID-19, shedding light on the interplay between the virus and subsequent complications, thereby shaping clinical approaches. Growing interest is directed to residual lung abnormalities of COVID-19 survivors. Although various radiological studies reported long-lasting pulmonary changes (e.g., ground glass opacities, reticulations, and bronchiectasis), the true incidence of pulmonary fibrosis and corresponding pathological findings in these patients remains largely unknown. There are a few high-impact and knowledgeable works on late complications in COVID-19 survivors, several coming from explant or autopsy cases, and rare cases from in vivo sampling. The study of biopsy samples has further deepened our knowledge of the aftermath of COVID-19 on lung tissue, uncovering alterations at the cellular level and shifts in vascular and epithelial dynamics. Despite the substantial progress made, future research is needed to devise a uniform strategy for interpreting lung biopsies, with a focus on leveraging advanced tools such as molecular and digital pathology techniques, along with artificial intelligence.

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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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