Oxford Medical Case Reports最新文献_第5页

Severe symptomatic hypocalcemia with probable transient parathyroid dysfunction following radioiodine therapy for Graves' disease: a case report. Graves病放射性碘治疗后严重症状性低血钙伴可能短暂甲状旁腺功能障碍1例

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-09-02 eCollection Date: 2026-09-01 DOI: 10.1093/omcr/omag161

Anamarija Jankulovska, Natasha Stojanoska, Tanja Makazlieva, Nevena Manevska, Sinisha Stojanoski

{"title":"Severe symptomatic hypocalcemia with probable transient parathyroid dysfunction following radioiodine therapy for Graves' disease: a case report.","authors":"Anamarija Jankulovska, Natasha Stojanoska, Tanja Makazlieva, Nevena Manevska, Sinisha Stojanoski","doi":"10.1093/omcr/omag161","DOIUrl":"10.1093/omcr/omag161","url":null,"abstract":"Background: Radioactive iodine therapy (RAIT) is a definitive treatment for hyperthyroidism, but parathyroid effects are often underrecognized.Case presentation: A 66-year-old woman with a 30-year history of Graves' disease underwent RAIT (555 MBq 131I) after long-term treatment with thiamazole and briefly with propylthiouracil without achieving remission. Two weeks after RAIT, she developed paresthesia and muscle cramps, progressing to hospitalization one week later with positive Chvostek's and Trousseau's signs. Laboratory tests showed severe hypocalcemia (ionized calcium 0.70 mmol/L), vitamin D deficiency, and low parathyroid hormone levels, consistent with parathyroid dysfunction (CTCAE Grade 3 hypocalcemia). She required intravenous and oral calcium plus vitamin D, with gradual improvement. At 9-month follow-up, calcium levels remained stable on supplementation, suggesting prolonged recovery of parathyroid function. She later developed post-RAIT hypothyroidism.Conclusion: This case highlights the importance of considering transient parathyroid dysfunction in patients with symptomatic hypocalcemia after RAIT and supports long-term biochemical monitoring and supplementation.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 9","pages":"omag161"},"PeriodicalIF":0.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nivolumab after recurrent pembrolizumab-associated hepatotoxicity in PD-L1-high metastatic squamous non-small cell lung cancer: a case report. pd - l1高转移性鳞状非小细胞肺癌复发性派姆单抗相关肝毒性后的纳武单抗治疗：1例报告

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-08-22 eCollection Date: 2026-08-01 DOI: 10.1093/omcr/omag159

Adam Bowen, Katlyn Wendel, Muhammad-Danish Saleem, Zijin Lin, Ramalakshmi Thulluri, Borys Hrinczenko

引用次数: 0

Visceral variant of Lemierre's syndrome presenting with liver abscess, hepatic vein thrombophlebitis, and septic pulmonary emboli. 内脏型勒米尔综合征，表现为肝脓肿、肝静脉血栓性静脉炎和脓毒性肺栓塞。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-08-22 eCollection Date: 2026-08-01 DOI: 10.1093/omcr/omag160

Huei-Chu Cheng, Ying-Lin Tan, Li-Wei Lin, Chee-Fah Chong

引用次数: 0

Melphalan-induced serpentine supravenous hyperpigmentation with associated venous thrombosis. melphalan诱导的蛇形静脉上色素沉着伴静脉血栓形成。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-08-22 eCollection Date: 2026-08-01 DOI: 10.1093/omcr/omag158

Sofia Gueroum, Bouchra Baghad, Fatima Zahra Benhayoun, Hanane Rachadi, Soumiya Chiheb

{"title":"Melphalan-induced serpentine supravenous hyperpigmentation with associated venous thrombosis.","authors":"Sofia Gueroum, Bouchra Baghad, Fatima Zahra Benhayoun, Hanane Rachadi, Soumiya Chiheb","doi":"10.1093/omcr/omag158","DOIUrl":"10.1093/omcr/omag158","url":null,"abstract":"Serpentine supravenous hyperpigmentation (SSH) is a rare cutaneous adverse reaction characterized by linear hyperpigmentation along superficial veins following intravenous drug administration, most commonly chemotherapy. We report a rare case of melphalan-induced SSH complicated by superficial venous thrombosis. A 54-year-old man treated for kappa light-chain multiple myeloma developed asymptomatic serpiginous hyperpigmented lesions along the superficial venous network one day after peripheral intravenous melphalan infusion prior to autologous stem cell transplantation. Ten days later, the lesions became painful, and Doppler ultrasound revealed thrombosis of the involved superficial veins. The patient was successfully treated with oral anticoagulation and local care. SSH is generally considered benign and self-limited; however, painful lesions should prompt evaluation for vascular complications such as thrombosis. This case expands the spectrum of chemotherapeutic agents associated with SSH and highlights the importance of early recognition of atypical presentations and complications.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 8","pages":"omag158"},"PeriodicalIF":0.6,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extrahepatically growing hepatocellular carcinoma diagnosed after presentation with peritoneal dissemination: a case report. 以腹膜播散为表现后诊断为肝外生长的肝细胞癌1例。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-08-22 eCollection Date: 2026-08-01 DOI: 10.1093/omcr/omag157

Kosuke Isomura, Keisuke Ida, Machi Shibata, Shinjiro Kobayashi, Satoshi Koizumi, Shinya Mikami

{"title":"Extrahepatically growing hepatocellular carcinoma diagnosed after presentation with peritoneal dissemination: a case report.","authors":"Kosuke Isomura, Keisuke Ida, Machi Shibata, Shinjiro Kobayashi, Satoshi Koizumi, Shinya Mikami","doi":"10.1093/omcr/omag157","DOIUrl":"10.1093/omcr/omag157","url":null,"abstract":"A man in his 40s presented with mildly elevated alpha-fetoprotein (AFP) levels during routine screening. Initial evaluation, including abdominal ultrasonography, revealed no intrahepatic mass, and the patient was placed under surveillance. Approximately 20 months later, AFP and PIVKA-II levels increased to > 200 000 ng/mL and 1524 mAU/mL, respectively. Contrast-enhanced computed tomography (CT) demonstrated diffusely enhancing peritoneal nodules with ascites; however, no definite intrahepatic tumor was detected. Diagnostic laparoscopy revealed multiple soft, reddish-brown nodules involving the peritoneum, omentum, and mesentery. Histopathological examination with immunohistochemistry confirmed disseminated hepatocellular carcinoma (HCC). Retrospective image review identified a small hypervascular nodule with washout extending from the left lateral liver segment toward the left triangular ligament, consistent with a pedunculated extrahepatic HCC. Despite treatment, the patient died 14 months after diagnostic laparoscopy. This case demonstrates that extrahepatically growing HCC may initially present with peritoneal dissemination, even in the absence of an apparent intrahepatic mass.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 8","pages":"omag157"},"PeriodicalIF":0.6,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A solitary lytic rib lesion mimicking primary Chest Wall malignancy as the initial presentation of multiple myeloma. 一个孤立的溶解性肋骨病变模仿原发性胸壁恶性肿瘤作为多发性骨髓瘤的最初表现。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-08-22 eCollection Date: 2026-08-01 DOI: 10.1093/omcr/omag152

İsmail Tombul, Elgün Valiyev, Tuğçe A Akbal Ersöz, Mehmet Zengin

引用次数: 0

E-cigarette or vaping product use-associated lung injury in a postpartum patient: a case report. 产后患者使用电子烟或电子烟产品相关肺损伤：病例报告。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-08-12 eCollection Date: 2026-08-01 DOI: 10.1093/omcr/omag154

Muhammad Usman, Muhammad Uzair Mazhar, Amna Zafar, Laiba Murtaza, Abdul Basit, Jeet Dhaania, Masood Azhar

{"title":"E-cigarette or vaping product use-associated lung injury in a postpartum patient: a case report.","authors":"Muhammad Usman, Muhammad Uzair Mazhar, Amna Zafar, Laiba Murtaza, Abdul Basit, Jeet Dhaania, Masood Azhar","doi":"10.1093/omcr/omag154","DOIUrl":"10.1093/omcr/omag154","url":null,"abstract":"Background: E-cigarette or vaping product use-associated lung injury (EVALI) is characterized by acute respiratory failure and bilateral pulmonary infiltrates. It presents a significant diagnostic challenge, particularly when it mimics common postpartum complications.Case presentation: We describe a 28-year-old female who developed severe hypoxemic respiratory failure four days after a normal vaginal delivery. While initial clinical suspicion focused on obstetric etiologies like flash pulmonary edema or pneumonia, the patient's eventual disclosure of resumed vaping led to a diagnosis of EVALI. Following the administration of systemic corticosteroids, she experienced rapid and complete clinical recovery.Conclusion: This case, one of the first cases of EVALI in the immediate postpartum period, highlights the importance of obtaining comprehensive social history, particularly in a clinical context which broadens the differential diagnosis for unexplained respiratory failure.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 8","pages":"omag154"},"PeriodicalIF":0.6,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MMR deficient dedifferentiated endometrial carcinoma with synchronous uterine leiomyosarcoma: a rare collision tumour-case report and literature review. MMR缺陷型去分化子宫内膜癌合并同步子宫平滑肌肉瘤1例罕见碰撞瘤报告及文献复习。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-08-12 eCollection Date: 2026-08-01 DOI: 10.1093/omcr/omag155

Mohammed Sami Saeed, Hafza Asma Adnan, Adzmi Hakim Rahman, Samiya Ibrahim, Awani Patel

{"title":"MMR deficient dedifferentiated endometrial carcinoma with synchronous uterine leiomyosarcoma: a rare collision tumour-case report and literature review.","authors":"Mohammed Sami Saeed, Hafza Asma Adnan, Adzmi Hakim Rahman, Samiya Ibrahim, Awani Patel","doi":"10.1093/omcr/omag155","DOIUrl":"10.1093/omcr/omag155","url":null,"abstract":"Introduction: Dedifferentiated endometrial carcinoma (DEC) is a rare and aggressive uterine malignancy composed of low-grade endometrioid carcinoma admixed with an undifferentiated component and is associated with a poorer prognosis than conventional high-grade endometrioid carcinoma. Its synchronous occurrence with uterine leiomyosarcoma as a collision tumour is exceptionally rare.Case presentation: A 74-year-old postmenopausal woman presented with abnormal uterine bleeding. Imaging revealed an endometrial mass, and she underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. Histopathological examination demonstrated DEC with subclonal mismatch repair (MMR) deficiency and a morphologically distinct leiomyosarcoma. Immunohistochemistry showed loss of MLH1 and PMS2 expression in approximately 40% of tumour cells within the dedifferentiated component, with retained expression in the low-grade component. MLH1 promoter hypermethylation analysis demonstrated a methylation level of 55%, supporting a sporadic origin. A morphologically and immunophenotypically distinct uterine leiomyosarcoma was identified within the same specimen, consistent with a true collision tumour. The diagnosis was confirmed through comprehensive morphological, immunohistochemical, and molecular analyses. Postoperative imaging demonstrated nodal disease, and the patient subsequently received adjuvant therapy. At 1-year follow-up, she remained in complete remission.Conclusion: This rare collision tumour highlights the importance of integrated histopathological and molecular evaluation, particularly in recognising subclonal MMR deficiency and tumour heterogeneity.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 8","pages":"omag155"},"PeriodicalIF":0.6,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary small-cell neuroendocrine carcinoma of the bladder: a very rare histological subtype. 原发性膀胱小细胞神经内分泌癌：一种非常罕见的组织学亚型。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-08-12 eCollection Date: 2026-08-01 DOI: 10.1093/omcr/omag156

Siham Mesmoudi, Ali Mohammed Miko, Salma Bencheikh, Taha Yassine Aaboudech, Sabrine Derqaoui, Ahmed Jahid, Zakiya Bernoussi, Ayoub Bouhnib, Saad Mesbahi, Ahmed Ibrahimi, Kaoutar Znati

{"title":"Primary small-cell neuroendocrine carcinoma of the bladder: a very rare histological subtype.","authors":"Siham Mesmoudi, Ali Mohammed Miko, Salma Bencheikh, Taha Yassine Aaboudech, Sabrine Derqaoui, Ahmed Jahid, Zakiya Bernoussi, Ayoub Bouhnib, Saad Mesbahi, Ahmed Ibrahimi, Kaoutar Znati","doi":"10.1093/omcr/omag156","DOIUrl":"10.1093/omcr/omag156","url":null,"abstract":"Primary small cell neuroendocrine carcinoma (SCNC) of the bladder is an exceptionally aggressive malignancy. We report the case of an 80-year-old male, a chronic smoker, presenting with an 8-month history of intermittent total hematuria. Cystoscopy revealed a 72 mm mass infiltrating the bladder dome, posterior, and lateral walls. Histopathological analysis of transurethral resection specimens demonstrated a necrotic diffuse proliferation of monomorphic small cells infiltrating the muscularis propria. Immunohistochemistry showed positivity for synaptophysin, chromogranin A, CD56, and TTF1, whereas GATA3 and p63 were negative. The Ki-67 index exceeded 90%. Systemic staging (cT3bN0M0) confirmed the primary bladder origin. Although multimodal management, including neoadjuvant chemotherapy and radical cystoprostatectomy, was recommended, the patient-initiated chemotherapy but declined surgery. Primary bladder SCNC is a highly invasive entity requiring early diagnosis and multidisciplinary care. The diagnosis is strictly anatomopathological. Differentiating this entity from primary pulmonary small cell carcinoma is a critical challenge, making systemic radiological staging mandatory.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 8","pages":"omag156"},"PeriodicalIF":0.6,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TURP-like syndrome without surgery: severe dilutional hyponatraemia following prolonged sterile water bladder washouts for radiation cystitis: a case report. 未经手术的turp样综合征：放射性膀胱炎长期无菌膀胱冲洗后的严重稀释性低钠血症1例报告。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-08-11 eCollection Date: 2026-08-01 DOI: 10.1093/omcr/omag150

Hafiz Awais Javed, Daisy Beard, Christopher Launchbury, Rehan Masood, Amna Zeeshan, Haris Marath

{"title":"TURP-like syndrome without surgery: severe dilutional hyponatraemia following prolonged sterile water bladder washouts for radiation cystitis: a case report.","authors":"Hafiz Awais Javed, Daisy Beard, Christopher Launchbury, Rehan Masood, Amna Zeeshan, Haris Marath","doi":"10.1093/omcr/omag150","DOIUrl":"10.1093/omcr/omag150","url":null,"abstract":"Severe dilutional hyponatraemia is a recognised complication of transurethral resection of the prostate (TURP syndrome) caused by systemic absorption of hypotonic irrigation fluid, but similar events outside the operative setting are rarely reported. We describe a 77-year-old White male with radiation cystitis who underwent 12 days of sterile water bladder washouts alongside continuous 0.9% saline bladder irrigation for persistent haematuria. Serum sodium declined from 132 to 112 mmol/L and improved only after bladder washouts and irrigation were discontinued. Cystoscopy confirmed radiation cystitis with mucosal ulceration. The clinical course strongly suggests that systemic absorption of electrolyte-free sterile water caused the profound hypotonic hyponatraemia, whereas concurrent absorption of isotonic saline contributed to extracellular volume expansion. This case highlights that prolonged sterile water bladder washouts may produce a TURP-like syndrome in the absence of surgery. Early recognition, serial electrolyte monitoring and prompt source control are essential to prevent potentially life-threatening complications.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 8","pages":"omag150"},"PeriodicalIF":0.6,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0