肺神经内分泌肿瘤的临床需要及病理答案。

IF 4.4 Q1 PATHOLOGY
PATHOLOGICA Pub Date : 2025-06-01 Epub Date: 2025-06-27 DOI:10.32074/1591-951X-N1102
Giuseppe Pelosi, Alice Laffi, Mauro Papotti, Sylvie Lantuejoul, Jean-Yves Scoazec, Maria Gemelli, Riccardo Ricotta, Sergio Harari, Eleonora Duregon, Riccardo Papa, Angelica Sonzogni, Fabrizio Bianchi, Antonino Bruno, Barbara Bassani, Silvia Uccella, Carlo Carnaghi, Alexia Francesca Bertuzzi
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引用次数: 0

摘要

肺神经内分泌肿瘤(NENs)是一种包括典型类癌(TC)和非典型类癌(AC)在内的多种恶性肿瘤。这些是低至中级神经内分泌肿瘤(NETs),大细胞神经内分泌癌(LCNEC)和小细胞肺癌(SCLC),它们是成熟的高级神经内分泌癌(nec),具有相似的临床结果。通过肿瘤学家和病理学家之间的同行互动,我们针对8个实际问题构建了一种基于问答的实用方法,旨在为临床决策提供共享解决方案。这些问题在临床推理和鉴别诊断、联合亚型、原发性和转移性肿瘤、小诊断材料、预测性生物标志物、肿瘤分期以及标准化术语的指导下被逐项列出。本研究利用肿瘤学家和病理学家之间的密切互动作为工具,更好地描述肺NENs的决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical needs and pathology's answers in neuroendocrine neoplasms of the lung.

Lung neuroendocrine neoplasms (NENs) make up a variegated ensemble of malignancies encompassing typical carcinoid (TC) and atypical carcinoid (AC). These are low to intermediate grade neuroendocrine tumors (NETs), and large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC), which are full-fledged high-grade neuroendocrine carcinomas (NECs) showing similar clinical outcomes. Through a peer interaction between oncologist and pathologist, we herein constructed a practical approach based on questioning and answering regarding 8 practical issues aimed to provide shared solutions for clinical decision-making. These issues were itemized as sequential steps guided by clinical reasoning and concerned differential diagnosis, combined subtypes, primary and metastatic tumors, small diagnostic material, predictive biomarkers, tumor staging and, lastly, standardizing terminology. This study takes advantage of the close interaction between oncologists and pathologists as a tool to better delineate the decision-making on lung NENs.

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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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