传统和数字工作流程之间的诊断一致性。1427例前列腺活检的研究。

IF 4.4 Q1 PATHOLOGY
PATHOLOGICA Pub Date : 2023-08-01 DOI:10.32074/1591-951X-896
Evelin Torresani, Maria Adalgisa Gentilini, Stefano Grassi, Luca Cima, Irene Pedrolli, Tommaso Cai, Marco Puglisi, Valentino Vattovani, Bianca Guadin, Matteo Brunelli, Claudio Doglioni, Mattia Barbareschi
{"title":"传统和数字工作流程之间的诊断一致性。1427例前列腺活检的研究。","authors":"Evelin Torresani, Maria Adalgisa Gentilini, Stefano Grassi, Luca Cima, Irene Pedrolli, Tommaso Cai, Marco Puglisi, Valentino Vattovani, Bianca Guadin, Matteo Brunelli, Claudio Doglioni, Mattia Barbareschi","doi":"10.32074/1591-951X-896","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate intra-observer diagnostic reproducibility using traditional slides (TS) versus whole slide images (WSI).</p><p><strong>Methods: </strong>TS and WSI of 1427 prostatic biopsies (107 consecutive patients) were evaluated by a single pathologist. Agreement between readings was evaluated with Gwet's Agreement coefficient (AC) and Landis and Koch benchmark scale.</p><p><strong>Results: </strong>The positive/negative agreement between the readings was almost perfect (AC<sub>1</sub>= 0.962; 95% CI[0.949,0.974]), with method independent distribution of discrepancies. Among positive biopsies, 212 had identical Gleason score (GS) on TS and WSI and discordant GS in 69 cases (AC<sub>2</sub> = 0.932; 95% CI[0.907, 0.956]). Concordant negative and positive patient classification was observed in 39 and 64 cases, respectively; two cases were assigned to the positive group on TS and 2 on WSI configuring an almost perfect agreement (AC<sub>1</sub>=0.929; 95% C1[0.860, 0.998]). ISUP Grade group (ISUP GG) agreement was evaluated in the 60 concordantly positive cases: in 45 cases it was identical on TS and WSI; in 10 biopsies the discrepancy implied a modification of the assigned ISUP GG of ≤ 1 class and in 5 the discrepancy implied a modification of 2 classes. Gwet's agreement coefficient was (95% CI [0.834, 0.962]), i.e.: almost perfect agreement.</p><p><strong>Conclusions: </strong>Our data show almost perfect agreement between digital and traditional diagnostic activity in a routine setting, confirming that digital pathology can be safely introduced into routine workflows.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"115 4","pages":"221-226"},"PeriodicalIF":4.4000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688250/pdf/","citationCount":"0","resultStr":"{\"title\":\"Diagnostic concordance between traditional and digital workflows. A study on 1427 prostate biopsies.\",\"authors\":\"Evelin Torresani, Maria Adalgisa Gentilini, Stefano Grassi, Luca Cima, Irene Pedrolli, Tommaso Cai, Marco Puglisi, Valentino Vattovani, Bianca Guadin, Matteo Brunelli, Claudio Doglioni, Mattia Barbareschi\",\"doi\":\"10.32074/1591-951X-896\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate intra-observer diagnostic reproducibility using traditional slides (TS) versus whole slide images (WSI).</p><p><strong>Methods: </strong>TS and WSI of 1427 prostatic biopsies (107 consecutive patients) were evaluated by a single pathologist. Agreement between readings was evaluated with Gwet's Agreement coefficient (AC) and Landis and Koch benchmark scale.</p><p><strong>Results: </strong>The positive/negative agreement between the readings was almost perfect (AC<sub>1</sub>= 0.962; 95% CI[0.949,0.974]), with method independent distribution of discrepancies. Among positive biopsies, 212 had identical Gleason score (GS) on TS and WSI and discordant GS in 69 cases (AC<sub>2</sub> = 0.932; 95% CI[0.907, 0.956]). Concordant negative and positive patient classification was observed in 39 and 64 cases, respectively; two cases were assigned to the positive group on TS and 2 on WSI configuring an almost perfect agreement (AC<sub>1</sub>=0.929; 95% C1[0.860, 0.998]). ISUP Grade group (ISUP GG) agreement was evaluated in the 60 concordantly positive cases: in 45 cases it was identical on TS and WSI; in 10 biopsies the discrepancy implied a modification of the assigned ISUP GG of ≤ 1 class and in 5 the discrepancy implied a modification of 2 classes. Gwet's agreement coefficient was (95% CI [0.834, 0.962]), i.e.: almost perfect agreement.</p><p><strong>Conclusions: </strong>Our data show almost perfect agreement between digital and traditional diagnostic activity in a routine setting, confirming that digital pathology can be safely introduced into routine workflows.</p>\",\"PeriodicalId\":45893,\"journal\":{\"name\":\"PATHOLOGICA\",\"volume\":\"115 4\",\"pages\":\"221-226\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688250/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"PATHOLOGICA\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32074/1591-951X-896\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"PATHOLOGICA","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32074/1591-951X-896","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的:评价传统载玻片(TS)与全载玻片(WSI)在观察者内诊断的可重复性。方法:对连续107例1427例前列腺活检患者的TS和WSI进行单一病理学评估。使用Gwet的一致系数(AC)和Landis和Koch基准量表评估读数之间的一致性。结果:两组读数正/负一致性几乎完美(AC1= 0.962;95% CI[0.949,0.974]),差异分布与方法无关。阳性活检患者TS、WSI Gleason评分一致的212例,不一致的69例(AC2 = 0.932;95% ci[0.907, 0.956])。阴性和阳性患者分型一致的分别为39例和64例;TS阳性组2例,WSI阳性组2例,基本一致(AC1=0.929;95% c1[0.860, 0.998])。在60例一致阳性病例中评估ISUP分级组(ISUP GG)一致性,其中45例TS和WSI相同;在10个活检中,差异意味着指定的ISUP GG的修改≤1级,在5个差异意味着修改2级。Gwet的一致系数为(95% CI[0.834, 0.962]),即:几乎完全一致。结论:我们的数据显示,在常规设置中,数字化和传统诊断活动几乎完全一致,证实了数字化病理学可以安全地引入常规工作流程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic concordance between traditional and digital workflows. A study on 1427 prostate biopsies.

Objective: To evaluate intra-observer diagnostic reproducibility using traditional slides (TS) versus whole slide images (WSI).

Methods: TS and WSI of 1427 prostatic biopsies (107 consecutive patients) were evaluated by a single pathologist. Agreement between readings was evaluated with Gwet's Agreement coefficient (AC) and Landis and Koch benchmark scale.

Results: The positive/negative agreement between the readings was almost perfect (AC1= 0.962; 95% CI[0.949,0.974]), with method independent distribution of discrepancies. Among positive biopsies, 212 had identical Gleason score (GS) on TS and WSI and discordant GS in 69 cases (AC2 = 0.932; 95% CI[0.907, 0.956]). Concordant negative and positive patient classification was observed in 39 and 64 cases, respectively; two cases were assigned to the positive group on TS and 2 on WSI configuring an almost perfect agreement (AC1=0.929; 95% C1[0.860, 0.998]). ISUP Grade group (ISUP GG) agreement was evaluated in the 60 concordantly positive cases: in 45 cases it was identical on TS and WSI; in 10 biopsies the discrepancy implied a modification of the assigned ISUP GG of ≤ 1 class and in 5 the discrepancy implied a modification of 2 classes. Gwet's agreement coefficient was (95% CI [0.834, 0.962]), i.e.: almost perfect agreement.

Conclusions: Our data show almost perfect agreement between digital and traditional diagnostic activity in a routine setting, confirming that digital pathology can be safely introduced into routine workflows.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信