Oxford Medical Case Reports最新文献_第4页

Sevelamer carbonate crystal associated colitis in a hemodialysis patient: a case report. 血液透析患者舍维拉默碳酸盐岩晶体相关性结肠炎1例报告。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-09-14 eCollection Date: 2026-09-01 DOI: 10.1093/omcr/omag175

Omair Bseiso, Ma'moun Qawasmeh, Anas Zahdeh, Obay Isayed, Abrar Omari, Motaz Natsheh

{"title":"Sevelamer carbonate crystal associated colitis in a hemodialysis patient: a case report.","authors":"Omair Bseiso, Ma'moun Qawasmeh, Anas Zahdeh, Obay Isayed, Abrar Omari, Motaz Natsheh","doi":"10.1093/omcr/omag175","DOIUrl":"10.1093/omcr/omag175","url":null,"abstract":"Sevelamer carbonate, a non-calcium phosphate binder widely used in end-stage renal disease (ESRD), is an increasingly recognized but underdiagnosed cause of medication-induced colitis through gastrointestinal crystal deposition. We report a 56-year-old Palestinian male with ESRD on hemodialysis who presented with a one-month history of watery non-bloody diarrhea, vomiting, and diffuse abdominal pain. He had been repeatedly misdiagnosed with amebic colitis and treated with metronidazole without improvement. Colonoscopy revealed diffuse patchy erythema throughout the colon with right-sided predominance. Histopathology confirmed sevelamer-induced active colitis, demonstrating characteristic brownish fish scale-like crystals with active neutrophilic infiltrate. Sevelamer carbonate was discontinued with subsequent clinical improvement. This case highlights a clinically important diagnostic pitfall in resource-limited settings where amebic colitis is endemic and empiric metronidazole is commonly the first-line response to chronic diarrhea in dialysis patients.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 9","pages":"omag175"},"PeriodicalIF":0.6,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148971707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic submucosal dissection for a colorectal tumor with coexisting muscle-retracting sign and underlying diverticulum: the first reported case. 内镜下粘膜下剥离术治疗伴有肌肉收缩征及憩室的结直肠肿瘤：首例报道。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-09-08 eCollection Date: 2026-09-01 DOI: 10.1093/omcr/omag169

Taiji Yoshimoto, Daisuke Matsuyama, Ayaka Nakanishi, Kei Nakatani, Kosuke Nagakura, Hiroo Ishii, Hiroshi Takihara

{"title":"Endoscopic submucosal dissection for a colorectal tumor with coexisting muscle-retracting sign and underlying diverticulum: the first reported case.","authors":"Taiji Yoshimoto, Daisuke Matsuyama, Ayaka Nakanishi, Kei Nakatani, Kosuke Nagakura, Hiroo Ishii, Hiroshi Takihara","doi":"10.1093/omcr/omag169","DOIUrl":"10.1093/omcr/omag169","url":null,"abstract":"Endoscopic submucosal dissection (ESD) for colorectal lesions becomes particularly challenging in the presence of the muscle-retracting sign (MRS), and the risk of perforation is further increased when a diverticulum underlies the lesion. We report a case of ESD for a 25-mm Paris type 0-Is tumor in the sigmoid colon surrounded by multiple diverticula. During ESD, a broad MRS obscured the appropriate submucosal plane. Careful dissection revealed a diverticulum directly beneath the lesion, indicating a focal defect of the muscularis propria. Subsequently, an intraoperative perforation occurred but was immediately detected and successfully closed using endoscopic clips, allowing completion of en bloc resection. Postoperative computed tomography demonstrated minimal free air, and the patient recovered uneventfully with conservative management. This case highlights that even in an extremely high-risk situation involving both an MRS and an underlying diverticulum, careful dissection and prompt endoscopic closure may avoid surgery and achieve curative resection.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 9","pages":"omag169"},"PeriodicalIF":0.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective cTACE to a segment target hepatocellular carcinoma lesion during atezolizumab plus bevacizumab therapy achieving delayed hypovascularization and shrinkage of non-target intrahepatic lesions: a case report. 在阿特唑单抗加贝伐单抗治疗期间，选择性cace治疗肝细胞癌病变，实现延迟低血管化和非靶向肝内病变缩小：一个病例报告。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-09-08 eCollection Date: 2026-09-01 DOI: 10.1093/omcr/omag171

Hidenobu Hara, Hiroaki Matsumoto, Ami Yoshinaga, Hikari Ishii, Kei Onodera, Yoko Henta, Risa Katsumata, Ryosuke Fujii, Harujiro Yamamoto, Tomohisa Ashikawa, Kazuomi Sakaki, Shiori Ito, Takehito Asakawa, Kohei Yoshino, Shinya Sakita

{"title":"Selective cTACE to a segment target hepatocellular carcinoma lesion during atezolizumab plus bevacizumab therapy achieving delayed hypovascularization and shrinkage of non-target intrahepatic lesions: a case report.","authors":"Hidenobu Hara, Hiroaki Matsumoto, Ami Yoshinaga, Hikari Ishii, Kei Onodera, Yoko Henta, Risa Katsumata, Ryosuke Fujii, Harujiro Yamamoto, Tomohisa Ashikawa, Kazuomi Sakaki, Shiori Ito, Takehito Asakawa, Kohei Yoshino, Shinya Sakita","doi":"10.1093/omcr/omag171","DOIUrl":"10.1093/omcr/omag171","url":null,"abstract":"Atezolizumab plus bevacizumab (Atez/Bev) is the standard first-line systemic therapy for unresectable hepatocellular carcinoma (HCC). We report HCC with intrahepatic progression during Atez/Bev in which selective conventional transarterial chemoembolization (cTACE) to a single lesion was followed by non-target lesion shrinkage. An 82-year-old woman with metabolic dysfunction-associated steatotic liver disease was diagnosed with BCLC stage B hepatocellular carcinoma in segments 5/7. After TACE, residual viable tumor persisted in segment 5, and Atez/Bev was initiated. After 4 cycles, a new intrahepatic lesion appeared in segment 8, and after 7 cycles, lesions in segments 5/7/8 enlarged, meeting the mRECIST progressive disease criteria. Systemic therapy continued, and selective cTACE for the segment 5 lesion was added. At 3 months post-cTACE, segment 5 viability decreased, but overall mRECIST remained progressive disease. At 6 months (November 20XX + 1), arterial enhancement in segment 5 resolved and non-target segment 7/8 lesions became hypovascular and shrank, achieving partial response.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 9","pages":"omag171"},"PeriodicalIF":0.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-amoxicillin-induced reactivation of auto-brewery syndrome in a patient treated for community acquired pneumonia: a clinical case report. 社区获得性肺炎患者阿莫西林诱导的自动酿酒综合征再激活：临床病例报告。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-09-08 eCollection Date: 2026-09-01 DOI: 10.1093/omcr/omag167

Philipp Widmer, Flavia A Miesch, Barbara Scotti, Gian Erni, Roland Sperb

引用次数: 0

A jaw-dropping complication of Epilepsia Partialis continua following Opercular seizure. 一种令人瞠目结舌的持续部分性癫痫的并发症。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-09-08 eCollection Date: 2026-09-01 DOI: 10.1093/omcr/omag170

Sunil Munakomi, Naphibanroi Lamar, Ishan Shrestha

引用次数: 0

Retrograde intrarenal surgery in a non-fused left crossed ectopic kidney with large renal calculus: a case report and review of literature. 逆行肾内手术治疗未融合的左交叉异位肾伴大肾结石1例报告及文献复习。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-09-02 eCollection Date: 2026-09-01 DOI: 10.1093/omcr/omag162

Adeel Anwaar, Inam Ul Haq, Abdul Munim Khan, Farooq Hameed, Aymar Akilimali

引用次数: 0

A rare case of choroidal melanoma in Iraq: a case report. 伊拉克一例罕见脉络膜黑色素瘤病例报告。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-09-02 eCollection Date: 2026-09-01 DOI: 10.1093/omcr/omag163

Mohanned H Al-Sallami, Estabraq H Al-Kubaisi, Jawad K Al-Diwan

引用次数: 0

Mixed exocrine-neuroendocrine intraductal papillary mucinous neoplasms of the pancreas: a case series. 胰腺导管内混合性外分泌-神经内分泌乳头状粘液瘤：一个病例系列。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-09-02 eCollection Date: 2026-09-01 DOI: 10.1093/omcr/omag147

Jaimin P Chauhan, Aryan K Sharma, Abed M Zaitoun, Dileep N Lobo

{"title":"Mixed exocrine-neuroendocrine intraductal papillary mucinous neoplasms of the pancreas: a case series.","authors":"Jaimin P Chauhan, Aryan K Sharma, Abed M Zaitoun, Dileep N Lobo","doi":"10.1093/omcr/omag147","DOIUrl":"10.1093/omcr/omag147","url":null,"abstract":"We retrospectively reviewed histopathological and immunohistochemical data from patients with mixed exocrine-neuroendocrine intraductal papillary mucinous neoplasms (IPMNs) of the pancreas identified at a single centre between December 2023 and June 2026. Surgical specimens underwent detailed evaluation, including mucin profiling (MUC1, MUC2, MUC5AC) and neuroendocrine markers (synaptophysin, chromogranin A). Ten patients (median age 68.5 years, range: 31-78 years; 6 male) presented mainly with abdominal pain, weight loss, or jaundice. Most lesions were intestinal type IPMNs with focal or interspersed neuroendocrine components. Mucin expression patterns aligned with established subtype profiles, and neuroendocrine differentiation was confirmed immunohistochemically. Only one of the lesions met the World Health Organization (WHO) criteria for mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) due to the non-invasive IPMN component. This case series highlights a distinct subset of mixed non-invasive IPMN-neuroendocrine tumours not currently recognized in WHO classifications. We propose recognition of this entity to improve diagnostic precision and guide management.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 9","pages":"omag147"},"PeriodicalIF":0.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of anti-nephrin antibody-positive, steroid-dependent nephrotic syndrome with successful discontinuation of immunosuppressants following rituximab. 1例抗肾素抗体阳性，类固醇依赖性肾病综合征成功停用免疫抑制剂后利妥昔单抗。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-09-02 eCollection Date: 2026-09-01 DOI: 10.1093/omcr/omag164

Kota Shinzato, Norifumi Hayashi, Ryoko Akai, Yu Kagaya, Yutaka Hiratuji, Sho Kumano, Kazuaki Okino, Keiji Fujimoto, Takao Iwawaki, Kengo Furuichi

{"title":"A case of anti-nephrin antibody-positive, steroid-dependent nephrotic syndrome with successful discontinuation of immunosuppressants following rituximab.","authors":"Kota Shinzato, Norifumi Hayashi, Ryoko Akai, Yu Kagaya, Yutaka Hiratuji, Sho Kumano, Kazuaki Okino, Keiji Fujimoto, Takao Iwawaki, Kengo Furuichi","doi":"10.1093/omcr/omag164","DOIUrl":"10.1093/omcr/omag164","url":null,"abstract":"Minimal change nephrotic syndrome (MCNS) is a major cause of nephrotic syndrome in children and adults. Recent studies identified circulating anti-nephrin antibodies in 30%-50% of patients, linking them to severe proteinuria and frequent relapses. We describe a Japanese woman in her 40s with steroid-dependent nephrotic syndrome (SDNS). Anti-nephrin antibodies were identified in serum obtained at disease onset by immunoprecipitation and ELISA, and kidney biopsy showed punctate IgG colocalizing with nephrin. Before rituximab (RTX), she experienced relapses accompanied by increased anti-nephrin antibody reactivity. A low-dose RTX regimen (200 mg every 6 months for seven doses) enabled maintenance of complete remission and discontinuation of prednisolone and cyclosporine, with B-cell depletion confirmed by CD19 monitoring. She has maintained remission for two years after RTX discontinuation, without re-elevation of anti-nephrin antibody reactivity. This case supports a possible role of anti-nephrin antibodies in disease activity and suggests that low-dose RTX may contribute to durable remission.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 9","pages":"omag164"},"PeriodicalIF":0.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multisystem FDG-avid sarcoidosis with osseous involvement mimicking disseminated metastatic malignancy. 伴有骨受累的多系统fdg嗜性结节病，模拟播散性转移性恶性肿瘤。

IF 0.6

Oxford Medical Case Reports Pub Date : 2026-09-02 eCollection Date: 2026-09-01 DOI: 10.1093/omcr/omag165

Jamil Wafi, Mohammed Alkhanafsa, Soud Deek, Aya Alqattaa, Mohammed Alkhatib, Bara Wazwaz, Irfan Ul Haq

{"title":"Multisystem FDG-avid sarcoidosis with osseous involvement mimicking disseminated metastatic malignancy.","authors":"Jamil Wafi, Mohammed Alkhanafsa, Soud Deek, Aya Alqattaa, Mohammed Alkhatib, Bara Wazwaz, Irfan Ul Haq","doi":"10.1093/omcr/omag165","DOIUrl":"10.1093/omcr/omag165","url":null,"abstract":"Sarcoidosis may closely mimic disseminated malignancy on FDG-PET/CT because active granulomatous inflammation can demonstrate intense multisystem FDG uptake. We report a 59-year-old woman with previously diagnosed pulmonary sarcoidosis who presented with acute dyspnea and right leg pain and was found to have segmental and subsegmental pulmonary emboli on CT pulmonary angiography. FDG-PET/CT demonstrated extensive intensely hypermetabolic mediastinal, hilar, abdominal and pelvic lymphadenopathy with pulmonary, hepatic, splenic and multifocal osseous involvement, including a right iliac lesion (SUVmax 12.3), raising strong suspicion for disseminated metastatic malignancy or lymphoproliferative disease. CT-guided biopsy of the iliac lesion revealed non-necrotizing granulomatous inflammation without evidence of malignancy or infection, confirming multisystem sarcoidosis with osseous involvement. This case highlights the importance of histological confirmation when FDG-PET/CT findings in sarcoidosis mimic metastatic disease.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2026 9","pages":"omag165"},"PeriodicalIF":0.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0