G-CSF-induced Aortitis in an elderly woman successfully managed with prednisolone: a case report and literature review.

IF 0.4 Q3 MEDICINE, GENERAL & INTERNAL

Oxford Medical Case Reports Pub Date : 2025-08-25 eCollection Date: 2025-08-01 DOI:10.1093/omcr/omaf144

Taeko Kurosawa, Masahiro Ohara, Ayako Nakame, Yuki Ichinose, Akihiro Fujimoto, Asami Nukui, Kei Yamaguchi, Aya Asano, Hiroko Shimada, Hideki Yokogawa, Kazuo Matsuura, Hiroshi Ishiguro, Takahiro Hasebe, Akihiko Osaki, Toshiaki Saeki

{"title":"G-CSF-induced Aortitis in an elderly woman successfully managed with prednisolone: a case report and literature review.","authors":"Taeko Kurosawa, Masahiro Ohara, Ayako Nakame, Yuki Ichinose, Akihiro Fujimoto, Asami Nukui, Kei Yamaguchi, Aya Asano, Hiroko Shimada, Hideki Yokogawa, Kazuo Matsuura, Hiroshi Ishiguro, Takahiro Hasebe, Akihiko Osaki, Toshiaki Saeki","doi":"10.1093/omcr/omaf144","DOIUrl":null,"url":null,"abstract":"<p><p>Cancer incidence among old is increasing. Since age is important risk factor for febrile neutropenia (FN), use of granulocyte-colony stimulating factor (G-CSF) and its complication is clinically important. A 72-year old woman has completed definitive surgery for left breast cancer and was started on postoperative chemotherapy. After 12 doses of paclitaxel, she received 1st cycle of epirubicin and cyclophosphamide (day 1), and pegfilgrastim, a pegylated G-CSF to decrease the risk of FN (day 2). On day 13, she was admitted due to persistent fever since day 9. Laboratory tests revealed elevated neutrophil counts and C-reactive protein. Despite empirical antibiotics, her fever persisted and severe back pain developed (day 15). Contrast-enhanced computed tomography revealed wall thickening and increased density around the aortic arch and brachiocephalic artery. Diagnosis of pegfilgrastim-induced vasculitis was made after excluding autoimmune vasculitis. Prednisolone (60 mg/day) was administered and the fever and back pain subsided the following day.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 8","pages":"omaf144"},"PeriodicalIF":0.4000,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375805/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oxford Medical Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/omcr/omaf144","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Cancer incidence among old is increasing. Since age is important risk factor for febrile neutropenia (FN), use of granulocyte-colony stimulating factor (G-CSF) and its complication is clinically important. A 72-year old woman has completed definitive surgery for left breast cancer and was started on postoperative chemotherapy. After 12 doses of paclitaxel, she received 1st cycle of epirubicin and cyclophosphamide (day 1), and pegfilgrastim, a pegylated G-CSF to decrease the risk of FN (day 2). On day 13, she was admitted due to persistent fever since day 9. Laboratory tests revealed elevated neutrophil counts and C-reactive protein. Despite empirical antibiotics, her fever persisted and severe back pain developed (day 15). Contrast-enhanced computed tomography revealed wall thickening and increased density around the aortic arch and brachiocephalic artery. Diagnosis of pegfilgrastim-induced vasculitis was made after excluding autoimmune vasculitis. Prednisolone (60 mg/day) was administered and the fever and back pain subsided the following day.

Abstract Image

查看原文本刊更多论文

强的松龙成功治疗老年妇女g - csf诱导的主动脉炎：1例报告和文献复习。

老年人的癌症发病率正在上升。由于年龄是发热性中性粒细胞减少症（FN）的重要危险因素，因此使用粒细胞集落刺激因子（G-CSF）及其并发症在临床上具有重要意义。一位72岁的女性完成了左侧乳腺癌的最终手术，并开始术后化疗。12剂紫杉醇后，患者接受第1周期表柔比星和环磷酰胺（第1天）和聚乙二醇化G-CSF聚非格昔汀（第2天），以降低FN的风险。第13天，因第9天持续发热入院。实验室检查显示中性粒细胞计数和c反应蛋白升高。尽管使用经验性抗生素，患者仍持续发热并出现严重背痛（第15天）。增强计算机断层扫描显示主动脉弓和头臂动脉周围壁增厚和密度增加。排除自身免疫性血管炎后诊断为聚非格昔汀所致血管炎。给予强的松龙（60 mg/天），第二天发热和背部疼痛消退。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Oxford Medical Case Reports MEDICINE, GENERAL & INTERNAL-

CiteScore

0.90

自引率

0.00%

发文量

125

审稿时长

19 weeks

期刊介绍： Oxford Medical Case Reports (OMCR) is an open access, peer-reviewed online journal publishing original and educationally valuable case reports that expand the field of medicine. The journal covers all medical specialities including cardiology, rheumatology, nephrology, oncology, neurology, and reproduction, comprising a comprehensive resource for physicians in all fields and at all stages of training. Oxford Medical Case Reports deposits all articles in PubMed Central (PMC). Physicians and researchers can find your work through PubMed , helping you reach the widest possible audience. The journal is also indexed in the Web of Science Core Collection . Oxford Medical Case Reports publishes case reports under the following categories: Allergy Audiovestibular medicine Cardiology and cardiovascular systems Critical care medicine Dermatology Emergency medicine Endocrinology and metabolism Gastroenterology and hepatology Geriatrics and gerontology Haematology Immunology Infectious diseases and tropical medicine Medical disorders in pregnancy Medical ophthalmology Nephrology Neurology Oncology Paediatrics Pain Palliative medicine Pharmacology and pharmacy Psychiatry Radiology, nuclear medicine, and medical imaging Respiratory disorders Rheumatology Sexual and reproductive health Sports Medicine Substance abuse.