PATHOLOGICA最新文献_第9页

Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification. 第五次中枢神经系统世界卫生组织分类中的儿童型弥漫性高级别胶质瘤。

IF 4.4

PATHOLOGICA Pub Date : 2022-12-01 DOI: 10.32074/1591-951X-830

Francesca Gianno, Isabella Giovannoni, Barbara Cafferata, Francesca Diomedi-Camassei, Simone Minasi, Sabina Barresi, Francesca Romana Buttarelli, Viola Alesi, Antonello Cardoni, Manila Antonelli, Chiara Puggioni, Giovanna Stefania Colafati, Andrea Carai, Maria Vinci, Angela Mastronuzzi, Evelina Miele, Rita Alaggio, Felice Giangaspero, Sabrina Rossi

{"title":"Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification.","authors":"Francesca Gianno, Isabella Giovannoni, Barbara Cafferata, Francesca Diomedi-Camassei, Simone Minasi, Sabina Barresi, Francesca Romana Buttarelli, Viola Alesi, Antonello Cardoni, Manila Antonelli, Chiara Puggioni, Giovanna Stefania Colafati, Andrea Carai, Maria Vinci, Angela Mastronuzzi, Evelina Miele, Rita Alaggio, Felice Giangaspero, Sabrina Rossi","doi":"10.32074/1591-951X-830","DOIUrl":"10.32074/1591-951X-830","url":null,"abstract":"As a relevant element of novelty, the fifth CNS WHO Classification highlights the distinctive pathobiology underlying gliomas arising primarily in children by recognizing for the first time the families of paediatric-type diffuse gliomas, both high-grade and low-grade. This review will focus on the family of paediatric-type diffuse high-grade gliomas, which includes four tumour types: 1) Diffuse midline glioma H3 K27-altered; 2) Diffuse hemispheric glioma H3 G34-mutant; 3) Diffuse paediatric-type high-grade glioma H3-wildtype and IDH-wildtype; and 4) Infant-type hemispheric glioma. The essential and desirable diagnostic criteria as well as the entities entering in the differential will be discussed for each tumour type. A special focus will be given on the issues encountered in the daily practice, especially regarding the diagnosis of the diffuse paediatric-type high-grade glioma H3-wildtype and IDH-wildtype. The advantages and the limits of the multiple molecular tests which may be utilised to define the entities of this tumour family will be evaluated in each diagnostic context.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"114 6","pages":"422-435"},"PeriodicalIF":4.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/27/77/pathol-2022-06-422.PMC9763979.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10479728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary mixed squamous and glandular papilloma: diagnostic challenges of a rare lesion when the clock is ticking. How to avoid interpretation mistakes. 肺混合性鳞状和腺状乳头状瘤:一种罕见病变的诊断挑战。如何避免口译错误。

IF 3.5

PATHOLOGICA Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-809

Iteeka Arora, Nandita Gupta, M Angeles Montero, Patrizia Viola

引用次数: 0

PD-L1 evaluation in the gastrointestinal tract: from biological rationale to its clinical application. 胃肠道PD-L1评价:从生物学原理到临床应用

IF 3.5

PATHOLOGICA Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-803

Luca Mastracci, Federica Grillo, Paola Parente, Irene Gullo, Michela Campora, Valentina Angerilli, Chiara Rossi, Maria Luisa Sacramento, Gianmaria Pennelli, Alessandro Vanoli, Matteo Fassan

{"title":"PD-L1 evaluation in the gastrointestinal tract: from biological rationale to its clinical application.","authors":"Luca Mastracci, Federica Grillo, Paola Parente, Irene Gullo, Michela Campora, Valentina Angerilli, Chiara Rossi, Maria Luisa Sacramento, Gianmaria Pennelli, Alessandro Vanoli, Matteo Fassan","doi":"10.32074/1591-951X-803","DOIUrl":"https://doi.org/10.32074/1591-951X-803","url":null,"abstract":"Immune-checkpoint inhibitors targeting the PD-1/PD-L1 axis have brought significant clinical benefit in many solid cancer types, including gastrointestinal malignancies. However, it has been estimated that only 20-40% of patients respond to treatment. The pattern of expression and potential predictive value of PD-L1 as an immunohistochemical biomarker has been extensively studied in gastrointestinal neoplasms. Until now, its predictive value has been demonstrated, and is currently in use only in upper gastrointestinal malignancies (gastroesophageal adenocarcinoma and esophageal squamous cell carcinoma).In this Review, we describe the technical aspects and challenges related to PD-L1 immunohistochemical assays, the current role of PD-L1 as a biomarker in clinical practice and we outline the main studies and clinical trials analyzing the prognostic and predictive value of PD-L1 in gastrointestinal cancers.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"114 5","pages":"352-364"},"PeriodicalIF":3.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f2/c8/pathol-2022-05-352.PMC9614301.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40434351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Primary intraosseous solitary fibrous tumor: an extremely rare case report and brief review of the literature. 原发性骨内孤立性纤维性肿瘤:一例极为罕见的病例报告及文献回顾。

IF 3.5

PATHOLOGICA Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-524

Giulia Coppola, Carmine Zoccali, Jacopo Baldi, Alessio Annovazzi, Thedora Daralioti, Mariavittoria Vescovo, Renato Covello

{"title":"Primary intraosseous solitary fibrous tumor: an extremely rare case report and brief review of the literature.","authors":"Giulia Coppola, Carmine Zoccali, Jacopo Baldi, Alessio Annovazzi, Thedora Daralioti, Mariavittoria Vescovo, Renato Covello","doi":"10.32074/1591-951X-524","DOIUrl":"https://doi.org/10.32074/1591-951X-524","url":null,"abstract":"Solitary fibrous tumor (SFT), a rare mesenchymal neoplasm of fibroblastic origin, was initially discovered in the mediastinal pleura and then described in many extra-pleural sites.The reports of primary solitary fibrous tumor of bone are extremely rare and only a few cases have been previously mentioned in the literature, most of which in flat and short bones.Here we present the case of a 53-year-old female, who was referred to the emergency department of a peripheral hospital after an accidental fall. Imaging studies revealed an intertrochanteric fracture with an underlying intramedullary lytic lesion. A biopsy was performed and a diagnosis of Ewing sarcoma was initially suggested. She arrived at our hospital where we reevaluated the case. The biopsy was reviewed and a diagnosis of intraosseous SFT was proposed. She underwent en-block resection of the proximal right femur.Primary SFTs of the bone are, like in our case, easily misdiagnosed due to the low specificity of the imaging studies and the extreme rarity of the localization. An accurate diagnosis and early resection are very important and with careful long-term follow-up is essential, particularly in those who with malignant behavior, for the early detection of possible recurrence or metastasis.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"114 5","pages":"376-380"},"PeriodicalIF":3.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/f0/pathol-2022-05-376.PMC9614297.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40434353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DOG-1 positive primary acinic cell carcinoma of the lung and investigation of molecular status. DOG-1阳性原发性肺腺泡细胞癌及其分子状态的研究。

IF 3.5

PATHOLOGICA Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-786

Lorenzo Nibid, Luca Frasca, Giovanna Sabarese, Daniela Righi, Silvia Taccogna, Pierfilippo Crucitti, Paolo Graziano, Giuseppe Perrone

引用次数: 2

Metastatic mucinous ovarian carcinoma simulating lung primary: an integrated diagnostic lesson. 转移性黏液性卵巢癌模拟肺原发:一个综合的诊断教训。

IF 3.5

PATHOLOGICA Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-802

Giuseppe Pelosi, Marco De Luca, Maria Cannone, Emanuela Balladore, Isabella Ricotti, Davide Toniolo, Matteo Incarbone

引用次数: 0

Pleural Kaposi sarcoma: an unusual clinical case. 胸膜卡波济肉瘤一例罕见的临床病例。

IF 3.5

PATHOLOGICA Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-778

Alessandro Marando, Giuseppe Isimbaldi, Sascia Pietro Servillo, Emanuela Bonoldi

引用次数: 0

Ecology and games in cancer: new insights into the disease. 癌症的生态学和博弈:对疾病的新见解。

IF 3.5

PATHOLOGICA Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-798

Claudia Manini, José I López

引用次数: 0

What psammoma bodies can represent in the thyroid. What we recently learnt from a story of lack of evidence. 沙粒体在甲状腺中的表现。我们最近从一个缺乏证据的故事中学到了什么。

IF 3.5

PATHOLOGICA Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-815

Lina Cardisciani, Federica Policardo, Pietro Tralongo, Vincenzo Fiorentino, Esther Diana Rossi

{"title":"What psammoma bodies can represent in the thyroid. What we recently learnt from a story of lack of evidence.","authors":"Lina Cardisciani, Federica Policardo, Pietro Tralongo, Vincenzo Fiorentino, Esther Diana Rossi","doi":"10.32074/1591-951X-815","DOIUrl":"https://doi.org/10.32074/1591-951X-815","url":null,"abstract":"The detection of psammoma bodies (PBs) in the thyroid gland is commonly associated to classic papillary thyroid carcinoma (PTC) and are frequently encountered in differnt subtypes of PTCs. Nonetheless, the evidence of PBs without a PTC may represent a diagnostic challenge. The general statement is that PBs represent a metastatic finding of PTC either when encountered inside the thyroid parenchyma or in the perithyroidal lymph nodes. The majority of authors assess that in presence of PBs, a search for an occult PTC is strongly encouraged and mandatory, especially if a lobectomy had been performed. In fact, it is not uncommon that a contralateral or ipsilateral tumor, mostly PTC, is found leading to the suggestion that the best recommendation is to submit the entire thyroid tissue. Nonetheless, when a cancer has not been found, the possibility of the rare evenience that PBs are likely to be associated with benign conditions should be considered among the differential diagnosis. Herein a short commentary and review of the literature on PBs detection and its diagnosis, based on our recent experience.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"114 5","pages":"373-375"},"PeriodicalIF":3.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/7c/pathol-2022-05-373.PMC9614304.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40434352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Primary adenosquamous carcinoma of the endometrium with glassy cell features. A diagnostic pitfall as a very rare tumour type in the endometrium. 原发性子宫内膜腺鳞癌具有玻璃状细胞特征。子宫内膜肿瘤是一种非常罕见的诊断缺陷。

IF 3.5

PATHOLOGICA Pub Date : 2022-08-01 DOI: 10.32074/1591-951X-757

Selim Sevim, Duygu Enneli, Ezgi Dicle Serbes, Cevriye Cansiz Ersoz, Seher Yuksel

引用次数: 1