{"title":"An unusual presentation of cutaneous sarcoidosis induced by Koebner's phenomenon.","authors":"Maryam Ghaleb, Ouiame El Jouari, Salim Gallouj","doi":"10.1093/omcr/omaf147","DOIUrl":null,"url":null,"abstract":"<p><p>We report an unusual case of cutaneous sarcoidosis presenting as papulonodular lesions strictly localized to the nasal bridge and medial canthus-corresponding to areas of pressure from eyeglass frames. This rare distribution suggests the involvement of Koebner's phenomenon, a form of reactive isomorphism rarely reported in sarcoidosis. The cutaneous lesions, present for four years, led to dermatological evaluation and subsequent histopathological confirmation of sarcoidosis. Biological and radiological investigations further revealed pulmonary involvement, establishing the diagnosis of systemic sarcoidosis. The patient was treated with hydroxychloroquine and intra-lesional corticosteroids, showing marked improvement after three months and no recurrence at six months. This case underscores the importance of recognizing atypical presentations of cutaneous sarcoidosis, which may serve as an early clinical gateway to the diagnosis of systemic disease.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 8","pages":"omaf147"},"PeriodicalIF":0.4000,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375809/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oxford Medical Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/omcr/omaf147","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
We report an unusual case of cutaneous sarcoidosis presenting as papulonodular lesions strictly localized to the nasal bridge and medial canthus-corresponding to areas of pressure from eyeglass frames. This rare distribution suggests the involvement of Koebner's phenomenon, a form of reactive isomorphism rarely reported in sarcoidosis. The cutaneous lesions, present for four years, led to dermatological evaluation and subsequent histopathological confirmation of sarcoidosis. Biological and radiological investigations further revealed pulmonary involvement, establishing the diagnosis of systemic sarcoidosis. The patient was treated with hydroxychloroquine and intra-lesional corticosteroids, showing marked improvement after three months and no recurrence at six months. This case underscores the importance of recognizing atypical presentations of cutaneous sarcoidosis, which may serve as an early clinical gateway to the diagnosis of systemic disease.
期刊介绍:
Oxford Medical Case Reports (OMCR) is an open access, peer-reviewed online journal publishing original and educationally valuable case reports that expand the field of medicine. The journal covers all medical specialities including cardiology, rheumatology, nephrology, oncology, neurology, and reproduction, comprising a comprehensive resource for physicians in all fields and at all stages of training. Oxford Medical Case Reports deposits all articles in PubMed Central (PMC). Physicians and researchers can find your work through PubMed , helping you reach the widest possible audience. The journal is also indexed in the Web of Science Core Collection . Oxford Medical Case Reports publishes case reports under the following categories: Allergy Audiovestibular medicine Cardiology and cardiovascular systems Critical care medicine Dermatology Emergency medicine Endocrinology and metabolism Gastroenterology and hepatology Geriatrics and gerontology Haematology Immunology Infectious diseases and tropical medicine Medical disorders in pregnancy Medical ophthalmology Nephrology Neurology Oncology Paediatrics Pain Palliative medicine Pharmacology and pharmacy Psychiatry Radiology, nuclear medicine, and medical imaging Respiratory disorders Rheumatology Sexual and reproductive health Sports Medicine Substance abuse.